Development Level

Tbio 61 | 10,625
Tchem 10 | 1,890
Tdark 5 | 7,003
Tclin 2 | 602

IMPC Term

preweaning lethality, complete... 7 | 633
embryonic lethality prior to o... 6 | 148
embryonic lethality prior to t... 4 | 187
abnormal embryo size 2 | 112
abnormal behavior 1 | 226
abnormal embryo turning 1 | 15
abnormal liver size 1 | 4
abnormal pericardium morpholog... 1 | 11
abnormal pharyngeal arch morph... 1 | 2
abnormal retina morphology 1 | 100
decreased circulating serum al... 1 | 79
decreased circulating sodium l... 1 | 18
decreased hematocrit 1 | 25
embryonic growth retardation 1 | 28
hypoactivity 1 | 89
increased body weight 1 | 42
increased circulating HDL chol... 1 | 63
increased circulating free fat... 1 | 17
increased circulating potassiu... 1 | 31
increased heart weight 1 | 37
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 93
increased mean corpuscular hem... 1 | 25
increased mean corpuscular vol... 1 | 91
polydactyly 1 | 22
prenatal lethality prior to he... 1 | 64

Disease

ovarian cancer 47 | 8,484
osteosarcoma 34 | 7,933
lung cancer 24 | 4,466
Cockayne syndrome 23 | 54
malignant mesothelioma 22 | 3,162
psoriasis 21 | 6,685
Cancer 19 | 2,346
Xeroderma pigmentosum 18 | 41
group 3 medulloblastoma 17 | 2,254
medulloblastoma, large-cell 15 | 6,234
primitive neuroectodermal tumor 14 | 3,031
Photosensitive trichothiodystrophy 13 | 24
Multiple myeloma 12 | 1,327
glioblastoma 12 | 5,572
intraductal papillary-mucinous neoplasm (IPMN) 12 | 3,289
Carcinoma 11 | 2,147
Waldenstrons macroglobulinemia 10 | 765
diabetes mellitus 10 | 1,663
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,988
non-small cell lung cancer 10 | 2,798
acute myeloid leukemia 9 | 780
atypical teratoid / rhabdoid tumor 9 | 4,369
Breast cancer 8 | 3,094
oligodendroglioma 8 | 2,849
ependymoma 7 | 2,514
pediatric high grade glioma 7 | 2,712
Peripheral Neuropathy 6 | 303
Pick disease 6 | 1,893
Stomach Neoplasms 6 | 282
astrocytic glioma 6 | 2,241
astrocytoma 6 | 1,493
atypical teratoid/rhabdoid tumor 6 | 1,095
nasopharyngeal carcinoma 6 | 1,056
pituitary cancer 6 | 1,972
Bladder Neoplasm 5 | 109
Colorectal Neoplasms 5 | 217
Rheumatoid Arthritis 5 | 1,160
UV-sensitive syndrome 5 | 7
hepatocellular carcinoma 5 | 532
pancreatic cancer 5 | 2,300
CAMFAK syndrome 4 | 4
Cerebrooculofacioskeletal Syndrome 1 4 | 4
Intellectual disability 4 | 573
Pena Shokeir syndrome Type 2 4 | 4
Stevens-Johnson syndrome 4 | 78
adrenocortical carcinoma 4 | 1,427
adult high grade glioma 4 | 2,148
ductal carcinoma in situ 4 | 1,745
lung carcinoma 4 | 2,844
medulloblastoma 4 | 1,524
non primary Sjogren syndrome sicca 4 | 840
sonic hedgehog group medulloblastoma 4 | 1,482
Alzheimer's disease 3 | 644
Arsenic Poisoning 3 | 59
Cataract 3 | 104
Cockayne Syndrome, Type I 3 | 3
Cockayne Syndrome, Type II 3 | 3
Disease Progression 3 | 125
Fanconi's anemia 3 | 50
IGA Glomerulonephritis 3 | 454
Micronuclei, Chromosome-Defective 3 | 19
Progeria 3 | 22
Trichothiodystrophy Syndromes 3 | 5
acute quadriplegic myopathy 3 | 1,157
breast carcinoma 3 | 1,614
dermatomyositis 3 | 933
gastric cancer 3 | 430
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,956
invasive ductal carcinoma 3 | 2,950
juvenile dermatomyositis 3 | 1,189
lung adenocarcinoma 3 | 2,713
pancreatic carcinoma 3 | 567
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,795
pilocytic astrocytoma 3 | 3,086
posterior fossa group A ependymoma 3 | 1,511
progressive supranuclear palsy 3 | 674
tuberculosis 3 | 1,557
tuberculosis and treatment for 6 months 3 | 686
Bipolar Disorder 2 | 266
Cerebrovascular disease 2 | 231
Chronic Lymphocytic Leukemia 2 | 242
Colonic Neoplasms 2 | 126
Endometrial Neoplasms 2 | 50
Endometriosis 2 | 535
Lung Neoplasms 2 | 171
Melanoma 2 | 261
Microcephaly 2 | 149
Neoplasm Metastasis 2 | 138
Neoplasms, Germ Cell and Embryonal 2 | 13
Neurodegenerative disease 2 | 383
Prostatic Neoplasms 2 | 471
Schizophrenia 2 | 501
Seckel syndrome 2 | 34
Squamous cell carcinoma of esophagus 2 | 82
Vaccinia 2 | 37
colon cancer 2 | 1,475
cystic fibrosis and chronic rhinosinusitis 2 | 213
primary pancreatic ductal adenocarcinoma 2 | 1,271
spina bifida 2 | 1,064
subependymal giant cell astrocytoma 2 | 2,287

Tissue

Blood and immune system 78 | 17,995
Cardiovascular System 78 | 17,958
Digestive Tract 78 | 18,473
Endocrine System 78 | 18,512
Female tissues 78 | 18,647
Liver and Pancreas 78 | 18,136
Male tissues 78 | 17,969
Nervous System 78 | 18,561
Respiratory system 78 | 17,484
Skin and soft tissues 78 | 18,115
Urinary Tract 78 | 18,444

Target Family

Non-IDG 44 | 11,971
Enzyme 32 | 4,146
Epigenetic 1 | 242
Kinase 1 | 634

Reactome Pathway

Transcription-Coupled Nucleoti... 78 | 78
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proliferating cell nuclear antigen PCNA Tchem Non-IDG -1.10426 11.5 1277
Replication protein A 32 kDa subunit RPA2 Tbio Non-IDG -1.76828 59.7 468
Replication factor C subunit 3 RFC3 Tbio Non-IDG -1.28299 19.5 161
Replication factor C subunit 5 RFC5 Tbio Non-IDG -1.02728 11.1 64
DNA-directed RNA polymerase II subunit RPB7 POLR2G Tbio Enzyme -1.74939 59.4 153
General transcription factor IIH subunit 3 GTF2H3 Tbio Non-IDG -0.79392 6.02 65
General transcription factor IIH subunit 2 GTF2H2 Tbio Non-IDG -0.87357 6.84 120
Ubiquitin carboxyl-terminal hydrolase 7 USP7 Tchem Enzyme -2.17350 165.7 375
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.21113 124.2 150
Replication factor C subunit 2 RFC2 Tbio Non-IDG -1.34287 19.7 194