Development Level

Tbio 97 | 11,445
Tchem 59 | 1,598
Tclin 54 | 613
Tdark 11 | 6,588

Collection

Ion Channel: IDG Consortium (T... 21 | 99
Kinase: IDG Consortium (Target... 3 | 125

IMPC Phenotype

preweaning lethality, incomple... 12 | 499
preweaning lethality, complete... 9 | 979
abnormal behavior 8 | 298
hyperactivity 7 | 148
decreased body weight 6 | 161
decreased total body fat amoun... 6 | 207
increased circulating sodium l... 6 | 71
decreased bone mineral content 4 | 151
decreased bone mineral density 4 | 126
enlarged heart 4 | 210
increased startle reflex 4 | 112
tremors 4 | 39
abnormal bone mineralization 3 | 38
abnormal bone structure 3 | 187
abnormal gait 3 | 69
decreased circulating HDL chol... 3 | 68
decreased circulating LDL chol... 3 | 38
decreased circulating choleste... 3 | 93
decreased grip strength 3 | 116
increased bone mineral content 3 | 108
increased circulating chloride... 3 | 41
abnormal behavioral response t... 2 | 66
abnormal epididymis morphology 2 | 42
abnormal heart morphology 2 | 162
abnormal lens morphology 2 | 81
abnormal response to tactile s... 2 | 17
abnormal retinal blood vessel ... 2 | 26
abnormal startle reflex 2 | 15
abnormal testis morphology 2 | 43
decreased body length 2 | 101
decreased circulating fructosa... 2 | 30
decreased circulating insulin ... 2 | 76
decreased circulating serum al... 2 | 82
decreased circulating total pr... 2 | 49
decreased circulating triglyce... 2 | 79
decreased neutrophil cell numb... 2 | 42
decreased vertical activity 2 | 208
increased circulating alanine ... 2 | 13
increased circulating iron lev... 2 | 30
increased lean body mass 2 | 172
increased mean corpuscular vol... 2 | 92
increased total body fat amoun... 2 | 134
small superior vagus ganglion 2 | 74
small testis 2 | 58
abnormal ear morphology 1 | 9
abnormal hair growth 1 | 10
abnormal head morphology 1 | 10
abnormal joint morphology 1 | 23
abnormal locomotor behavior 1 | 24
abnormal optic disc morphology 1 | 10
abnormal seminal vesicle morph... 1 | 114
abnormal sleep behavior 1 | 70
abnormal spleen morphology 1 | 55
abnormal vocalization 1 | 21
abnormal whole-body plethysmog... 1 | 4
absent pinna reflex 1 | 23
absent startle reflex 1 | 24
brachydactyly 1 | 19
cataract 1 | 92
convulsive seizures 1 | 13
decreased T cell number 1 | 15
decreased caudal vertebrae num... 1 | 53
decreased circulating amylase ... 1 | 28
decreased circulating calcium ... 1 | 36
decreased circulating chloride... 1 | 30
decreased circulating free fat... 1 | 31
decreased circulating sodium l... 1 | 22
decreased erythrocyte cell num... 1 | 62
decreased exploration in new e... 1 | 11
decreased fasted circulating g... 1 | 65
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 31
decreased prepulse inhibition 1 | 82
decreased pulmonary respirator... 1 | 5
decreased red blood cell distr... 1 | 41
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged epididymis 1 | 31
enlarged spleen 1 | 41
hydrometra 1 | 53
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
impaired pupillary reflex 1 | 26
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased circulating fructosa... 1 | 13
increased circulating triglyce... 1 | 42
increased heart weight 1 | 62
increased hemoglobin content 1 | 45
increased mean platelet volume 1 | 45
increased prepulse inhibition 1 | 32
increased vertical activity 1 | 24
limb grasping 1 | 41
short tibia 1 | 97
small kidney 1 | 16
syndactyly 1 | 23
thin ventricular wall 1 | 24
thrombocytosis 1 | 27

Disease

Carcinoma 171 | 11,493
glioblastoma 134 | 5,792
medulloblastoma, large-cell 133 | 6,241
atypical teratoid / rhabdoid tumor 125 | 5,112
ependymoma 120 | 4,679
adult high grade glioma 109 | 3,801
primitive neuroectodermal tumor 99 | 3,035
psoriasis 98 | 6,694
Astrocytoma, Pilocytic 97 | 3,081
group 3 medulloblastoma 97 | 4,104
ovarian cancer 94 | 8,520
oligodendroglioma 93 | 2,850
Schizophrenia 90 | 1,160
osteosarcoma 90 | 7,950
astrocytic glioma 83 | 2,597
lung carcinoma 72 | 2,843
subependymal giant cell astrocytoma 68 | 2,287
Pick disease 67 | 1,894
Bipolar Disorder 63 | 666
lung cancer 61 | 4,740
Kidney cancer 59 | 2,613
Epilepsy 57 | 792
Breast cancer 44 | 3,578
malignant mesothelioma 44 | 3,232
Alcoholic Intoxication, Chronic 43 | 289
Depressive disorder 40 | 409
pituitary cancer 40 | 1,972
Mental Depression 37 | 333
invasive ductal carcinoma 34 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 33 | 2,955
non-small cell lung cancer 33 | 2,890
Intellectual disability 32 | 1,016
Autistic Disorder 31 | 364
Parkinson's disease 31 | 392
Seizures 31 | 596
Major Depressive Disorder 30 | 301
intraductal papillary-mucinous neoplasm (IPMN) 29 | 3,291
lung adenocarcinoma 29 | 2,716
group 4 medulloblastoma 28 | 1,855
intraductal papillary-mucinous carcinoma (IPMC) 28 | 2,989
Alcohol dependence 27 | 107
General anesthesia 27 | 53
Alzheimer's disease 26 | 658
interstitial cystitis 26 | 2,312
pancreatic cancer 26 | 2,398
Unipolar Depression 24 | 250
Mood Disorders 23 | 184
ductal carcinoma in situ 23 | 1,745
Tonic-clonic epilepsy 22 | 47
Toxic encephalopathy 22 | 141
astrocytoma 22 | 1,146
tuberculosis 22 | 2,010
Autosomal recessive predisposition 21 | 1,442
Cancer 21 | 2,499
colon cancer 21 | 1,478
breast carcinoma 20 | 1,638
Cognitive delay 19 | 608
Global developmental delay 19 | 608
Mental and motor retardation 19 | 608
ulcerative colitis 19 | 1,819
Cocaine-Related Disorders 18 | 92
Liver cancer 18 | 604
Local anesthesia 18 | 40
Nicotine dependence 18 | 54
Dull intelligence 17 | 645
Low intelligence 17 | 645
Mental Retardation 17 | 645
Mental deficiency 17 | 645
Poor school performance 17 | 645
Rheumatoid arthritis 17 | 1,191
active Crohn's disease 17 | 922
pediatric high grade glioma 17 | 1,064
Muscle hypotonia 16 | 571
Alcoholism 15 | 45
Anxiety 15 | 136
Attention deficit hyperactivity disorder 15 | 278
Lennox-Gastaut syndrome 15 | 34
Obesity 15 | 678
Simple partial seizure 15 | 26
Substance Withdrawal Syndrome 15 | 55
non primary Sjogren syndrome sicca 15 | 891
Amyotrophic lateral sclerosis 14 | 451
Cocaine Dependence 14 | 51
Dementia 14 | 175
Epilepsy characterized by intractable complex partial seizures 14 | 28
Melanoma 14 | 711
active ulcerative colitis 14 | 764
cystic fibrosis 14 | 1,696
juvenile dermatomyositis 14 | 1,187
Down syndrome 13 | 499
Irritable bowel syndrome 13 | 60
Migraine Prevention 13 | 23
Tetanus 13 | 68
adrenocortical carcinoma 13 | 1,428
pancreatic ductal adenocarcinoma liver metastasis 13 | 1,962
Cleft Palate 12 | 271
Multiple myeloma 12 | 1,332
cutaneous lupus erythematosus 12 | 1,057
diabetes mellitus 12 | 1,728
gastric carcinoma 12 | 807

Tissue

Endocrine System 214 | 18,159
Nervous System 206 | 16,725
Digestive Tract 204 | 17,369
Female tissues 198 | 17,400
Skin and soft tissues 198 | 17,230
Blood and immune system 194 | 16,909
Male tissues 194 | 17,142
Liver and Pancreas 186 | 16,750
Urinary Tract 183 | 16,678
Respiratory system 176 | 16,393
Cardiovascular System 162 | 15,192

Target Family

Ion Channel 76 | 344
Non-IDG 68 | 12,091
Enzyme 33 | 4,145
Kinase 21 | 634
Transporter 20 | 473
GPCR 2 | 408
Transcription Factor 1 | 1,400

Reactome Pathway

Transmission across Chemical S... 221 | 221
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Neuroplastin NPTN Tbio Non-IDG -2.31075 211.6 201
Adenylate cyclase type 8 ADCY8 Tbio Enzyme -2.04645 112.4 147
Ribosomal protein S6 kinase alpha-6 RPS6KA6 Tchem Kinase -1.26563 21.6 158
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 GNG8 Tdark Non-IDG -2.17483 154.8 34
Glutamate receptor-interacting protein 1 GRIP1 Tbio Non-IDG -2.18570 152.7 157
Synapsin-1 SYN1 Tbio Non-IDG -2.86836 712.4 770
Protein kinase C beta type PRKCB Tchem Kinase -2.00437 93.5 598
Neuronal acetylcholine receptor subunit beta-2 CHRNB2 Tclin Ion Channel -1.62448 37.6 174
Calcium/calmodulin-dependent protein kinase type II subunit gamma CAMK2G Tchem Kinase -0.94556 7.03 308
Calcium/calmodulin-dependent protein kinase type II subunit beta CAMK2B Tchem Kinase -1.14550 13.6 344