Development Level

Tbio 7 | 10,625
Tchem 6 | 1,890

IMPC Term

abnormal seminal vesicle morph... 1 | 47
decreased circulating insulin ... 1 | 75
decreased fasted circulating g... 1 | 49
decreased heart weight 1 | 44

Disease

invasive ductal carcinoma 5 | 2,950
ovarian cancer 5 | 8,484
psoriasis 5 | 6,685
ulcerative colitis 5 | 2,087
breast carcinoma 4 | 1,614
cutaneous lupus erythematosus 4 | 1,056
ductal carcinoma in situ 4 | 1,745
interstitial cystitis 4 | 2,299
lung cancer 4 | 4,466
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,795
primary Sjogren syndrome 4 | 789
Breast cancer 3 | 3,094
Cancer 3 | 2,346
Huntington's disease 3 | 72
Pellagra 3 | 25
cystic fibrosis 3 | 1,665
lung carcinoma 3 | 2,844
malignant mesothelioma 3 | 3,162
non-small cell lung cancer 3 | 2,798
osteosarcoma 3 | 7,933
Atopic dermatitis 2 | 944
Dermatitis, Allergic Contact 2 | 66
Endometriosis 2 | 535
IGA Glomerulonephritis 2 | 454
Inflammation 2 | 109
Lysinuric protein intolerance 2 | 15
Neurodegenerative Disorders 2 | 37
Obesity 2 | 616
Polycystic Ovary Syndrome 2 | 332
Schizophrenia 2 | 501
Waldenstrons macroglobulinemia 2 | 765
active Crohn's disease 2 | 918
adrenocortical carcinoma 2 | 1,427
glioblastoma 2 | 5,572
head and neck cancer and chronic obstructive pulmonary disease 2 | 237
inflammatory breast cancer 2 | 404
lung adenocarcinoma 2 | 2,713
mucosa-associated lymphoid tissue lymphoma 2 | 480
oligodendroglioma 2 | 2,849
pituitary cancer 2 | 1,972
posterior fossa group A ependymoma 2 | 1,511
tuberculosis 2 | 1,557
tuberculosis and treatment for 3 months 2 | 327
tuberculosis and treatment for 6 months 2 | 686
Amyotrophic Lateral Sclerosis 1 | 431
Autistic Disorder 1 | 320
Chronic obstructive pulmonary disease 1 | 146
Colon carcinoma in situ 1 | 8
Cystinuria 1 | 18
Detrusor sphincter dyssynergia 1 | 8
Gaucher disease type 3 1 | 76
Gilles de la Tourette syndrome 1 | 47
Heavy chain disease 1 | 6
Hydroxykynureninuria 1 | 1
Hypospadias 1 | 65
Iridocyclitis 1 | 12
Kidney Neoplasm 1 | 27
Latent syphilis 1 | 3
Mammary Neoplasms 1 | 410
Multiple Sclerosis 1 | 498
Multiple myeloma 1 | 1,327
Narcolepsy 1 | 58
Neoplasm Recurrence, Local 1 | 23
Parkinson's disease 1 | 364
Primary syphilis 1 | 4
Secondary syphilis 1 | 3
Senile cataract 1 | 4
Starvation 1 | 1
adult high grade glioma 1 | 2,148
astrocytic glioma 1 | 2,241
chronic rhinosinusitis 1 | 512
colon cancer 1 | 1,475
cystic fibrosis and chronic rhinosinusitis 1 | 213
diabetes mellitus 1 | 1,663
ependymoma 1 | 2,514
gastric carcinoma 1 | 832
head and neck cancer 1 | 270
intraductal papillary-mucinous adenoma (IPMA) 1 | 2,956
intraductal papillary-mucinous neoplasm (IPMN) 1 | 3,289
juvenile dermatomyositis 1 | 1,189
medulloblastoma 1 | 1,524
nephrosclerosis 1 | 329
non diabetic and post-ischemic heart failure 1 | 200
non primary Sjogren syndrome sicca 1 | 840
pancreatic cancer 1 | 2,300
pediatric high grade glioma 1 | 2,712
periodontitis 1 | 269
pilocytic astrocytoma 1 | 3,086
primitive neuroectodermal tumor 1 | 3,031
sarcoidosis 1 | 358
spina bifida 1 | 1,064
uncontrolled asthma 1 | 67

Tissue

Blood and immune system 13 | 17,995
Cardiovascular System 13 | 17,958
Digestive Tract 13 | 18,473
Endocrine System 13 | 18,512
Female tissues 13 | 18,647
Liver and Pancreas 13 | 18,136
Male tissues 13 | 17,969
Nervous System 13 | 18,561
Respiratory system 13 | 17,484
Skin and soft tissues 13 | 18,115
Urinary Tract 13 | 18,444

Target Family

Enzyme 11 | 4,146
Transporter 2 | 473

Reactome Pathway

Tryptophan catabolism 13 | 13
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Indoleamine 2,3-dioxygenase 2 IDO2 Tchem Enzyme -1.88853 82.2 208
Kynurenine--oxoglutarate transaminase 3 KYAT3 Tbio Enzyme -0.73734 5.53 47
Large neutral amino acids transporter small subunit 1 SLC7A5 Tbio Transporter 135.6 220
Indoleamine 2,3-dioxygenase 1 IDO1 Tchem Enzyme -2.43090 330.1 543
Kynurenine 3-monooxygenase KMO Tchem Enzyme -1.99436 104.9 101
Kynurenine formamidase AFMID Tbio Enzyme -1.61805 42.7 56
Tryptophan 2,3-dioxygenase TDO2 Tchem Enzyme -2.00734 106.2 130
4F2 cell-surface antigen heavy chain SLC3A2 Tbio Transporter -2.77929 614.7 459
Kynurenine--oxoglutarate transaminase 1 KYAT1 Tbio Enzyme -1.77708 65.5 152
3-hydroxyanthranilate 3,4-dioxygenase HAAO Tbio Enzyme -1.63862 45.8 89