Development Level

Tbio 171 | 10,625
Tchem 98 | 1,890
Tclin 46 | 602
Tdark 6 | 7,003

Collection

Kinase: IDG Consortium (Targets) 3 | 125
Kinase: IDG Consortium (Complete/Control) 1 | 37

IMPC Phenotype

preweaning lethality, complete... 16 | 633
decreased body weight 9 | 174
decreased total body fat amoun... 8 | 186
abnormal bone structure 6 | 131
abnormal embryo size 6 | 112
decreased bone mineral content 6 | 157
decreased circulating choleste... 6 | 85
decreased lean body mass 6 | 195
embryonic lethality prior to t... 6 | 187
decreased circulating HDL chol... 5 | 77
decreased lumbar vertebrae num... 5 | 62
abnormal retina morphology 4 | 100
decreased circulating LDL chol... 4 | 37
decreased circulating alanine ... 4 | 53
decreased circulating triglyce... 4 | 83
enlarged heart 4 | 111
increased mean corpuscular hem... 4 | 93
abnormal behavior 3 | 226
abnormal bone mineralization 3 | 55
abnormal retinal pigmentation 3 | 61
cataract 3 | 26
decreased body length 3 | 108
decreased grip strength 3 | 123
decreased kidney weight 3 | 7
increased bone mineral content 3 | 92
increased circulating alkaline... 3 | 119
increased grip strength 3 | 83
male infertility 3 | 62
thrombocytopenia 3 | 46
abnormal coat-hair pigmentatio... 2 | 54
abnormal cornea morphology 2 | 24
abnormal forebrain development 2 | 18
abnormal head morphology 2 | 10
abnormal hindbrain development 2 | 24
abnormal lens morphology 2 | 73
abnormal midbrain development 2 | 22
abnormal neural tube closure 2 | 37
abnormal seminal vesicle morph... 2 | 47
decreased blood urea nitrogen ... 2 | 31
decreased caudal vertebrae num... 2 | 49
decreased circulating bilirubi... 2 | 14
decreased circulating creatini... 2 | 31
decreased circulating glucose ... 2 | 121
decreased circulating insulin ... 2 | 75
decreased circulating potassiu... 2 | 17
decreased circulating serum al... 2 | 79
decreased circulating sodium l... 2 | 18
decreased circulating total pr... 2 | 41
decreased fasted circulating g... 2 | 49
decreased heart weight 2 | 44
decreased lactate dehydrogenas... 2 | 14
decreased neutrophil cell numb... 2 | 37
decreased rib number 2 | 59
decreased spleen weight 2 | 13
decreased thoracic vertebrae n... 2 | 7
dilated heart left ventricle 2 | 10
impaired pupillary reflex 2 | 14
impaired righting response 2 | 19
increased blood urea nitrogen ... 2 | 44
increased body length 2 | 20
increased circulating HDL chol... 2 | 63
increased circulating LDL chol... 2 | 15
increased circulating iron lev... 2 | 25
increased circulating phosphat... 2 | 24
increased circulating potassiu... 2 | 31
increased hemoglobin content 2 | 45
increased lean body mass 2 | 107
increased sacral vertebrae num... 2 | 62
increased startle reflex 2 | 38
prenatal lethality prior to he... 2 | 64
preweaning lethality, incomple... 2 | 260
short tibia 2 | 82
abnormal body wall morphology 1 | 7
abnormal gait 1 | 51
abnormal respiratory quotient 1 | 9
abnormal rib morphology 1 | 28
abnormal startle reflex 1 | 14
absent pinna reflex 1 | 21
corneal opacity 1 | 25
decreased NK cell number 1 | 16
decreased bone mineral density 1 | 126
decreased circulating calcium ... 1 | 33
decreased circulating chloride... 1 | 32
decreased effector memory CD8-... 1 | 24
decreased eosinophil cell numb... 1 | 41
decreased exploration in new e... 1 | 9
decreased total retina thickne... 1 | 20
female infertility 1 | 34
increased bone mineral density 1 | 52
increased circulating choleste... 1 | 53
increased effector memory CD4-... 1 | 15
increased mean corpuscular vol... 1 | 91
increased mean platelet volume 1 | 19
limb grasping 1 | 35
persistence of hyaloid vascula... 1 | 22
prenatal lethality 1 | 16
stereotypic behavior 1 | 3
tremors 1 | 34
trunk curl 1 | 15
vertebral fusion 1 | 23

Disease

ovarian cancer 189 | 8,491
osteosarcoma 178 | 7,933
glioblastoma 146 | 5,572
psoriasis 135 | 6,685
Cancer 134 | 2,346
medulloblastoma, large-cell 132 | 6,234
lung cancer 122 | 4,473
atypical teratoid / rhabdoid tumor 101 | 4,369
pilocytic astrocytoma 87 | 3,086
Breast cancer 83 | 3,098
Carcinoma 79 | 2,147
invasive ductal carcinoma 79 | 2,950
intraductal papillary-mucinous neoplasm (IPMN) 76 | 3,289
ependymoma 74 | 2,514
oligodendroglioma 74 | 2,849
pediatric high grade glioma 73 | 2,712
malignant mesothelioma 72 | 3,163
subependymal giant cell astrocytoma 68 | 2,287
lung adenocarcinoma 67 | 2,714
interstitial cystitis 66 | 2,299
lung carcinoma 66 | 2,844
non-small cell lung cancer 63 | 2,798
intraductal papillary-mucinous adenoma (IPMA) 60 | 2,956
primitive neuroectodermal tumor 60 | 3,031
astrocytic glioma 59 | 2,241
pancreatic cancer 59 | 2,300
ulcerative colitis 58 | 2,087
intraductal papillary-mucinous carcinoma (IPMC) 57 | 2,988
Multiple myeloma 54 | 1,327
diabetes mellitus 51 | 1,663
tuberculosis 47 | 1,563
cystic fibrosis 46 | 1,670
group 4 medulloblastoma 46 | 1,875
medulloblastoma 45 | 1,524
pituitary cancer 45 | 1,972
group 3 medulloblastoma 42 | 2,254
Pick disease 41 | 1,893
astrocytoma 41 | 1,493
ductal carcinoma in situ 39 | 1,745
Rheumatoid Arthritis 38 | 1,170
pancreatic ductal adenocarcinoma liver metastasis 38 | 1,795
breast carcinoma 37 | 1,614
adult high grade glioma 35 | 2,148
colon cancer 35 | 1,475
primary pancreatic ductal adenocarcinoma 33 | 1,271
Mammary Neoplasms 31 | 410
Waldenstrons macroglobulinemia 31 | 764
juvenile dermatomyositis 30 | 1,189
Schizophrenia 28 | 503
adrenocortical carcinoma 28 | 1,427
cutaneous lupus erythematosus 26 | 1,056
posterior fossa group A ependymoma 26 | 1,511
Intellectual disability 25 | 573
Prostatic Neoplasms 25 | 471
dermatomyositis 25 | 966
posterior fossa group B ependymoma 25 | 1,530
non-small cell lung carcinoma 24 | 413
Parkinson's disease 23 | 364
esophageal adenocarcinoma 23 | 737
spina bifida 23 | 1,064
Alzheimer's disease 22 | 644
gastric carcinoma 22 | 832
Liver carcinoma 21 | 217
Obesity 21 | 616
Renal Cell Carcinoma 21 | 199
atypical teratoid/rhabdoid tumor 21 | 1,095
Heart disease 20 | 279
Kidney disease 20 | 397
Lung Neoplasms 20 | 171
Stomach Neoplasms 20 | 282
Vascular disease 20 | 281
non primary Sjogren syndrome sicca 20 | 840
tuberculosis and treatment for 6 months 20 | 686
Atherosclerosis 19 | 275
Autistic Disorder 19 | 320
HIV Infections 19 | 99
pancreatic carcinoma 19 | 567
sonic hedgehog group medulloblastoma 18 | 1,482
Myocardial Ischemia 17 | 169
Neoplasm Invasiveness 17 | 127
acute quadriplegic myopathy 17 | 1,157
hepatocellular carcinoma 17 | 550
primary Sjogren syndrome 17 | 788
Asthma 16 | 349
Down syndrome 16 | 548
Osteoporosis 16 | 259
acute myeloid leukemia 16 | 785
autosomal dominant Emery-Dreifuss muscular dystrophy 16 | 499
mucosa-associated lymphoid tissue lymphoma 16 | 480
Atopic dermatitis 15 | 944
Hypertension 15 | 293
IGA Glomerulonephritis 15 | 454
Melanoma 15 | 261
nasopharyngeal carcinoma 15 | 1,056
Arthritis 14 | 248
Crohn's disease 14 | 304
Duchenne muscular dystrophy 14 | 602
Polycystic Ovary Syndrome 14 | 334
fibroadenoma 14 | 557
gastric cancer 14 | 436

Tissue

Endocrine System 321 | 18,511
Female tissues 321 | 18,646
Nervous System 321 | 18,560
Digestive Tract 320 | 18,472
Urinary Tract 320 | 18,443
Liver and Pancreas 319 | 18,135
Blood and immune system 318 | 17,994
Cardiovascular System 317 | 17,957
Skin and soft tissues 317 | 18,114
Male tissues 316 | 17,968
Respiratory system 312 | 17,483

Target Family

Non-IDG 159 | 11,969
Enzyme 86 | 4,146
Kinase 67 | 634
Ion Channel 9 | 341

Reactome Pathway

VEGFA-VEGFR2 Pathway 321 | 321
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.86495 767.9 361
Receptor tyrosine-protein kinase erbB-2 ERBB2 Tclin Kinase -4.25806 19000.3 3336
Ras/Rap GTPase-activating protein SynGAP SYNGAP1 Tbio Enzyme -1.86167 72.3 167
Ras GTPase-activating protein nGAP RASAL2 Tbio Enzyme -1.50499 28.6 91
Serine/threonine-protein kinase B-raf BRAF Tclin Kinase -2.28702 199.1 1276
Fibroblast growth factor receptor substrate 3 FRS3 Tbio Non-IDG -0.89335 9.09 133
GTPase KRas KRAS Tbio Enzyme -3.77389 5694.2 421
Pro-epidermal growth factor EGF Tbio Non-IDG -3.74596 4837.7 851
Ras GTPase-activating protein 4 RASA4 Tbio Enzyme -2.46005 289.6 46
Granulocyte-macrophage colony-stimulating factor receptor subunit alpha CSF2RA Tclin Non-IDG -2.15518 132.8 381