Development Level

Tbio 71 | 11,445
Tchem 16 | 1,598
Tclin 9 | 613
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, complete... 12 | 979
abnormal behavior 3 | 298
cataract 3 | 92
decreased total body fat amoun... 3 | 207
preweaning lethality, incomple... 3 | 499
abnormal heart morphology 2 | 162
abnormal lens morphology 2 | 81
corneal opacity 2 | 32
decreased bone mineral content 2 | 151
decreased bone mineral density 2 | 126
decreased lean body mass 2 | 135
decreased prepulse inhibition 2 | 82
decreased startle reflex 2 | 75
enlarged heart 2 | 210
increased bone mineral content 2 | 108
increased heart weight 2 | 62
increased lean body mass 2 | 172
increased total body fat amoun... 2 | 134
thrombocytopenia 2 | 56
abnormal behavioral response t... 1 | 66
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal craniofacial morpholo... 1 | 33
abnormal embryo size 1 | 220
abnormal embryo turning 1 | 31
abnormal epididymis morphology 1 | 42
abnormal eye anterior chamber ... 1 | 9
abnormal eyelid morphology 1 | 7
abnormal femur morphology 1 | 14
abnormal forelimb morphology 1 | 2
abnormal head morphology 1 | 10
abnormal head size 1 | 6
abnormal heart left ventricle ... 1 | 16
abnormal iris morphology 1 | 13
abnormal kidney morphology 1 | 65
abnormal locomotor behavior 1 | 24
abnormal lung morphology 1 | 26
abnormal placement of pupils 1 | 6
abnormal response to tactile s... 1 | 17
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal sleep behavior 1 | 70
abnormal spleen morphology 1 | 55
abnormal startle reflex 1 | 15
abnormal testis morphology 1 | 43
abnormal tooth morphology 1 | 24
abnormal vertebrae morphology 1 | 18
decreased CD4-positive, alpha ... 1 | 7
decreased IgG1 level 1 | 8
decreased IgG2b level 1 | 4
decreased T cell number 1 | 15
decreased caudal vertebrae num... 1 | 53
decreased circulating choleste... 1 | 93
decreased circulating insulin ... 1 | 76
decreased circulating total pr... 1 | 49
decreased eosinophil cell numb... 1 | 24
decreased erythrocyte cell num... 1 | 62
decreased hemoglobin content 1 | 68
decreased lymphocyte cell numb... 1 | 83
decreased respiratory quotient 1 | 16
decreased vertical activity 1 | 208
dilated heart left ventricle 1 | 11
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged epididymis 1 | 31
enlarged heart atrium 1 | 4
enlarged spleen 1 | 41
hypoactivity 1 | 132
increased B cell number 1 | 9
increased anti-nuclear antigen... 1 | 19
increased bone mineral density 1 | 72
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased or absent threshold ... 1 | 101
increased startle reflex 1 | 112
irregularly shaped pupil 1 | 7
mammalian phenotype 1 | 17
microphthalmia 1 | 26
narrow eye opening 1 | 12
persistence of hyaloid vascula... 1 | 33
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
small seminal vesicle 1 | 10
small testis 1 | 58
syndactyly 1 | 23
trunk curl 1 | 16

Disease

ovarian cancer 72 | 8,520
Carcinoma 60 | 11,493
lung cancer 49 | 4,740
osteosarcoma 46 | 7,950
psoriasis 46 | 6,694
glioblastoma 45 | 5,792
Cancer 42 | 2,499
Multiple myeloma 35 | 1,332
atypical teratoid / rhabdoid tumor 32 | 5,112
Breast cancer 31 | 3,578
medulloblastoma, large-cell 29 | 6,241
ependymoma 27 | 4,679
malignant mesothelioma 24 | 3,232
pancreatic cancer 22 | 2,398
Astrocytoma, Pilocytic 21 | 3,081
group 3 medulloblastoma 20 | 4,104
oligodendroglioma 20 | 2,850
subependymal giant cell astrocytoma 20 | 2,287
adult high grade glioma 19 | 3,801
invasive ductal carcinoma 19 | 2,951
lung carcinoma 19 | 2,843
pancreatic ductal adenocarcinoma liver metastasis 19 | 1,962
dermatomyositis 18 | 966
intraductal papillary-mucinous neoplasm (IPMN) 18 | 3,291
tuberculosis 18 | 2,010
acute quadriplegic myopathy 17 | 1,158
astrocytoma 17 | 1,146
diabetes mellitus 17 | 1,728
intraductal papillary-mucinous adenoma (IPMA) 17 | 2,955
HIV Infections 16 | 102
primitive neuroectodermal tumor 16 | 3,035
Kidney cancer 15 | 2,613
interstitial cystitis 15 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 15 | 2,989
Breast Neoplasms 14 | 445
astrocytic glioma 14 | 2,597
juvenile dermatomyositis 14 | 1,187
non-small cell lung cancer 14 | 2,890
Lung Neoplasms 13 | 232
Pick disease 13 | 1,894
breast carcinoma 13 | 1,638
ulcerative colitis 13 | 1,819
Colonic Neoplasms 12 | 142
Mammary Neoplasms 12 | 425
Waldenstrons macroglobulinemia 12 | 765
pediatric high grade glioma 12 | 1,064
pituitary cancer 12 | 1,972
Adenocarcinoma 11 | 122
Immune system cancer 11 | 140
Stomach Neoplasms 11 | 300
Vascular disease 11 | 319
autosomal dominant Emery-Dreifuss muscular dystrophy 11 | 510
ductal carcinoma in situ 11 | 1,745
gastric carcinoma 11 | 807
group 4 medulloblastoma 11 | 1,855
lung adenocarcinoma 11 | 2,716
primary pancreatic ductal adenocarcinoma 11 | 1,109
Amyotrophic lateral sclerosis 10 | 451
Bladder Neoplasm 10 | 112
Carcinoma, Squamous Cell 10 | 110
Liver Cirrhosis, Experimental 10 | 769
Lymphoid leukemia 10 | 160
Prostatic Neoplasms 10 | 495
Rheumatoid arthritis 10 | 1,191
Urinary Bladder Neoplasms 10 | 114
Adenoma 9 | 167
Colorectal Neoplasms 9 | 243
Esophageal Squamous Cell Carcinoma 9 | 77
Obesity 9 | 678
Osteoporosis 9 | 363
Schizophrenia 9 | 1,160
Squamous cell carcinoma of esophagus 9 | 77
colon cancer 9 | 1,478
Adenoid Cystic Carcinoma 8 | 99
Carcinoma, Adenoid Cystic 8 | 99
Carcinoma, Hepatocellular 8 | 228
Crohn's disease 8 | 321
Intellectual disability 8 | 1,016
Kidney disease 8 | 430
Liver Cirrhosis 8 | 181
Liver cancer 8 | 604
Liver carcinoma 8 | 240
Liver disease 8 | 237
Neoplasm Metastasis 8 | 168
Pancreatic Neoplasm 8 | 85
Squamous cell carcinoma 8 | 129
Stomach cancer 8 | 30
Strabismus 8 | 270
acute myeloid leukemia 8 | 783
cutaneous lupus erythematosus 8 | 1,057
cystic fibrosis 8 | 1,696
primary Sjogren syndrome 8 | 735
spina bifida 8 | 1,074
Chronic Lymphocytic Leukemia 7 | 262
Duchenne muscular dystrophy 7 | 601
Epilepsy 7 | 792
Seizures 7 | 596
adrenocortical carcinoma 7 | 1,428
hepatocellular carcinoma 7 | 547
nasopharyngeal carcinoma 7 | 1,058

Tissue

Blood and immune system 94 | 16,909
Digestive Tract 94 | 17,369
Endocrine System 94 | 18,159
Female tissues 94 | 17,400
Liver and Pancreas 94 | 16,750
Male tissues 94 | 17,142
Nervous System 94 | 16,725
Respiratory system 94 | 16,393
Skin and soft tissues 94 | 17,230
Urinary Tract 94 | 16,678
Cardiovascular System 93 | 15,192

Target Family

Enzyme 43 | 4,145
Non-IDG 27 | 12,091
Transcription Factor 19 | 1,400
Epigenetic 6 | 242
Kinase 1 | 634
Nuclear Receptor 1 | 48

Reactome Pathway

Transcriptional regulation by ... 97 | 97
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proteasome activator complex subunit 2 PSME2 Tbio Non-IDG -1.47440 29.1 305
Proteasome subunit beta type-10 PSMB10 Tchem Enzyme -1.88722 74.3 178
Mastermind-like domain-containing protein 1 MAMLD1 Tbio Non-IDG -1.97732 91.2 52
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
Forkhead box protein O3 FOXO3 Tbio Transcription Factor -2.94477 863.9 864
Polyubiquitin-B UBB Tbio Non-IDG -1.98860 97.4 427
Polyubiquitin-C UBC Tbio Non-IDG -2.90157 61.9 143
Bromodomain-containing protein 2 BRD2 Tchem Epigenetic -2.48992 0.00000 324
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.12534 131.4 181
Ubiquitin-40S ribosomal protein S27a RPS27A Tbio Non-IDG -1.66231 61.9 139