Development Level

Tbio 465 | 11,445
Tchem 142 | 1,598
Tdark 60 | 6,588
Tclin 50 | 613

Collection

Ion Channel: IDG Consortium (T... 14 | 99
Kinase: IDG Consortium (Target... 3 | 125
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 51 | 979
preweaning lethality, incomple... 26 | 499
embryonic lethality prior to t... 17 | 278
abnormal behavior 14 | 298
embryonic lethality prior to o... 14 | 239
abnormal bone structure 11 | 187
abnormal seminal vesicle morph... 11 | 114
decreased total body fat amoun... 10 | 207
decreased vertical activity 10 | 208
increased circulating alkaline... 10 | 122
abnormal embryo size 9 | 220
decreased circulating choleste... 9 | 93
increased startle reflex 9 | 112
decreased prepulse inhibition 8 | 82
enlarged heart 8 | 210
hyperactivity 8 | 148
impaired glucose tolerance 8 | 75
increased mean corpuscular hem... 8 | 96
decreased circulating HDL chol... 7 | 68
increased circulating HDL chol... 7 | 80
increased heart weight 7 | 62
abnormal heart morphology 6 | 162
abnormal kidney morphology 6 | 65
abnormal sleep behavior 6 | 70
embryonic growth retardation 6 | 106
hypoactivity 6 | 132
increased circulating choleste... 6 | 66
prolonged QT interval 6 | 38
decreased body weight 5 | 161
decreased bone mineral content 5 | 151
decreased bone mineral density 5 | 126
decreased caudal vertebrae num... 5 | 53
decreased circulating glucose ... 5 | 126
decreased erythrocyte cell num... 5 | 62
decreased hemoglobin content 5 | 68
decreased mean corpuscular hem... 5 | 50
decreased mean corpuscular vol... 5 | 79
enlarged spleen 5 | 41
increased lean body mass 5 | 172
increased total body fat amoun... 5 | 134
prolonged ST segment 5 | 36
abnormal eye morphology 4 | 68
abnormal lens morphology 4 | 81
abnormal retina morphology 4 | 71
cardiovascular system phenotyp... 4 | 36
cataract 4 | 92
decreased circulating serum al... 4 | 82
decreased fasted circulating g... 4 | 65
decreased mean platelet volume 4 | 25
improved glucose tolerance 4 | 79
increased circulating total pr... 4 | 28
increased circulating triglyce... 4 | 42
increased mean corpuscular vol... 4 | 92
small superior vagus ganglion 4 | 74
abnormal coat appearance 3 | 31
abnormal gait 3 | 69
abnormal neural tube closure 3 | 46
abnormal tail morphology 3 | 25
abnormal vibrissa morphology 3 | 25
decreased circulating LDL chol... 3 | 38
decreased circulating alkaline... 3 | 46
decreased circulating total pr... 3 | 49
decreased circulating triglyce... 3 | 79
decreased leukocyte cell numbe... 3 | 73
decreased lymphocyte cell numb... 3 | 83
decreased neutrophil cell numb... 3 | 42
decreased startle reflex 3 | 75
edema 3 | 59
hydrometra 3 | 53
impaired righting response 3 | 26
increased blood urea nitrogen ... 3 | 48
increased body length 3 | 32
increased circulating amylase ... 3 | 25
increased circulating creatini... 3 | 38
increased circulating free fat... 3 | 20
increased circulating iron lev... 3 | 30
increased circulating serum al... 3 | 22
increased leukocyte cell numbe... 3 | 47
increased monocyte cell number 3 | 63
increased or absent threshold ... 3 | 101
limb grasping 3 | 41
prenatal lethality prior to he... 3 | 87
small adrenal glands 3 | 16
vertebral fusion 3 | 23
abnormal epididymis morphology 2 | 42
abnormal spleen morphology 2 | 55
absent vibrissae 2 | 12
decreased circulating bilirubi... 2 | 19
decreased circulating calcium ... 2 | 36
decreased hematocrit 2 | 46
increased body weight 2 | 25
increased bone mineral content 2 | 108
increased circulating aspartat... 2 | 15
increased circulating bilirubi... 2 | 16
increased circulating sodium l... 2 | 71
increased fasted circulating g... 2 | 76
increased mean platelet volume 2 | 45
increased prepulse inhibition 2 | 32
short tibia 2 | 97
thrombocytosis 2 | 27

Disease

Carcinoma 511 | 11,493
ovarian cancer 347 | 8,520
osteosarcoma 307 | 7,950
psoriasis 286 | 6,694
medulloblastoma, large-cell 263 | 6,241
glioblastoma 258 | 5,792
atypical teratoid / rhabdoid tumor 217 | 5,112
ependymoma 206 | 4,679
lung cancer 202 | 4,740
group 3 medulloblastoma 163 | 4,104
adult high grade glioma 159 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 158 | 3,291
Breast cancer 151 | 3,578
intraductal papillary-mucinous adenoma (IPMA) 151 | 2,955
lung carcinoma 149 | 2,843
malignant mesothelioma 142 | 3,232
Kidney cancer 141 | 2,613
intraductal papillary-mucinous carcinoma (IPMC) 140 | 2,989
Astrocytoma, Pilocytic 133 | 3,081
oligodendroglioma 131 | 2,850
primitive neuroectodermal tumor 130 | 3,035
invasive ductal carcinoma 128 | 2,951
pancreatic cancer 128 | 2,398
lung adenocarcinoma 123 | 2,716
non-small cell lung cancer 120 | 2,890
pancreatic ductal adenocarcinoma liver metastasis 118 | 1,962
astrocytic glioma 117 | 2,597
Autosomal recessive predisposition 115 | 1,442
subependymal giant cell astrocytoma 113 | 2,287
pituitary cancer 103 | 1,972
interstitial cystitis 101 | 2,312
Pick disease 100 | 1,894
cystic fibrosis 95 | 1,696
Cancer 94 | 2,499
tuberculosis 92 | 2,010
ductal carcinoma in situ 91 | 1,745
diabetes mellitus 87 | 1,728
ulcerative colitis 87 | 1,819
Multiple myeloma 74 | 1,332
active Crohn's disease 71 | 922
colon cancer 71 | 1,478
Epilepsy 64 | 792
Obesity 64 | 678
group 4 medulloblastoma 62 | 1,855
Schizophrenia 61 | 1,160
adrenocortical carcinoma 60 | 1,428
breast carcinoma 60 | 1,638
active ulcerative colitis 57 | 764
Rheumatoid arthritis 56 | 1,191
Hypertension 54 | 396
Intellectual disability 50 | 1,016
Kidney disease 50 | 430
acute quadriplegic myopathy 50 | 1,158
astrocytoma 50 | 1,146
Alzheimer's disease 49 | 658
Liver Cirrhosis, Experimental 47 | 769
primary pancreatic ductal adenocarcinoma 47 | 1,109
Seizures 46 | 596
non primary Sjogren syndrome sicca 45 | 891
pediatric high grade glioma 45 | 1,064
cutaneous lupus erythematosus 44 | 1,057
Anemia 43 | 365
Melanoma 40 | 711
nasopharyngeal carcinoma 40 | 1,058
Liver cancer 39 | 604
Neurodegenerative disease 39 | 414
juvenile dermatomyositis 39 | 1,187
Bipolar Disorder 38 | 666
Failure to gain weight 38 | 365
Hypertensive disease 38 | 292
Pediatric failure to thrive 38 | 365
dermatomyositis 38 | 966
Hepatomegaly 37 | 285
progressive supranuclear palsy 37 | 676
Atherosclerosis 36 | 291
Dull intelligence 36 | 645
Low intelligence 36 | 645
Mental Retardation 36 | 645
Mental deficiency 36 | 645
Poor school performance 36 | 645
Waldenstrons macroglobulinemia 36 | 765
Atopic dermatitis 35 | 952
Skin cancer 35 | 469
gastric carcinoma 35 | 807
Coronary artery disease 34 | 268
Duchenne muscular dystrophy 33 | 601
aldosterone-producing adenoma 33 | 665
spina bifida 33 | 1,074
Diarrhea 32 | 253
Down syndrome 32 | 499
Muscle hypotonia 32 | 571
esophageal adenocarcinoma 32 | 737
Cognitive delay 31 | 608
Colorectal Neoplasms 31 | 243
Global developmental delay 31 | 608
Lipid metabolism disorder 31 | 114
Mental and motor retardation 31 | 608
Vascular disease 31 | 319
nephrosclerosis 31 | 333
Short stature 30 | 531

Tissue

Endocrine System 698 | 18,159
Digestive Tract 691 | 17,369
Urinary Tract 680 | 16,678
Female tissues 678 | 17,400
Male tissues 678 | 17,142
Liver and Pancreas 670 | 16,750
Skin and soft tissues 670 | 17,230
Nervous System 669 | 16,725
Blood and immune system 660 | 16,909
Respiratory system 635 | 16,393
Cardiovascular System 584 | 15,192

Target Family

Transporter 301 | 473
Non-IDG 185 | 12,091
Enzyme 136 | 4,145
Ion Channel 72 | 344
Kinase 16 | 634
Transcription Factor 3 | 1,400
Nuclear Receptor 2 | 48
Epigenetic 1 | 242
GPCR 1 | 408

Reactome Pathway

Transport of small molecules 717 | 717
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Transient receptor potential cation channel subfamily V member 2 TRPV2 Tchem Ion Channel -2.28525 197.9 203
Cationic amino acid transporter 3 SLC7A3 Tbio Transporter -2.20835 146.6 38
Adenylate cyclase type 8 ADCY8 Tbio Enzyme -2.04645 112.4 147
Solute carrier family 2, facilitated glucose transporter member 8 SLC2A8 Tbio Transporter -1.54482 35.6 110
Electrogenic sodium bicarbonate cotransporter 1 SLC4A4 Tbio Transporter -2.63743 436.2 124
GTP-binding protein SAR1b SAR1B Tbio Enzyme -1.91051 79.7 184
Proteasome activator complex subunit 2 PSME2 Tbio Non-IDG -1.47440 29.1 305
Solute carrier family 12 member 7 SLC12A7 Tbio Transporter -1.46102 28.2 156
Sodium/potassium-transporting ATPase subunit alpha-4 ATP1A4 Tclin Transporter -1.73566 51.3 5
Lipase maturation factor 1 LMF1 Tbio Enzyme -1.30021 24.5 35