Development Level

Tbio 72 | 11,445
Tchem 13 | 1,598
Tdark 8 | 6,588
Tclin 1 | 613

IMPC Phenotype

preweaning lethality, complete... 13 | 979
embryonic lethality prior to t... 7 | 278
embryonic lethality prior to o... 5 | 239
decreased body weight 4 | 161
decreased lean body mass 3 | 135
decreased total body fat amoun... 3 | 207
increased total body fat amoun... 3 | 134
abnormal retina morphology 2 | 71
decreased body length 2 | 101
decreased circulating glucose ... 2 | 126
decreased circulating insulin ... 2 | 76
decreased hemoglobin content 2 | 68
decreased red blood cell distr... 2 | 41
enlarged heart 2 | 210
increased circulating HDL chol... 2 | 80
increased heart weight 2 | 62
increased lean body mass 2 | 172
prenatal lethality prior to he... 2 | 87
abnormal behavior 1 | 298
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal coat-hair pigmentatio... 1 | 64
abnormal embryo size 1 | 220
abnormal forebrain development 1 | 20
abnormal gait 1 | 69
abnormal head morphology 1 | 10
abnormal heart morphology 1 | 162
abnormal hindbrain development 1 | 16
abnormal kidney morphology 1 | 65
abnormal neural tube closure 1 | 46
abnormal seminal vesicle morph... 1 | 114
abnormal startle reflex 1 | 15
abnormal vitreous body morphol... 1 | 10
decreased IgG1 level 1 | 8
decreased T cell number 1 | 15
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating amylase ... 1 | 28
decreased circulating choleste... 1 | 93
decreased circulating glycerol... 1 | 16
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased grip strength 1 | 116
decreased hematocrit 1 | 46
decreased lymphocyte cell numb... 1 | 83
decreased spleen weight 1 | 10
decreased vertical activity 1 | 208
hyperactivity 1 | 148
increased bone mineral density 1 | 72
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased circulating creatini... 1 | 38
increased circulating fructosa... 1 | 13
increased circulating triglyce... 1 | 42
increased grip strength 1 | 41
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased or absent threshold ... 1 | 101
increased startle reflex 1 | 112
mammalian phenotype 1 | 17
short tibia 1 | 97
vertebral fusion 1 | 23

Disease

ovarian cancer 64 | 8,520
osteosarcoma 59 | 7,950
Carcinoma 57 | 11,493
psoriasis 43 | 6,694
glioblastoma 42 | 5,792
atypical teratoid / rhabdoid tumor 33 | 5,112
lung cancer 32 | 4,740
medulloblastoma, large-cell 32 | 6,241
pancreatic ductal adenocarcinoma liver metastasis 28 | 1,962
group 3 medulloblastoma 27 | 4,104
ependymoma 24 | 4,679
Multiple myeloma 22 | 1,332
adult high grade glioma 22 | 3,801
diabetes mellitus 22 | 1,728
Cancer 20 | 2,499
non-small cell lung cancer 20 | 2,890
Breast cancer 18 | 3,578
Astrocytoma, Pilocytic 17 | 3,081
lung adenocarcinoma 17 | 2,716
lung carcinoma 16 | 2,843
malignant mesothelioma 16 | 3,232
Autosomal recessive predisposition 15 | 1,442
acute quadriplegic myopathy 15 | 1,158
invasive ductal carcinoma 15 | 2,951
pancreatic cancer 15 | 2,398
tuberculosis 15 | 2,010
astrocytoma 13 | 1,146
group 4 medulloblastoma 13 | 1,855
intraductal papillary-mucinous neoplasm (IPMN) 13 | 3,291
subependymal giant cell astrocytoma 13 | 2,287
astrocytic glioma 12 | 2,597
intraductal papillary-mucinous carcinoma (IPMC) 12 | 2,989
juvenile dermatomyositis 12 | 1,187
pituitary cancer 11 | 1,972
primitive neuroectodermal tumor 11 | 3,035
Bipolar Disorder 10 | 666
Kidney cancer 10 | 2,613
Obesity 10 | 678
Pick disease 10 | 1,894
Rheumatoid arthritis 10 | 1,191
colon cancer 10 | 1,478
ulcerative colitis 10 | 1,819
Prostatic Neoplasms 9 | 495
Vascular disease 9 | 319
active Crohn's disease 9 | 922
hepatocellular carcinoma 9 | 547
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,955
non primary Sjogren syndrome sicca 9 | 891
oligodendroglioma 9 | 2,850
Alzheimer's disease 8 | 658
Cognitive delay 8 | 608
Global developmental delay 8 | 608
Mental and motor retardation 8 | 608
Neurodegenerative disease 8 | 414
dermatomyositis 8 | 966
Cerebral atrophy 7 | 178
Intellectual disability 7 | 1,016
acute myeloid leukemia 7 | 783
breast carcinoma 7 | 1,638
cystic fibrosis 7 | 1,696
esophageal adenocarcinoma 7 | 737
interstitial cystitis 7 | 2,312
pediatric high grade glioma 7 | 1,064
spina bifida 7 | 1,074
Depressive disorder 6 | 409
Epilepsy 6 | 792
Polycystic ovary syndrome 6 | 360
Short stature 6 | 531
adrenocortical carcinoma 6 | 1,428
autosomal dominant Emery-Dreifuss muscular dystrophy 6 | 510
gastric cancer 6 | 459
periodontitis 6 | 293
Carcinoma, Hepatocellular 5 | 228
Degenerative brain disorder 5 | 100
Dull intelligence 5 | 645
Feeding difficulties 5 | 127
Fetal Growth Retardation 5 | 189
Hyperglycemia 5 | 137
Infant, Small for Gestational Age 5 | 176
Intrauterine retardation 5 | 176
Liver Cirrhosis, Experimental 5 | 769
Liver carcinoma 5 | 240
Low intelligence 5 | 645
Mental Retardation 5 | 645
Mental deficiency 5 | 645
Multiple Sclerosis 5 | 540
Muscle hypotonia 5 | 571
Neurogenic Muscular Atrophy 5 | 139
Neurogenic muscle atrophy, especially in the lower limbs 5 | 139
Poor school performance 5 | 645
Schizophrenia 5 | 1,160
Skeletal muscle atrophy 5 | 139
Small head 5 | 374
Waldenstrons macroglobulinemia 5 | 765
muscle degeneration 5 | 139
pancreatic carcinoma 5 | 562
Duchenne muscular dystrophy 4 | 601
Endometriosis 4 | 540
Mental Depression 4 | 333
ductal carcinoma in situ 4 | 1,745

Tissue

Blood and immune system 94 | 16,909
Digestive Tract 94 | 17,369
Endocrine System 94 | 18,159
Female tissues 94 | 17,400
Liver and Pancreas 94 | 16,750
Nervous System 94 | 16,725
Urinary Tract 94 | 16,678
Male tissues 93 | 17,142
Respiratory system 93 | 16,393
Skin and soft tissues 93 | 17,230
Cardiovascular System 92 | 15,192

Target Family

Non-IDG 42 | 12,091
Enzyme 32 | 4,145
Transcription Factor 15 | 1,400
Kinase 3 | 634
Epigenetic 2 | 242

Reactome Pathway

Unfolded Protein Response (UPR... 94 | 94
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cullin-7 CUL7 Tbio Non-IDG -1.49747 38.0 139
Peptidyl-prolyl cis-trans isomerase FKBP14 FKBP14 Tbio Enzyme -1.72246 54.5 157
X-box-binding protein 1 XBP1 Tchem Transcription Factor -2.90444 780.2 514
Exosome complex exonuclease RRP44 DIS3 Tbio Enzyme -1.80730 64.2 141
Eukaryotic translation initiation factor 2-alpha kinase 3 EIF2AK3 Tchem Kinase -3.05781 896.8 450
Exosome complex component RRP4 EXOSC2 Tbio Non-IDG -0.28065 2.13 121
Stress-associated endoplasmic reticulum protein 1 SERP1 Tbio Non-IDG -1.37994 31.0 79
Exostosin-like 3 EXTL3 Tbio Enzyme -2.69110 483.9 208
Exosome complex component MTR3 EXOSC6 Tbio Enzyme -0.78888 5.11 84
Asparagine synthetase [glutamine-hydrolyzing] ASNS Tchem Enzyme -2.40144 244.3 223