Development Level

Tbio 200 | 11,445
Tdark 75 | 6,588
Tchem 22 | 1,598

IMPC Phenotype

preweaning lethality, complete... 42 | 979
embryonic lethality prior to o... 17 | 239
embryonic lethality prior to t... 12 | 278
abnormal embryo size 9 | 220
embryonic growth retardation 5 | 106
abnormal bone structure 4 | 187
increased total body fat amoun... 4 | 134
decreased circulating glucose ... 3 | 126
decreased grip strength 3 | 116
abnormal behavior 2 | 298
abnormal lens morphology 2 | 81
abnormal neural tube closure 2 | 46
decreased circulating sodium l... 2 | 22
decreased fasted circulating g... 2 | 65
decreased lean body mass 2 | 135
decreased mean corpuscular hem... 2 | 31
decreased mean corpuscular vol... 2 | 79
hypoactivity 2 | 132
impaired glucose tolerance 2 | 75
impaired pupillary reflex 2 | 26
increased circulating chloride... 2 | 41
increased circulating free fat... 2 | 20
increased fasted circulating g... 2 | 76
increased lean body mass 2 | 172
increased or absent threshold ... 2 | 101
abnormal QT variability 1 | 10
abnormal bone mineralization 1 | 38
abnormal craniofacial morpholo... 1 | 33
abnormal cranium morphology 1 | 36
abnormal eye morphology 1 | 68
abnormal forebrain development 1 | 20
abnormal forebrain morphology 1 | 10
abnormal heart left ventricle ... 1 | 16
abnormal hindbrain development 1 | 16
abnormal lung morphology 1 | 26
abnormal midbrain development 1 | 20
abnormal retina morphology 1 | 71
abnormal spinal cord morpholog... 1 | 9
abnormal spleen morphology 1 | 55
abnormal tail morphology 1 | 25
cataract 1 | 92
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating chloride... 1 | 30
decreased circulating glycerol... 1 | 16
decreased granulocyte number 1 | 6
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 50
decreased red blood cell distr... 1 | 41
decreased total body fat amoun... 1 | 207
decreased urine magnesium leve... 1 | 3
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
hemorrhage 1 | 23
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating aspartat... 1 | 15
increased circulating bilirubi... 1 | 16
increased circulating choleste... 1 | 66
increased circulating creatini... 1 | 38
increased circulating glycerol... 1 | 9
increased circulating potassiu... 1 | 29
increased circulating sodium l... 1 | 71
increased erythrocyte cell num... 1 | 39
increased exploration in new e... 1 | 8
increased grip strength 1 | 41
increased mean corpuscular hem... 1 | 96
increased monocyte cell number 1 | 63
increased prepulse inhibition 1 | 32
increased red blood cell distr... 1 | 34
increased startle reflex 1 | 112
increased thermal nociceptive ... 1 | 9
pale yolk sac 1 | 25
pallor 1 | 34
prenatal lethality prior to he... 1 | 87
prolonged QT interval 1 | 38
short tibia 1 | 97
small adrenal glands 1 | 16
small spleen 1 | 19

Disease

ovarian cancer 174 | 8,520
Carcinoma 106 | 11,493
lung cancer 104 | 4,740
osteosarcoma 93 | 7,950
Multiple myeloma 83 | 1,332
medulloblastoma, large-cell 69 | 6,241
psoriasis 62 | 6,694
glioblastoma 54 | 5,792
intraductal papillary-mucinous neoplasm (IPMN) 52 | 3,291
diabetes mellitus 49 | 1,728
pancreatic ductal adenocarcinoma liver metastasis 49 | 1,962
Breast cancer 46 | 3,578
group 3 medulloblastoma 45 | 4,104
atypical teratoid / rhabdoid tumor 39 | 5,112
intraductal papillary-mucinous adenoma (IPMA) 33 | 2,955
Waldenstrons macroglobulinemia 32 | 765
intraductal papillary-mucinous carcinoma (IPMC) 31 | 2,989
non-small cell lung cancer 30 | 2,890
Autosomal recessive predisposition 27 | 1,442
acute quadriplegic myopathy 27 | 1,158
lung adenocarcinoma 27 | 2,716
acute myeloid leukemia 26 | 783
ependymoma 26 | 4,679
oligodendroglioma 26 | 2,850
Diamond-Blackfan anemia 25 | 31
non primary Sjogren syndrome sicca 25 | 891
Cancer 24 | 2,499
malignant mesothelioma 24 | 3,232
adult high grade glioma 23 | 3,801
invasive ductal carcinoma 23 | 2,951
astrocytoma 21 | 1,146
dermatomyositis 21 | 966
colon cancer 20 | 1,478
sonic hedgehog group medulloblastoma 20 | 467
astrocytic glioma 19 | 2,597
Anemia 18 | 365
Breast Neoplasms 18 | 445
Epilepsy 18 | 792
Mammary Neoplasms 18 | 425
subependymal giant cell astrocytoma 18 | 2,287
pediatric high grade glioma 17 | 1,064
primitive neuroectodermal tumor 17 | 3,035
cystic fibrosis 16 | 1,696
Muscle hypotonia 15 | 571
Pick disease 15 | 1,894
breast carcinoma 15 | 1,638
Anemia, Macrocytic 14 | 18
Astrocytoma, Pilocytic 14 | 3,081
Cleft Palate 14 | 271
Cognitive delay 14 | 608
Delayed Puberty 14 | 97
Global developmental delay 14 | 608
Mental and motor retardation 14 | 608
Abnormality of the urinary system 13 | 21
Anemia, Diamond-Blackfan 13 | 16
Cardiac Arrhythmia 13 | 103
Cardiac conduction abnormalities 13 | 78
Conduction disorder of the heart 13 | 79
EKG abnormalities 13 | 78
Electrocardiogram abnormal 13 | 81
Electrocardiogram change 13 | 78
Fatigue 13 | 182
Hand deformities 13 | 32
Intermittent migraine headaches 13 | 68
Migraine Disorders 13 | 76
Pallor 13 | 40
Stomach Neoplasms 13 | 300
Uranostaphyloschisis 13 | 167
genital abnormal 13 | 17
juvenile dermatomyositis 13 | 1,187
pancreatic cancer 13 | 2,398
reproductive system abnormality 13 | 17
Seizures 12 | 596
group 4 medulloblastoma 12 | 1,855
Adenocarcinoma of lung 11 | 142
Disease Progression 11 | 136
Leigh disease 11 | 100
Neurodegenerative disease 11 | 414
Small head 11 | 374
Failure to gain weight 10 | 365
Pediatric failure to thrive 10 | 365
active Crohn's disease 10 | 922
primary pancreatic ductal adenocarcinoma 10 | 1,109
ulcerative colitis 10 | 1,819
Disease Models, Animal 9 | 155
Kidney cancer 9 | 2,613
hereditary spastic paraplegia 9 | 318
tuberculosis 9 | 2,010
Infantile onset 8 | 238
Leukodystrophy 8 | 55
Muscle Spasticity 8 | 195
Myositis 8 | 30
Nystagmus 8 | 317
Optic Atrophy 8 | 242
Prostatic Neoplasms 8 | 495
lung carcinoma 8 | 2,843
mucosa-associated lymphoid tissue lymphoma 8 | 484
Cerebellar Ataxia 7 | 304
Duchenne muscular dystrophy 7 | 601
Intellectual disability 7 | 1,016

Tissue

Endocrine System 291 | 18,159
Blood and immune system 290 | 16,909
Digestive Tract 290 | 17,369
Male tissues 290 | 17,142
Skin and soft tissues 290 | 17,230
Cardiovascular System 289 | 15,192
Female tissues 289 | 17,400
Liver and Pancreas 289 | 16,750
Nervous System 289 | 16,725
Respiratory system 289 | 16,393
Urinary Tract 289 | 16,678

Target Family

Non-IDG 236 | 12,091
Enzyme 61 | 4,145

Reactome Pathway

Translation 297 | 297
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
60S ribosomal protein L3 RPL3 Tbio Non-IDG -2.02901 103.9 190
40S ribosomal protein S19 RPS19 Tbio Non-IDG -3.14746 1380.8 267
60S ribosomal protein L36 RPL36 Tbio Non-IDG -1.62928 39.9 123
Elongation factor G, mitochondrial GFM1 Tbio Non-IDG -2.39993 250.5 121
Signal peptidase complex subunit 1 SPCS1 Tdark Enzyme -0.80900 6.46 44
39S ribosomal protein L22, mitochondrial MRPL22 Tdark Non-IDG 0.70 0.21 64
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A GSPT1 Tbio Enzyme -1.35573 22.8 99
Eukaryotic translation initiation factor 3 subunit C EIF3C Tbio Non-IDG -1.20680 14.1 159
Eukaryotic translation initiation factor 3 subunit B EIF3B Tbio Non-IDG -1.83618 70.5 84
60S ribosomal protein L35 RPL35 Tbio Non-IDG -1.30696 19.1 124