Development Level

Tbio 57 | 11,445
Tdark 13 | 6,588

IMPC Phenotype

preweaning lethality, complete... 8 | 979
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
preweaning lethality, incomple... 2 | 499
abnormal behavior 1 | 298
abnormal heart morphology 1 | 162
decreased body weight 1 | 161
decreased circulating sodium l... 1 | 22
decreased vertical activity 1 | 208
enlarged heart 1 | 210
hyperactivity 1 | 148
increased circulating free fat... 1 | 20

Disease

Carcinoma 41 | 11,493
ovarian cancer 39 | 8,520
lung cancer 35 | 4,740
osteosarcoma 26 | 7,950
group 3 medulloblastoma 23 | 4,104
Breast cancer 21 | 3,578
psoriasis 20 | 6,694
atypical teratoid / rhabdoid tumor 19 | 5,112
medulloblastoma, large-cell 18 | 6,241
glioblastoma 16 | 5,792
Multiple myeloma 15 | 1,332
invasive ductal carcinoma 15 | 2,951
non-small cell lung cancer 15 | 2,890
Kidney cancer 14 | 2,613
intraductal papillary-mucinous neoplasm (IPMN) 13 | 3,291
malignant mesothelioma 13 | 3,232
breast carcinoma 12 | 1,638
lung adenocarcinoma 12 | 2,716
dermatomyositis 11 | 966
ductal carcinoma in situ 11 | 1,745
ependymoma 11 | 4,679
primitive neuroectodermal tumor 11 | 3,035
astrocytic glioma 9 | 2,597
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,989
oligodendroglioma 9 | 2,850
Cancer 8 | 2,499
Pick disease 8 | 1,894
Waldenstrons macroglobulinemia 8 | 765
acute quadriplegic myopathy 8 | 1,158
adult high grade glioma 8 | 3,801
colon cancer 7 | 1,478
pancreatic cancer 7 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962
diabetes mellitus 6 | 1,728
group 4 medulloblastoma 6 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
Astrocytoma, Pilocytic 5 | 3,081
acute myeloid leukemia 5 | 783
cutaneous lupus erythematosus 5 | 1,057
cystic fibrosis 5 | 1,696
nasopharyngeal carcinoma 5 | 1,058
spina bifida 5 | 1,074
Atopic dermatitis 4 | 952
Hereditary spherocytosis type 5 4 | 12
Rheumatoid arthritis 4 | 1,191
astrocytoma 4 | 1,146
non-small cell lung carcinoma 4 | 317
pancreatic carcinoma 4 | 562
pediatric high grade glioma 4 | 1,064
subependymal giant cell astrocytoma 4 | 2,287
tuberculosis 4 | 2,010
Amyotrophic lateral sclerosis 3 | 451
Breast Neoplasms 3 | 445
Cleft Palate 3 | 271
Connective tissue disease 3 | 62
Lupus erythematosus 3 | 57
Mammary Neoplasms 3 | 425
adrenocortical carcinoma 3 | 1,428
gastric cancer 3 | 459
hepatocellular carcinoma 3 | 547
juvenile dermatomyositis 3 | 1,187
lung carcinoma 3 | 2,843
pituitary cancer 3 | 1,972
sonic hedgehog group medulloblastoma 3 | 467
Alcoholic Intoxication, Chronic 2 | 289
Autosomal recessive predisposition 2 | 1,442
Cockayne syndrome 2 | 60
Congenital myasthenic syndrome 5 2 | 11
Down syndrome 2 | 499
Endometriosis 2 | 540
Galloway-Mowat syndrome 2 | 15
HIV Infections 2 | 102
Influenza 2 | 142
Leukemia 2 | 104
Leukemia, Myelocytic, Acute 2 | 120
Liver cancer 2 | 604
Mesothelioma, Malignant 2 | 105
NEPHROTIC SYNDROME, STEROID-RESISTANT, AUTOSOMAL RECESSIVE 2 | 4
Nephrotic syndrome, idiopathic, steroid-resistant 2 | 4
Retinitis pigmentosa 20 2 | 5
Schizophrenia 2 | 1,160
Thyroiditis 2 | 29
interstitial cystitis 2 | 2,312
interstitial lung disease 2 | 298
non primary Sjogren syndrome sicca 2 | 891
progressive supranuclear palsy 2 | 676
ulcerative colitis 2 | 1,819
Ankylosing spondylitis 1 | 140
Bejel 1 | 5
Brain disease 1 | 96
Infectious mononucleosis 1 | 14
Neoplasm Recurrence, Local 1 | 37
Nijmegen breakage syndrome 1 | 24
Primary ciliary dyskinesia 1 | 76
Vaccinia 1 | 36
Weight Gain 1 | 100
Xeroderma pigmentosum group B 1 | 20
Yaws 1 | 7
fascioscapulohumeral muscular dystrophy 1 | 100
inflammatory breast cancer 1 | 286

Tissue

Endocrine System 69 | 18,159
Blood and immune system 68 | 16,909
Digestive Tract 68 | 17,369
Female tissues 68 | 17,400
Skin and soft tissues 68 | 17,230
Cardiovascular System 67 | 15,192
Liver and Pancreas 67 | 16,750
Male tissues 67 | 17,142
Nervous System 67 | 16,725
Respiratory system 67 | 16,393
Urinary Tract 67 | 16,678

Target Family

Non-IDG 55 | 12,091
Enzyme 15 | 4,145

Reactome Pathway

Transcriptional regulation by ... 70 | 70
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Nucleoporin NDC1 NDC1 Tbio Non-IDG -0.66901 4.57 46
DNA-directed RNA polymerase II subunit RPB2 POLR2B Tbio Enzyme -2.49730 299.8 149
Histone H2B type 1-N HIST1H2BN Tbio Non-IDG -1.51422 30.2 60
Histone H2B type 1-L HIST1H2BL Tdark Non-IDG 0.35 0.40 48
Nucleoprotein TPR TPR Tbio Non-IDG -2.11491 135.6 161
DNA-directed RNA polymerases I, II, and III subunit RPABC2 POLR2F Tbio Enzyme -1.13403 13.9 68
Nuclear pore complex protein Nup160 NUP160 Tbio Non-IDG -1.13177 13.6 169
Histone H2A type 1-B/E HIST1H2AB Tbio Non-IDG -1.27041 18.5 133
Nuclear pore complex protein Nup85 NUP85 Tbio Non-IDG -1.23703 17.9 139
DNA-directed RNA polymerases I, II, and III subunit RPABC4 POLR2K Tbio Enzyme -0.90716 7.36 65