Development Level

Tbio 145 | 11,445
Tchem 32 | 1,598
Tdark 14 | 6,588
Tclin 12 | 613

Collection

Kinase: IDG Consortium (Target... 2 | 125
RFA-RM-18-021 2 | 328

IMPC Phenotype

preweaning lethality, complete... 20 | 979
decreased vertical activity 7 | 208
preweaning lethality, incomple... 6 | 499
abnormal behavior 5 | 298
abnormal embryo size 5 | 220
enlarged heart 4 | 210
increased bone mineral content 4 | 108
abnormal heart morphology 3 | 162
abnormal seminal vesicle morph... 3 | 114
decreased circulating choleste... 3 | 93
decreased total body fat amoun... 3 | 207
embryonic lethality prior to t... 3 | 278
impaired glucose tolerance 3 | 75
male infertility 3 | 123
abnormal bone structure 2 | 187
abnormal lung morphology 2 | 26
abnormal testis morphology 2 | 43
decreased bone mineral content 2 | 151
decreased bone mineral density 2 | 126
decreased caudal vertebrae num... 2 | 53
decreased circulating HDL chol... 2 | 68
decreased circulating alkaline... 2 | 46
decreased circulating glucose ... 2 | 126
decreased circulating insulin ... 2 | 76
decreased leukocyte cell numbe... 2 | 73
decreased lymphocyte cell numb... 2 | 83
edema 2 | 59
embryonic growth retardation 2 | 106
embryonic lethality prior to o... 2 | 239
enlarged spleen 2 | 41
increased bone mineral density 2 | 72
increased circulating creatini... 2 | 38
increased grip strength 2 | 41
increased lean body mass 2 | 172
increased neutrophil cell numb... 2 | 46
prenatal lethality prior to he... 2 | 87
small superior vagus ganglion 2 | 74
small testis 2 | 58
abnormal behavioral response t... 1 | 66
abnormal brain morphology 1 | 13
abnormal colon morphology 1 | 3
abnormal craniofacial morpholo... 1 | 33
abnormal epididymis morphology 1 | 42
abnormal esophagus morphology 1 | 5
abnormal eye morphology 1 | 68
abnormal gait 1 | 69
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal liver morphology 1 | 17
abnormal pericardium morpholog... 1 | 26
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal spleen morphology 1 | 55
abnormal tooth morphology 1 | 24
abnormal vertebrae morphology 1 | 18
anophthalmia 1 | 33
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
decreased circulating LDL chol... 1 | 38
decreased circulating fructosa... 1 | 30
decreased circulating magnesiu... 1 | 13
decreased circulating phosphat... 1 | 27
decreased circulating total pr... 1 | 49
decreased grip strength 1 | 116
decreased heart left ventricle... 1 | 28
decreased heart weight 1 | 27
decreased lean body mass 1 | 135
decreased prepulse inhibition 1 | 82
decreased threshold for audito... 1 | 26
enlarged kidney 1 | 14
enlarged lymph nodes 1 | 37
female infertility 1 | 60
hyperactivity 1 | 148
hypoactivity 1 | 132
improved glucose tolerance 1 | 79
increased cardiac muscle contr... 1 | 8
increased circulating HDL chol... 1 | 80
increased circulating calcium ... 1 | 34
increased circulating chloride... 1 | 41
increased circulating choleste... 1 | 66
increased circulating phosphat... 1 | 26
increased circulating sodium l... 1 | 71
increased circulating total pr... 1 | 28
increased circulating triglyce... 1 | 42
increased eosinophil cell numb... 1 | 11
increased fasted circulating g... 1 | 76
increased heart rate 1 | 23
increased heart weight 1 | 62
increased hemoglobin content 1 | 45
increased large unstained cell... 1 | 5
increased mean corpuscular vol... 1 | 92
increased mean platelet volume 1 | 45
increased monocyte cell number 1 | 63
increased or absent threshold ... 1 | 101
increased red blood cell distr... 1 | 34
increased startle reflex 1 | 112
microphthalmia 1 | 26
persistence of hyaloid vascula... 1 | 33
short tibia 1 | 97
tremors 1 | 39

Disease

ovarian cancer 125 | 8,520
Carcinoma 119 | 11,493
osteosarcoma 106 | 7,950
psoriasis 91 | 6,694
Cancer 83 | 2,499
lung cancer 76 | 4,740
glioblastoma 73 | 5,792
medulloblastoma, large-cell 65 | 6,241
Breast cancer 64 | 3,578
atypical teratoid / rhabdoid tumor 53 | 5,112
group 3 medulloblastoma 50 | 4,104
ependymoma 46 | 4,679
invasive ductal carcinoma 43 | 2,951
non-small cell lung cancer 42 | 2,890
Multiple myeloma 40 | 1,332
intraductal papillary-mucinous carcinoma (IPMC) 39 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 39 | 3,291
malignant mesothelioma 39 | 3,232
lung adenocarcinoma 37 | 2,716
Kidney cancer 36 | 2,613
intraductal papillary-mucinous adenoma (IPMA) 36 | 2,955
Rheumatoid arthritis 35 | 1,191
oligodendroglioma 33 | 2,850
pancreatic cancer 33 | 2,398
subependymal giant cell astrocytoma 32 | 2,287
primitive neuroectodermal tumor 30 | 3,035
tuberculosis 30 | 2,010
Pick disease 29 | 1,894
astrocytic glioma 29 | 2,597
Astrocytoma, Pilocytic 28 | 3,081
adult high grade glioma 26 | 3,801
diabetes mellitus 26 | 1,728
ductal carcinoma in situ 26 | 1,745
interstitial cystitis 26 | 2,312
Schizophrenia 25 | 1,160
lung carcinoma 25 | 2,843
breast carcinoma 23 | 1,638
group 4 medulloblastoma 23 | 1,855
pancreatic ductal adenocarcinoma liver metastasis 23 | 1,962
Waldenstrons macroglobulinemia 22 | 765
dermatomyositis 22 | 966
pituitary cancer 22 | 1,972
Intellectual disability 19 | 1,016
colon cancer 19 | 1,478
cystic fibrosis 19 | 1,696
juvenile dermatomyositis 19 | 1,187
HIV Infections 18 | 102
cutaneous lupus erythematosus 18 | 1,057
Short stature 17 | 531
spina bifida 17 | 1,074
ulcerative colitis 17 | 1,819
Breast Neoplasms 16 | 445
astrocytoma 16 | 1,146
pediatric high grade glioma 16 | 1,064
Anemia 15 | 365
acute quadriplegic myopathy 15 | 1,158
Mammary Neoplasms 14 | 425
Acquired scoliosis 13 | 281
Curvature of spine 13 | 282
Dull intelligence 13 | 645
Immune system cancer 13 | 140
Liver cancer 13 | 604
Low intelligence 13 | 645
Mental Retardation 13 | 645
Mental deficiency 13 | 645
Poor school performance 13 | 645
nasopharyngeal carcinoma 13 | 1,058
primary pancreatic ductal adenocarcinoma 13 | 1,109
progressive supranuclear palsy 13 | 676
Arthritis, Rheumatoid 12 | 174
Liver Cirrhosis, Experimental 12 | 769
Melanoma 12 | 711
Muscle hypotonia 12 | 571
Small head 12 | 374
acute myeloid leukemia 12 | 783
primary Sjogren syndrome 12 | 735
Bipolar Disorder 11 | 666
Down syndrome 11 | 499
Epilepsy 11 | 792
Kidney disease 11 | 430
Lymphoid leukemia 11 | 160
Multiple Sclerosis 11 | 540
Osteoporosis 11 | 363
Strabismus 11 | 270
Thrombocytopenia 11 | 197
hepatocellular carcinoma 11 | 547
Asthma 10 | 385
Atopic dermatitis 10 | 952
Bladder Neoplasm 10 | 112
Carcinoma, Hepatocellular 10 | 228
Cognitive delay 10 | 608
Feeding difficulties in infancy 10 | 175
Global developmental delay 10 | 608
Leukemia 10 | 104
Liver carcinoma 10 | 240
Mental and motor retardation 10 | 608
Seizures 10 | 596
Urinary Bladder Neoplasms 10 | 114
Vascular disease 10 | 319
adrenocortical carcinoma 10 | 1,428

Tissue

Endocrine System 201 | 18,159
Blood and immune system 199 | 16,909
Digestive Tract 199 | 17,369
Female tissues 198 | 17,400
Male tissues 198 | 17,142
Skin and soft tissues 198 | 17,230
Liver and Pancreas 196 | 16,750
Urinary Tract 196 | 16,678
Nervous System 195 | 16,725
Respiratory system 194 | 16,393
Cardiovascular System 190 | 15,192

Target Family

Non-IDG 95 | 12,091
Enzyme 50 | 4,145
Transcription Factor 23 | 1,400
Epigenetic 20 | 242
Kinase 10 | 634
TF/Epigenetic 3 | 38
Nuclear Receptor 2 | 48

Reactome Pathway

Transcriptional regulation by ... 203 | 203
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proteasome activator complex subunit 4 PSME4 Tdark Non-IDG -1.60128 39.3 43
Protein argonaute-4 AGO4 Tbio Non-IDG -1.42077 23.0 121
Glycerol-3-phosphate acyltransferase 1, mitochondrial GPAM Tbio Enzyme -1.93041 83.4 177
Histone H2A.J H2AFJ Tdark Non-IDG -0.00172 0.83 99
Proteasome activator complex subunit 2 PSME2 Tbio Non-IDG -1.47440 29.1 305
Suppressor of cytokine signaling 4 SOCS4 Tbio Non-IDG -1.22763 14.8 224
Histone H2B type 1-N HIST1H2BN Tbio Non-IDG -1.51422 30.2 60
Histone H2B type 1-L HIST1H2BL Tdark Non-IDG 0.35 0.40 48
Transcription factor PU.1 SPI1 Tbio Transcription Factor -3.05079 1139.0 397
Histone H2B type 1-M HIST1H2BM Tdark Non-IDG 0.17 0.33 21