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Development Level

Tbio 58 | 11,445
Tchem 17 | 1,598
Tclin 7 | 613
Tdark 5 | 6,588

Collection

Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 13 | 979
abnormal embryo size 5 | 220
embryonic lethality prior to t... 5 | 278
preweaning lethality, incomple... 5 | 499
decreased vertical activity 4 | 208
embryonic lethality prior to o... 3 | 239
abnormal behavior 2 | 298
abnormal heart morphology 2 | 162
abnormal neural tube closure 2 | 46
abnormal placenta size 2 | 20
decreased bone mineral density 2 | 126
decreased circulating amylase ... 2 | 28
decreased leukocyte cell numbe... 2 | 73
decreased neutrophil cell numb... 2 | 42
decreased total body fat amoun... 2 | 207
embryonic growth retardation 2 | 106
hyperactivity 2 | 148
increased circulating alkaline... 2 | 122
increased or absent threshold ... 2 | 101
pale yolk sac 2 | 25
abnormal bone structure 1 | 187
abnormal brain morphology 1 | 13
abnormal cornea morphology 1 | 31
abnormal embryo turning 1 | 31
abnormal eye morphology 1 | 68
abnormal forebrain development 1 | 20
abnormal gait 1 | 69
abnormal kidney morphology 1 | 65
abnormal motor capabilities-co... 1 | 5
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal skin condition 1 | 6
abnormal spleen morphology 1 | 55
abnormal tail bud morphology 1 | 8
abnormal tooth morphology 1 | 24
absent optic nerve 1 | 2
decreased anxiety-related resp... 1 | 12
decreased bone mineral content 1 | 151
decreased circulating calcium ... 1 | 36
decreased circulating choleste... 1 | 93
decreased circulating creatine... 1 | 4
decreased circulating glucose ... 1 | 126
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased fasted circulating g... 1 | 65
decreased heart weight 1 | 27
decreased mean corpuscular hem... 1 | 31
decreased startle reflex 1 | 75
decreased thermal nociceptive ... 1 | 2
edema 1 | 59
enlarged heart 1 | 210
enlarged uterus 1 | 11
female infertility 1 | 60
hydroencephaly 1 | 14
hydrometra 1 | 53
impaired glucose tolerance 1 | 75
increased body length 1 | 32
increased body weight 1 | 25
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating creatine... 1 | 5
increased circulating free fat... 1 | 20
increased circulating glycerol... 1 | 9
increased fasted circulating g... 1 | 76
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 96
increased monocyte cell number 1 | 63
increased prepulse inhibition 1 | 32
increased red blood cell distr... 1 | 34
increased startle reflex 1 | 112
increased thermal nociceptive ... 1 | 9
male infertility 1 | 123
microphthalmia 1 | 26
pale liver 1 | 6
pallor 1 | 34
persistence of hyaloid vascula... 1 | 33
prolonged PR interval 1 | 15
short tibia 1 | 97
small spleen 1 | 19
small superior vagus ganglion 1 | 74

Disease

Carcinoma 57 | 11,493
osteosarcoma 55 | 7,950
ovarian cancer 54 | 8,520
psoriasis 42 | 6,694
medulloblastoma, large-cell 34 | 6,241
glioblastoma 33 | 5,792
Cancer 32 | 2,499
lung cancer 29 | 4,740
malignant mesothelioma 27 | 3,232
atypical teratoid / rhabdoid tumor 24 | 5,112
group 3 medulloblastoma 23 | 4,104
diabetes mellitus 22 | 1,728
Breast cancer 21 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 21 | 3,291
Obesity 20 | 678
Schizophrenia 20 | 1,160
astrocytoma 20 | 1,146
invasive ductal carcinoma 20 | 2,951
Kidney cancer 18 | 2,613
ependymoma 18 | 4,679
intraductal papillary-mucinous adenoma (IPMA) 18 | 2,955
primitive neuroectodermal tumor 18 | 3,035
ulcerative colitis 17 | 1,819
intraductal papillary-mucinous carcinoma (IPMC) 16 | 2,989
oligodendroglioma 16 | 2,850
pituitary cancer 16 | 1,972
Pick disease 15 | 1,894
acute quadriplegic myopathy 15 | 1,158
breast carcinoma 15 | 1,638
lung adenocarcinoma 15 | 2,716
tuberculosis 15 | 2,010
Breast Neoplasms 14 | 445
Mammary Neoplasms 14 | 425
Rheumatoid arthritis 14 | 1,191
ductal carcinoma in situ 14 | 1,745
adult high grade glioma 13 | 3,801
astrocytic glioma 13 | 2,597
Atherosclerosis 12 | 291
Carcinoma, Hepatocellular 12 | 228
Liver carcinoma 12 | 240
lung carcinoma 12 | 2,843
non-small cell lung cancer 12 | 2,890
Fatty liver disease 11 | 103
Lipid metabolism disorder 11 | 114
Prostatic Neoplasms 11 | 495
fibroadenoma 11 | 559
group 4 medulloblastoma 11 | 1,855
Astrocytoma, Pilocytic 10 | 3,081
Autosomal recessive predisposition 10 | 1,442
Diabetes Mellitus, Experimental 10 | 108
Endometriosis 10 | 540
Hyperglycemia 10 | 137
Liver Cirrhosis, Experimental 10 | 769
adrenocortical carcinoma 10 | 1,428
juvenile dermatomyositis 10 | 1,187
Diabetes Mellitus, Non-Insulin-Dependent 9 | 145
Diabetes Mellitus, Type 2 9 | 142
Hypertension 9 | 396
Hypertensive disease 9 | 292
Multiple myeloma 9 | 1,332
autosomal dominant Emery-Dreifuss muscular dystrophy 9 | 510
interstitial cystitis 9 | 2,312
pancreatic cancer 9 | 2,398
subependymal giant cell astrocytoma 9 | 2,287
Atopic dermatitis 8 | 952
Coronary artery disease 8 | 268
Hyperinsulinism 8 | 133
Insulin Resistance 8 | 72
Intellectual disability 8 | 1,016
acute myeloid leukemia 8 | 783
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,962
Fatty Liver 7 | 70
Kidney Failure, Chronic 7 | 46
colon cancer 7 | 1,478
cystic fibrosis 7 | 1,696
dermatomyositis 7 | 966
spina bifida 7 | 1,074
Autistic Disorder 6 | 364
Bipolar Disorder 6 | 666
Carcinoma, Squamous Cell 6 | 110
Colonic Neoplasms 6 | 142
Crohn's disease 6 | 321
Heart disease 6 | 306
Immune system cancer 6 | 140
Lipodystrophy 6 | 40
Liver disease 6 | 237
Lymphoid leukemia 6 | 160
Melanoma 6 | 711
Osteoporosis 6 | 363
Seizures 6 | 596
Squamous cell carcinoma 6 | 129
Stomach Neoplasms 6 | 300
chronic lymphosyte leukemia 6 | 204
mucosa-associated lymphoid tissue lymphoma 6 | 484
nasopharyngeal carcinoma 6 | 1,058
primary pancreatic ductal adenocarcinoma 6 | 1,109
tuberculosis and treatment for 6 months 6 | 409
Depressive disorder 5 | 409
Myocardial Ischemia 5 | 169
aldosterone-producing adenoma 5 | 665

Tissue

Blood and immune system 87 | 16,909
Digestive Tract 87 | 17,369
Endocrine System 87 | 18,159
Female tissues 87 | 17,400
Liver and Pancreas 87 | 16,750
Nervous System 87 | 16,725
Urinary Tract 87 | 16,678
Male tissues 86 | 17,142
Respiratory system 86 | 16,393
Skin and soft tissues 86 | 17,230
Cardiovascular System 85 | 15,192

Target Family

Enzyme 32 | 4,145
Non-IDG 22 | 12,091
Transcription Factor 14 | 1,400
Epigenetic 7 | 242
Nuclear Receptor 7 | 48
Kinase 4 | 634
Transporter 1 | 473

Reactome Pathway

Transcriptional regulation of ... 87 | 87
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
CCAAT/enhancer-binding protein beta CEBPB Tbio Transcription Factor -2.96589 857.9 436
Zinc finger protein 638 ZNF638 Tbio Non-IDG -0.68946 6.04 67
Histone-arginine methyltransferase CARM1 CARM1 Tchem Epigenetic -2.04034 130.8 476
Mediator of RNA polymerase II transcription subunit 29 MED29 Tbio Enzyme -1.76053 56.0 45
Mediator of RNA polymerase II transcription subunit 15 MED15 Tbio Enzyme -1.60315 40.6 144
Mediator of RNA polymerase II transcription subunit 16 MED16 Tbio Enzyme -0.82499 7.04 154
Thyroid hormone receptor-associated protein 3 THRAP3 Tbio Non-IDG -0.87769 8.81 136
Fatty acid-binding protein, adipocyte FABP4 Tchem Non-IDG -2.73935 617.7 605
Mediator of RNA polymerase II transcription subunit 31 MED31 Tbio Enzyme -1.19048 15.1 61
Mediator of RNA polymerase II transcription subunit 13 MED13 Tbio Enzyme -1.52250 26.0 53