Development Level

Tchem 10 | 1,388
Tclin 4 | 612
Tbio 3 | 11,651

IMPC Phenotype

preweaning lethality, complete... 2 | 979
preweaning lethality, incomple... 2 | 499
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal embryo size 1 | 220
abnormal femur morphology 1 | 14
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
increased circulating alanine ... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating aspartat... 1 | 15
increased circulating glucose ... 1 | 24
increased circulating iron lev... 1 | 30
prenatal lethality 1 | 28
short tibia 1 | 97
small epididymis 1 | 3

Disease

ovarian cancer 15 | 8,520
Carcinoma 14 | 11,493
Cancer 13 | 2,499
lung cancer 12 | 4,740
glioblastoma 11 | 5,792
osteosarcoma 11 | 7,950
psoriasis 10 | 6,694
Breast cancer 9 | 3,578
Kidney cancer 9 | 2,613
lung adenocarcinoma 9 | 2,716
atypical teratoid / rhabdoid tumor 8 | 5,112
ependymoma 8 | 4,679
medulloblastoma, large-cell 8 | 6,241
astrocytic glioma 7 | 2,597
group 3 medulloblastoma 7 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,291
subependymal giant cell astrocytoma 7 | 2,287
Astrocytoma, Pilocytic 6 | 3,081
adult high grade glioma 6 | 3,801
tuberculosis 6 | 2,010
Breast Neoplasms 5 | 445
Cardiomegaly 5 | 116
Colorectal Neoplasms 5 | 243
Heart disease 5 | 306
Hemangioma 5 | 69
Hemangiosarcoma 5 | 18
Liver cancer 5 | 604
Mammary Neoplasms 5 | 425
Noonan syndrome 5 | 34
Schizophrenia 5 | 1,160
Stomach Neoplasms 5 | 300
cystic fibrosis 5 | 1,696
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
invasive ductal carcinoma 5 | 2,951
oligodendroglioma 5 | 2,850
primitive neuroectodermal tumor 5 | 3,035
ulcerative colitis 5 | 1,819
Autosomal recessive predisposition 4 | 1,442
Basal cell carcinoma 4 | 54
Basal cell nevi 4 | 23
Bipolar Disorder 4 | 666
Carcinoma, Squamous Cell 4 | 110
Dull intelligence 4 | 645
Endometrial cancer 4 | 311
Exanthem 4 | 37
Intellectual disability 4 | 1,016
Low intelligence 4 | 645
Melanoma 4 | 711
Mental Retardation 4 | 645
Mental deficiency 4 | 645
Muscle hypotonia 4 | 571
Neoplasms, Experimental 4 | 40
Papillary thyroid carcinoma 4 | 43
Pick disease 4 | 1,894
Poor school performance 4 | 645
Rhabdomyosarcoma 4 | 39
Rheumatoid arthritis 4 | 1,191
Seizures 4 | 596
Squamous cell carcinoma 4 | 129
group 4 medulloblastoma 4 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
lung carcinoma 4 | 2,843
malignant mesothelioma 4 | 3,232
Abnormality of vision 3 | 40
Adenocarcinoma 3 | 122
Alopecia 3 | 115
Asymmetric growth 3 | 5
Bleeding tendency 3 | 37
Capillary hemangioma 3 | 12
Cardiac Arrhythmia 3 | 103
Cardiac conduction abnormalities 3 | 78
Cerebellar hypoplasia and atrophy 3 | 41
Conduction disorder of the heart 3 | 79
DOID:2627 3 | 94
Decreased to absent deep tendon reflexes 3 | 42
Dental abnormalities 3 | 60
Diabetes Mellitus, Experimental 3 | 108
Downward slant of palpebral fissure 3 | 158
EKG abnormalities 3 | 78
Electrocardiogram abnormal 3 | 81
Electrocardiogram change 3 | 78
Frequent fractures 3 | 53
Generalized osteopenia 3 | 99
Hemangioma, Cavernous 3 | 20
Horseshoe Kidney 3 | 16
Hypopigmentation disorder 3 | 25
Ichthyoses 3 | 41
Increased fracture rate 3 | 53
Irregular hyperpigmentation 3 | 33
Kyphoscoliosis deformity of spine 3 | 60
Melanocytic nevus 3 | 43
Noncancerous mole 3 | 28
Osteopenia 3 | 99
Prominent back of the head 3 | 21
Prominent occiput 3 | 21
Renal Cell Carcinoma 3 | 214
Sebaceous adenoma 3 | 26
Telecanthus 3 | 62
Tooth Abnormalities 3 | 69
Varying degree of multiple fractures 3 | 53

Tissue

Blood and immune system 17 | 16,909
Cardiovascular System 17 | 15,192
Digestive Tract 17 | 17,369
Endocrine System 17 | 18,159
Female tissues 17 | 17,400
Liver and Pancreas 17 | 16,750
Male tissues 17 | 17,142
Nervous System 17 | 16,725
Respiratory system 17 | 16,393
Skin and soft tissues 17 | 17,230
Urinary Tract 17 | 16,678

Target Family

Kinase 8 | 634
Enzyme 5 | 4,145
Ion Channel 3 | 344
Non-IDG 1 | 12,091

Reactome Pathway

VEGFR2 mediated cell prolifera... 17 | 17
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ras GTPase-activating protein 1 RASA1 Tbio Enzyme -2.61637 404.4 402
Sphingosine kinase 1 SPHK1 Tchem Kinase -2.72994 583.6 518
Vascular endothelial growth factor A VEGFA Tclin Non-IDG -4.27197 19076.6 1809
3-phosphoinositide-dependent protein kinase 1 PDPK1 Tchem Kinase -2.12025 204.9 608
Proto-oncogene tyrosine-protein kinase Src SRC Tclin Kinase -4.00292 9201.7 1455
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 PLCG1 Tchem Enzyme -2.90339 786.2 846
Protein kinase C zeta type PRKCZ Tchem Kinase -2.13834 126.9 626
Protein kinase C delta type PRKCD Tclin Kinase -2.18452 141.4 804
Protein kinase C beta type PRKCB Tchem Kinase -2.00437 93.5 598
GTPase KRas KRAS Tbio Enzyme -3.80300 6069.9 574