Development Level

Tbio 54 | 10,625
Tdark 17 | 7,003

IMPC Term

preweaning lethality, complete... 5 | 633
abnormal behavior 1 | 226
decreased body weight 1 | 174
decreased circulating sodium l... 1 | 18
embryonic lethality prior to o... 1 | 148
embryonic lethality prior to t... 1 | 187
hyperactivity 1 | 108
increased circulating free fat... 1 | 17

Disease

ovarian cancer 39 | 8,484
lung cancer 36 | 4,466
osteosarcoma 27 | 7,933
Breast cancer 20 | 3,094
psoriasis 20 | 6,685
medulloblastoma, large-cell 19 | 6,234
group 3 medulloblastoma 18 | 2,254
atypical teratoid / rhabdoid tumor 16 | 4,369
glioblastoma 16 | 5,572
Multiple myeloma 15 | 1,327
invasive ductal carcinoma 15 | 2,950
non-small cell lung cancer 14 | 2,798
Carcinoma 13 | 2,147
intraductal papillary-mucinous neoplasm (IPMN) 13 | 3,289
breast carcinoma 12 | 1,614
lung adenocarcinoma 12 | 2,713
malignant mesothelioma 12 | 3,162
dermatomyositis 11 | 933
ductal carcinoma in situ 11 | 1,745
pediatric high grade glioma 11 | 2,712
primitive neuroectodermal tumor 11 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,988
oligodendroglioma 9 | 2,849
Cancer 8 | 2,346
Pick disease 8 | 1,893
Waldenstrons macroglobulinemia 8 | 765
acute quadriplegic myopathy 8 | 1,157
astrocytic glioma 7 | 2,241
colon cancer 7 | 1,475
ependymoma 7 | 2,514
pancreatic cancer 7 | 2,300
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,795
astrocytoma 6 | 1,493
diabetes mellitus 6 | 1,663
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,956
sonic hedgehog group medulloblastoma 6 | 1,482
Rheumatoid Arthritis 5 | 1,160
acute myeloid leukemia 5 | 780
cutaneous lupus erythematosus 5 | 1,056
cystic fibrosis 5 | 1,665
group 4 medulloblastoma 5 | 1,875
nasopharyngeal carcinoma 5 | 1,056
non-small cell lung carcinoma 5 | 413
pilocytic astrocytoma 5 | 3,086
spina bifida 5 | 1,064
Atopic dermatitis 4 | 944
medulloblastoma 4 | 1,524
pancreatic carcinoma 4 | 567
subependymal giant cell astrocytoma 4 | 2,287
Cleft palate 3 | 125
Connective tissue disease 3 | 59
Leishmaniasis 3 | 49
Lupus erythematosus 3 | 80
Mammary Neoplasms 3 | 410
adrenocortical carcinoma 3 | 1,427
atypical teratoid/rhabdoid tumor 3 | 1,095
gastric cancer 3 | 430
hepatocellular carcinoma 3 | 532
juvenile dermatomyositis 3 | 1,189
lung carcinoma 3 | 2,844
pituitary cancer 3 | 1,972
posterior fossa group A ependymoma 3 | 1,511
posterior fossa group B ependymoma 3 | 1,530
ulcerative colitis 3 | 2,087
Amyotrophic Lateral Sclerosis 2 | 431
Cockayne syndrome 2 | 54
Down syndrome 2 | 548
Endometriosis 2 | 535
HIV Infections 2 | 100
IGA Glomerulonephritis 2 | 454
Influenza 2 | 142
Leukemia 2 | 88
Leukemia, Myelocytic, Acute 2 | 113
Thyroiditis 2 | 25
Vaccinia 2 | 37
inflammatory breast cancer 2 | 404
interstitial cystitis 2 | 2,299
interstitial lung disease 2 | 291
non primary Sjogren syndrome sicca 2 | 840
progressive supranuclear palsy 2 | 674
triple-A syndrome 2 | 18
tuberculosis 2 | 1,557
Bipolar Disorder 1 | 266
Chromosome 18p deletion syndrome 1 | 5
Chronic Lymphocytic Leukemia 1 | 242
Cocaine-Related Disorders 1 | 88
Degenerative polyarthritis 1 | 93
Disseminated intravascular coagulation 1 | 32
Edwards syndrome 1 | 15
Familial atrial fibrillation 1 | 16
Fungal meningitis 1 | 7
Gaucher disease type 1 1 | 171
Myeloid Leukemia 1 | 19
Patau syndrome 1 | 15
Seckel syndrome 1 | 34
Shwachman-Diamond syndrome 1 | 16
Turner syndrome 1 | 31
cystic fibrosis and chronic rhinosinusitis 1 | 213
hereditary spastic paraplegia 1 | 313
permanent atrial fibrillation 1 | 44

Tissue

Female tissues 71 | 18,647
Male tissues 71 | 17,969
Blood and immune system 70 | 17,995
Cardiovascular System 70 | 17,958
Endocrine System 70 | 18,512
Nervous System 70 | 18,561
Digestive Tract 69 | 18,473
Liver and Pancreas 69 | 18,136
Urinary Tract 69 | 18,444
Respiratory system 68 | 17,484
Skin and soft tissues 62 | 18,115

Target Family

Non-IDG 56 | 11,971
Enzyme 15 | 4,146

Reactome Pathway

Transcriptional regulation by ... 71 | 71
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
Nuclear pore complex protein Nup98-Nup96 NUP98 Tbio Enzyme -2.21148 186.3 172
DNA-directed RNA polymerase II subunit RPB7 POLR2G Tbio Enzyme -1.74939 59.4 153
Nucleoporin p58/p45 NUP58 Tdark Non-IDG -0.70757 5.23 31
Trinucleotide repeat-containing gene 6A protein TNRC6A Tbio Non-IDG -2.03159 112.3 66
Nucleoporin-like protein 2 NUPL2 Tbio Non-IDG -0.99049 10.1 66
Histone H2B type 1-C/E/F/G/I HIST1H2BC Tbio Non-IDG -1.35785 22.1 103
DNA-directed RNA polymerase II subunit RPB4 POLR2D Tdark Enzyme -0.50937 3.13 114
GTP-binding nuclear protein Ran RAN Tbio Enzyme -2.52041 303.8 437
DNA-directed RNA polymerases I, II, and III subunit RPABC5 POLR2L Tbio Enzyme -0.98287 10.2 60