Development Level

Tbio 132 | 11,651
Tdark 25 | 6,593
Tchem 10 | 1,388
Tclin 1 | 612

IMPC Phenotype

preweaning lethality, complete... 21 | 979
decreased circulating choleste... 6 | 93
embryonic lethality prior to t... 5 | 278
decreased circulating HDL chol... 4 | 68
decreased circulating LDL chol... 4 | 38
abnormal seminal vesicle morph... 3 | 114
decreased body weight 3 | 161
decreased caudal vertebrae num... 3 | 53
decreased total body fat amoun... 3 | 207
embryonic lethality prior to o... 3 | 239
preweaning lethality, incomple... 3 | 499
abnormal embryo size 2 | 220
abnormal kidney morphology 2 | 65
abnormal lens morphology 2 | 81
cataract 2 | 92
decreased circulating alanine ... 2 | 47
decreased circulating free fat... 2 | 31
decreased lactate dehydrogenas... 2 | 16
decreased vertical activity 2 | 208
embryonic growth retardation 2 | 106
hydrometra 2 | 53
impaired glucose tolerance 2 | 75
increased mean corpuscular hem... 2 | 96
small testis 2 | 58
abnormal allantois morphology 1 | 8
abnormal behavior 1 | 298
abnormal blood vessel morpholo... 1 | 5
abnormal chorioallantoic fusio... 1 | 8
abnormal embryo turning 1 | 31
abnormal eye morphology 1 | 68
abnormal forebrain development 1 | 20
abnormal gait 1 | 69
abnormal heart morphology 1 | 162
abnormal hindbrain development 1 | 16
abnormal left-right axis patte... 1 | 2
abnormal limb bud morphology 1 | 17
abnormal liver morphology 1 | 17
abnormal lung morphology 1 | 26
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal neural tube morpholog... 1 | 12
abnormal optic vesicle formati... 1 | 4
abnormal otic vesicle morpholo... 1 | 3
abnormal pericardium morpholog... 1 | 26
abnormal pharyngeal arch morph... 1 | 8
abnormal retina morphology 1 | 71
abnormal skin condition 1 | 6
abnormal somite shape 1 | 5
abnormal stomach morphology 1 | 10
abnormal tail bud morphology 1 | 8
abnormal testis morphology 1 | 43
abnormal vibrissa morphology 1 | 25
abnormal visceral yolk sac mor... 1 | 6
abnormal vitelline vasculature... 1 | 6
brachydactyly 1 | 19
cardiovascular system phenotyp... 1 | 36
decreased blood urea nitrogen ... 1 | 51
decreased bone mineral content 1 | 151
decreased circulating alkaline... 1 | 46
decreased circulating amylase ... 1 | 28
decreased circulating aspartat... 1 | 34
decreased circulating calcium ... 1 | 36
decreased circulating creatini... 1 | 39
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased hematocrit 1 | 46
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 50
decreased threshold for audito... 1 | 26
edema 1 | 59
enlarged heart 1 | 210
enlarged heart atrium 1 | 4
enlarged lymph nodes 1 | 37
enlarged seminal vesicle 1 | 10
hydroencephaly 1 | 14
hypoactivity 1 | 132
increased anti-nuclear antigen... 1 | 19
increased blood urea nitrogen ... 1 | 48
increased circulating creatini... 1 | 38
increased circulating free fat... 1 | 20
increased circulating triglyce... 1 | 42
increased fasted circulating g... 1 | 76
increased grip strength 1 | 41
increased hematocrit 1 | 46
increased mean corpuscular vol... 1 | 92
increased mean platelet volume 1 | 45
increased red blood cell distr... 1 | 34
increased total body fat amoun... 1 | 134
microphthalmia 1 | 26
pale yolk sac 1 | 25
pallor 1 | 34
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
short tibia 1 | 97
syndactyly 1 | 23
thrombocytosis 1 | 27

Disease

ovarian cancer 109 | 8,520
Carcinoma 98 | 11,493
osteosarcoma 89 | 7,950
glioblastoma 71 | 5,792
psoriasis 60 | 6,694
medulloblastoma, large-cell 57 | 6,241
atypical teratoid / rhabdoid tumor 52 | 5,112
ependymoma 47 | 4,679
lung cancer 47 | 4,740
Breast cancer 38 | 3,578
Kidney cancer 38 | 2,613
intraductal papillary-mucinous adenoma (IPMA) 37 | 2,955
adult high grade glioma 35 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 34 | 3,291
lung adenocarcinoma 33 | 2,716
intraductal papillary-mucinous carcinoma (IPMC) 32 | 2,989
malignant mesothelioma 32 | 3,232
Multiple myeloma 31 | 1,332
Astrocytoma, Pilocytic 29 | 3,081
pancreatic ductal adenocarcinoma liver metastasis 29 | 1,962
group 3 medulloblastoma 28 | 4,104
invasive ductal carcinoma 28 | 2,951
non-small cell lung cancer 28 | 2,890
pancreatic cancer 28 | 2,398
primitive neuroectodermal tumor 28 | 3,035
lung carcinoma 25 | 2,843
tuberculosis 25 | 2,010
oligodendroglioma 24 | 2,850
diabetes mellitus 23 | 1,728
Autosomal recessive predisposition 22 | 1,442
acute quadriplegic myopathy 21 | 1,158
astrocytic glioma 21 | 2,597
group 4 medulloblastoma 21 | 1,855
Pick disease 20 | 1,894
non primary Sjogren syndrome sicca 19 | 891
Cancer 18 | 2,499
Rheumatoid arthritis 17 | 1,191
breast carcinoma 17 | 1,638
cystic fibrosis 17 | 1,696
dermatomyositis 17 | 966
pituitary cancer 17 | 1,972
ulcerative colitis 17 | 1,819
astrocytoma 16 | 1,146
spina bifida 16 | 1,074
subependymal giant cell astrocytoma 16 | 2,287
interstitial cystitis 15 | 2,312
cutaneous lupus erythematosus 14 | 1,057
hepatocellular carcinoma 14 | 547
juvenile dermatomyositis 14 | 1,187
Intellectual disability 12 | 1,016
active Crohn's disease 12 | 922
pancreatic carcinoma 12 | 562
Bipolar Disorder 11 | 666
Schizophrenia 11 | 1,160
acute myeloid leukemia 11 | 783
esophageal adenocarcinoma 11 | 737
Duchenne muscular dystrophy 10 | 601
Melanoma 10 | 711
Muscle hypotonia 10 | 571
Waldenstrons macroglobulinemia 10 | 765
colon cancer 10 | 1,478
pediatric high grade glioma 10 | 1,064
primary pancreatic ductal adenocarcinoma 10 | 1,109
Congenital disorder of glycosylation 9 | 54
adrenocortical carcinoma 9 | 1,428
autosomal dominant Emery-Dreifuss muscular dystrophy 9 | 510
tuberculosis and treatment for 6 months 9 | 409
Anemia 8 | 365
Cognitive delay 8 | 608
Epilepsy 8 | 792
Global developmental delay 8 | 608
Liver cancer 8 | 604
Mental and motor retardation 8 | 608
aldosterone-producing adenoma 8 | 665
ductal carcinoma in situ 8 | 1,745
gastric cancer 8 | 459
Dull intelligence 7 | 645
Endometrial cancer 7 | 311
Low intelligence 7 | 645
Mental Retardation 7 | 645
Mental deficiency 7 | 645
Poor school performance 7 | 645
active ulcerative colitis 7 | 764
medulloblastoma 7 | 720
mucosa-associated lymphoid tissue lymphoma 7 | 484
posterior fossa group A ependymoma 7 | 468
primary Sjogren syndrome 7 | 735
sonic hedgehog group medulloblastoma 7 | 467
Amyotrophic lateral sclerosis 6 | 451
Down syndrome 6 | 499
Endometriosis 6 | 540
Neuropathy 6 | 261
Polycystic ovary syndrome 6 | 360
Seizures 6 | 596
Short stature 6 | 531
Skin cancer 6 | 469
atypical teratoid/rhabdoid tumor 6 | 357
gastric carcinoma 6 | 807
hereditary spastic paraplegia 6 | 318
nephrosclerosis 6 | 333

Tissue

Endocrine System 166 | 18,159
Digestive Tract 165 | 17,369
Female tissues 165 | 17,400
Skin and soft tissues 165 | 17,230
Liver and Pancreas 164 | 16,750
Nervous System 164 | 16,725
Blood and immune system 163 | 16,909
Male tissues 162 | 17,142
Urinary Tract 162 | 16,678
Respiratory system 161 | 16,393
Cardiovascular System 160 | 15,192

Target Family

Non-IDG 119 | 12,091
Enzyme 46 | 4,145
Ion Channel 1 | 344
Kinase 1 | 634
Transcription Factor 1 | 1,400

Reactome Pathway

Transport to the Golgi and sub... 168 | 168
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTP-binding protein SAR1b SAR1B Tbio Enzyme -1.91051 79.7 184
Trafficking protein particle complex subunit 2-like protein TRAPPC2L Tdark Non-IDG -0.18066 0.74 35
F-actin-capping protein subunit alpha-3 CAPZA3 Tdark Non-IDG -0.56455 3.20 78
ADP-ribosylation factor GTPase-activating protein 2 ARFGAP2 Tbio Enzyme -0.97596 10.1 144
Spectrin beta chain, non-erythrocytic 5 SPTBN5 Tbio Non-IDG -0.41365 2.99 32
Coatomer subunit beta COPB1 Tbio Non-IDG -1.94049 82.6 148
Coatomer subunit alpha COPA Tbio Non-IDG -2.45140 283.3 88
Cytoplasmic dynein 1 light intermediate chain 1 DYNC1LI1 Tbio Non-IDG -1.67860 45.9 100
Trafficking protein particle complex subunit 1 TRAPPC1 Tdark Non-IDG -0.68524 4.44 46
Coatomer subunit gamma-1 COPG1 Tbio Non-IDG -1.70829 49.0 89