Development Level

Tbio 80 | 10,625
Tchem 12 | 1,890
Tdark 8 | 7,003
Tclin 3 | 602

Collection

Eligible Ion Channel Proteins 1 | 117

IMPC Term

preweaning lethality, incomple... 4 | 260
decreased total body fat amoun... 3 | 186
increased circulating alkaline... 3 | 119
abnormal bone structure 2 | 131
abnormal retina morphology 2 | 100
abnormal retinal pigmentation 2 | 61
decreased bone mineral content 2 | 157
decreased bone mineral density 2 | 126
decreased fasted circulating g... 2 | 49
increased circulating sodium l... 2 | 71
increased grip strength 2 | 83
abnormal coat appearance 1 | 25
abnormal coat/hair pigmentatio... 1 | 54
abnormal coping response 1 | 12
abnormal epididymis morphology 1 | 31
abnormal eye morphology 1 | 38
abnormal femur morphology 1 | 14
abnormal incisor color 1 | 2
abnormal iris morphology 1 | 12
abnormal iris transilluminatio... 1 | 1
abnormal lens morphology 1 | 73
abnormal spine curvature 1 | 7
abnormal vitreous body morphol... 1 | 7
absent pinna reflex 1 | 21
cataract 1 | 26
decreased CD4-positive, CD25-p... 1 | 24
decreased body length 1 | 108
decreased circulating chloride... 1 | 32
decreased circulating glucose ... 1 | 121
decreased hemoglobin content 1 | 53
decreased lean body mass 1 | 195
decreased mean corpuscular vol... 1 | 50
decreased prepulse inhibition 1 | 52
decreased rib number 1 | 59
decreased startle reflex 1 | 48
enlarged epididymis 1 | 27
enlarged thymus 1 | 4
eyelids fail to open 1 | 2
impaired glucose tolerance 1 | 52
impaired righting response 1 | 19
improved glucose tolerance 1 | 56
increased blood urea nitrogen ... 1 | 44
increased circulating HDL chol... 1 | 63
increased circulating amylase ... 1 | 13
increased circulating calcium ... 1 | 32
increased circulating choleste... 1 | 53
increased circulating creatini... 1 | 29
increased circulating iron lev... 1 | 25
increased circulating magnesiu... 1 | 10
increased circulating serum al... 1 | 25
increased mean corpuscular hem... 1 | 93
increased startle reflex 1 | 38
kyphosis 1 | 5
persistence of hyaloid vascula... 1 | 22
straub tail 1 | 26
trunk curl 1 | 15

Disease

glioblastoma 43 | 5,572
medulloblastoma, large-cell 42 | 6,234
osteosarcoma 40 | 7,933
ovarian cancer 40 | 8,484
atypical teratoid / rhabdoid tumor 36 | 4,369
psoriasis 35 | 6,685
ependymoma 27 | 2,514
lung cancer 27 | 4,466
primitive neuroectodermal tumor 25 | 3,031
pediatric high grade glioma 24 | 2,712
intraductal papillary-mucinous adenoma (IPMA) 23 | 2,956
oligodendroglioma 23 | 2,849
pilocytic astrocytoma 23 | 3,086
intraductal papillary-mucinous neoplasm (IPMN) 22 | 3,289
malignant mesothelioma 22 | 3,162
pituitary cancer 22 | 1,972
intraductal papillary-mucinous carcinoma (IPMC) 21 | 2,988
lung carcinoma 21 | 2,844
pancreatic cancer 20 | 2,300
ulcerative colitis 20 | 2,087
invasive ductal carcinoma 19 | 2,950
Breast cancer 18 | 3,094
astrocytic glioma 18 | 2,241
non-small cell lung cancer 18 | 2,798
Carcinoma 16 | 2,147
colon cancer 16 | 1,475
group 4 medulloblastoma 16 | 1,875
subependymal giant cell astrocytoma 16 | 2,287
Pick disease 15 | 1,893
cystic fibrosis 15 | 1,665
ductal carcinoma in situ 15 | 1,745
tuberculosis 15 | 1,557
atypical teratoid/rhabdoid tumor 14 | 1,095
Epilepsy 13 | 346
lung adenocarcinoma 13 | 2,713
Cancer 12 | 2,346
Metabolic acidosis 12 | 49
sonic hedgehog group medulloblastoma 12 | 1,482
group 3 medulloblastoma 11 | 2,254
interstitial cystitis 11 | 2,299
primary pancreatic ductal adenocarcinoma 11 | 1,271
active Crohn's disease 10 | 918
adult high grade glioma 10 | 2,148
astrocytoma 10 | 1,493
posterior fossa group A ependymoma 10 | 1,511
posterior fossa group B ependymoma 10 | 1,530
Lysinuric protein intolerance 9 | 15
Cystinuria 8 | 18
Diastrophic dysplasia 8 | 21
Schizophrenia 8 | 501
cutaneous lupus erythematosus 8 | 1,056
medulloblastoma 8 | 1,524
non primary Sjogren syndrome sicca 8 | 840
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,795
Hartnup disease 7 | 13
breast carcinoma 7 | 1,614
gastric carcinoma 7 | 832
nephrosclerosis 7 | 329
Alzheimer's disease 6 | 644
Brain Ischemia 6 | 87
Edema 6 | 38
Endometriosis 6 | 535
IGA Glomerulonephritis 6 | 454
active ulcerative colitis 6 | 477
Amyotrophic Lateral Sclerosis 5 | 431
Atopic dermatitis 5 | 944
Autistic Disorder 5 | 320
Calcinosis 5 | 62
Diarrhea 5 | 155
Hyperphosphatemia 5 | 32
Hypertension 5 | 287
Kidney disease 5 | 396
Multiple myeloma 5 | 1,327
Nephrolithiasis 5 | 30
Prostatic Neoplasms 5 | 471
Rheumatoid Arthritis 5 | 1,160
Schnyder corneal dystrophy 5 | 23
Seizures 5 | 95
acute quadriplegic myopathy 5 | 1,157
aldosterone-producing adenoma 5 | 664
juvenile dermatomyositis 5 | 1,189
spina bifida 5 | 1,064
Barrett's esophagus 4 | 183
Heart disease 4 | 279
Hypophosphatemia 4 | 31
Iminoglycinuria 4 | 4
Intellectual disability 4 | 573
Neurodegenerative disease 4 | 383
Renal tubular acidosis 4 | 14
acute myeloid leukemia 4 | 780
chronic rhinosinusitis 4 | 512
diabetes mellitus 4 | 1,663
esophageal adenocarcinoma 4 | 737
facioscapulohumeral dystrophy 4 | 286
fibroadenoma 4 | 557
head and neck cancer and chronic obstructive pulmonary disease 4 | 237
mucosa-associated lymphoid tissue lymphoma 4 | 480
nasopharyngeal carcinoma 4 | 1,056
pancreatic carcinoma 4 | 567
progressive supranuclear palsy 4 | 674

Tissue

Digestive Tract 102 | 18,473
Endocrine System 102 | 18,512
Female tissues 102 | 18,647
Liver and Pancreas 102 | 18,136
Nervous System 102 | 18,561
Skin and soft tissues 102 | 18,115
Male tissues 101 | 17,969
Urinary Tract 101 | 18,444
Blood and immune system 100 | 17,995
Cardiovascular System 100 | 17,958
Respiratory system 100 | 17,484

Target Family

Transporter 98 | 473
Ion Channel 2 | 341
Non-IDG 2 | 11,971
Enzyme 1 | 4,146

Reactome Pathway

Transport of inorganic cations... 103 | 103
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Sodium/hydrogen exchanger 4 SLC9A4 Tdark Transporter -1.25841 17.4 6
Sodium/calcium exchanger 2 SLC8A2 Tbio Transporter -1.56223 31.9 51
Solute carrier family 26 member 9 SLC26A9 Tbio Transporter -1.20448 19.3 27
Sodium-dependent phosphate transporter 2 SLC20A2 Tbio Transporter -2.18737 165.3 97
Vesicular glutamate transporter 3 SLC17A8 Tbio Transporter -1.97274 103.1 38
Sulfate transporter SLC26A2 Tbio Transporter -2.43817 275.5 68
Band 3 anion transport protein SLC4A1 Tbio Transporter -3.02453 1271.7 133
Solute carrier family 15 member 1 SLC15A1 Tchem Transporter -2.70013 532.5 167
Excitatory amino acid transporter 4 SLC1A6 Tbio Transporter -1.83815 70.5 92
Sodium-dependent neutral amino acid transporter B(0)AT1 SLC6A19 Tbio Transporter -1.80389 64.5 22