Development Level

Tbio 129 | 10,625
Tdark 17 | 7,003
Tchem 13 | 1,890

IMPC Phenotype

preweaning lethality, complete... 7 | 633
embryonic lethality prior to o... 3 | 148
embryonic lethality prior to t... 3 | 187
abnormal coat appearance 1 | 25
abnormal embryo size 1 | 112
abnormal spleen morphology 1 | 36
abnormal thoracic vertebrae mo... 1 | 16
decreased circulating calcium ... 1 | 33
decreased circulating glucose ... 1 | 121
decreased circulating glycerol... 1 | 19
decreased fasted circulating g... 1 | 49
decreased heart weight 1 | 44
decreased hemoglobin content 1 | 53
decreased lean body mass 1 | 195
decreased mean corpuscular hem... 1 | 19
decreased mean corpuscular vol... 1 | 50
decreased neutrophil cell numb... 1 | 37
decreased rib number 1 | 59
enlarged heart 1 | 111
enlarged lymph nodes 1 | 27
increased circulating chloride... 1 | 43
increased circulating free fat... 1 | 17
increased circulating glycerol... 1 | 11
increased circulating sodium l... 1 | 71
increased exploration in new e... 1 | 56
increased grip strength 1 | 83
increased mean corpuscular hem... 1 | 93
increased or absent threshold ... 1 | 128
shortened QT interval 1 | 4
small adrenal glands 1 | 15
small spleen 1 | 11

Disease

ovarian cancer 81 | 8,491
lung cancer 57 | 4,473
Multiple myeloma 53 | 1,327
osteosarcoma 46 | 7,933
medulloblastoma, large-cell 42 | 6,234
intraductal papillary-mucinous neoplasm (IPMN) 40 | 3,289
diabetes mellitus 36 | 1,663
psoriasis 29 | 6,685
glioblastoma 28 | 5,572
sonic hedgehog group medulloblastoma 28 | 1,482
Diamond-Blackfan anemia 24 | 30
Waldenstrons macroglobulinemia 24 | 764
acute quadriplegic myopathy 22 | 1,157
intraductal papillary-mucinous adenoma (IPMA) 22 | 2,956
Breast cancer 21 | 3,098
intraductal papillary-mucinous carcinoma (IPMC) 21 | 2,988
atypical teratoid / rhabdoid tumor 20 | 4,369
pancreatic ductal adenocarcinoma liver metastasis 20 | 1,795
oligodendroglioma 19 | 2,849
lung adenocarcinoma 17 | 2,714
Cancer 16 | 2,346
astrocytoma 16 | 1,493
pediatric high grade glioma 16 | 2,712
invasive ductal carcinoma 15 | 2,950
group 3 medulloblastoma 14 | 2,254
pilocytic astrocytoma 14 | 3,086
Anemia, Diamond-Blackfan 13 | 15
cystic fibrosis 13 | 1,670
ependymoma 13 | 2,514
malignant mesothelioma 13 | 3,163
non-small cell lung cancer 13 | 2,798
subependymal giant cell astrocytoma 13 | 2,287
dermatomyositis 12 | 966
primitive neuroectodermal tumor 12 | 3,031
Mammary Neoplasms 10 | 410
Stomach Neoplasms 10 | 282
acute myeloid leukemia 10 | 785
pancreatic cancer 10 | 2,300
colon cancer 9 | 1,475
ulcerative colitis 9 | 2,087
Disease Progression 8 | 125
breast carcinoma 8 | 1,614
glioblastoma multiforme 8 | 347
juvenile dermatomyositis 8 | 1,189
primary pancreatic ductal adenocarcinoma 8 | 1,271
Anemia 7 | 252
Duchenne muscular dystrophy 7 | 602
Pick disease 7 | 1,893
Prostatic Neoplasms 7 | 471
adult high grade glioma 7 | 2,148
inflammatory breast cancer 7 | 404
mucosa-associated lymphoid tissue lymphoma 7 | 480
active Crohn's disease 6 | 918
astrocytic glioma 6 | 2,241
atypical teratoid/rhabdoid tumor 6 | 1,095
group 4 medulloblastoma 6 | 1,875
hereditary spastic paraplegia 6 | 313
posterior fossa group A ependymoma 6 | 1,511
Childhood Ataxia with Central Nervous System Hypomyelinization 5 | 5
Leukodystrophy 5 | 30
Leukodystrophy with vanishing white matter 5 | 5
Leukoencephalopathy With Vanishing White Matter 5 | 5
OVARIOLEUKODYSTROPHY 5 | 5
interstitial cystitis 5 | 2,299
lung carcinoma 5 | 2,844
pituitary cancer 5 | 1,972
Animal Mammary Neoplasms 4 | 135
Mammary Neoplasms, Experimental 4 | 149
Neoplasm Metastasis 4 | 138
Optic atrophy 4 | 43
Parkinson Disease 4 | 105
Polycystic Ovary Syndrome 4 | 334
Rheumatoid Arthritis 4 | 1,170
Spinocerebellar ataxia type 2 4 | 19
adrenocortical carcinoma 4 | 1,427
cutaneous lupus erythematosus 4 | 1,056
non primary Sjogren syndrome sicca 4 | 840
spina bifida 4 | 1,064
Amyotrophic Lateral Sclerosis 3 | 432
Brain disease 3 | 84
Down syndrome 3 | 548
HIV Infections 3 | 99
IGA Glomerulonephritis 3 | 454
Intellectual disability 3 | 573
Irregular astigmatism 3 | 11
Neoplasm Invasiveness 3 | 127
Pure red-cell aplasia 3 | 4
Renal Cell Carcinoma 3 | 199
Weight Gain 3 | 87
aldosterone-producing adenoma 3 | 664
progressive supranuclear palsy 3 | 674
substance-related disorder 3 | 104
tuberculosis and treatment for 6 months 3 | 686
Alzheimer's disease 2 | 644
Multiple Sclerosis 2 | 498
Type 2 diabetes mellitus 2 | 192
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 499
hepatocellular carcinoma 2 | 550
medulloblastoma 2 | 1,524
tuberculosis 2 | 1,563

Tissue

Blood and immune system 158 | 17,994
Cardiovascular System 158 | 17,957
Digestive Tract 158 | 18,472
Endocrine System 158 | 18,511
Female tissues 158 | 18,646
Liver and Pancreas 158 | 18,135
Male tissues 158 | 17,968
Nervous System 158 | 18,560
Respiratory system 158 | 17,483
Urinary Tract 158 | 18,443
Skin and soft tissues 156 | 18,114

Target Family

Non-IDG 145 | 11,969
Enzyme 14 | 4,146

Reactome Pathway

Translation 159 | 159
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
40S ribosomal protein S19 RPS19 Tbio Non-IDG -3.12258 1305.7 243
Signal recognition particle 14 kDa protein SRP14 Tbio Non-IDG -1.25810 14.5 95
60S ribosomal protein L13a RPL13A Tbio Non-IDG -1.62587 63.2 46
40S ribosomal protein S7 RPS7 Tbio Non-IDG -1.83618 67.7 104
Signal peptidase complex catalytic subunit SEC11C SEC11C Tdark Enzyme -0.46982 3.55 21
60S ribosomal protein L38 RPL38 Tdark Non-IDG -1.39373 24.2 45
40S ribosomal protein S21 RPS21 Tbio Non-IDG -1.89981 78.2 62
Translocon-associated protein subunit gamma SSR3 Tdark Non-IDG -0.80778 5.68 24
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 RPN1 Tbio Enzyme -2.15344 139.1 249
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 RPN2 Tbio Enzyme -1.46978 30.0 91