Development Level

Tbio 239 | 10,625
Tchem 99 | 1,890
Tdark 12 | 7,003
Tclin 6 | 602

Collection

Eligible Kinase Proteins 6 | 134

IMPC Term

preweaning lethality, complete... 24 | 633
embryonic lethality prior to o... 11 | 148
embryonic lethality prior to t... 11 | 187
preweaning lethality, incomple... 6 | 260
abnormal behavior 5 | 226
increased mean corpuscular hem... 5 | 93
abnormal embryo size 4 | 112
abnormal lens morphology 4 | 73
decreased body length 4 | 108
decreased body weight 4 | 174
decreased circulating LDL chol... 4 | 37
decreased lean body mass 4 | 195
enlarged heart 4 | 111
increased exploration in new e... 4 | 56
abnormal skin coloration 3 | 18
cataract 3 | 26
decreased startle reflex 3 | 48
decreased total body fat amoun... 3 | 186
enlarged spleen 3 | 26
hypoactivity 3 | 89
increased circulating LDL chol... 3 | 15
increased circulating sodium l... 3 | 71
increased mean corpuscular vol... 3 | 91
pallor 3 | 13
prenatal lethality prior to he... 3 | 64
abnormal bone structure 2 | 131
abnormal epididymis morphology 2 | 31
abnormal heart morphology 2 | 51
abnormal limb bud morphology 2 | 15
abnormal maxilla morphology 2 | 16
abnormal placenta morphology 2 | 4
abnormal retina morphology 2 | 100
abnormal skin morphology 2 | 23
abnormal spleen morphology 2 | 36
abnormal tooth morphology 2 | 24
decreased T cell number 2 | 31
decreased blood urea nitrogen ... 2 | 31
decreased bone mineral density 2 | 126
decreased caudal vertebrae num... 2 | 49
decreased circulating HDL chol... 2 | 77
decreased circulating choleste... 2 | 85
decreased circulating glucose ... 2 | 121
decreased circulating serum al... 2 | 79
decreased erythrocyte cell num... 2 | 43
decreased fasted circulating g... 2 | 49
decreased mean corpuscular vol... 2 | 50
enlarged epididymis 2 | 27
hyperactivity 2 | 108
increased fasted circulating g... 2 | 68
increased grip strength 2 | 83
increased mean platelet volume 2 | 19
increased neutrophil cell numb... 2 | 15
male infertility 2 | 62
small testis 2 | 37
abnormal behavioral response t... 1 | 52
abnormal coat/ hair morphology 1 | 18
abnormal cranium morphology 1 | 32
abnormal locomotor activation 1 | 26
abnormal neural tube closure 1 | 37
abnormal respiratory quotient 1 | 9
abnormal retinal blood vessel ... 1 | 18
abnormal rib morphology 1 | 28
abnormal skin appearance 1 | 8
abnormal snout morphology 1 | 18
abnormal tail movements 1 | 12
abnormal testis morphology 1 | 30
abnormal urinary bladder morph... 1 | 2
abnormal vertebrae morphology 1 | 14
corneal opacity 1 | 25
decreased CD4-positive, CD25-p... 1 | 24
decreased CD8-positive, alpha-... 1 | 26
decreased KLRG1-positive NK ce... 1 | 9
decreased NK cell number 1 | 16
decreased anxiety-related resp... 1 | 12
decreased circulating magnesiu... 1 | 11
decreased circulating potassiu... 1 | 17
decreased circulating sodium l... 1 | 18
decreased circulating triglyce... 1 | 83
decreased grip strength 1 | 123
decreased hematocrit 1 | 25
decreased mean corpuscular hem... 1 | 34
decreased mean platelet volume 1 | 12
decreased neutrophil cell numb... 1 | 37
decreased total retina thickne... 1 | 20
dilated heart left ventricle 1 | 10
embryonic growth retardation 1 | 28
enlarged lymph nodes 1 | 27
hemorrhage 1 | 12
hydrops fetalis 1 | 22
increased blood urea nitrogen ... 1 | 44
increased blood uric acid leve... 1 | 5
increased bone mineral density 1 | 52
increased circulating HDL chol... 1 | 63
increased circulating choleste... 1 | 53
increased circulating creatini... 1 | 29
increased sacral vertebrae num... 1 | 62
prenatal lethality 1 | 16
short tibia 1 | 82
tremors 1 | 34
vertebral fusion 1 | 23

Disease

ovarian cancer 222 | 8,484
osteosarcoma 189 | 7,933
lung cancer 144 | 4,466
Cancer 142 | 2,346
medulloblastoma, large-cell 142 | 6,234
glioblastoma 134 | 5,572
psoriasis 133 | 6,685
malignant mesothelioma 90 | 3,162
atypical teratoid / rhabdoid tumor 87 | 4,369
Breast cancer 85 | 3,094
primitive neuroectodermal tumor 79 | 3,031
intraductal papillary-mucinous neoplasm (IPMN) 75 | 3,289
non-small cell lung cancer 72 | 2,798
group 3 medulloblastoma 68 | 2,254
oligodendroglioma 68 | 2,849
pediatric high grade glioma 60 | 2,712
intraductal papillary-mucinous carcinoma (IPMC) 59 | 2,988
ependymoma 58 | 2,514
astrocytic glioma 56 | 2,241
pancreatic cancer 54 | 2,300
lung adenocarcinoma 53 | 2,713
invasive ductal carcinoma 52 | 2,950
Carcinoma 50 | 2,147
subependymal giant cell astrocytoma 50 | 2,287
Multiple myeloma 47 | 1,327
adult high grade glioma 47 | 2,148
colon cancer 47 | 1,475
diabetes mellitus 45 | 1,663
Pick disease 43 | 1,893
group 4 medulloblastoma 43 | 1,875
intraductal papillary-mucinous adenoma (IPMA) 43 | 2,956
adrenocortical carcinoma 42 | 1,427
pilocytic astrocytoma 42 | 3,086
pancreatic ductal adenocarcinoma liver metastasis 41 | 1,795
ductal carcinoma in situ 40 | 1,745
pituitary cancer 39 | 1,972
acute quadriplegic myopathy 37 | 1,157
medulloblastoma 37 | 1,524
tuberculosis 37 | 1,557
Waldenstrons macroglobulinemia 36 | 765
atypical teratoid/rhabdoid tumor 35 | 1,095
juvenile dermatomyositis 35 | 1,189
astrocytoma 34 | 1,493
ulcerative colitis 34 | 2,087
lung carcinoma 33 | 2,844
nasopharyngeal carcinoma 33 | 1,056
Rheumatoid Arthritis 31 | 1,160
breast carcinoma 29 | 1,614
Mammary Neoplasms 28 | 410
acute myeloid leukemia 28 | 780
primary pancreatic ductal adenocarcinoma 28 | 1,271
posterior fossa group A ependymoma 27 | 1,511
sonic hedgehog group medulloblastoma 27 | 1,482
non primary Sjogren syndrome sicca 26 | 840
Intellectual disability 25 | 573
dermatomyositis 25 | 933
interstitial cystitis 25 | 2,299
Endometriosis 23 | 535
tuberculosis and treatment for 6 months 22 | 686
Prostatic Neoplasms 21 | 471
pancreatic carcinoma 21 | 567
Atopic dermatitis 20 | 944
Peripheral Neuropathy 20 | 303
Stomach Neoplasms 20 | 282
cutaneous lupus erythematosus 20 | 1,056
Alzheimer's disease 19 | 644
gastric cancer 19 | 430
Lung Neoplasms 18 | 171
Neoplastic Syndromes, Hereditary 18 | 48
esophageal adenocarcinoma 18 | 737
Amyotrophic Lateral Sclerosis 17 | 431
Liver carcinoma 17 | 217
cystic fibrosis 17 | 1,665
gastric carcinoma 17 | 832
Melanoma 16 | 261
active Crohn's disease 16 | 918
Cockayne syndrome 15 | 54
IGA Glomerulonephritis 15 | 454
Obesity 15 | 616
Parkinson's disease 15 | 364
Chronic Lymphocytic Leukemia 14 | 242
Renal Cell Carcinoma 14 | 199
Vascular disease 14 | 281
aldosterone-producing adenoma 14 | 664
autosomal dominant Emery-Dreifuss muscular dystrophy 14 | 499
hepatocellular carcinoma 14 | 532
ovarian neoplasm 14 | 97
posterior fossa group B ependymoma 14 | 1,530
spina bifida 14 | 1,064
Colorectal Neoplasms 13 | 217
Squamous cell carcinoma 13 | 94
progressive supranuclear palsy 13 | 674
Adenoma 12 | 165
Ataxia telangiectasia 12 | 31
Bloom syndrome 12 | 30
Kidney disease 12 | 396
Neurodegenerative disease 12 | 383
Polycystic Ovary Syndrome 12 | 332
primary Sjogren syndrome 12 | 789
Schizophrenia 11 | 501

Tissue

Blood and immune system 355 | 17,995
Digestive Tract 355 | 18,473
Endocrine System 355 | 18,512
Female tissues 355 | 18,647
Liver and Pancreas 355 | 18,136
Male tissues 355 | 17,969
Nervous System 355 | 18,561
Cardiovascular System 354 | 17,958
Respiratory system 354 | 17,484
Urinary Tract 354 | 18,444
Skin and soft tissues 351 | 18,115

Target Family

Non-IDG 179 | 11,971
Enzyme 88 | 4,146
Kinase 42 | 634
Epigenetic 24 | 242
Transcription Factor 21 | 1,400
TF/Epigenetic 2 | 38

Reactome Pathway

Transcriptional Regulation by ... 356 | 356
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
G2/mitotic-specific cyclin-B1 CCNB1 Tchem Non-IDG -3.09727 1121.4 955
Proliferating cell nuclear antigen PCNA Tchem Non-IDG -1.10426 11.5 1277
Replication protein A 32 kDa subunit RPA2 Tbio Non-IDG -1.76828 59.7 468
E3 ubiquitin-protein ligase Mdm2 MDM2 Tchem Enzyme -3.38438 2174.7 1062
Cytochrome c oxidase subunit 6A1, mitochondrial COX6A1 Tbio Enzyme -1.00384 11.8 165
Replication factor C subunit 3 RFC3 Tbio Non-IDG -1.28299 19.5 161
Replication factor C subunit 5 RFC5 Tbio Non-IDG -1.02728 11.1 64
Protein SCO2 homolog, mitochondrial SCO2 Tbio Non-IDG -2.16453 144.3 98
Cytochrome c oxidase subunit 7C, mitochondrial COX7C Tdark Enzyme -0.99133 9.67 34