Development Level
Tbio | 58 | 11,445 | |
Tchem | 17 | 1,598 | |
Tclin | 7 | 613 | |
Tdark | 5 | 6,588 |
Collection
Kinase: IDG Consortium (Comple... | 1 | 37 |
IMPC Phenotype
preweaning lethality, complete... | 13 | 979 | |
abnormal embryo size | 5 | 220 | |
embryonic lethality prior to t... | 5 | 278 | |
preweaning lethality, incomple... | 5 | 499 | |
decreased vertical activity | 4 | 208 | |
embryonic lethality prior to o... | 3 | 239 | |
abnormal behavior | 2 | 298 | |
abnormal heart morphology | 2 | 162 | |
abnormal neural tube closure | 2 | 46 | |
abnormal placenta size | 2 | 20 | |
decreased bone mineral density | 2 | 126 | |
decreased circulating amylase ... | 2 | 28 | |
decreased leukocyte cell numbe... | 2 | 73 | |
decreased neutrophil cell numb... | 2 | 42 | |
decreased total body fat amoun... | 2 | 207 | |
embryonic growth retardation | 2 | 106 | |
hyperactivity | 2 | 148 | |
increased circulating alkaline... | 2 | 122 | |
increased or absent threshold ... | 2 | 101 | |
pale yolk sac | 2 | 25 | |
abnormal bone structure | 1 | 187 | |
abnormal brain morphology | 1 | 13 | |
abnormal cornea morphology | 1 | 31 | |
abnormal embryo turning | 1 | 31 | |
abnormal eye morphology | 1 | 68 | |
abnormal forebrain development | 1 | 20 | |
abnormal gait | 1 | 69 | |
abnormal kidney morphology | 1 | 65 | |
abnormal motor capabilities-co... | 1 | 5 | |
abnormal retina morphology | 1 | 71 | |
abnormal seminal vesicle morph... | 1 | 114 | |
abnormal skin condition | 1 | 6 | |
abnormal spleen morphology | 1 | 55 | |
abnormal tail bud morphology | 1 | 8 | |
abnormal tooth morphology | 1 | 24 | |
absent optic nerve | 1 | 2 | |
decreased anxiety-related resp... | 1 | 12 | |
decreased bone mineral content | 1 | 151 | |
decreased circulating calcium ... | 1 | 36 | |
decreased circulating choleste... | 1 | 93 | |
decreased circulating creatine... | 1 | 4 | |
decreased circulating glucose ... | 1 | 126 | |
decreased circulating serum al... | 1 | 82 | |
decreased circulating sodium l... | 1 | 22 | |
decreased circulating triglyce... | 1 | 79 | |
decreased fasted circulating g... | 1 | 65 | |
decreased heart weight | 1 | 27 | |
decreased mean corpuscular hem... | 1 | 31 | |
decreased startle reflex | 1 | 75 | |
decreased thermal nociceptive ... | 1 | 2 | |
edema | 1 | 59 | |
enlarged heart | 1 | 210 | |
enlarged uterus | 1 | 11 | |
female infertility | 1 | 60 | |
hydroencephaly | 1 | 14 | |
hydrometra | 1 | 53 | |
impaired glucose tolerance | 1 | 75 | |
increased body length | 1 | 32 | |
increased body weight | 1 | 25 | |
increased bone mineral content | 1 | 108 | |
increased bone mineral density | 1 | 72 | |
increased circulating creatine... | 1 | 5 | |
increased circulating free fat... | 1 | 20 | |
increased circulating glycerol... | 1 | 9 | |
increased fasted circulating g... | 1 | 76 | |
increased lean body mass | 1 | 172 | |
increased leukocyte cell numbe... | 1 | 47 | |
increased mean corpuscular hem... | 1 | 96 | |
increased monocyte cell number | 1 | 63 | |
increased prepulse inhibition | 1 | 32 | |
increased red blood cell distr... | 1 | 34 | |
increased startle reflex | 1 | 112 | |
increased thermal nociceptive ... | 1 | 9 | |
male infertility | 1 | 123 | |
microphthalmia | 1 | 26 | |
pale liver | 1 | 6 | |
pallor | 1 | 34 | |
persistence of hyaloid vascula... | 1 | 33 | |
prolonged PR interval | 1 | 15 | |
short tibia | 1 | 97 | |
small spleen | 1 | 19 | |
small superior vagus ganglion | 1 | 74 |
Disease
Tissue
Blood and immune system | 87 | 16,909 | |
Digestive Tract | 87 | 17,369 | |
Endocrine System | 87 | 18,159 | |
Female tissues | 87 | 17,400 | |
Liver and Pancreas | 87 | 16,750 | |
Nervous System | 87 | 16,725 | |
Urinary Tract | 87 | 16,678 | |
Male tissues | 86 | 17,142 | |
Respiratory system | 86 | 16,393 | |
Skin and soft tissues | 86 | 17,230 | |
Cardiovascular System | 85 | 15,192 |
Target Family
Enzyme | 32 | 4,145 | |
Non-IDG | 22 | 12,091 | |
Transcription Factor | 14 | 1,400 | |
Epigenetic | 7 | 242 | |
Nuclear Receptor | 7 | 48 | |
Kinase | 4 | 634 | |
Transporter | 1 | 473 |
Reactome Pathway
Transcriptional regulation of ... | 87 | 87 | |
Signal Transduction | 2,657 | 2,657 | |
Immune System | 2,101 | 2,101 | |
Metabolism of proteins | 2,091 | 2,091 | |
Metabolism | 2,081 | 2,081 | |
Post-translational protein mod... | 1,398 | 1,398 | |
Gene expression (Transcription... | 1,369 | 1,369 | |
RNA Polymerase II Transcriptio... | 1,228 | 1,228 | |
Signaling by GPCR | 1,217 | 1,217 | |
Innate Immune System | 1,176 | 1,176 | |
GPCR downstream signalling | 1,157 | 1,157 | |
Generic Transcription Pathway | 1,108 | 1,108 | |
Developmental Biology | 1,026 | 1,026 | |
Adaptive Immune System | 892 | 892 | |
Disease | 879 | 879 | |
Cytokine Signaling in Immune s... | 752 | 752 | |
Metabolism of lipids | 739 | 739 | |
Vesicle-mediated transport | 720 | 720 | |
Transport of small molecules | 717 | 717 | |
Metabolism of RNA | 682 | 682 | |
Hemostasis | 666 | 666 | |
Membrane Trafficking | 608 | 608 | |
Cell Cycle | 590 | 590 | |
G alpha (s) signalling events | 574 | 574 | |
Neutrophil degranulation | 539 | 539 | |
Axon guidance | 533 | 533 | |
Cell Cycle, Mitotic | 488 | 488 | |
Cellular responses to external... | 463 | 463 | |
GPCR ligand binding | 459 | 459 | |
Signaling by Interleukins | 448 | 448 | |
Class I MHC mediated antigen p... | 435 | 435 | |
Signaling by Receptor Tyrosine... | 430 | 430 | |
Olfactory Signaling Pathway | 428 | 428 | |
Infectious disease | 404 | 404 | |
G alpha (i) signalling events | 394 | 394 | |
Cellular responses to stress | 386 | 386 | |
Signaling by Rho GTPases | 386 | 386 | |
Metabolism of amino acids and ... | 370 | 370 | |
Diseases of signal transductio... | 367 | 367 | |
Neuronal System | 367 | 367 | |
Transcriptional Regulation by ... | 365 | 365 | |
M Phase | 344 | 344 | |
Class A/1 (Rhodopsin-like rece... | 322 | 322 | |
Antigen processing: Ubiquitina... | 306 | 306 | |
Extracellular matrix organizat... | 297 | 297 | |
Translation | 297 | 297 | |
Signaling by WNT | 293 | 293 | |
Intracellular signaling by sec... | 289 | 289 | |
DNA Repair | 288 | 288 | |
Asparagine N-linked glycosylat... | 287 | 287 | |
MAPK family signaling cascades | 285 | 285 | |
Deubiquitination | 276 | 276 | |
Interferon Signaling | 275 | 275 | |
Immunoregulatory interactions ... | 272 | 272 | |
Metabolism of carbohydrates | 271 | 271 | |
Cell Cycle Checkpoints | 270 | 270 | |
Organelle biogenesis and maint... | 261 | 261 | |
PIP3 activates AKT signaling | 259 | 259 | |
RHO GTPase Effectors | 257 | 257 | |
Platelet activation, signaling... | 256 | 256 | |
HIV Infection | 254 | 254 | |
MAPK1/MAPK3 signaling | 244 | 244 | |
SLC-mediated transmembrane tra... | 243 | 243 | |
Processing of Capped Intron-Co... | 238 | 238 | |
RAF/MAP kinase cascade | 238 | 238 | |
Chromatin modifying enzymes | 236 | 236 | |
Chromatin organization | 236 | 236 | |
Neddylation | 234 | 234 | |
Transmission across Chemical S... | 221 | 221 | |
Biological oxidations | 220 | 220 | |
Signaling by ROBO receptors | 219 | 219 | |
Keratinization | 216 | 216 | |
rRNA processing | 216 | 216 | |
G alpha (q) signalling events | 211 | 211 | |
Cell surface interactions at t... | 210 | 210 | |
Phospholipid metabolism | 209 | 209 | |
Fc epsilon receptor (FCERI) si... | 204 | 204 | |
Transcriptional regulation by ... | 203 | 203 | |
Ub-specific processing proteas... | 203 | 203 | |
TCF dependent signaling in res... | 199 | 199 | |
Muscle contraction | 198 | 198 | |
rRNA processing in the nucleus... | 192 | 192 | |
Metabolism of vitamins and cof... | 188 | 188 | |
Peptide ligand-binding recepto... | 188 | 188 | |
mRNA Splicing | 187 | 187 | |
Cilium Assembly | 186 | 186 | |
Intra-Golgi and retrograde Gol... | 186 | 186 | |
Mitotic G2-G2/M phases | 184 | 184 | |
Mitotic Metaphase and Anaphase | 183 | 183 | |
G2/M Transition | 182 | 182 | |
Major pathway of rRNA processi... | 182 | 182 | |
Mitotic Anaphase | 182 | 182 | |
Mitotic Prometaphase | 181 | 181 | |
Fatty acid metabolism | 180 | 180 | |
mRNA Splicing - Major Pathway | 179 | 179 | |
Ion channel transport | 177 | 177 | |
Signaling by the B Cell Recept... | 176 | 176 | |
Regulation of expression of SL... | 173 | 173 | |
Programmed Cell Death | 172 | 172 | |
Interferon gamma signaling | 171 | 171 | |
Separation of Sister Chromatid... | 170 | 170 |
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