Development Level

Tbio 142 | 11,651
Tdark 28 | 6,593
Tchem 25 | 1,388
Tclin 8 | 612

IMPC Phenotype

preweaning lethality, complete... 22 | 979
decreased total body fat amoun... 5 | 207
decreased body weight 4 | 161
male infertility 4 | 123
thrombocytopenia 4 | 56
abnormal behavior 3 | 298
decreased circulating choleste... 3 | 93
decreased lean body mass 3 | 135
embryonic lethality prior to t... 3 | 278
hypoactivity 3 | 132
increased circulating HDL chol... 3 | 80
increased circulating choleste... 3 | 66
increased mean corpuscular hem... 3 | 96
increased startle reflex 3 | 112
preweaning lethality, incomple... 3 | 499
abnormal embryo size 2 | 220
abnormal facial morphology 2 | 17
abnormal head shape 2 | 10
abnormal limb morphology 2 | 13
anophthalmia 2 | 33
decreased body length 2 | 101
female infertility 2 | 60
increased circulating alkaline... 2 | 122
increased circulating glucose ... 2 | 24
increased heart weight 2 | 62
microphthalmia 2 | 26
prolonged QT interval 2 | 38
prolonged ST segment 2 | 36
abnormal behavioral response t... 1 | 66
abnormal body wall morphology 1 | 9
abnormal coat- hair morphology 1 | 19
abnormal cornea morphology 1 | 31
abnormal craniofacial morpholo... 1 | 33
abnormal cranium morphology 1 | 36
abnormal embryo development 1 | 7
abnormal eyelid fusion 1 | 3
abnormal eyelid morphology 1 | 7
abnormal forebrain morphology 1 | 10
abnormal gait 1 | 69
abnormal head size 1 | 6
abnormal heart morphology 1 | 162
abnormal hindbrain morphology 1 | 10
abnormal incisor morphology 1 | 4
abnormal iris morphology 1 | 13
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal lung morphology 1 | 26
abnormal maxilla morphology 1 | 17
abnormal midbrain morphology 1 | 10
abnormal neural tube closure 1 | 46
abnormal tail morphology 1 | 25
cardiovascular system phenotyp... 1 | 36
cleft palate 1 | 8
corneal opacity 1 | 32
decreased KLRG1+ CD8 alpha bet... 1 | 2
decreased blood urea nitrogen ... 1 | 51
decreased bone mineral content 1 | 151
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating alkaline... 1 | 46
decreased circulating aspartat... 1 | 34
decreased circulating calcium ... 1 | 36
decreased circulating creatini... 1 | 39
decreased circulating fructosa... 1 | 30
decreased circulating total pr... 1 | 49
decreased grip strength 1 | 116
decreased hemoglobin content 1 | 68
decreased lactate dehydrogenas... 1 | 16
decreased mean platelet volume 1 | 25
decreased neutrophil cell numb... 1 | 42
decreased prepulse inhibition 1 | 82
decreased red blood cell distr... 1 | 41
decreased startle reflex 1 | 75
decreased vertical activity 1 | 208
edema 1 | 59
embryonic lethality prior to o... 1 | 239
enlarged heart 1 | 210
hyperactivity 1 | 148
increased anti-nuclear antigen... 1 | 19
increased circulating LDL chol... 1 | 13
increased circulating amylase ... 1 | 25
increased circulating bilirubi... 1 | 16
increased circulating magnesiu... 1 | 10
increased circulating phosphat... 1 | 26
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular vol... 1 | 92
increased mean platelet volume 1 | 45
increased or absent threshold ... 1 | 101
increased red blood cell distr... 1 | 34
irregularly shaped pupil 1 | 7
long tibia 1 | 25
narrow eye opening 1 | 12
pallor 1 | 34
persistence of hyaloid vascula... 1 | 33
polydactyly 1 | 7
prenatal lethality prior to he... 1 | 87
protruding tongue 1 | 3
syndactyly 1 | 23
thin ventricular wall 1 | 24
thrombocytosis 1 | 27

Disease

ovarian cancer 124 | 8,520
Carcinoma 121 | 11,493
osteosarcoma 88 | 7,950
psoriasis 78 | 6,694
lung cancer 72 | 4,740
glioblastoma 65 | 5,792
Cancer 53 | 2,499
medulloblastoma, large-cell 53 | 6,241
atypical teratoid / rhabdoid tumor 50 | 5,112
Breast cancer 48 | 3,578
Multiple myeloma 41 | 1,332
malignant mesothelioma 39 | 3,232
non-small cell lung cancer 35 | 2,890
ependymoma 33 | 4,679
group 3 medulloblastoma 33 | 4,104
lung adenocarcinoma 32 | 2,716
adult high grade glioma 31 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 30 | 3,291
invasive ductal carcinoma 27 | 2,951
Kidney cancer 26 | 2,613
dermatomyositis 25 | 966
oligodendroglioma 25 | 2,850
pancreatic cancer 25 | 2,398
intraductal papillary-mucinous carcinoma (IPMC) 24 | 2,989
primitive neuroectodermal tumor 24 | 3,035
subependymal giant cell astrocytoma 24 | 2,287
astrocytic glioma 22 | 2,597
juvenile dermatomyositis 22 | 1,187
lung carcinoma 22 | 2,843
intraductal papillary-mucinous adenoma (IPMA) 21 | 2,955
pancreatic ductal adenocarcinoma liver metastasis 21 | 1,962
diabetes mellitus 20 | 1,728
Astrocytoma, Pilocytic 18 | 3,081
HIV Infections 18 | 102
breast carcinoma 18 | 1,638
tuberculosis 18 | 2,010
group 4 medulloblastoma 17 | 1,855
Waldenstrons macroglobulinemia 16 | 765
Pick disease 15 | 1,894
cutaneous lupus erythematosus 15 | 1,057
cystic fibrosis 15 | 1,696
astrocytoma 14 | 1,146
colon cancer 14 | 1,478
ductal carcinoma in situ 14 | 1,745
acute quadriplegic myopathy 13 | 1,158
adrenocortical carcinoma 13 | 1,428
interstitial cystitis 13 | 2,312
Liver Cirrhosis, Experimental 12 | 769
acute myeloid leukemia 12 | 783
hepatocellular carcinoma 12 | 547
ulcerative colitis 12 | 1,819
non-small cell lung carcinoma 11 | 317
primary Sjogren syndrome 11 | 735
Breast Neoplasms 10 | 445
Carcinoma, Hepatocellular 10 | 228
Liver carcinoma 10 | 240
Mammary Neoplasms 10 | 425
Rheumatoid arthritis 10 | 1,191
Vascular disease 10 | 319
non primary Sjogren syndrome sicca 10 | 891
Prostatic Neoplasms 9 | 495
Schizophrenia 9 | 1,160
active Crohn's disease 9 | 922
pituitary cancer 9 | 1,972
Atopic dermatitis 8 | 952
Hypertensive disease 8 | 292
Intellectual disability 8 | 1,016
Melanoma 8 | 711
Osteoporosis 8 | 363
Parkinson's disease 8 | 392
gastric cancer 8 | 459
nasopharyngeal carcinoma 8 | 1,058
spina bifida 8 | 1,074
Amyotrophic lateral sclerosis 7 | 451
Asthma 7 | 385
Cleft Palate 7 | 271
Epilepsy 7 | 792
Liver cancer 7 | 604
Pancreatic Neoplasm 7 | 85
esophageal adenocarcinoma 7 | 737
pediatric high grade glioma 7 | 1,064
primary pancreatic ductal adenocarcinoma 7 | 1,109
Anemia 6 | 365
Autosomal recessive predisposition 6 | 1,442
Bladder Neoplasm 6 | 112
Colonic Neoplasms 6 | 142
Colorectal Neoplasms 6 | 243
Endometrial cancer 6 | 311
Endometriosis 6 | 540
Failure to gain weight 6 | 365
Lung Neoplasms 6 | 232
Male infertility 6 | 206
Orbital separation excessive 6 | 244
Pancreatic Neoplasms 6 | 85
Pediatric failure to thrive 6 | 365
Short stature 6 | 531
Skin cancer 6 | 469
Urinary Bladder Neoplasms 6 | 114
inflammatory breast cancer 6 | 286
pancreatic carcinoma 6 | 562

Tissue

Endocrine System 186 | 18,159
Female tissues 184 | 17,400
Blood and immune system 183 | 16,909
Male tissues 183 | 17,142
Digestive Tract 182 | 17,369
Liver and Pancreas 182 | 16,750
Nervous System 182 | 16,725
Respiratory system 182 | 16,393
Skin and soft tissues 182 | 17,230
Urinary Tract 182 | 16,678
Cardiovascular System 179 | 15,192

Target Family

Enzyme 113 | 4,145
Non-IDG 71 | 12,091
Transcription Factor 11 | 1,400
Kinase 5 | 634
Epigenetic 1 | 242
Ion Channel 1 | 344
Nuclear Receptor 1 | 48

Reactome Pathway

Ub-specific processing proteas... 203 | 203
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ubiquitin carboxyl-terminal hydrolase 3 USP3 Tbio Enzyme -1.16770 14.5 246
NF-kappa-B essential modulator IKBKG Tbio Kinase -3.07452 1188.4 879
Ubiquitin carboxyl-terminal hydrolase 16 USP16 Tbio Enzyme -0.67094 5.97 248
26S proteasome regulatory subunit 6A PSMC3 Tbio Enzyme -1.29086 19.3 302
Ubiquitin carboxyl-terminal hydrolase 48 USP48 Tbio Enzyme -0.56820 3.47 116
Ubiquitin carboxyl-terminal hydrolase 14 USP14 Tbio Enzyme -1.85726 75.4 223
TNF receptor-associated factor 6 TRAF6 Tbio Non-IDG -2.74221 511.1 403
Centriolar coiled-coil protein of 110 kDa CCP110 Tbio Non-IDG -1.45267 26.4 109
Ubl carboxyl-terminal hydrolase 18 USP18 Tbio Enzyme -1.81381 78.4 84
E3 ubiquitin-protein ligase SIAH2 SIAH2 Tbio Enzyme -1.80363 66.5 173