Development Level

Tbio 60 | 10,625
Tchem 17 | 1,890
Tdark 8 | 7,003
Tclin 1 | 602

IMPC Term

preweaning lethality, complete... 10 | 633
embryonic lethality prior to t... 6 | 187
embryonic lethality prior to o... 5 | 148
decreased body weight 4 | 174
abnormal bone mineralization 2 | 55
decreased body length 2 | 108
decreased lean body mass 2 | 195
decreased total body fat amoun... 2 | 186
enlarged heart 2 | 111
prenatal lethality prior to he... 2 | 64
preweaning lethality, incomple... 2 | 260
short tibia 2 | 82
abnormal behavior 1 | 226
abnormal bone structure 1 | 131
abnormal coat/hair pigmentatio... 1 | 54
abnormal embryo size 1 | 112
abnormal forebrain development 1 | 18
abnormal gait 1 | 51
abnormal head morphology 1 | 10
abnormal heart morphology 1 | 51
abnormal hindbrain development 1 | 24
abnormal kidney morphology 1 | 30
abnormal lens morphology 1 | 73
abnormal neural tube closure 1 | 37
abnormal retina morphology 1 | 100
abnormal retinal pigmentation 1 | 61
abnormal seminal vesicle morph... 1 | 47
abnormal startle reflex 1 | 14
absent vibrissae 1 | 14
decreased IgG1 level 1 | 4
decreased T cell number 1 | 31
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 49
decreased circulating choleste... 1 | 85
decreased circulating glucose ... 1 | 121
decreased circulating glycerol... 1 | 19
decreased circulating insulin ... 1 | 75
decreased circulating total pr... 1 | 41
decreased circulating triglyce... 1 | 83
decreased effector memory CD4-... 1 | 6
decreased erythrocyte cell num... 1 | 43
decreased grip strength 1 | 123
decreased hemoglobin content 1 | 53
decreased lumbar vertebrae num... 1 | 62
decreased mean corpuscular hem... 1 | 19
decreased mean corpuscular vol... 1 | 50
decreased spleen weight 1 | 13
decreased threshold for audito... 1 | 32
hyperactivity 1 | 108
increased circulating HDL chol... 1 | 63
increased circulating choleste... 1 | 53
increased circulating creatini... 1 | 29
increased circulating fructosa... 1 | 11
increased grip strength 1 | 83
increased heart weight 1 | 37
increased lean body mass 1 | 107
increased mean corpuscular vol... 1 | 91
increased or absent threshold ... 1 | 128
increased sacral vertebrae num... 1 | 62
increased total body fat amoun... 1 | 57
shortened head 1 | 2
vertebral fusion 1 | 23

Disease

ovarian cancer 61 | 8,484
osteosarcoma 55 | 7,933
psoriasis 39 | 6,685
glioblastoma 38 | 5,572
lung cancer 28 | 4,466
medulloblastoma, large-cell 28 | 6,234
atypical teratoid / rhabdoid tumor 27 | 4,369
pancreatic ductal adenocarcinoma liver metastasis 25 | 1,795
diabetes mellitus 22 | 1,663
Multiple myeloma 21 | 1,327
Cancer 19 | 2,346
non-small cell lung cancer 18 | 2,798
pediatric high grade glioma 17 | 2,712
astrocytoma 16 | 1,493
group 3 medulloblastoma 16 | 2,254
lung adenocarcinoma 15 | 2,713
lung carcinoma 15 | 2,844
malignant mesothelioma 15 | 3,162
pancreatic cancer 15 | 2,300
pilocytic astrocytoma 15 | 3,086
Breast cancer 14 | 3,094
acute quadriplegic myopathy 14 | 1,157
ependymoma 13 | 2,514
group 4 medulloblastoma 13 | 1,875
invasive ductal carcinoma 13 | 2,950
intraductal papillary-mucinous neoplasm (IPMN) 12 | 3,289
subependymal giant cell astrocytoma 12 | 2,287
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,988
juvenile dermatomyositis 11 | 1,189
colon cancer 10 | 1,475
pituitary cancer 10 | 1,972
tuberculosis 10 | 1,557
Rheumatoid Arthritis 9 | 1,160
adult high grade glioma 9 | 2,148
astrocytic glioma 9 | 2,241
non primary Sjogren syndrome sicca 9 | 840
primitive neuroectodermal tumor 9 | 3,031
Neurodegenerative disease 8 | 383
Obesity 8 | 616
Pick disease 8 | 1,893
Prostatic Neoplasms 8 | 471
active Crohn's disease 8 | 918
dermatomyositis 8 | 933
hepatocellular carcinoma 8 | 532
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,956
oligodendroglioma 8 | 2,849
ulcerative colitis 8 | 2,087
Vascular disease 7 | 281
cystic fibrosis 7 | 1,665
interstitial cystitis 7 | 2,299
posterior fossa group A ependymoma 7 | 1,511
posterior fossa group B ependymoma 7 | 1,530
Alzheimer's disease 6 | 644
acute myeloid leukemia 6 | 780
adrenocortical carcinoma 6 | 1,427
esophageal adenocarcinoma 6 | 737
spina bifida 6 | 1,064
Liver carcinoma 5 | 217
Polycystic Ovary Syndrome 5 | 332
Waldenstrons macroglobulinemia 5 | 765
autosomal dominant Emery-Dreifuss muscular dystrophy 5 | 499
breast carcinoma 5 | 1,614
medulloblastoma 5 | 1,524
pancreatic carcinoma 5 | 567
primary pancreatic ductal adenocarcinoma 5 | 1,271
Atherosclerosis 4 | 275
Barrett's esophagus 4 | 183
Bipolar Disorder 4 | 266
Carcinoma 4 | 2,147
Duchenne muscular dystrophy 4 | 602
Hypertension 4 | 287
Kidney disease 4 | 396
Multiple Sclerosis 4 | 498
Peripheral Neuropathy 4 | 303
X-linked cerebral adrenoleukodystrophy 4 | 115
gastric cancer 4 | 430
gastric carcinoma 4 | 832
periodontitis 4 | 269
progressive supranuclear palsy 4 | 674
sarcoidosis 4 | 358
sonic hedgehog group medulloblastoma 4 | 1,482
Cerebrovascular disease 3 | 231
Coronary artery disease 3 | 240
Down syndrome 3 | 548
Endometriosis 3 | 535
Epilepsy 3 | 346
Heart disease 3 | 279
IGA Glomerulonephritis 3 | 454
Inflammatory bowel disease 3 | 142
Metabolic syndrome X 3 | 155
Myocardial Ischemia 3 | 169
Parkinson's disease 3 | 364
Status Epilepticus 3 | 85
adrenocortical adenoma 3 | 134
aldosterone-producing adenoma 3 | 664
atypical teratoid/rhabdoid tumor 3 | 1,095
inflammatory breast cancer 3 | 404
mucosa-associated lymphoid tissue lymphoma 3 | 480
nasopharyngeal carcinoma 3 | 1,056
tuberculosis and treatment for 6 months 3 | 686

Tissue

Blood and immune system 86 | 17,995
Cardiovascular System 86 | 17,958
Digestive Tract 86 | 18,473
Endocrine System 86 | 18,512
Female tissues 86 | 18,647
Liver and Pancreas 86 | 18,136
Male tissues 86 | 17,969
Nervous System 86 | 18,561
Respiratory system 86 | 17,484
Skin and soft tissues 86 | 18,115
Urinary Tract 86 | 18,444

Target Family

Non-IDG 40 | 11,971
Enzyme 31 | 4,146
Transcription Factor 10 | 1,400
Kinase 3 | 634
Epigenetic 2 | 242

Reactome Pathway

Unfolded Protein Response (UPR... 86 | 86
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Endoplasmin HSP90B1 Tchem Non-IDG -2.72785 604.5 748
m7GpppN-mRNA hydrolase DCP2 Tbio Enzyme -1.89749 80.7 139
Protein transport protein Sec61 subunit alpha isoform 1 SEC61A1 Tbio Non-IDG -2.43916 280.2 94
78 kDa glucose-regulated protein HSPA5 Tchem Non-IDG -3.28487 2003.3 918
Protein transport protein Sec61 subunit gamma SEC61G Tdark Non-IDG -0.37727 2.21 27
Glycogen synthase kinase-3 alpha GSK3A Tclin Kinase -1.81647 52.3 722
Exostosin-like 3 EXTL3 Tbio Enzyme -2.64135 453.0 177
Hepatoma-derived growth factor HDGF Tbio Epigenetic -2.04271 125.7 182
C-C motif chemokine 2 CCL2 Tchem Non-IDG -3.79323 6604.2 1001
Wolframin WFS1 Tbio Non-IDG -2.36163 250.2 110