Development Level

Tbio 48 | 10,625
Tchem 23 | 1,890
Tdark 7 | 7,003
Tclin 6 | 602

Collection

Kinase: IDG Consortium (Complete/Control) 1 | 37

IMPC Phenotype

preweaning lethality, complete... 9 | 633
embryonic lethality prior to t... 3 | 187
preweaning lethality, incomple... 3 | 260
abnormal embryo size 2 | 112
decreased circulating amylase ... 2 | 24
decreased lean body mass 2 | 195
decreased leukocyte cell numbe... 2 | 54
increased circulating alkaline... 2 | 119
abnormal behavior 1 | 226
abnormal bone structure 1 | 131
abnormal coping response 1 | 12
abnormal cornea morphology 1 | 24
abnormal eye morphology 1 | 38
abnormal gait 1 | 51
abnormal motor capabilities-co... 1 | 4
abnormal placenta size 1 | 10
abnormal respiratory quotient 1 | 9
abnormal skin condition 1 | 6
abnormal tail bud morphology 1 | 6
abnormal tooth morphology 1 | 24
absent heartbeat 1 | 6
absent optic nerve 1 | 1
decreased CD4-positive, CD25-p... 1 | 24
decreased KLRG1+ CD4 alpha bet... 1 | 2
decreased Ly6C low monocyte nu... 1 | 23
decreased anxiety-related resp... 1 | 12
decreased body length 1 | 108
decreased circulating alkaline... 1 | 41
decreased circulating calcium ... 1 | 33
decreased circulating choleste... 1 | 85
decreased circulating glucose ... 1 | 121
decreased circulating serum al... 1 | 79
decreased circulating sodium l... 1 | 18
decreased fasted circulating g... 1 | 49
decreased mean corpuscular hem... 1 | 19
decreased startle reflex 1 | 48
decreased thermal nociceptive ... 1 | 4
decreased threshold for audito... 1 | 32
decreased total body fat amoun... 1 | 186
embryonic lethality prior to o... 1 | 148
female infertility 1 | 34
hydrops fetalis 1 | 22
impaired glucose tolerance 1 | 52
increased Ly6C high monocyte n... 1 | 12
increased body weight 1 | 42
increased circulating free fat... 1 | 17
increased circulating glycerol... 1 | 11
increased circulating triglyce... 1 | 24
increased fasted circulating g... 1 | 68
increased leukocyte cell numbe... 1 | 37
increased mean corpuscular hem... 1 | 93
increased or absent threshold ... 1 | 128
increased thermal nociceptive ... 1 | 9
long tibia 1 | 13
male infertility 1 | 62
microphthalmia 1 | 15
pale liver 1 | 5
pale yolk sac 1 | 12
persistence of hyaloid vascula... 1 | 22
short tibia 1 | 82

Disease

ovarian cancer 53 | 8,491
osteosarcoma 52 | 7,933
psoriasis 41 | 6,685
Cancer 34 | 2,346
medulloblastoma, large-cell 33 | 6,234
glioblastoma 31 | 5,572
lung cancer 25 | 4,473
malignant mesothelioma 23 | 3,163
Obesity 22 | 616
atypical teratoid / rhabdoid tumor 22 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 22 | 3,289
astrocytoma 21 | 1,493
diabetes mellitus 21 | 1,663
invasive ductal carcinoma 20 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 19 | 2,956
ulcerative colitis 18 | 2,087
Breast cancer 17 | 3,098
intraductal papillary-mucinous carcinoma (IPMC) 17 | 2,988
primitive neuroectodermal tumor 17 | 3,031
breast carcinoma 16 | 1,614
pituitary cancer 16 | 1,972
acute quadriplegic myopathy 15 | 1,157
lung adenocarcinoma 15 | 2,714
Carcinoma 14 | 2,147
Pick disease 14 | 1,893
Rheumatoid Arthritis 14 | 1,170
ductal carcinoma in situ 14 | 1,745
group 4 medulloblastoma 14 | 1,875
oligodendroglioma 14 | 2,849
tuberculosis 14 | 1,563
Metabolic syndrome X 13 | 155
ependymoma 13 | 2,514
Mammary Neoplasms 12 | 410
fibroadenoma 12 | 557
lung carcinoma 12 | 2,844
Atherosclerosis 11 | 275
Endometriosis 11 | 535
Hyperglycemia 11 | 120
Lipid metabolism disorder 11 | 102
group 3 medulloblastoma 11 | 2,254
Diabetes Mellitus, Non-Insulin-Dependent 10 | 161
Fatty liver disease 10 | 86
Multiple myeloma 10 | 1,327
Prostatic Neoplasms 10 | 471
adrenocortical carcinoma 10 | 1,427
astrocytic glioma 10 | 2,241
autosomal dominant Emery-Dreifuss muscular dystrophy 10 | 499
non-small cell lung cancer 10 | 2,798
pediatric high grade glioma 10 | 2,712
pilocytic astrocytoma 10 | 3,086
Atopic dermatitis 9 | 944
Coronary artery disease 9 | 240
Diabetes Mellitus, Experimental 9 | 106
Hypertensive disease 9 | 193
Insulin Resistance 9 | 50
Liver carcinoma 9 | 217
interstitial cystitis 9 | 2,299
juvenile dermatomyositis 9 | 1,189
pancreatic cancer 9 | 2,300
posterior fossa group B ependymoma 9 | 1,530
Hyperinsulinism 8 | 63
Hypertension 8 | 293
Kidney Failure, Chronic 8 | 45
acute myeloid leukemia 8 | 785
colon cancer 8 | 1,475
dermatomyositis 8 | 966
subependymal giant cell astrocytoma 8 | 2,287
tuberculosis and treatment for 6 months 8 | 686
Cerebrovascular disease 7 | 231
Heart disease 7 | 279
Intellectual disability 7 | 573
Lipodystrophy 7 | 32
Liver disease 7 | 219
Osteoporosis 7 | 259
adult high grade glioma 7 | 2,148
medulloblastoma 7 | 1,524
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,795
primary pancreatic ductal adenocarcinoma 7 | 1,271
spina bifida 7 | 1,064
Colonic Neoplasms 6 | 126
Inflammation 6 | 109
Myocardial Ischemia 6 | 169
chronic lymphosyte leukemia 6 | 232
cystic fibrosis 6 | 1,670
mucosa-associated lymphoid tissue lymphoma 6 | 480
nasopharyngeal carcinoma 6 | 1,056
Alzheimer's disease 5 | 644
Asthma 5 | 349
Crohn Disease 5 | 97
Crohn's disease 5 | 304
Drug-Induced Liver Injury 5 | 118
Duchenne muscular dystrophy 5 | 602
Kidney disease 5 | 397
Mammary Neoplasms, Experimental 5 | 149
Neoplasm Metastasis 5 | 138
Polycystic Ovary Syndrome 5 | 334
Reperfusion Injury 5 | 84
Schizophrenia 5 | 503
aldosterone-producing adenoma 5 | 664
non primary Sjogren syndrome sicca 5 | 840

Tissue

Blood and immune system 84 | 17,994
Cardiovascular System 84 | 17,957
Digestive Tract 84 | 18,472
Endocrine System 84 | 18,511
Female tissues 84 | 18,646
Liver and Pancreas 84 | 18,135
Male tissues 84 | 17,968
Nervous System 84 | 18,560
Respiratory system 84 | 17,483
Skin and soft tissues 84 | 18,114
Urinary Tract 84 | 18,443

Target Family

Enzyme 32 | 4,146
Non-IDG 22 | 11,969
Transcription Factor 14 | 1,400
Epigenetic 7 | 242
Kinase 4 | 634
Nuclear Receptor 4 | 48
Transporter 1 | 473

Reactome Pathway

Transcriptional regulation of ... 84 | 84
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proto-oncogene Wnt-1 WNT1 Tbio Non-IDG -2.73870 492.7 294
Mediator of RNA polymerase II transcription subunit 7 MED7 Tbio Enzyme -1.04585 10.2 155
Mediator of RNA polymerase II transcription subunit 25 MED25 Tbio Enzyme -1.76765 56.0 62
Trimethylguanosine synthase TGS1 Tbio Enzyme -1.36236 24.4 85
Mediator of RNA polymerase II transcription subunit 23 MED23 Tbio Enzyme -1.42178 30.0 128
Angiopoietin-related protein 4 ANGPTL4 Tbio Non-IDG -2.41477 298.0 270
Krueppel-like factor 5 KLF5 Tchem Transcription Factor -2.19039 189.7 186
Cyclin-dependent kinase 19 CDK19 Tchem Kinase -1.30571 16.4 133
Mediator of RNA polymerase II transcription subunit 1 MED1 Tbio Enzyme -1.88337 79.6 319
Retinoic acid receptor RXR-alpha RXRA Tclin Nuclear Receptor -2.47322 228.6 266