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Development Level

Tbio 58 | 11,445
Tchem 17 | 1,598
Tclin 7 | 613
Tdark 5 | 6,588

Collection

Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 13 | 979
abnormal embryo size 5 | 220
embryonic lethality prior to t... 5 | 278
preweaning lethality, incomple... 5 | 499
decreased vertical activity 4 | 208
embryonic lethality prior to o... 3 | 239
abnormal behavior 2 | 298
abnormal heart morphology 2 | 162
abnormal neural tube closure 2 | 46
abnormal placenta size 2 | 20
decreased bone mineral density 2 | 126
decreased circulating amylase ... 2 | 28
decreased leukocyte cell numbe... 2 | 73
decreased neutrophil cell numb... 2 | 42
decreased total body fat amoun... 2 | 207
embryonic growth retardation 2 | 106
hyperactivity 2 | 148
increased circulating alkaline... 2 | 122
increased or absent threshold ... 2 | 101
pale yolk sac 2 | 25
abnormal bone structure 1 | 187
abnormal brain morphology 1 | 13
abnormal cornea morphology 1 | 31
abnormal embryo turning 1 | 31
abnormal eye morphology 1 | 68
abnormal forebrain development 1 | 20
abnormal gait 1 | 69
abnormal kidney morphology 1 | 65
abnormal motor capabilities-co... 1 | 5
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal skin condition 1 | 6
abnormal spleen morphology 1 | 55
abnormal tail bud morphology 1 | 8
abnormal tooth morphology 1 | 24
absent optic nerve 1 | 2
decreased anxiety-related resp... 1 | 12
decreased bone mineral content 1 | 151
decreased circulating calcium ... 1 | 36
decreased circulating choleste... 1 | 93
decreased circulating creatine... 1 | 4
decreased circulating glucose ... 1 | 126
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased fasted circulating g... 1 | 65
decreased heart weight 1 | 27
decreased mean corpuscular hem... 1 | 31
decreased startle reflex 1 | 75
decreased thermal nociceptive ... 1 | 2
edema 1 | 59
enlarged heart 1 | 210
enlarged uterus 1 | 11
female infertility 1 | 60
hydroencephaly 1 | 14
hydrometra 1 | 53
impaired glucose tolerance 1 | 75
increased body length 1 | 32
increased body weight 1 | 25
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating creatine... 1 | 5
increased circulating free fat... 1 | 20
increased circulating glycerol... 1 | 9
increased fasted circulating g... 1 | 76
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 96
increased monocyte cell number 1 | 63
increased prepulse inhibition 1 | 32
increased red blood cell distr... 1 | 34
increased startle reflex 1 | 112
increased thermal nociceptive ... 1 | 9
male infertility 1 | 123
microphthalmia 1 | 26
pale liver 1 | 6
pallor 1 | 34
persistence of hyaloid vascula... 1 | 33
prolonged PR interval 1 | 15
short tibia 1 | 97
small spleen 1 | 19
small superior vagus ganglion 1 | 74

Disease

Carcinoma 57 | 11,493
osteosarcoma 55 | 7,950
ovarian cancer 54 | 8,520
psoriasis 42 | 6,694
medulloblastoma, large-cell 34 | 6,241
glioblastoma 33 | 5,792
Cancer 32 | 2,499
lung cancer 29 | 4,740
malignant mesothelioma 27 | 3,232
atypical teratoid / rhabdoid tumor 24 | 5,112
group 3 medulloblastoma 23 | 4,104
diabetes mellitus 22 | 1,728
Breast cancer 21 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 21 | 3,291
Obesity 20 | 678
Schizophrenia 20 | 1,160
astrocytoma 20 | 1,146
invasive ductal carcinoma 20 | 2,951
Kidney cancer 18 | 2,613
ependymoma 18 | 4,679
intraductal papillary-mucinous adenoma (IPMA) 18 | 2,955
primitive neuroectodermal tumor 18 | 3,035
ulcerative colitis 17 | 1,819
intraductal papillary-mucinous carcinoma (IPMC) 16 | 2,989
oligodendroglioma 16 | 2,850
pituitary cancer 16 | 1,972
Pick disease 15 | 1,894
acute quadriplegic myopathy 15 | 1,158
breast carcinoma 15 | 1,638
lung adenocarcinoma 15 | 2,716
tuberculosis 15 | 2,010
Breast Neoplasms 14 | 445
Mammary Neoplasms 14 | 425
Rheumatoid arthritis 14 | 1,191
ductal carcinoma in situ 14 | 1,745
adult high grade glioma 13 | 3,801
astrocytic glioma 13 | 2,597
Atherosclerosis 12 | 291
Carcinoma, Hepatocellular 12 | 228
Liver carcinoma 12 | 240
lung carcinoma 12 | 2,843
non-small cell lung cancer 12 | 2,890
Fatty liver disease 11 | 103
Lipid metabolism disorder 11 | 114
Prostatic Neoplasms 11 | 495
fibroadenoma 11 | 559
group 4 medulloblastoma 11 | 1,855
Astrocytoma, Pilocytic 10 | 3,081
Autosomal recessive predisposition 10 | 1,442
Diabetes Mellitus, Experimental 10 | 108
Endometriosis 10 | 540
Hyperglycemia 10 | 137
Liver Cirrhosis, Experimental 10 | 769
adrenocortical carcinoma 10 | 1,428
juvenile dermatomyositis 10 | 1,187
Diabetes Mellitus, Non-Insulin-Dependent 9 | 145
Diabetes Mellitus, Type 2 9 | 142
Hypertension 9 | 396
Hypertensive disease 9 | 292
Multiple myeloma 9 | 1,332
autosomal dominant Emery-Dreifuss muscular dystrophy 9 | 510
interstitial cystitis 9 | 2,312
pancreatic cancer 9 | 2,398
subependymal giant cell astrocytoma 9 | 2,287
Atopic dermatitis 8 | 952
Coronary artery disease 8 | 268
Hyperinsulinism 8 | 133
Insulin Resistance 8 | 72
Intellectual disability 8 | 1,016
acute myeloid leukemia 8 | 783
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,962
Fatty Liver 7 | 70
Kidney Failure, Chronic 7 | 46
colon cancer 7 | 1,478
cystic fibrosis 7 | 1,696
dermatomyositis 7 | 966
spina bifida 7 | 1,074
Autistic Disorder 6 | 364
Bipolar Disorder 6 | 666
Carcinoma, Squamous Cell 6 | 110
Colonic Neoplasms 6 | 142
Crohn's disease 6 | 321
Heart disease 6 | 306
Immune system cancer 6 | 140
Lipodystrophy 6 | 40
Liver disease 6 | 237
Lymphoid leukemia 6 | 160
Melanoma 6 | 711
Osteoporosis 6 | 363
Seizures 6 | 596
Squamous cell carcinoma 6 | 129
Stomach Neoplasms 6 | 300
chronic lymphosyte leukemia 6 | 204
mucosa-associated lymphoid tissue lymphoma 6 | 484
nasopharyngeal carcinoma 6 | 1,058
primary pancreatic ductal adenocarcinoma 6 | 1,109
tuberculosis and treatment for 6 months 6 | 409
Depressive disorder 5 | 409
Myocardial Ischemia 5 | 169
aldosterone-producing adenoma 5 | 665

Tissue

Blood and immune system 87 | 16,909
Digestive Tract 87 | 17,369
Endocrine System 87 | 18,159
Female tissues 87 | 17,400
Liver and Pancreas 87 | 16,750
Nervous System 87 | 16,725
Urinary Tract 87 | 16,678
Male tissues 86 | 17,142
Respiratory system 86 | 16,393
Skin and soft tissues 86 | 17,230
Cardiovascular System 85 | 15,192

Target Family

Enzyme 32 | 4,145
Non-IDG 22 | 12,091
Transcription Factor 14 | 1,400
Epigenetic 7 | 242
Nuclear Receptor 7 | 48
Kinase 4 | 634
Transporter 1 | 473

Reactome Pathway

Transcriptional regulation of ... 87 | 87
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mediator of RNA polymerase II transcription subunit 29 MED29 Tbio Enzyme -1.76053 56.0 45
Mediator of RNA polymerase II transcription subunit 15 MED15 Tbio Enzyme -1.60315 40.6 144
Zinc finger protein 638 ZNF638 Tbio Non-IDG -0.68946 6.04 67
Histone-arginine methyltransferase CARM1 CARM1 Tchem Epigenetic -2.04034 130.8 476
Fatty acid-binding protein, adipocyte FABP4 Tchem Non-IDG -2.73935 617.7 605
Mediator of RNA polymerase II transcription subunit 31 MED31 Tbio Enzyme -1.19048 15.1 61
Mediator of RNA polymerase II transcription subunit 16 MED16 Tbio Enzyme -0.82499 7.04 154
Thyroid hormone receptor-associated protein 3 THRAP3 Tbio Non-IDG -0.87769 8.81 136
Krueppel-like factor 4 KLF4 Tbio Transcription Factor -2.89447 774.1 686
Sterol regulatory element-binding protein 2 SREBF2 Tchem Transcription Factor -2.61148 361.0 205