Development Level

Tbio 121 | 10,625
Tchem 44 | 1,890
Tdark 29 | 7,003
Tclin 9 | 602

IMPC Term

preweaning lethality, complete... 16 | 633
decreased lean body mass 5 | 195
decreased body weight 4 | 174
decreased total body fat amoun... 4 | 186
thrombocytopenia 4 | 46
decreased body length 3 | 108
embryonic lethality prior to t... 3 | 187
increased mean corpuscular hem... 3 | 93
decreased CD4-positive, CD25-p... 2 | 24
decreased circulating aspartat... 2 | 27
decreased circulating total pr... 2 | 41
decreased gamma-delta T cell n... 2 | 18
decreased lumbar vertebrae num... 2 | 62
decreased mean corpuscular vol... 2 | 50
decreased neutrophil cell numb... 2 | 37
increased CD4-positive, alpha ... 2 | 15
increased NK cell number 2 | 19
increased alpha-beta T cell nu... 2 | 9
increased circulating HDL chol... 2 | 63
increased circulating alkaline... 2 | 119
increased circulating choleste... 2 | 53
increased circulating glucose ... 2 | 16
increased grip strength 2 | 83
increased heart weight 2 | 37
increased mean corpuscular vol... 2 | 91
increased sacral vertebrae num... 2 | 62
preweaning lethality, incomple... 2 | 260
abnormal behavior 1 | 226
abnormal coat/ hair morphology 1 | 18
abnormal coping response 1 | 12
abnormal cornea morphology 1 | 24
abnormal cranium morphology 1 | 32
abnormal eyelid morphology 1 | 6
abnormal gait 1 | 51
abnormal hair texture 1 | 4
abnormal heart position or ori... 1 | 1
abnormal incisor morphology 1 | 3
abnormal lens morphology 1 | 73
abnormal maxilla morphology 1 | 16
cardiovascular system phenotyp... 1 | 35
corneal opacity 1 | 25
decreased B cell number 1 | 30
decreased Ly6C high monocyte n... 1 | 18
decreased Ly6C low monocyte nu... 1 | 23
decreased blood urea nitrogen ... 1 | 31
decreased circulating alanine ... 1 | 53
decreased circulating calcium ... 1 | 33
decreased circulating choleste... 1 | 85
decreased circulating creatini... 1 | 31
decreased circulating fructosa... 1 | 31
decreased circulating glucose ... 1 | 121
decreased circulating triglyce... 1 | 83
decreased effector memory CD4-... 1 | 6
decreased grip strength 1 | 123
decreased heart weight 1 | 44
decreased hemoglobin content 1 | 53
decreased leukocyte cell numbe... 1 | 54
decreased mature B cell number 1 | 25
decreased mean corpuscular hem... 1 | 34
decreased monocyte cell number 1 | 28
decreased prepulse inhibition 1 | 52
decreased respiratory quotient 1 | 12
decreased rib number 1 | 59
decreased startle reflex 1 | 48
embryonic lethality prior to o... 1 | 148
hyperactivity 1 | 108
improved glucose tolerance 1 | 56
increased CD8-positive, alpha-... 1 | 11
increased T cell number 1 | 15
increased circulating LDL chol... 1 | 15
increased circulating amylase ... 1 | 13
increased circulating aspartat... 1 | 17
increased circulating bilirubi... 1 | 16
increased circulating magnesiu... 1 | 10
increased circulating phosphat... 1 | 24
increased circulating potassiu... 1 | 31
increased circulating serum al... 1 | 25
increased granulocyte number 1 | 8
increased lymphocyte cell numb... 1 | 9
increased monocyte cell number 1 | 27
increased rib number 1 | 41
microcephaly 1 | 3
narrow eye opening 1 | 15
persistence of hyaloid vascula... 1 | 22
polydactyly 1 | 22
prenatal lethality prior to he... 1 | 64
thrombocytosis 1 | 23

Disease

ovarian cancer 126 | 8,484
osteosarcoma 89 | 7,933
psoriasis 79 | 6,685
lung cancer 70 | 4,466
glioblastoma 63 | 5,572
medulloblastoma, large-cell 53 | 6,234
Cancer 50 | 2,346
atypical teratoid / rhabdoid tumor 49 | 4,369
Breast cancer 47 | 3,094
Multiple myeloma 41 | 1,327
malignant mesothelioma 39 | 3,162
non-small cell lung cancer 34 | 2,798
lung adenocarcinoma 33 | 2,713
intraductal papillary-mucinous neoplasm (IPMN) 30 | 3,289
invasive ductal carcinoma 28 | 2,950
dermatomyositis 25 | 933
oligodendroglioma 25 | 2,849
pancreatic cancer 25 | 2,300
intraductal papillary-mucinous carcinoma (IPMC) 24 | 2,988
primitive neuroectodermal tumor 24 | 3,031
Carcinoma 23 | 2,147
subependymal giant cell astrocytoma 23 | 2,287
juvenile dermatomyositis 22 | 1,189
lung carcinoma 22 | 2,844
pediatric high grade glioma 22 | 2,712
group 3 medulloblastoma 21 | 2,254
intraductal papillary-mucinous adenoma (IPMA) 21 | 2,956
pancreatic ductal adenocarcinoma liver metastasis 21 | 1,795
ependymoma 20 | 2,514
pilocytic astrocytoma 19 | 3,086
HIV Infections 18 | 100
astrocytic glioma 18 | 2,241
astrocytoma 18 | 1,493
diabetes mellitus 18 | 1,663
group 4 medulloblastoma 17 | 1,875
Waldenstrons macroglobulinemia 16 | 765
adult high grade glioma 16 | 2,148
breast carcinoma 16 | 1,614
tuberculosis 16 | 1,557
ulcerative colitis 16 | 2,087
Pick disease 15 | 1,893
colon cancer 15 | 1,475
cutaneous lupus erythematosus 15 | 1,056
cystic fibrosis 15 | 1,665
ductal carcinoma in situ 15 | 1,745
medulloblastoma 14 | 1,524
posterior fossa group A ependymoma 14 | 1,511
acute quadriplegic myopathy 13 | 1,157
adrenocortical carcinoma 13 | 1,427
interstitial cystitis 13 | 2,299
non-small cell lung carcinoma 12 | 413
acute myeloid leukemia 11 | 780
primary Sjogren syndrome 11 | 789
Prostatic Neoplasms 10 | 471
Rheumatoid Arthritis 10 | 1,160
hepatocellular carcinoma 10 | 532
non primary Sjogren syndrome sicca 10 | 840
Liver carcinoma 9 | 217
Mammary Neoplasms 9 | 410
active Crohn's disease 9 | 918
pituitary cancer 9 | 1,972
Atopic dermatitis 8 | 944
Parkinson's disease 8 | 364
Vascular disease 8 | 281
gastric cancer 8 | 430
nasopharyngeal carcinoma 8 | 1,056
pancreatic carcinoma 8 | 567
primary pancreatic ductal adenocarcinoma 8 | 1,271
spina bifida 8 | 1,064
tuberculosis and treatment for 6 months 8 | 686
Amyotrophic Lateral Sclerosis 7 | 431
esophageal adenocarcinoma 7 | 737
inflammatory breast cancer 7 | 404
Asthma 6 | 349
Bladder Neoplasm 6 | 109
Colorectal Neoplasms 6 | 217
Endometriosis 6 | 535
Male infertility 6 | 170
Melanoma 6 | 261
Peripheral Neuropathy 6 | 303
posterior fossa group B ependymoma 6 | 1,530
sonic hedgehog group medulloblastoma 6 | 1,482
Adenoma 5 | 165
Alzheimer's disease 5 | 644
Chronic Lymphocytic Leukemia 5 | 242
Cleft palate 5 | 125
Craniofacial Abnormalities 5 | 147
Crohn's disease 5 | 304
Familial adenomatous polyposis 5 | 31
IGA Glomerulonephritis 5 | 454
Kidney disease 5 | 396
Lung Neoplasms 5 | 171
Mantle cell lymphoma 5 | 18
Pancreatic Neoplasm 5 | 79
Polycystic Ovary Syndrome 5 | 332
Squamous cell carcinoma of esophagus 5 | 82
Stomach Neoplasms 5 | 282
aldosterone-producing adenoma 5 | 664
progressive supranuclear palsy 5 | 674
Schizophrenia 4 | 501

Tissue

Nervous System 202 | 18,561
Female tissues 201 | 18,647
Blood and immune system 199 | 17,995
Urinary Tract 192 | 18,444
Endocrine System 191 | 18,512
Digestive Tract 189 | 18,473
Liver and Pancreas 189 | 18,136
Male tissues 187 | 17,969
Cardiovascular System 186 | 17,958
Respiratory system 186 | 17,484
Skin and soft tissues 181 | 18,115

Target Family

Enzyme 113 | 4,146
Non-IDG 70 | 11,971
Transcription Factor 11 | 1,400
Kinase 5 | 634
Epigenetic 1 | 242
GPCR 1 | 406
Ion Channel 1 | 341
Nuclear Receptor 1 | 48

Reactome Pathway

Ub-specific processing proteas... 203 | 203
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ubiquitin carboxyl-terminal hydrolase 24 USP24 Tbio Enzyme -1.53939 36.4 61
Ubiquitin carboxyl-terminal hydrolase 22 USP22 Tbio Enzyme -1.59877 51.0 199
Ubiquitin carboxyl-terminal hydrolase 17-like protein 1 USP17L1 Tdark Enzyme 10.9 3
E3 ubiquitin-protein ligase Mdm2 MDM2 Tchem Enzyme -3.38438 2174.7 1062
TNF receptor-associated factor 2 TRAF2 Tbio Non-IDG -1.85843 68.9 516
Ubiquitin carboxyl-terminal hydrolase 11 USP11 Tbio Enzyme -1.06624 14.9 210
Beta-arrestin-1 ARRB1 Tchem Non-IDG -2.54226 366.3 416
Probable ubiquitin carboxyl-terminal hydrolase FAF-X USP9X Tbio Enzyme -1.79254 69.5 187
Ubiquitin carboxyl-terminal hydrolase 17-like protein 5 USP17L5 Tdark Enzyme 0.00000 8
Ubiquitin carboxyl-terminal hydrolase 7 USP7 Tchem Enzyme -2.17350 165.7 375