Development Level

Tbio 17 | 10,625
Tchem 3 | 1,890
Tclin 3 | 602

IMPC Term

increased circulating alkaline... 2 | 119
abnormal behavior 1 | 226
abnormal coat appearance 1 | 25
abnormal lens morphology 1 | 73
abnormal posture 1 | 5
abnormal retina morphology 1 | 100
abnormal sleep behavior 1 | 63
absent pinna reflex 1 | 21
decreased circulating HDL chol... 1 | 77
decreased circulating chloride... 1 | 32
decreased circulating fructosa... 1 | 31
decreased circulating serum al... 1 | 79
decreased heart weight 1 | 44
decreased lumbar vertebrae num... 1 | 62
decreased mean corpuscular vol... 1 | 50
hyperactivity 1 | 108
impaired glucose tolerance 1 | 52
increased CD4-positive, CD25-p... 1 | 1
increased NK T cell number 1 | 11
increased circulating HDL chol... 1 | 63
increased circulating LDL chol... 1 | 15
increased circulating choleste... 1 | 53
increased circulating free fat... 1 | 17
increased circulating triglyce... 1 | 24
increased exploration in new e... 1 | 56
increased hematocrit 1 | 36
increased leukocyte cell numbe... 1 | 37
increased sacral vertebrae num... 1 | 62
preweaning lethality, complete... 1 | 633
preweaning lethality, incomple... 1 | 260

Disease

ovarian cancer 13 | 8,484
psoriasis 12 | 6,685
invasive ductal carcinoma 9 | 2,950
osteosarcoma 9 | 7,933
glioblastoma 8 | 5,572
lung cancer 8 | 4,466
medulloblastoma, large-cell 8 | 6,234
oligodendroglioma 8 | 2,849
diabetes mellitus 7 | 1,663
malignant mesothelioma 7 | 3,162
Atherosclerosis 6 | 275
Breast cancer 6 | 3,094
atypical teratoid / rhabdoid tumor 6 | 4,369
ductal carcinoma in situ 6 | 1,745
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,289
lung adenocarcinoma 6 | 2,713
pancreatic cancer 6 | 2,300
Alzheimer's disease 5 | 644
Lipid metabolism disorder 5 | 102
esophageal adenocarcinoma 5 | 737
interstitial cystitis 5 | 2,299
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,956
non-small cell lung cancer 5 | 2,798
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,795
subependymal giant cell astrocytoma 5 | 2,287
Abetalipoproteinemia 4 | 8
Coronary artery disease 4 | 240
Multiple myeloma 4 | 1,327
Obesity 4 | 616
acute quadriplegic myopathy 4 | 1,157
adrenocortical carcinoma 4 | 1,427
adult high grade glioma 4 | 2,148
astrocytic glioma 4 | 2,241
astrocytoma 4 | 1,493
breast carcinoma 4 | 1,614
group 4 medulloblastoma 4 | 1,875
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,988
posterior fossa group A ependymoma 4 | 1,511
tuberculosis 4 | 1,557
Autistic Disorder 3 | 320
Carcinoma 3 | 2,147
Cardiovascular system disease 3 | 194
Fatty Liver 3 | 48
Kidney cancer 3 | 118
Metabolic syndrome X 3 | 155
active Crohn's disease 3 | 918
acute myeloid leukemia 3 | 780
fibroadenoma 3 | 557
head and neck cancer and chronic obstructive pulmonary disease 3 | 237
pediatric high grade glioma 3 | 2,712
pilocytic astrocytoma 3 | 3,086
pituitary cancer 3 | 1,972
posterior fossa group B ependymoma 3 | 1,530
ulcerative colitis 3 | 2,087
Cancer 2 | 2,346
Cardiovascular Diseases 2 | 50
Cerebrovascular disease 2 | 231
Cholestasis 2 | 93
Familial hypercholesterolemia - homozygous 2 | 4
Fatty liver disease 2 | 84
Hypercholesterolemia 2 | 27
Hypercholesterolemia, Familial 2 | 16
Intellectual disability 2 | 573
Lissencephaly 2 | 61
Liver disease 2 | 219
Pick disease 2 | 1,893
Rheumatoid Arthritis 2 | 1,160
Type 2 diabetes mellitus 2 | 189
Vascular disease 2 | 281
Waldenstrons macroglobulinemia 2 | 765
active ulcerative colitis 2 | 477
cystic fibrosis 2 | 1,665
ependymoma 2 | 2,514
group 3 medulloblastoma 2 | 2,254
inflammatory breast cancer 2 | 404
lung carcinoma 2 | 2,844
primary Sjogren syndrome 2 | 789
primary pancreatic ductal adenocarcinoma 2 | 1,271
primitive neuroectodermal tumor 2 | 3,031
spina bifida 2 | 1,064
tuberculosis and treatment for 6 months 2 | 686
Bipolar Disorder 1 | 266
Colonic Neoplasms 1 | 126
Coronary heart disease 1 | 59
Epilepsy 1 | 346
Heart disease 1 | 279
Hypothyroidism 1 | 89
Kidney disease 1 | 396
Liver cancer 1 | 31
Liver carcinoma 1 | 217
Major Depressive Disorder 1 | 106
Neurodegenerative disease 1 | 383
Osteoporosis 1 | 257
Pain agnosia 1 | 99
Peripheral T-cell lymphoma 1 | 24
Steatorrhea 1 | 20
Stomach Neoplasms 1 | 282
Wolff-Parkinson-White syndrome 1 | 11
atypical teratoid/rhabdoid tumor 1 | 1,095
pulmonary arterial hypertension 1 | 36

Tissue

Blood and immune system 23 | 17,995
Cardiovascular System 23 | 17,958
Digestive Tract 23 | 18,473
Endocrine System 23 | 18,512
Liver and Pancreas 23 | 18,136
Nervous System 23 | 18,561
Skin and soft tissues 23 | 18,115
Urinary Tract 23 | 18,444
Female tissues 22 | 18,647
Male tissues 22 | 17,969
Respiratory system 22 | 17,484

Target Family

Non-IDG 16 | 11,971
Enzyme 4 | 4,146
Nuclear Receptor 2 | 48
Kinase 1 | 634

Reactome Pathway

VLDL interactions 23 | 23
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Apolipoprotein C-I APOC1 Tbio Non-IDG -2.37678 252.9 236
AP-2 complex subunit alpha-2 AP2A2 Tbio Non-IDG -0.63932 4.63 109
Apolipoprotein B receptor APOBR Tbio Non-IDG -0.96571 11.5 113
E3 ubiquitin-protein ligase MYLIP MYLIP Tbio Enzyme -2.01928 109.1 122
Proprotein convertase subtilisin/kexin type 9 PCSK9 Tclin Enzyme -3.06315 1328.4 406
Very low-density lipoprotein receptor VLDLR Tbio Non-IDG -2.38706 250.2 235
Lipolysis-stimulated lipoprotein receptor LSR Tbio Non-IDG -1.87069 75.5 79
Reelin RELN Tbio Non-IDG -2.75279 620.5 124
AP-2 complex subunit alpha-1 AP2A1 Tbio Non-IDG -0.45693 2.75 176
Clathrin heavy chain 1 CLTC Tbio Non-IDG -1.60240 36.3 159