Development Level

Tbio 68 | 11,178
Tchem 17 | 1,885
Tdark 8 | 6,569
Tclin 1 | 612

IMPC Phenotype

preweaning lethality, complete... 13 | 979
embryonic lethality prior to t... 7 | 278
embryonic lethality prior to o... 5 | 239
decreased body weight 4 | 161
decreased lean body mass 3 | 135
decreased total body fat amoun... 3 | 207
increased total body fat amoun... 3 | 134
abnormal retina morphology 2 | 71
decreased body length 2 | 101
decreased circulating glucose ... 2 | 126
decreased circulating insulin ... 2 | 76
decreased hemoglobin content 2 | 68
decreased red blood cell distr... 2 | 41
enlarged heart 2 | 210
increased circulating HDL chol... 2 | 80
increased heart weight 2 | 62
increased lean body mass 2 | 172
prenatal lethality prior to he... 2 | 87
abnormal behavior 1 | 298
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal coat-hair pigmentatio... 1 | 64
abnormal embryo size 1 | 220
abnormal forebrain development 1 | 20
abnormal gait 1 | 69
abnormal head morphology 1 | 10
abnormal heart morphology 1 | 162
abnormal hindbrain development 1 | 16
abnormal kidney morphology 1 | 65
abnormal neural tube closure 1 | 46
abnormal seminal vesicle morph... 1 | 114
abnormal startle reflex 1 | 15
abnormal vitreous body morphol... 1 | 10
decreased IgG1 level 1 | 8
decreased T cell number 1 | 15
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating amylase ... 1 | 28
decreased circulating choleste... 1 | 93
decreased circulating glycerol... 1 | 16
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased grip strength 1 | 116
decreased hematocrit 1 | 46
decreased lymphocyte cell numb... 1 | 83
decreased spleen weight 1 | 10
decreased vertical activity 1 | 208
hyperactivity 1 | 148
increased bone mineral density 1 | 72
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased circulating creatini... 1 | 38
increased circulating fructosa... 1 | 13
increased circulating triglyce... 1 | 42
increased grip strength 1 | 41
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased or absent threshold ... 1 | 101
increased startle reflex 1 | 112
mammalian phenotype 1 | 17
short tibia 1 | 97
vertebral fusion 1 | 23

Disease

ovarian cancer 60 | 8,297
Carcinoma 56 | 11,192
osteosarcoma 56 | 7,766
psoriasis 41 | 6,514
glioblastoma 39 | 5,635
atypical teratoid / rhabdoid tumor 32 | 4,971
medulloblastoma, large-cell 31 | 6,086
lung cancer 30 | 4,607
pancreatic ductal adenocarcinoma liver metastasis 27 | 1,911
group 3 medulloblastoma 26 | 4,002
ependymoma 24 | 4,559
adult high grade glioma 22 | 3,701
Multiple myeloma 21 | 1,296
diabetes mellitus 21 | 1,683
non-small cell lung cancer 19 | 2,799
Cancer 18 | 2,388
Astrocytoma, Pilocytic 17 | 3,006
Breast cancer 17 | 3,469
lung adenocarcinoma 16 | 2,627
Autosomal recessive predisposition 15 | 1,407
acute quadriplegic myopathy 15 | 1,133
malignant mesothelioma 15 | 3,135
invasive ductal carcinoma 14 | 2,867
lung carcinoma 14 | 2,755
pancreatic cancer 14 | 2,322
tuberculosis 14 | 1,963
astrocytoma 13 | 1,113
intraductal papillary-mucinous neoplasm (IPMN) 13 | 3,204
subependymal giant cell astrocytoma 13 | 2,230
astrocytic glioma 12 | 2,530
intraductal papillary-mucinous carcinoma (IPMC) 12 | 2,902
juvenile dermatomyositis 12 | 1,147
group 4 medulloblastoma 11 | 1,806
primitive neuroectodermal tumor 11 | 2,957
Pick disease 10 | 1,856
Rheumatoid arthritis 10 | 1,156
colon cancer 10 | 1,428
pituitary cancer 10 | 1,915
Bipolar Disorder 9 | 646
Kidney cancer 9 | 2,548
Obesity 9 | 655
active Crohn's disease 9 | 882
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,872
non primary Sjogren syndrome sicca 9 | 861
oligodendroglioma 9 | 2,768
ulcerative colitis 9 | 1,765
Alzheimer's disease 8 | 640
Neurodegenerative disease 8 | 402
Vascular disease 8 | 294
dermatomyositis 8 | 941
hepatocellular carcinoma 8 | 536
Cognitive delay 7 | 596
Global developmental delay 7 | 596
Mental and motor retardation 7 | 596
Prostatic Neoplasms 7 | 472
spina bifida 7 | 1,053
Cerebral atrophy 6 | 175
Intellectual disability 6 | 998
acute myeloid leukemia 6 | 760
autosomal dominant Emery-Dreifuss muscular dystrophy 6 | 492
breast carcinoma 6 | 1,589
esophageal adenocarcinoma 6 | 696
interstitial cystitis 6 | 2,237
pediatric high grade glioma 6 | 1,035
periodontitis 6 | 280
Depressive disorder 5 | 401
Epilepsy 5 | 775
Feeding difficulties 5 | 127
Multiple Sclerosis 5 | 527
Muscle hypotonia 5 | 562
Neurogenic Muscular Atrophy 5 | 136
Neurogenic muscle atrophy, especially in the lower limbs 5 | 136
Polycystic ovary syndrome 5 | 348
Schizophrenia 5 | 1,136
Short stature 5 | 514
Skeletal muscle atrophy 5 | 136
Waldenstrons macroglobulinemia 5 | 742
adrenocortical carcinoma 5 | 1,385
cystic fibrosis 5 | 1,629
gastric cancer 5 | 445
muscle degeneration 5 | 136
pancreatic carcinoma 5 | 555
Byzanthine arch palate 4 | 194
Coronary artery disease 4 | 253
Duchenne muscular dystrophy 4 | 587
Dull intelligence 4 | 634
Dysarthria 4 | 190
Failure to gain weight 4 | 359
Intrauterine retardation 4 | 174
Low intelligence 4 | 634
Mental deficiency 4 | 634
Motor delay 4 | 144
No development of motor milestones 4 | 144
Parkinson's disease 4 | 378
Pediatric failure to thrive 4 | 359
Poor school performance 4 | 634
Small head 4 | 366
active ulcerative colitis 4 | 736
ductal carcinoma in situ 4 | 1,686
progressive supranuclear palsy 4 | 656

Tissue

Blood and immune system 94 | 16,909
Digestive Tract 94 | 17,369
Endocrine System 94 | 18,159
Female tissues 94 | 17,400
Liver and Pancreas 94 | 16,750
Nervous System 94 | 16,725
Urinary Tract 94 | 16,678
Male tissues 93 | 17,142
Respiratory system 93 | 16,393
Skin and soft tissues 93 | 17,230
Cardiovascular System 92 | 15,192

Target Family

Non-IDG 42 | 12,091
Enzyme 32 | 4,145
Transcription Factor 15 | 1,400
Kinase 3 | 634
Epigenetic 2 | 242

Reactome Pathway

Unfolded Protein Response (UPR... 94 | 94
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
ATP-dependent DNA helicase DDX11 DDX11 Tbio Enzyme -1.05592 30.0 163
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform PPP2R5B Tbio Enzyme -0.59131 2.64 81
Protein YIF1A YIF1A Tdark Non-IDG -1.22548 14.6 29
DnaJ homolog subfamily B member 9 DNAJB9 Tbio Non-IDG -2.07766 122.1 167
Cyclic AMP-responsive element-binding protein 3-like protein 4 CREB3L4 Tbio Transcription Factor -1.64875 47.6 188
Exostosin-like 2 EXTL2 Tbio Enzyme -1.08858 13.8 124
E3 ubiquitin-protein ligase synoviolin SYVN1 Tbio Enzyme -1.52336 36.2 267
Exosome complex component RRP41 EXOSC4 Tbio Enzyme -1.96200 85.3 113
Cyclic AMP-responsive element-binding protein 3-like protein 3 CREB3L3 Tbio Transcription Factor -1.51965 41.5 33
Cyclic AMP-dependent transcription factor ATF-3 ATF3 Tbio Transcription Factor -2.67021 520.8 401