Development Level

Tbio 44 | 11,445
Tchem 39 | 1,598
Tclin 10 | 613

Collection

Kinase: IDG Consortium (Target... 3 | 125
RFA-RM-18-021 3 | 328

IMPC Phenotype

preweaning lethality, complete... 7 | 979
preweaning lethality, incomple... 5 | 499
abnormal bone structure 3 | 187
abnormal embryo size 3 | 220
abnormal retina morphology 3 | 71
embryonic lethality prior to t... 3 | 278
increased circulating alkaline... 3 | 122
increased lean body mass 3 | 172
increased mean corpuscular hem... 3 | 96
abnormal behavior 2 | 298
abnormal bone mineralization 2 | 38
abnormal cornea morphology 2 | 31
anophthalmia 2 | 33
decreased blood urea nitrogen ... 2 | 51
decreased body weight 2 | 161
decreased circulating LDL chol... 2 | 38
decreased circulating amylase ... 2 | 28
decreased circulating creatini... 2 | 39
decreased circulating triglyce... 2 | 79
decreased fasted circulating g... 2 | 65
decreased total body fat amoun... 2 | 207
edema 2 | 59
embryonic lethality prior to o... 2 | 239
increased bone mineral content 2 | 108
increased circulating LDL chol... 2 | 13
increased circulating glucose ... 2 | 24
increased circulating iron lev... 2 | 30
increased grip strength 2 | 41
increased hemoglobin content 2 | 45
increased spleen weight 2 | 10
increased total body fat amoun... 2 | 134
prenatal lethality 2 | 28
short tibia 2 | 97
small testis 2 | 58
abnormal clavicle morphology 1 | 6
abnormal cranium morphology 1 | 36
abnormal eye morphology 1 | 68
abnormal femur morphology 1 | 14
abnormal glucose homeostasis 1 | 4
abnormal head morphology 1 | 10
abnormal heart morphology 1 | 162
abnormal iris morphology 1 | 13
abnormal iris pigmentation 1 | 4
abnormal joint morphology 1 | 23
abnormal lens morphology 1 | 81
abnormal optic disc morphology 1 | 10
abnormal seminal vesicle morph... 1 | 114
abnormal skin morphology 1 | 50
abnormal snout morphology 1 | 23
abnormal startle reflex 1 | 15
abnormal stomach morphology 1 | 10
abnormal testis morphology 1 | 43
absent urinary bladder 1 | 1
cataract 1 | 92
decreased bone mineral content 1 | 151
decreased circulating alanine ... 1 | 47
decreased circulating bilirubi... 1 | 19
decreased circulating choleste... 1 | 93
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased circulating phosphat... 1 | 27
decreased circulating potassiu... 1 | 20
decreased circulating serum al... 1 | 82
decreased coping response 1 | 8
decreased heart left ventricle... 1 | 28
decreased hematocrit 1 | 46
decreased neutrophil cell numb... 1 | 42
decreased spleen weight 1 | 10
dilated heart left ventricle 1 | 11
embryonic growth retardation 1 | 106
enlarged heart 1 | 210
enlarged kidney 1 | 14
impaired righting response 1 | 26
increased blood urea nitrogen ... 1 | 48
increased body length 1 | 32
increased bone mineral density 1 | 72
increased cardiac stroke volum... 1 | 1
increased circulating alanine ... 1 | 13
increased circulating amylase ... 1 | 25
increased circulating aspartat... 1 | 15
increased circulating choleste... 1 | 66
increased circulating potassiu... 1 | 29
increased circulating triglyce... 1 | 42
increased heart rate 1 | 23
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular vol... 1 | 92
increased mean platelet volume 1 | 45
increased neutrophil cell numb... 1 | 46
increased startle reflex 1 | 112
male infertility 1 | 123
mammalian phenotype 1 | 17
persistence of hyaloid vascula... 1 | 33
prenatal lethality prior to he... 1 | 87
shortened RR interval 1 | 17
small epididymis 1 | 3
stereotypic behavior 1 | 3
thin ventricular wall 1 | 24
thrombocytopenia 1 | 56
thrombocytosis 1 | 27
trunk curl 1 | 16

Disease

Carcinoma 74 | 11,493
ovarian cancer 64 | 8,520
osteosarcoma 59 | 7,950
glioblastoma 52 | 5,792
Cancer 48 | 2,499
medulloblastoma, large-cell 41 | 6,241
psoriasis 41 | 6,694
lung cancer 39 | 4,740
atypical teratoid / rhabdoid tumor 37 | 5,112
ependymoma 36 | 4,679
Breast cancer 33 | 3,578
Astrocytoma, Pilocytic 30 | 3,081
Kidney cancer 30 | 2,613
adult high grade glioma 28 | 3,801
invasive ductal carcinoma 28 | 2,951
intraductal papillary-mucinous neoplasm (IPMN) 27 | 3,291
group 3 medulloblastoma 26 | 4,104
subependymal giant cell astrocytoma 26 | 2,287
diabetes mellitus 23 | 1,728
interstitial cystitis 23 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 23 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 23 | 2,989
non-small cell lung cancer 23 | 2,890
tuberculosis 23 | 2,010
pancreatic cancer 22 | 2,398
primitive neuroectodermal tumor 22 | 3,035
lung carcinoma 21 | 2,843
oligodendroglioma 21 | 2,850
lung adenocarcinoma 20 | 2,716
astrocytic glioma 19 | 2,597
group 4 medulloblastoma 19 | 1,855
ulcerative colitis 19 | 1,819
Schizophrenia 17 | 1,160
cystic fibrosis 17 | 1,696
malignant mesothelioma 16 | 3,232
Autosomal recessive predisposition 15 | 1,442
Pick disease 15 | 1,894
Breast Neoplasms 14 | 445
Intellectual disability 14 | 1,016
Liver Cirrhosis, Experimental 14 | 769
Mammary Neoplasms 14 | 425
pancreatic ductal adenocarcinoma liver metastasis 14 | 1,962
pituitary cancer 14 | 1,972
Hypertension 13 | 396
Rheumatoid arthritis 13 | 1,191
Stomach Neoplasms 13 | 300
Waldenstrons macroglobulinemia 13 | 765
breast carcinoma 13 | 1,638
colon cancer 13 | 1,478
juvenile dermatomyositis 13 | 1,187
Kidney disease 12 | 430
Prostatic Neoplasms 12 | 495
ductal carcinoma in situ 12 | 1,745
Heart disease 11 | 306
Melanoma 11 | 711
Renal Cell Carcinoma 11 | 214
adrenocortical carcinoma 11 | 1,428
Bipolar Disorder 10 | 666
Dull intelligence 10 | 645
Endometrial cancer 10 | 311
Epilepsy 10 | 792
Low intelligence 10 | 645
Mental Retardation 10 | 645
Mental deficiency 10 | 645
Obesity 10 | 678
Poor school performance 10 | 645
Seizures 10 | 596
pancreatic carcinoma 10 | 562
primary pancreatic ductal adenocarcinoma 10 | 1,109
Alzheimer's disease 9 | 658
Atherosclerosis 9 | 291
Carcinoma, Hepatocellular 9 | 228
Cardiomegaly 9 | 116
Colorectal Neoplasms 9 | 243
Hepatomegaly 9 | 285
Hypertensive disease 9 | 292
Liver cancer 9 | 604
Liver carcinoma 9 | 240
Multiple myeloma 9 | 1,332
Neoplasm Metastasis 9 | 168
Vascular disease 9 | 319
acute quadriplegic myopathy 9 | 1,158
astrocytoma 9 | 1,146
cutaneous lupus erythematosus 9 | 1,057
pediatric high grade glioma 9 | 1,064
Arthritis 8 | 290
Carcinoma, Squamous Cell 8 | 110
Diabetes Mellitus, Experimental 8 | 108
Malabsorption 8 | 82
Skin cancer 8 | 469
Splenomegaly 8 | 190
Squamous cell carcinoma 8 | 129
dermatomyositis 8 | 966
esophageal adenocarcinoma 8 | 737
medulloblastoma 8 | 720
spina bifida 8 | 1,074
Cognitive delay 7 | 608
Glaucoma 7 | 239
Global developmental delay 7 | 608
Mental and motor retardation 7 | 608

Tissue

Endocrine System 92 | 18,159
Male tissues 92 | 17,142
Blood and immune system 91 | 16,909
Cardiovascular System 91 | 15,192
Digestive Tract 91 | 17,369
Female tissues 91 | 17,400
Liver and Pancreas 91 | 16,750
Nervous System 91 | 16,725
Respiratory system 91 | 16,393
Skin and soft tissues 91 | 17,230
Urinary Tract 91 | 16,678

Target Family

Non-IDG 43 | 12,091
Kinase 34 | 634
Enzyme 12 | 4,145
Ion Channel 4 | 344

Reactome Pathway

VEGFA-VEGFR2 Pathway 93 | 93
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Rapamycin-insensitive companion of mTOR RICTOR Tbio Non-IDG -2.79454 597.0 440
Rho-associated protein kinase 1 ROCK1 Tclin Kinase -2.64622 378.2 461
Protein kinase C beta type PRKCB Tchem Kinase -2.00437 93.5 598
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328
SHC-transforming protein 2 SHC2 Tbio Non-IDG -2.47843 293.4 113
Cytochrome b-245 heavy chain CYBB Tchem Ion Channel -3.09698 1276.8 315
Wiskott-Aldrich syndrome protein family member 2 WASF2 Tbio Non-IDG -2.90666 762.6 254
Heat shock protein beta-1 HSPB1 Tchem Non-IDG -2.97780 974.9 1992