Development Level

Tbio 17 | 10,625
Tchem 3 | 1,890
Tclin 3 | 602

IMPC Phenotype

increased circulating alkaline... 2 | 119
abnormal behavior 1 | 226
abnormal coat appearance 1 | 25
abnormal lens morphology 1 | 73
abnormal posture 1 | 5
abnormal retina morphology 1 | 100
abnormal sleep behavior 1 | 63
absent pinna reflex 1 | 21
decreased circulating HDL chol... 1 | 77
decreased circulating chloride... 1 | 32
decreased circulating fructosa... 1 | 31
decreased circulating serum al... 1 | 79
decreased heart weight 1 | 44
decreased lumbar vertebrae num... 1 | 62
decreased mean corpuscular vol... 1 | 50
hyperactivity 1 | 108
impaired glucose tolerance 1 | 52
increased CD4-positive, CD25-p... 1 | 1
increased NK T cell number 1 | 11
increased circulating HDL chol... 1 | 63
increased circulating LDL chol... 1 | 15
increased circulating choleste... 1 | 53
increased circulating free fat... 1 | 17
increased circulating triglyce... 1 | 24
increased exploration in new e... 1 | 56
increased hematocrit 1 | 36
increased leukocyte cell numbe... 1 | 37
increased sacral vertebrae num... 1 | 62
preweaning lethality, complete... 1 | 633
preweaning lethality, incomple... 1 | 260

Disease

ovarian cancer 13 | 8,491
psoriasis 12 | 6,685
invasive ductal carcinoma 9 | 2,950
osteosarcoma 9 | 7,933
glioblastoma 8 | 5,572
lung cancer 8 | 4,473
medulloblastoma, large-cell 8 | 6,234
oligodendroglioma 8 | 2,849
diabetes mellitus 7 | 1,663
malignant mesothelioma 7 | 3,163
Atherosclerosis 6 | 275
Breast cancer 6 | 3,098
atypical teratoid / rhabdoid tumor 6 | 4,369
ductal carcinoma in situ 6 | 1,745
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,289
lung adenocarcinoma 6 | 2,714
pancreatic cancer 6 | 2,300
Alzheimer's disease 5 | 644
Lipid metabolism disorder 5 | 102
esophageal adenocarcinoma 5 | 737
interstitial cystitis 5 | 2,299
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,956
non-small cell lung cancer 5 | 2,798
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,795
subependymal giant cell astrocytoma 5 | 2,287
Abetalipoproteinemia 4 | 8
Coronary artery disease 4 | 240
Multiple myeloma 4 | 1,327
Obesity 4 | 616
acute quadriplegic myopathy 4 | 1,157
adrenocortical carcinoma 4 | 1,427
adult high grade glioma 4 | 2,148
astrocytic glioma 4 | 2,241
astrocytoma 4 | 1,493
breast carcinoma 4 | 1,614
group 4 medulloblastoma 4 | 1,875
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,988
posterior fossa group A ependymoma 4 | 1,511
tuberculosis 4 | 1,563
Autistic Disorder 3 | 320
Carcinoma 3 | 2,147
Cardiovascular system disease 3 | 194
Fatty Liver 3 | 48
Kidney cancer 3 | 121
Metabolic syndrome X 3 | 155
active Crohn's disease 3 | 918
acute myeloid leukemia 3 | 785
fibroadenoma 3 | 557
head and neck cancer and chronic obstructive pulmonary disease 3 | 237
pediatric high grade glioma 3 | 2,712
pilocytic astrocytoma 3 | 3,086
pituitary cancer 3 | 1,972
posterior fossa group B ependymoma 3 | 1,530
ulcerative colitis 3 | 2,087
Cancer 2 | 2,346
Cardiovascular Diseases 2 | 50
Cerebrovascular disease 2 | 231
Cholestasis 2 | 93
Familial hypercholesterolemia - homozygous 2 | 4
Fatty liver disease 2 | 86
Hypercholesterolemia 2 | 27
Hypercholesterolemia, Familial 2 | 18
Intellectual disability 2 | 573
Lissencephaly 2 | 61
Liver disease 2 | 219
Pick disease 2 | 1,893
Rheumatoid Arthritis 2 | 1,170
Type 2 diabetes mellitus 2 | 192
Vascular disease 2 | 281
Waldenstrons macroglobulinemia 2 | 764
active ulcerative colitis 2 | 477
cystic fibrosis 2 | 1,670
ependymoma 2 | 2,514
group 3 medulloblastoma 2 | 2,254
inflammatory breast cancer 2 | 404
lung carcinoma 2 | 2,844
primary Sjogren syndrome 2 | 788
primary pancreatic ductal adenocarcinoma 2 | 1,271
primitive neuroectodermal tumor 2 | 3,031
spina bifida 2 | 1,064
tuberculosis and treatment for 6 months 2 | 686
Adult T-Cell Lymphoma/Leukemia 1 | 30
Animal Mammary Neoplasms 1 | 135
Bipolar Disorder 1 | 266
Coronary heart disease 1 | 59
Depressive disorder 1 | 48
Drug-Induced Liver Injury 1 | 118
Hyperparathyroidism 1 | 43
Leber congenital amaurosis 1 | 72
Liver cancer 1 | 31
Major Depressive Disorder 1 | 106
Mammary Neoplasms, Experimental 1 | 149
Motor neuron disease 1 | 39
Neurodegenerative disease 1 | 383
Osteoporosis 1 | 259
Pain agnosia 1 | 99
Peripheral T-cell lymphoma 1 | 24
Steatorrhea 1 | 20
Wolff-Parkinson-White syndrome 1 | 11
interstitial lung disease 1 | 292

Tissue

Blood and immune system 23 | 17,994
Cardiovascular System 23 | 17,957
Digestive Tract 23 | 18,472
Endocrine System 23 | 18,511
Liver and Pancreas 23 | 18,135
Nervous System 23 | 18,560
Skin and soft tissues 23 | 18,114
Urinary Tract 23 | 18,443
Female tissues 22 | 18,646
Male tissues 22 | 17,968
Respiratory system 22 | 17,483

Target Family

Non-IDG 16 | 11,969
Enzyme 4 | 4,146
Nuclear Receptor 2 | 48
Kinase 1 | 634

Reactome Pathway

VLDL interactions 23 | 23
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Apolipoprotein B receptor APOBR Tbio Non-IDG -1.00321 11.5 113
AP-2 complex subunit beta AP2B1 Tbio Non-IDG -1.90682 75.1 192
AP-2 complex subunit sigma AP2S1 Tbio Non-IDG -1.39116 24.9 96
Clathrin heavy chain 1 CLTC Tbio Non-IDG -1.63705 36.3 159
AP-2 complex subunit alpha-2 AP2A2 Tbio Non-IDG -0.63932 4.63 109
Oxysterols receptor LXR-alpha NR1H3 Tchem Nuclear Receptor -2.16015 115.5 347
Disabled homolog 1 DAB1 Tbio Non-IDG -0.36015 3.38 368
Clathrin light chain A CLTA Tbio Non-IDG -1.30759 15.1 159
Apolipoprotein C-I APOC1 Tbio Non-IDG -2.38515 252.9 236
Protein disulfide-isomerase P4HB Tbio Enzyme -2.98685 952.9 340