Development Level

Tbio 36 | 11,445
Tchem 8 | 1,598
Tclin 4 | 613
Tdark 2 | 6,588

IMPC Phenotype

preweaning lethality, complete... 5 | 979
preweaning lethality, incomple... 4 | 499
decreased total body fat amoun... 3 | 207
increased bone mineral content 3 | 108
abnormal behavior 2 | 298
abnormal eye morphology 2 | 68
abnormal gait 2 | 69
decreased vertical activity 2 | 208
embryonic lethality prior to t... 2 | 278
enlarged heart 2 | 210
abnormal bone structure 1 | 187
abnormal cranium morphology 1 | 36
abnormal ear morphology 1 | 9
abnormal embryo size 1 | 220
abnormal facial morphology 1 | 17
abnormal forebrain development 1 | 20
abnormal heart morphology 1 | 162
abnormal neural tube closure 1 | 46
abnormal placenta size 1 | 20
abnormal retina morphology 1 | 71
decreased cardiac output 1 | 3
decreased circulating alkaline... 1 | 46
decreased circulating amylase ... 1 | 28
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating serum al... 1 | 82
decreased fasted circulating g... 1 | 65
decreased neutrophil cell numb... 1 | 42
decreased prepulse inhibition 1 | 82
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
enlarged uterus 1 | 11
hydrometra 1 | 53
hyperactivity 1 | 148
increased bone mineral density 1 | 72
increased circulating alkaline... 1 | 122
increased circulating fructosa... 1 | 13
increased circulating serum al... 1 | 22
increased circulating total pr... 1 | 28
increased lean body mass 1 | 172
increased monocyte cell number 1 | 63
increased startle reflex 1 | 112
long tibia 1 | 25
pale yolk sac 1 | 25
pallor 1 | 34
prenatal lethality prior to he... 1 | 87
prolonged QRS complex duration 1 | 8
small superior vagus ganglion 1 | 74
thin ventricular wall 1 | 24

Disease

Carcinoma 40 | 11,493
osteosarcoma 39 | 7,950
ovarian cancer 30 | 8,520
medulloblastoma, large-cell 26 | 6,241
glioblastoma 25 | 5,792
psoriasis 24 | 6,694
atypical teratoid / rhabdoid tumor 20 | 5,112
Cancer 18 | 2,499
adult high grade glioma 18 | 3,801
group 3 medulloblastoma 18 | 4,104
lung cancer 15 | 4,740
primitive neuroectodermal tumor 15 | 3,035
intraductal papillary-mucinous neoplasm (IPMN) 13 | 3,291
malignant mesothelioma 13 | 3,232
Kidney cancer 12 | 2,613
ependymoma 12 | 4,679
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,955
Multiple myeloma 11 | 1,332
Obesity 11 | 678
Pick disease 10 | 1,894
diabetes mellitus 10 | 1,728
invasive ductal carcinoma 10 | 2,951
Astrocytoma, Pilocytic 9 | 3,081
Breast cancer 9 | 3,578
astrocytic glioma 9 | 2,597
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,962
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,989
oligodendroglioma 8 | 2,850
tuberculosis 8 | 2,010
Schizophrenia 7 | 1,160
astrocytoma 7 | 1,146
pituitary cancer 7 | 1,972
subependymal giant cell astrocytoma 7 | 2,287
Breast Neoplasms 6 | 445
Mammary Neoplasms 6 | 425
Parkinson's disease 6 | 392
Prostatic Neoplasms 6 | 495
Rheumatoid arthritis 6 | 1,191
acute quadriplegic myopathy 6 | 1,158
dermatomyositis 6 | 966
group 4 medulloblastoma 6 | 1,855
non-small cell lung cancer 6 | 2,890
Depressive disorder 5 | 409
Intellectual disability 5 | 1,016
Vascular disease 5 | 319
breast carcinoma 5 | 1,638
interstitial cystitis 5 | 2,312
ulcerative colitis 5 | 1,819
Alzheimer's disease 4 | 658
Bipolar Disorder 4 | 666
Cardiomegaly 4 | 116
Diabetes Mellitus, Experimental 4 | 108
Endometriosis 4 | 540
Epilepsy 4 | 792
Fatty Liver 4 | 70
Hyperglycemia 4 | 137
Muscle hypotonia 4 | 571
Myocardial Infarction 4 | 151
Seizures 4 | 596
Waldenstrons macroglobulinemia 4 | 765
acute myeloid leukemia 4 | 783
gastric carcinoma 4 | 807
lung adenocarcinoma 4 | 2,716
pediatric high grade glioma 4 | 1,064
Atherosclerosis 3 | 291
Autistic Disorder 3 | 364
Bladder Neoplasm 3 | 112
Chemical and Drug Induced Liver Injury 3 | 195
Diabetes Mellitus, Non-Insulin-Dependent 3 | 145
Diabetes Mellitus, Type 2 3 | 142
Down syndrome 3 | 499
Dull intelligence 3 | 645
Huntington's disease 3 | 76
Hypoglycemia 3 | 152
Kidney Diseases 3 | 114
Liver neoplasms 3 | 130
Low intelligence 3 | 645
Mental Depression 3 | 333
Mental Retardation 3 | 645
Mental deficiency 3 | 645
Mesothelioma, Malignant 3 | 105
Methylmalonic acidemia 3 | 37
Osteoporosis 3 | 363
Peripheral T-cell lymphoma 3 | 25
Poor school performance 3 | 645
Primary cutaneous T-cell lymphoma 3 | 29
Short stature 3 | 531
Urinary Bladder Neoplasms 3 | 114
adrenocortical carcinoma 3 | 1,428
aldosterone-producing adenoma 3 | 665
atypical teratoid/rhabdoid tumor 3 | 357
colon cancer 3 | 1,478
cutaneous lupus erythematosus 3 | 1,057
cystic fibrosis 3 | 1,696
ductal carcinoma in situ 3 | 1,745
juvenile dermatomyositis 3 | 1,187
medulloblastoma 3 | 720
nasopharyngeal carcinoma 3 | 1,058
posterior fossa group B ependymoma 3 | 416
primary Sjogren syndrome 3 | 735

Tissue

Cardiovascular System 50 | 15,192
Digestive Tract 50 | 17,369
Endocrine System 50 | 18,159
Male tissues 50 | 17,142
Skin and soft tissues 50 | 17,230
Urinary Tract 50 | 16,678
Blood and immune system 49 | 16,909
Female tissues 49 | 17,400
Liver and Pancreas 49 | 16,750
Nervous System 49 | 16,725
Respiratory system 49 | 16,393

Target Family

Non-IDG 17 | 12,091
Enzyme 12 | 4,145
Epigenetic 8 | 242
Transcription Factor 8 | 1,400
Nuclear Receptor 4 | 48
Kinase 1 | 634

Reactome Pathway

Transcriptional activation of ... 50 | 50
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
NAD-dependent protein deacylase sirtuin-5, mitochondrial SIRT5 Tchem Epigenetic -2.36015 219.3 427
Histone-arginine methyltransferase CARM1 CARM1 Tchem Epigenetic -2.04034 130.8 476
Helicase with zinc finger domain 2 HELZ2 Tdark Enzyme -0.50849 4.27 30
5-aminolevulinate synthase, nonspecific, mitochondrial ALAS1 Tbio Enzyme -1.80580 61.7 153
Trimethylguanosine synthase TGS1 Tbio Enzyme -1.40283 26.5 103
Cytochrome c CYCS Tbio Non-IDG -3.76637 4945.6 833
Chromodomain-helicase-DNA-binding protein 9 CHD9 Tbio Epigenetic -0.90481 7.77 30
GA-binding protein alpha chain GABPA Tbio Transcription Factor -1.50283 31.7 289
PGC-1 and ERR-induced regulator in muscle protein 1 PERM1 Tdark Non-IDG -0.48311 2.91 21
Glutamate dehydrogenase 1, mitochondrial GLUD1 Tbio Enzyme -2.39787 257.7 148