Development Level

Tbio 70 | 11,445
Tdark 12 | 6,588
Tchem 9 | 1,598
Tclin 5 | 613

IMPC Phenotype

preweaning lethality, complete... 12 | 979
embryonic lethality prior to o... 3 | 239
embryonic lethality prior to t... 3 | 278
abnormal vocalization 2 | 21
hypoactivity 2 | 132
preweaning lethality, incomple... 2 | 499
abnormal behavior 1 | 298
abnormal behavioral response t... 1 | 66
abnormal cornea morphology 1 | 31
abnormal heart morphology 1 | 162
abnormal kidney morphology 1 | 65
abnormal lip morphology 1 | 2
abnormal seminal vesicle morph... 1 | 114
abnormal spine curvature 1 | 9
corneal opacity 1 | 32
decreased body weight 1 | 161
decreased caudal vertebrae num... 1 | 53
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased fluid intake 1 | 3
decreased hemoglobin content 1 | 68
decreased leukocyte cell numbe... 1 | 73
decreased mean corpuscular hem... 1 | 50
decreased vertical activity 1 | 208
enlarged heart 1 | 210
female infertility 1 | 60
hyperactivity 1 | 148
impaired pupillary reflex 1 | 26
increased blood urea nitrogen ... 1 | 48
increased blood uric acid leve... 1 | 5
increased body length 1 | 32
increased body weight 1 | 25
increased circulating alkaline... 1 | 122
increased mean platelet volume 1 | 45
long tibia 1 | 25
male infertility 1 | 123
pale yolk sac 1 | 25
prenatal lethality prior to he... 1 | 87
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
short tibia 1 | 97
shortened RR interval 1 | 17
vertebral fusion 1 | 23

Disease

ovarian cancer 59 | 8,520
Carcinoma 45 | 11,493
lung cancer 39 | 4,740
glioblastoma 34 | 5,792
osteosarcoma 34 | 7,950
psoriasis 33 | 6,694
Multiple myeloma 29 | 1,332
Cancer 23 | 2,499
atypical teratoid / rhabdoid tumor 23 | 5,112
medulloblastoma, large-cell 22 | 6,241
Breast cancer 21 | 3,578
ependymoma 19 | 4,679
malignant mesothelioma 18 | 3,232
HIV Infections 16 | 102
adult high grade glioma 16 | 3,801
group 3 medulloblastoma 15 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 15 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 15 | 3,291
lung adenocarcinoma 15 | 2,716
oligodendroglioma 15 | 2,850
dermatomyositis 14 | 966
invasive ductal carcinoma 14 | 2,951
non-small cell lung cancer 14 | 2,890
pancreatic ductal adenocarcinoma liver metastasis 14 | 1,962
Waldenstrons macroglobulinemia 12 | 765
astrocytic glioma 12 | 2,597
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,955
diabetes mellitus 11 | 1,728
Astrocytoma, Pilocytic 10 | 3,081
Pick disease 10 | 1,894
pancreatic cancer 10 | 2,398
subependymal giant cell astrocytoma 10 | 2,287
lung carcinoma 9 | 2,843
Intellectual disability 8 | 1,016
acute myeloid leukemia 8 | 783
astrocytoma 8 | 1,146
juvenile dermatomyositis 8 | 1,187
primitive neuroectodermal tumor 8 | 3,035
group 4 medulloblastoma 7 | 1,855
Alzheimer's disease 6 | 658
Cleft Palate 6 | 271
Kidney cancer 6 | 2,613
Liver Cirrhosis, Experimental 6 | 769
acute quadriplegic myopathy 6 | 1,158
breast carcinoma 6 | 1,638
colon cancer 6 | 1,478
cystic fibrosis 6 | 1,696
hepatocellular carcinoma 6 | 547
non primary Sjogren syndrome sicca 6 | 891
non-small cell lung carcinoma 6 | 317
tuberculosis 6 | 2,010
Mantle cell lymphoma 5 | 23
Osteoporosis 5 | 363
cutaneous lupus erythematosus 5 | 1,057
gastric cancer 5 | 459
pituitary cancer 5 | 1,972
ulcerative colitis 5 | 1,819
Anemia 4 | 365
active Crohn's disease 4 | 922
adrenocortical carcinoma 4 | 1,428
ductal carcinoma in situ 4 | 1,745
hereditary spastic paraplegia 4 | 318
primary Sjogren syndrome 4 | 735
primary pancreatic ductal adenocarcinoma 4 | 1,109
progressive supranuclear palsy 4 | 676
spina bifida 4 | 1,074
Acquired scoliosis 3 | 281
Aortic Valve Insufficiency 3 | 40
Atopic dermatitis 3 | 952
Bladder Neoplasm 3 | 112
Cardiomegaly 3 | 116
Cleft uvula 3 | 27
Colorectal Neoplasms 3 | 243
Connective tissue disease 3 | 62
Coronary artery disease 3 | 268
Craniosynostosis 3 | 74
Curvature of spine 3 | 282
Flexion contracture of proximal interphalangeal joint 3 | 75
Hypertensive disease 3 | 292
Hypoplastic mandible condyle 3 | 275
Liver neoplasms 3 | 130
Lung Neoplasms 3 | 232
Mandibular hypoplasia 3 | 275
Micrognathism 3 | 275
Neoplasm Metastasis 3 | 168
Parkinson's disease 3 | 392
Prostatic Neoplasms 3 | 495
Pulmonary Fibrosis 3 | 106
Schizophrenia 3 | 1,160
Ureteral obstruction 3 | 33
Urinary Bladder Neoplasms 3 | 114
active ulcerative colitis 3 | 764
interstitial cystitis 3 | 2,312
pancreatic carcinoma 3 | 562
sonic hedgehog group medulloblastoma 3 | 467
substance-related disorder 3 | 162
tuberculosis and treatment for 6 months 3 | 409
Congenital clubfoot 2 | 109
Exophthalmos 2 | 112
muscle degeneration 2 | 139

Tissue

Endocrine System 95 | 18,159
Blood and immune system 94 | 16,909
Digestive Tract 94 | 17,369
Female tissues 94 | 17,400
Male tissues 94 | 17,142
Nervous System 94 | 16,725
Respiratory system 94 | 16,393
Urinary Tract 94 | 16,678
Cardiovascular System 93 | 15,192
Liver and Pancreas 93 | 16,750
Skin and soft tissues 93 | 17,230

Target Family

Enzyme 47 | 4,145
Non-IDG 39 | 12,091
Epigenetic 4 | 242
Transcription Factor 4 | 1,400
Kinase 2 | 634

Reactome Pathway

UCH proteinases 96 | 96
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone H2A type 1-A HIST1H2AA Tbio Non-IDG -0.84480 8.19 69
Proteasome activator complex subunit 2 PSME2 Tbio Non-IDG -1.47440 29.1 305
Proteasome subunit beta type-10 PSMB10 Tchem Enzyme -1.88722 74.3 178
Ubiquitin carboxyl-terminal hydrolase 15 USP15 Tbio Enzyme -1.64742 41.6 242
Histone H2A type 1-B/E HIST1H2AB Tbio Non-IDG -1.27041 18.5 133
Polyubiquitin-B UBB Tbio Non-IDG -1.98860 97.4 427
Polyubiquitin-C UBC Tbio Non-IDG -2.90157 61.9 143
Proteasome activator complex subunit 4 PSME4 Tdark Non-IDG -1.60128 39.3 43
Histone H2A type 1-J HIST1H2AJ Tdark Non-IDG -0.13212 1.19 16
Lysine-specific histone demethylase 1B KDM1B Tbio Epigenetic -1.45110 27.6 106