Development Level

Tbio 121 | 10,625
Tchem 43 | 1,890
Tdark 29 | 7,003
Tclin 9 | 602

IMPC Phenotype

preweaning lethality, complete... 16 | 633
decreased lean body mass 5 | 195
decreased body weight 4 | 174
decreased total body fat amoun... 4 | 186
thrombocytopenia 4 | 46
decreased body length 3 | 108
embryonic lethality prior to t... 3 | 187
increased mean corpuscular hem... 3 | 93
decreased CD4-positive, CD25-p... 2 | 24
decreased circulating aspartat... 2 | 27
decreased circulating total pr... 2 | 41
decreased gamma-delta T cell n... 2 | 18
decreased lumbar vertebrae num... 2 | 62
decreased mean corpuscular vol... 2 | 50
decreased neutrophil cell numb... 2 | 37
increased CD4-positive, alpha ... 2 | 15
increased NK cell number 2 | 19
increased alpha-beta T cell nu... 2 | 9
increased circulating HDL chol... 2 | 63
increased circulating alkaline... 2 | 119
increased circulating choleste... 2 | 53
increased circulating glucose ... 2 | 16
increased grip strength 2 | 83
increased heart weight 2 | 37
increased mean corpuscular vol... 2 | 91
increased sacral vertebrae num... 2 | 62
preweaning lethality, incomple... 2 | 260
abnormal behavior 1 | 226
abnormal coat- hair morphology 1 | 18
abnormal coping response 1 | 12
abnormal cornea morphology 1 | 24
abnormal cranium morphology 1 | 32
abnormal eyelid morphology 1 | 6
abnormal gait 1 | 51
abnormal hair texture 1 | 4
abnormal heart position or ori... 1 | 1
abnormal incisor morphology 1 | 3
abnormal lens morphology 1 | 73
abnormal maxilla morphology 1 | 16
cardiovascular system phenotyp... 1 | 35
corneal opacity 1 | 25
decreased B cell number 1 | 30
decreased Ly6C high monocyte n... 1 | 18
decreased Ly6C low monocyte nu... 1 | 23
decreased blood urea nitrogen ... 1 | 31
decreased circulating alanine ... 1 | 53
decreased circulating calcium ... 1 | 33
decreased circulating choleste... 1 | 85
decreased circulating creatini... 1 | 31
decreased circulating fructosa... 1 | 31
decreased circulating glucose ... 1 | 121
decreased circulating triglyce... 1 | 83
decreased effector memory CD4-... 1 | 6
decreased grip strength 1 | 123
decreased heart weight 1 | 44
decreased hemoglobin content 1 | 53
decreased leukocyte cell numbe... 1 | 54
decreased mature B cell number 1 | 25
decreased mean corpuscular hem... 1 | 34
decreased monocyte cell number 1 | 28
decreased prepulse inhibition 1 | 52
decreased respiratory quotient 1 | 12
decreased rib number 1 | 59
decreased startle reflex 1 | 48
embryonic lethality prior to o... 1 | 148
hyperactivity 1 | 108
improved glucose tolerance 1 | 56
increased CD8-positive, alpha-... 1 | 11
increased T cell number 1 | 15
increased circulating LDL chol... 1 | 15
increased circulating amylase ... 1 | 13
increased circulating aspartat... 1 | 17
increased circulating bilirubi... 1 | 16
increased circulating magnesiu... 1 | 10
increased circulating phosphat... 1 | 24
increased circulating potassiu... 1 | 31
increased circulating serum al... 1 | 25
increased granulocyte number 1 | 8
increased lymphocyte cell numb... 1 | 9
increased monocyte cell number 1 | 27
increased rib number 1 | 41
microcephaly 1 | 3
narrow eye opening 1 | 15
persistence of hyaloid vascula... 1 | 22
polydactyly 1 | 22
prenatal lethality prior to he... 1 | 64
thrombocytosis 1 | 23

Disease

ovarian cancer 125 | 8,491
osteosarcoma 89 | 7,933
psoriasis 79 | 6,685
lung cancer 70 | 4,473
glioblastoma 63 | 5,572
medulloblastoma, large-cell 53 | 6,234
Cancer 50 | 2,346
atypical teratoid / rhabdoid tumor 49 | 4,369
Breast cancer 46 | 3,098
Multiple myeloma 40 | 1,327
malignant mesothelioma 39 | 3,163
non-small cell lung cancer 34 | 2,798
lung adenocarcinoma 33 | 2,714
intraductal papillary-mucinous neoplasm (IPMN) 30 | 3,289
invasive ductal carcinoma 28 | 2,950
oligodendroglioma 25 | 2,849
pancreatic cancer 25 | 2,300
dermatomyositis 24 | 966
intraductal papillary-mucinous carcinoma (IPMC) 24 | 2,988
primitive neuroectodermal tumor 24 | 3,031
Carcinoma 23 | 2,147
subependymal giant cell astrocytoma 23 | 2,287
juvenile dermatomyositis 22 | 1,189
lung carcinoma 22 | 2,844
pediatric high grade glioma 22 | 2,712
group 3 medulloblastoma 21 | 2,254
intraductal papillary-mucinous adenoma (IPMA) 21 | 2,956
pancreatic ductal adenocarcinoma liver metastasis 21 | 1,795
ependymoma 20 | 2,514
pilocytic astrocytoma 19 | 3,086
astrocytic glioma 18 | 2,241
astrocytoma 18 | 1,493
diabetes mellitus 18 | 1,663
HIV Infections 17 | 99
group 4 medulloblastoma 17 | 1,875
adult high grade glioma 16 | 2,148
breast carcinoma 16 | 1,614
tuberculosis 16 | 1,563
ulcerative colitis 16 | 2,087
Pick disease 15 | 1,893
Waldenstrons macroglobulinemia 15 | 764
colon cancer 15 | 1,475
cutaneous lupus erythematosus 15 | 1,056
cystic fibrosis 15 | 1,670
ductal carcinoma in situ 15 | 1,745
medulloblastoma 14 | 1,524
posterior fossa group A ependymoma 14 | 1,511
acute quadriplegic myopathy 13 | 1,157
adrenocortical carcinoma 13 | 1,427
interstitial cystitis 13 | 2,299
acute myeloid leukemia 12 | 785
hepatocellular carcinoma 12 | 550
non-small cell lung carcinoma 12 | 413
Prostatic Neoplasms 10 | 471
non primary Sjogren syndrome sicca 10 | 840
primary Sjogren syndrome 10 | 788
Liver carcinoma 9 | 217
Mammary Neoplasms 9 | 410
Rheumatoid Arthritis 9 | 1,170
active Crohn's disease 9 | 918
pituitary cancer 9 | 1,972
Atopic dermatitis 8 | 944
Parkinson's disease 8 | 364
Vascular disease 8 | 281
gastric cancer 8 | 436
nasopharyngeal carcinoma 8 | 1,056
pancreatic carcinoma 8 | 567
primary pancreatic ductal adenocarcinoma 8 | 1,271
spina bifida 8 | 1,064
tuberculosis and treatment for 6 months 8 | 686
Amyotrophic Lateral Sclerosis 7 | 432
esophageal adenocarcinoma 7 | 737
inflammatory breast cancer 7 | 404
Asthma 6 | 349
Bladder Neoplasm 6 | 109
Colorectal Neoplasms 6 | 217
Endometriosis 6 | 535
Male infertility 6 | 170
Melanoma 6 | 261
Peripheral Neuropathy 6 | 303
posterior fossa group B ependymoma 6 | 1,530
sonic hedgehog group medulloblastoma 6 | 1,482
Adenoma 5 | 165
Alzheimer's disease 5 | 644
Cleft palate 5 | 125
Colorectal Cancer 5 | 62
Craniofacial Abnormalities 5 | 147
Crohn's disease 5 | 304
Familial adenomatous polyposis 5 | 33
IGA Glomerulonephritis 5 | 454
Kidney disease 5 | 397
Lung Neoplasms 5 | 171
Mantle cell lymphoma 5 | 20
Pancreatic Neoplasm 5 | 79
Squamous cell carcinoma of esophagus 5 | 82
Stomach Neoplasms 5 | 282
aldosterone-producing adenoma 5 | 664
chronic lymphocytic leukemia 5 | 244
progressive supranuclear palsy 5 | 674
Schizophrenia 4 | 503

Tissue

Nervous System 201 | 18,560
Female tissues 200 | 18,646
Blood and immune system 198 | 17,994
Urinary Tract 191 | 18,443
Endocrine System 190 | 18,511
Digestive Tract 188 | 18,472
Liver and Pancreas 188 | 18,135
Male tissues 186 | 17,968
Cardiovascular System 185 | 17,957
Respiratory system 185 | 17,483
Skin and soft tissues 180 | 18,114

Target Family

Enzyme 112 | 4,146
Non-IDG 70 | 11,969
Transcription Factor 11 | 1,400
Kinase 5 | 634
Epigenetic 1 | 242
GPCR 1 | 408
Ion Channel 1 | 341
Nuclear Receptor 1 | 48

Reactome Pathway

Ub-specific processing proteas... 202 | 202
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone H2A type 1-J HIST1H2AJ Tdark Non-IDG -0.13212 1.19 10
Histone H2B type 1-M HIST1H2BM Tdark Non-IDG 0.16 0.33 20
Histone H2B type 1-L HIST1H2BL Tdark Non-IDG 0.35 0.40 42
Histone H2B type 1-N HIST1H2BN Tdark Non-IDG -1.51554 30.2 48
E3 ubiquitin-protein ligase RNF146 RNF146 Tbio Enzyme -0.92024 8.53 46
Histone H2A type 1-B/E HIST1H2AB Tbio Non-IDG -1.26707 18.9 109
Interferon-induced helicase C domain-containing protein 1 IFIH1 Tbio Enzyme -2.60557 384.3 296
Ubiquitin carboxyl-terminal hydrolase 17-like protein 20 USP17L20 Tdark Enzyme 0.00000 0
Myc proto-oncogene protein MYC Tbio Transcription Factor -4.09050 11730.8 2241
Ubiquitin carboxyl-terminal hydrolase 26 USP26 Tbio Enzyme -1.51447 32.7 53