Development Level

Tbio 132 | 10,625
Tchem 69 | 1,890
Tclin 43 | 602
Tdark 6 | 7,003

Collection

Eligible Ion Channel Proteins 1 | 117

IMPC Term

preweaning lethality, complete... 13 | 633
decreased body weight 7 | 174
decreased total body fat amoun... 7 | 186
decreased circulating HDL chol... 5 | 77
decreased circulating choleste... 5 | 85
embryonic lethality prior to t... 5 | 187
abnormal bone structure 4 | 131
abnormal embryo size 4 | 112
decreased bone mineral content 4 | 157
decreased circulating alanine ... 4 | 53
decreased lean body mass 4 | 195
enlarged heart 4 | 111
abnormal behavior 3 | 226
abnormal retina morphology 3 | 100
abnormal retinal pigmentation 3 | 61
decreased kidney weight 3 | 7
decreased lumbar vertebrae num... 3 | 62
thrombocytopenia 3 | 46
abnormal coat/hair pigmentatio... 2 | 54
abnormal cornea morphology 2 | 24
abnormal forebrain development 2 | 18
abnormal hindbrain development 2 | 24
abnormal midbrain development 2 | 22
abnormal neural tube closure 2 | 37
abnormal seminal vesicle morph... 2 | 47
cataract 2 | 26
decreased body length 2 | 108
decreased circulating LDL chol... 2 | 37
decreased circulating glucose ... 2 | 121
decreased circulating serum al... 2 | 79
decreased circulating sodium l... 2 | 18
decreased circulating total pr... 2 | 41
decreased circulating triglyce... 2 | 83
decreased grip strength 2 | 123
decreased heart weight 2 | 44
decreased lactate dehydrogenas... 2 | 14
decreased neutrophil cell numb... 2 | 37
decreased rib number 2 | 59
decreased spleen weight 2 | 13
decreased thoracic vertebrae n... 2 | 7
impaired pupillary reflex 2 | 14
increased bone mineral content 2 | 92
increased circulating HDL chol... 2 | 63
increased circulating alkaline... 2 | 119
increased circulating phosphat... 2 | 24
increased lean body mass 2 | 107
increased startle reflex 2 | 38
male infertility 2 | 62
abnormal QRS complex 1 | 25
abnormal body wall morphology 1 | 7
abnormal gait 1 | 51
abnormal hair growth 1 | 8
abnormal head morphology 1 | 10
abnormal lens morphology 1 | 73
abnormal rib morphology 1 | 28
absent pinna reflex 1 | 21
absent startle reflex 1 | 15
cardiovascular system phenotyp... 1 | 35
corneal opacity 1 | 25
decreased caudal vertebrae num... 1 | 49
decreased circulating bilirubi... 1 | 14
decreased circulating calcium ... 1 | 33
decreased circulating chloride... 1 | 32
decreased circulating potassiu... 1 | 17
decreased effector memory CD8-... 1 | 24
decreased eosinophil cell numb... 1 | 41
decreased exploration in new e... 1 | 9
decreased prepulse inhibition 1 | 52
dilated heart left ventricle 1 | 10
embryonic lethality prior to o... 1 | 148
enlarged lymph nodes 1 | 27
female infertility 1 | 34
hypoactivity 1 | 89
impaired righting response 1 | 19
increased blood urea nitrogen ... 1 | 44
increased body length 1 | 20
increased body weight 1 | 42
increased circulating alanine ... 1 | 11
increased circulating aspartat... 1 | 17
increased circulating chloride... 1 | 43
increased circulating fructosa... 1 | 11
increased circulating iron lev... 1 | 25
increased circulating potassiu... 1 | 31
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 24
increased exploration in new e... 1 | 56
increased grip strength 1 | 83
increased mean corpuscular vol... 1 | 91
increased mean platelet volume 1 | 19
increased or absent threshold ... 1 | 128
increased respiratory quotient 1 | 12
increased sacral vertebrae num... 1 | 62
increased total body fat amoun... 1 | 57
limb grasping 1 | 35
prenatal lethality prior to he... 1 | 64
rough coat 1 | 1
short tibia 1 | 82
sparse hair 1 | 6
tremors 1 | 34
vertebral fusion 1 | 23

Disease

ovarian cancer 144 | 8,484
osteosarcoma 133 | 7,933
glioblastoma 112 | 5,572
psoriasis 105 | 6,685
Cancer 104 | 2,346
medulloblastoma, large-cell 101 | 6,234
lung cancer 98 | 4,466
atypical teratoid / rhabdoid tumor 74 | 4,369
Breast cancer 64 | 3,094
pilocytic astrocytoma 64 | 3,086
malignant mesothelioma 63 | 3,162
oligodendroglioma 60 | 2,849
Carcinoma 58 | 2,147
intraductal papillary-mucinous neoplasm (IPMN) 58 | 3,289
invasive ductal carcinoma 57 | 2,950
lung adenocarcinoma 57 | 2,713
ependymoma 55 | 2,514
pediatric high grade glioma 55 | 2,712
subependymal giant cell astrocytoma 51 | 2,287
lung carcinoma 49 | 2,844
astrocytic glioma 48 | 2,241
interstitial cystitis 48 | 2,299
Multiple myeloma 46 | 1,327
non-small cell lung cancer 46 | 2,798
ulcerative colitis 45 | 2,087
primitive neuroectodermal tumor 44 | 3,031
intraductal papillary-mucinous adenoma (IPMA) 42 | 2,956
pancreatic cancer 42 | 2,300
intraductal papillary-mucinous carcinoma (IPMC) 40 | 2,988
cystic fibrosis 36 | 1,665
tuberculosis 35 | 1,557
astrocytoma 34 | 1,493
diabetes mellitus 34 | 1,663
pituitary cancer 34 | 1,972
group 3 medulloblastoma 33 | 2,254
group 4 medulloblastoma 33 | 1,875
Pick disease 31 | 1,893
Rheumatoid Arthritis 31 | 1,160
ductal carcinoma in situ 29 | 1,745
medulloblastoma 29 | 1,524
breast carcinoma 28 | 1,614
pancreatic ductal adenocarcinoma liver metastasis 28 | 1,795
adult high grade glioma 25 | 2,148
colon cancer 25 | 1,475
primary pancreatic ductal adenocarcinoma 25 | 1,271
Mammary Neoplasms 22 | 410
Schizophrenia 21 | 501
Waldenstrons macroglobulinemia 21 | 765
posterior fossa group B ependymoma 20 | 1,530
dermatomyositis 19 | 933
juvenile dermatomyositis 19 | 1,189
non-small cell lung carcinoma 19 | 413
spina bifida 19 | 1,064
Intellectual disability 18 | 573
Parkinson's disease 18 | 364
adrenocortical carcinoma 18 | 1,427
cutaneous lupus erythematosus 18 | 1,056
gastric carcinoma 18 | 832
posterior fossa group A ependymoma 18 | 1,511
HIV Infections 17 | 100
Prostatic Neoplasms 17 | 471
atypical teratoid/rhabdoid tumor 17 | 1,095
esophageal adenocarcinoma 17 | 737
Autistic Disorder 16 | 320
Lung Neoplasms 16 | 171
Liver carcinoma 15 | 217
Renal Cell Carcinoma 15 | 199
Stomach Neoplasms 15 | 282
non primary Sjogren syndrome sicca 15 | 840
Alzheimer's disease 14 | 644
Heart disease 14 | 279
Myocardial Ischemia 14 | 169
Neoplasm Invasiveness 14 | 127
Obesity 14 | 616
primary Sjogren syndrome 14 | 789
sonic hedgehog group medulloblastoma 14 | 1,482
Anemia 13 | 252
Animal Mammary Neoplasms 13 | 136
Asthma 13 | 349
Down syndrome 13 | 548
Mammary Neoplasms, Experimental 13 | 150
Noonan Syndrome 13 | 33
Osteoporosis 13 | 257
hepatocellular carcinoma 13 | 532
tuberculosis and treatment for 6 months 13 | 686
Atherosclerosis 12 | 275
Atopic dermatitis 12 | 944
Diarrhea 12 | 155
Melanoma 12 | 261
Peripheral Neuropathy 12 | 303
Polycystic Ovary Syndrome 12 | 332
Thrombocytopenia 12 | 105
Vascular disease 12 | 281
fibroadenoma 12 | 557
mucosa-associated lymphoid tissue lymphoma 12 | 480
pancreatic carcinoma 12 | 567
Crohn's disease 11 | 304
acute myeloid leukemia 11 | 780
acute quadriplegic myopathy 11 | 1,157
inflammatory breast cancer 11 | 404

Tissue

Endocrine System 250 | 18,512
Female tissues 250 | 18,647
Nervous System 250 | 18,561
Digestive Tract 249 | 18,473
Urinary Tract 249 | 18,444
Liver and Pancreas 248 | 18,136
Blood and immune system 247 | 17,995
Skin and soft tissues 247 | 18,115
Cardiovascular System 246 | 17,958
Male tissues 245 | 17,969
Respiratory system 241 | 17,484

Target Family

Non-IDG 118 | 11,971
Enzyme 81 | 4,146
Kinase 43 | 634
Ion Channel 8 | 341

Reactome Pathway

VEGFR2 mediated cell prolifera... 250 | 250
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Glial cell line-derived neurotrophic factor GDNF Tbio Non-IDG -3.30206 2301.5 303
Fibroblast growth factor 5 FGF5 Tbio Non-IDG -2.00731 99.9 143
Calcium/calmodulin-dependent protein kinase type II subunit alpha CAMK2A Tchem Kinase -1.76384 47.5 542
Fibrinogen alpha chain FGA Tbio Non-IDG -2.84597 716.2 457
Adenosylhomocysteinase 2 AHCYL1 Tchem Enzyme -1.57893 43.2 102
Beta-arrestin-1 ARRB1 Tchem Non-IDG -2.54226 366.3 416
Interleukin-2 receptor subunit beta IL2RB Tclin Non-IDG -2.08442 120.9 537
Beta-klotho KLB Tbio Enzyme -1.89423 69.9 47
Fibronectin FN1 Tchem Non-IDG -3.04098 1121.3 1253