Development Level

Tbio 405 | 10,625
Tchem 138 | 1,890
Tdark 66 | 7,003
Tclin 60 | 602

Collection

Eligible Ion Channel Proteins 29 | 117
Eligible Kinase Proteins 3 | 134

IMPC Term

preweaning lethality, complete... 32 | 633
preweaning lethality, incomple... 12 | 260
decreased total body fat amoun... 11 | 186
abnormal bone structure 10 | 131
embryonic lethality prior to t... 9 | 187
abnormal behavior 8 | 226
decreased bone mineral density 8 | 126
decreased lean body mass 8 | 195
increased circulating alkaline... 8 | 119
decreased bone mineral content 7 | 157
hypoactivity 6 | 89
increased grip strength 6 | 83
increased mean corpuscular hem... 6 | 93
abnormal retina morphology 5 | 100
decreased rib number 5 | 59
embryonic lethality prior to o... 5 | 148
impaired glucose tolerance 5 | 52
abnormal bone mineralization 4 | 55
abnormal coat appearance 4 | 25
abnormal lens morphology 4 | 73
decreased fasted circulating g... 4 | 49
decreased grip strength 4 | 123
decreased mean corpuscular vol... 4 | 50
decreased prepulse inhibition 4 | 52
increased bone mineral density 4 | 52
increased heart weight 4 | 37
short tibia 4 | 82
vertebral fusion 4 | 23
abnormal gait 3 | 51
abnormal retinal pigmentation 3 | 61
absent vibrissae 3 | 14
cardiovascular system phenotyp... 3 | 35
cataract 3 | 26
decreased body length 3 | 108
decreased body weight 3 | 174
decreased caudal vertebrae num... 3 | 49
decreased circulating HDL chol... 3 | 77
decreased circulating serum al... 3 | 79
decreased erythrocyte cell num... 3 | 43
decreased hemoglobin content 3 | 53
decreased mean corpuscular hem... 3 | 34
hyperactivity 3 | 108
increased blood urea nitrogen ... 3 | 44
increased body weight 3 | 42
increased circulating creatini... 3 | 29
increased circulating sodium l... 3 | 71
abnormal epididymis morphology 2 | 31
abnormal eye morphology 2 | 38
abnormal kidney morphology 2 | 30
abnormal seminal vesicle morph... 2 | 47
decreased circulating LDL chol... 2 | 37
decreased circulating alanine ... 2 | 53
decreased circulating amylase ... 2 | 24
decreased circulating chloride... 2 | 32
decreased circulating choleste... 2 | 85
decreased circulating fructosa... 2 | 31
decreased circulating glucose ... 2 | 121
decreased circulating total pr... 2 | 41
decreased circulating triglyce... 2 | 83
decreased heart weight 2 | 44
decreased leukocyte cell numbe... 2 | 54
decreased mean corpuscular hem... 2 | 19
decreased startle reflex 2 | 48
enlarged epididymis 2 | 27
impaired righting response 2 | 19
improved glucose tolerance 2 | 56
increased bone mineral content 2 | 92
increased circulating HDL chol... 2 | 63
increased circulating amylase ... 2 | 13
increased circulating aspartat... 2 | 17
increased circulating choleste... 2 | 53
increased circulating serum al... 2 | 25
increased circulating total pr... 2 | 20
increased exploration in new e... 2 | 56
increased mature B cell number 2 | 12
increased mean corpuscular vol... 2 | 91
increased or absent threshold ... 2 | 128
increased startle reflex 2 | 38
increased total body fat amoun... 2 | 57
limb grasping 2 | 35
small adrenal glands 2 | 15
small superior vagus ganglion 2 | 20
straub tail 2 | 26
thrombocytosis 2 | 23
abnormal cornea morphology 1 | 24
abnormal heart morphology 1 | 51
abnormal locomotor activation 1 | 26
abnormal rib morphology 1 | 28
abnormal spleen morphology 1 | 36
abnormal thoracic vertebrae mo... 1 | 16
abnormal tooth morphology 1 | 24
abnormal vocalization 1 | 21
decreased circulating sodium l... 1 | 18
increased body length 1 | 20
increased circulating iron lev... 1 | 25
increased circulating magnesiu... 1 | 10
increased lean body mass 1 | 107
increased sacral vertebrae num... 1 | 62
long tibia 1 | 13
persistence of hyaloid vascula... 1 | 22

Disease

ovarian cancer 309 | 8,484
osteosarcoma 280 | 7,933
psoriasis 264 | 6,685
medulloblastoma, large-cell 261 | 6,234
glioblastoma 236 | 5,572
lung cancer 184 | 4,466
atypical teratoid / rhabdoid tumor 172 | 4,369
lung carcinoma 141 | 2,844
primitive neuroectodermal tumor 139 | 3,031
intraductal papillary-mucinous adenoma (IPMA) 137 | 2,956
intraductal papillary-mucinous neoplasm (IPMN) 137 | 3,289
Carcinoma 130 | 2,147
pilocytic astrocytoma 129 | 3,086
pediatric high grade glioma 126 | 2,712
ependymoma 125 | 2,514
intraductal papillary-mucinous carcinoma (IPMC) 124 | 2,988
oligodendroglioma 124 | 2,849
malignant mesothelioma 122 | 3,162
Breast cancer 120 | 3,094
non-small cell lung cancer 111 | 2,798
pancreatic cancer 107 | 2,300
Pick disease 104 | 1,893
lung adenocarcinoma 104 | 2,713
invasive ductal carcinoma 101 | 2,950
subependymal giant cell astrocytoma 101 | 2,287
pituitary cancer 95 | 1,972
ulcerative colitis 94 | 2,087
astrocytic glioma 92 | 2,241
interstitial cystitis 88 | 2,299
group 3 medulloblastoma 86 | 2,254
cystic fibrosis 82 | 1,665
pancreatic ductal adenocarcinoma liver metastasis 82 | 1,795
Cancer 77 | 2,346
adult high grade glioma 74 | 2,148
ductal carcinoma in situ 70 | 1,745
astrocytoma 68 | 1,493
group 4 medulloblastoma 67 | 1,875
Multiple myeloma 66 | 1,327
colon cancer 65 | 1,475
atypical teratoid/rhabdoid tumor 62 | 1,095
diabetes mellitus 62 | 1,663
sonic hedgehog group medulloblastoma 61 | 1,482
tuberculosis 59 | 1,557
active Crohn's disease 58 | 918
medulloblastoma 54 | 1,524
primary pancreatic ductal adenocarcinoma 54 | 1,271
Rheumatoid Arthritis 52 | 1,160
posterior fossa group A ependymoma 52 | 1,511
posterior fossa group B ependymoma 50 | 1,530
adrenocortical carcinoma 48 | 1,427
acute quadriplegic myopathy 47 | 1,157
breast carcinoma 46 | 1,614
dermatomyositis 46 | 933
Epilepsy 45 | 346
Obesity 43 | 616
Kidney disease 41 | 396
cutaneous lupus erythematosus 41 | 1,056
non primary Sjogren syndrome sicca 39 | 840
Alzheimer's disease 38 | 644
progressive supranuclear palsy 36 | 674
Waldenstrons macroglobulinemia 35 | 765
juvenile dermatomyositis 35 | 1,189
gastric carcinoma 34 | 832
nasopharyngeal carcinoma 34 | 1,056
Hypertension 33 | 287
aldosterone-producing adenoma 32 | 664
Atopic dermatitis 31 | 944
Colorectal Neoplasms 31 | 217
Neurodegenerative disease 31 | 383
Hypertensive disease 29 | 193
nephrosclerosis 28 | 329
spina bifida 28 | 1,064
Schizophrenia 27 | 501
Duchenne muscular dystrophy 26 | 602
Parkinson's disease 26 | 364
Endometriosis 25 | 535
acute myeloid leukemia 25 | 780
esophageal adenocarcinoma 25 | 737
Down syndrome 24 | 548
mucosa-associated lymphoid tissue lymphoma 24 | 480
pancreatic carcinoma 24 | 567
primary Sjogren syndrome 24 | 789
active ulcerative colitis 23 | 477
chronic rhinosinusitis 23 | 512
Autistic Disorder 22 | 320
Intellectual disability 21 | 573
Anemia 20 | 252
IGA Glomerulonephritis 20 | 454
Metabolic acidosis 20 | 49
gastric cancer 20 | 430
Amyotrophic Lateral Sclerosis 19 | 431
HIV Infections 19 | 100
Prostatic Neoplasms 19 | 471
autosomal dominant Emery-Dreifuss muscular dystrophy 19 | 499
Peripheral Neuropathy 18 | 303
glioblastoma multiforme 18 | 347
tuberculosis and treatment for 6 months 18 | 686
Vascular disease 17 | 281
fibroadenoma 17 | 557
hepatocellular carcinoma 17 | 532

Tissue

Female tissues 665 | 18,647
Nervous System 665 | 18,561
Digestive Tract 664 | 18,473
Endocrine System 664 | 18,512
Urinary Tract 662 | 18,444
Liver and Pancreas 661 | 18,136
Skin and soft tissues 658 | 18,115
Blood and immune system 655 | 17,995
Male tissues 655 | 17,969
Cardiovascular System 651 | 17,958
Respiratory system 640 | 17,484

Target Family

Transporter 301 | 473
Non-IDG 145 | 11,971
Enzyme 103 | 4,146
Ion Channel 96 | 341
Kinase 21 | 634
Transcription Factor 2 | 1,400
GPCR 1 | 406

Reactome Pathway

Transmembrane transport of sma... 669 | 669
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
Probable phospholipid-transporting ATPase IIB ATP9B Tdark Transporter -0.57248 3.74 5
Cardiac phospholamban PLN Tbio Non-IDG -1.89899 84.7 326
Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 Tchem Ion Channel -1.68717 47.7 33
Solute carrier family 13 member 1 SLC13A1 Tbio Transporter -1.70334 62.7 18
Equilibrative nucleoside transporter 4 SLC29A4 Tbio Transporter -1.79381 73.1 189
Monocarboxylate transporter 8 SLC16A2 Tbio Transporter -2.32240 230.6 103
ATP-binding cassette sub-family A member 2 ABCA2 Tbio Transporter -1.41708 32.2 125
Solute carrier family 2, facilitated glucose transporter member 4 SLC2A4 Tchem Transporter -3.30074 2066.8 474
Sodium/hydrogen exchanger 4 SLC9A4 Tdark Transporter -1.25841 17.4 6