Development Level

Tbio 9 | 11,651
Tchem 4 | 1,388

IMPC Phenotype

abnormal seminal vesicle morph... 2 | 114
preweaning lethality, incomple... 2 | 499
abnormal embryo size 1 | 220
abnormal heart morphology 1 | 162
abnormal sensory capabilities-... 1 | 8
decreased circulating bilirubi... 1 | 19
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased circulating lipase l... 1 | 3
decreased circulating potassiu... 1 | 20
decreased eosinophil cell numb... 1 | 24
decreased fasted circulating g... 1 | 65
decreased lymphocyte cell numb... 1 | 83
decreased vertical activity 1 | 208
edema 1 | 59
enlarged heart 1 | 210
enlarged seminal vesicle 1 | 10
hydrometra 1 | 53
hyperactivity 1 | 148
increased bone mineral density 1 | 72
increased circulating fructosa... 1 | 13
increased circulating potassiu... 1 | 29
increased monocyte cell number 1 | 63
microphthalmia 1 | 26
small superior vagus ganglion 1 | 74

Disease

Carcinoma 12 | 11,493
tuberculosis 6 | 2,010
Breast cancer 5 | 3,578
Major Depressive Disorder 5 | 301
Unipolar Depression 5 | 250
interstitial cystitis 5 | 2,312
invasive ductal carcinoma 5 | 2,951
ovarian cancer 5 | 8,520
psoriasis 5 | 6,694
ulcerative colitis 5 | 1,819
Pellagra 4 | 26
breast carcinoma 4 | 1,638
cutaneous lupus erythematosus 4 | 1,057
cystic fibrosis 4 | 1,696
ductal carcinoma in situ 4 | 1,745
lung cancer 4 | 4,740
lung carcinoma 4 | 2,843
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
primary Sjogren syndrome 4 | 735
Cancer 3 | 2,499
active Crohn's disease 3 | 922
malignant mesothelioma 3 | 3,232
non-small cell lung cancer 3 | 2,890
osteosarcoma 3 | 7,950
Atopic dermatitis 2 | 952
Depressed mood 2 | 17
Dermatitis, Allergic Contact 2 | 67
Endometriosis 2 | 540
Huntington's disease 2 | 76
Inflammation 2 | 120
Liver Cirrhosis, Experimental 2 | 769
Lung Neoplasms 2 | 232
Lysinuric protein intolerance 2 | 15
Neurodegenerative Diseases 2 | 38
Neurodegenerative Disorders 2 | 79
Polycystic ovary syndrome 2 | 360
Schizophrenia 2 | 1,160
Waldenstrons macroglobulinemia 2 | 765
adrenocortical carcinoma 2 | 1,428
adult high grade glioma 2 | 3,801
ependymoma 2 | 4,679
glioblastoma 2 | 5,792
head and neck cancer and chronic obstructive pulmonary disease 2 | 239
lung adenocarcinoma 2 | 2,716
oligodendroglioma 2 | 2,850
Abnormal urinary amino-acid findings 1 | 38
Abnormality of the musculature 1 | 16
Aminoaciduria 1 | 38
Amyotrophic lateral sclerosis 1 | 451
Astrocytoma, Pilocytic 1 | 3,081
Autistic Disorder 1 | 364
Bipolar Disorder 1 | 666
Breast Neoplasms 1 | 445
Chronic obstructive pulmonary disease 1 | 184
Comatose 1 | 56
Congenital deafness 1 | 185
Cystinuria 1 | 18
Deafness 1 | 198
Depressive disorder 1 | 409
Elevated heart rate 1 | 25
Gaucher disease type 3 1 | 67
Gilles de la Tourette syndrome 1 | 47
Hearing Loss, Partial 1 | 185
Heavy chain disease 1 | 6
Hypotension 1 | 82
Kidney Neoplasm 1 | 29
Kidney Neoplasms 1 | 37
Latent syphilis 1 | 3
Mammary Neoplasms 1 | 425
Mental Depression 1 | 333
Metabolic acidosis 1 | 90
Multiple Sclerosis 1 | 540
Muscle Hypertonia 1 | 88
Narcolepsy 1 | 72
Neoplasm Recurrence, Local 1 | 37
Nonorganic psychosis 1 | 84
Parkinson's disease 1 | 392
Psychotic Disorders 1 | 151
Renal tubular disorder 1 | 12
Tachycardia 1 | 43
Weight Gain 1 | 100
active ulcerative colitis 1 | 764
chronic rhinosinusitis 1 | 512
colon cancer 1 | 1,478
gastric carcinoma 1 | 807
head and neck cancer 1 | 271
hearing impairment 1 | 199
intraductal papillary-mucinous adenoma (IPMA) 1 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 1 | 2,989
juvenile dermatomyositis 1 | 1,187
medulloblastoma 1 | 720
mucosa-associated lymphoid tissue lymphoma 1 | 484
nephrosclerosis 1 | 333
non diabetic and post-ischemic heart failure 1 | 200
pancreatic cancer 1 | 2,398
pituitary cancer 1 | 1,972
posterior fossa group A ependymoma 1 | 468
sarcoidosis 1 | 370
spina bifida 1 | 1,074
uncontrolled asthma 1 | 56

Tissue

Blood and immune system 13 | 16,909
Digestive Tract 13 | 17,369
Endocrine System 13 | 18,159
Female tissues 13 | 17,400
Liver and Pancreas 13 | 16,750
Respiratory system 13 | 16,393
Urinary Tract 13 | 16,678
Male tissues 12 | 17,142
Nervous System 12 | 16,725
Cardiovascular System 11 | 15,192
Skin and soft tissues 11 | 17,230

Target Family

Enzyme 10 | 4,145
Transporter 3 | 473

Reactome Pathway

Tryptophan catabolism 13 | 13
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proton-coupled amino acid transporter 4 SLC36A4 Tbio Transporter -1.46987 30.6 45
Indoleamine 2,3-dioxygenase 2 IDO2 Tbio Enzyme -1.96665 90.1 244
4F2 cell-surface antigen heavy chain SLC3A2 Tbio Transporter -2.82471 653.6 604
Kynurenine 3-monooxygenase KMO Tchem Enzyme -2.15501 134.1 127
Tryptophan 2,3-dioxygenase TDO2 Tchem Enzyme -2.89113 773.6 193
Indoleamine 2,3-dioxygenase 1 IDO1 Tchem Enzyme -2.62196 421.1 684
Kynurenine formamidase AFMID Tbio Enzyme -1.65562 44.8 67
Kynurenine--oxoglutarate transaminase 3 KYAT3 Tbio Enzyme -0.86445 6.75 59
Large neutral amino acids transporter small subunit 1 SLC7A5 Tbio Transporter -1.90516 156.1 254
Kynureninase KYNU Tchem Enzyme -1.61116 39.2 173