Development Level

Tbio 14 | 11,445
Tchem 8 | 1,598
Tclin 5 | 613

IMPC Phenotype

preweaning lethality, complete... 2 | 979
abnormal gait 1 | 69
abnormal snout morphology 1 | 23
abnormal vibrissa morphology 1 | 25
brachydactyly 1 | 19
decreased body weight 1 | 161
decreased circulating creatini... 1 | 39
decreased circulating insulin ... 1 | 76
decreased total body fat amoun... 1 | 207
embryonic lethality prior to t... 1 | 278
increased erythrocyte cell num... 1 | 39
increased grip strength 1 | 41
increased total body fat amoun... 1 | 134
male infertility 1 | 123
preweaning lethality, incomple... 1 | 499
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36

Disease

Carcinoma 20 | 11,493
glioblastoma 17 | 5,792
ovarian cancer 17 | 8,520
ependymoma 16 | 4,679
medulloblastoma, large-cell 16 | 6,241
adult high grade glioma 14 | 3,801
lung cancer 14 | 4,740
oligodendroglioma 13 | 2,850
osteosarcoma 13 | 7,950
Cancer 12 | 2,499
atypical teratoid / rhabdoid tumor 12 | 5,112
Astrocytoma, Pilocytic 11 | 3,081
group 3 medulloblastoma 11 | 4,104
psoriasis 11 | 6,694
subependymal giant cell astrocytoma 10 | 2,287
Pick disease 9 | 1,894
astrocytic glioma 9 | 2,597
lung carcinoma 9 | 2,843
Botulism 8 | 24
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,291
primitive neuroectodermal tumor 8 | 3,035
malignant mesothelioma 7 | 3,232
pancreatic cancer 7 | 2,398
Multiple myeloma 6 | 1,332
Schizophrenia 6 | 1,160
interstitial cystitis 6 | 2,312
ulcerative colitis 6 | 1,819
Breast cancer 5 | 3,578
Diarrhea 5 | 253
Epilepsy 5 | 792
Neurodegenerative disease 5 | 414
non-small cell lung cancer 5 | 2,890
Blepharoptosis 4 | 231
Diphtheria 4 | 40
Kidney cancer 4 | 2,613
Vascular disease 4 | 319
Waldenstrons macroglobulinemia 4 | 765
acute quadriplegic myopathy 4 | 1,158
astrocytoma 4 | 1,146
cystic fibrosis 4 | 1,696
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
invasive ductal carcinoma 4 | 2,951
juvenile dermatomyositis 4 | 1,187
lung adenocarcinoma 4 | 2,716
tuberculosis 4 | 2,010
Alzheimer's disease 3 | 658
Breast Neoplasms 3 | 445
Cardiofaciocutaneous syndrome 3 | 15
Cognitive delay 3 | 608
Colorectal Neoplasms 3 | 243
Costello Syndrome 3 | 17
Degenerative polyarthritis 3 | 115
Dysarthria 3 | 192
Global developmental delay 3 | 608
Intellectual disability 3 | 1,016
Major Depressive Disorder 3 | 301
Mammary Neoplasms 3 | 425
Mental and motor retardation 3 | 608
Noonan syndrome 3 | 34
Nystagmus 3 | 317
Osteoarthritis 3 | 184
Parkinson's disease 3 | 392
Tetanus 3 | 68
Unipolar Depression 3 | 250
breast carcinoma 3 | 1,638
dermatomyositis 3 | 966
ductal carcinoma in situ 3 | 1,745
gastric cancer 3 | 459
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
pancreatic carcinoma 3 | 562
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
pituitary cancer 3 | 1,972
Big calvaria 2 | 147
Cardiomyopathy 2 | 116
Coarse facial features 2 | 108
Congenital myasthenic syndrome 2 | 25
Frontal bossing 2 | 157
High forehead 2 | 102
Hypertrophic Cardiomyopathy 2 | 117
Ichthyoses 2 | 41
Increased head circumference 2 | 147
Increased size of cranium 2 | 147
Increased size of skull 2 | 147
Large auricle 2 | 87
Large dysplastic ears 2 | 87
Large pinnae 2 | 87
Large prominent ears 2 | 87
Large protruding ears 2 | 87
Large, floppy ears 2 | 87
Macrotia 2 | 87
Osteoporosis 2 | 363
Premature Birth 2 | 77
Premature birth of newborn 2 | 67
Skin hyperelastic 2 | 32
Sparse hair 2 | 59
Tall forehead 2 | 102
Thickened facial skin with coarse facial features 2 | 108
Thin, sparse hair 2 | 59
Underdeveloped brows 2 | 38
Underdeveloped supraorbital ridges 2 | 38

Tissue

Digestive Tract 27 | 17,369
Female tissues 27 | 17,400
Liver and Pancreas 27 | 16,750
Male tissues 27 | 17,142
Skin and soft tissues 27 | 17,230
Urinary Tract 27 | 16,678
Blood and immune system 26 | 16,909
Endocrine System 26 | 18,159
Nervous System 26 | 16,725
Respiratory system 25 | 16,393
Cardiovascular System 24 | 15,192

Target Family

Non-IDG 18 | 12,091
Kinase 7 | 634
Enzyme 2 | 4,145

Reactome Pathway

Uptake and actions of bacteria... 27 | 27
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Na(+)/H(+) exchange regulatory cofactor NHE-RF4 PDZD3 Tbio Non-IDG -0.76581 6.17 121
Programmed cell death 6-interacting protein PDCD6IP Tbio Non-IDG -1.59404 35.1 216
Synaptotagmin-2 SYT2 Tbio Non-IDG -1.93503 86.7 222
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Heat-stable enterotoxin receptor GUCY2C Tclin Kinase -2.33494 214.5 228
Elongation factor 2 EEF2 Tchem Non-IDG -2.95619 938.4 363
Thioredoxin reductase 1, cytoplasmic TXNRD1 Tclin Enzyme -2.28524 208.2 308
Dual specificity mitogen-activated protein kinase kinase 4 MAP2K4 Tchem Kinase -2.43646 236.7 998
Synaptic vesicle glycoprotein 2B SV2B Tbio Non-IDG -1.20339 12.5 100
Dual specificity mitogen-activated protein kinase kinase 7 MAP2K7 Tchem Kinase -3.66356 3766.3 513