Development Level

Tbio 63 | 11,178
Tchem 10 | 1,885
Tdark 3 | 6,569
Tclin 2 | 612

IMPC Phenotype

preweaning lethality, complete... 9 | 979
embryonic lethality prior to o... 7 | 239
embryonic lethality prior to t... 4 | 278
abnormal embryo size 2 | 220
abnormal behavior 1 | 298
abnormal embryo turning 1 | 31
abnormal eye morphology 1 | 68
abnormal heart morphology 1 | 162
abnormal heart shape 1 | 5
abnormal liver size 1 | 5
abnormal pericardium morpholog... 1 | 26
abnormal pharyngeal arch morph... 1 | 8
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal spleen morphology 1 | 55
abnormal thymus morphology 1 | 7
abnormal urinary bladder morph... 1 | 11
decreased KLRG1+ CD4 alpha bet... 1 | 5
decreased bone mineral density 1 | 126
decreased circulating glucose ... 1 | 126
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased prepulse inhibition 1 | 82
embryonic growth retardation 1 | 106
enlarged heart 1 | 210
hydrometra 1 | 53
improved glucose tolerance 1 | 79
increased anti-nuclear antigen... 1 | 19
increased body weight 1 | 25
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased circulating potassiu... 1 | 29
increased heart weight 1 | 62
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 96
increased mean corpuscular hem... 1 | 36
increased mean corpuscular vol... 1 | 92
prenatal lethality prior to he... 1 | 87
small seminal vesicle 1 | 10
small spleen 1 | 19
small superior vagus ganglion 1 | 74
small thymus 1 | 16

Disease

ovarian cancer 45 | 8,297
Carcinoma 40 | 11,192
osteosarcoma 34 | 7,766
Cockayne syndrome 27 | 59
lung cancer 27 | 4,607
malignant mesothelioma 21 | 3,135
group 3 medulloblastoma 20 | 4,002
psoriasis 20 | 6,514
Cancer 19 | 2,388
Xeroderma pigmentosum 15 | 42
Photosensitive trichothiodystrophy 14 | 30
medulloblastoma, large-cell 14 | 6,086
primitive neuroectodermal tumor 14 | 2,957
glioblastoma 13 | 5,635
atypical teratoid / rhabdoid tumor 12 | 4,971
intraductal papillary-mucinous neoplasm (IPMN) 12 | 3,204
Intellectual disability 11 | 998
Multiple myeloma 11 | 1,296
Short stature 11 | 514
diabetes mellitus 11 | 1,683
Autosomal recessive predisposition 10 | 1,407
Breast cancer 10 | 3,469
Cataract 10 | 290
Cryptorchidism 10 | 287
Dull intelligence 10 | 634
Hypogonadism 10 | 169
Kidney cancer 10 | 2,548
Low intelligence 10 | 634
Mental Retardation 10 | 634
Mental deficiency 10 | 634
Poor school performance 10 | 634
Sensorineural Hearing Loss (disorder) 10 | 281
Small head 10 | 366
Waldenstrons macroglobulinemia 10 | 742
ependymoma 10 | 4,559
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,902
non-small cell lung cancer 10 | 2,799
Lens Opacities 9 | 227
Photosensitivity of skin 9 | 51
Strabismus 9 | 265
Xeroderma pigmentosum group B 9 | 20
acute myeloid leukemia 9 | 760
Cerebellar Ataxia 8 | 302
Epilepsy 8 | 775
Hypoplastic mandible condyle 8 | 273
Mandibular hypoplasia 8 | 273
Micrognathism 8 | 273
Seizures 8 | 584
Xeroderma pigmentosum group D 8 | 32
adult high grade glioma 8 | 3,701
Atrophic condition of skin 7 | 24
Dry skin 7 | 74
Electroencephalogram abnormal 7 | 100
Failure to gain weight 7 | 359
Freckles 7 | 33
Melanoma 7 | 689
Muscle Spasticity 7 | 192
Muscle hypotonia 7 | 562
Optic Atrophy 7 | 239
Pediatric failure to thrive 7 | 359
Stomach Neoplasms 7 | 287
Xeroderma pigmentosum group G 7 | 16
Xerosis 7 | 74
oligodendroglioma 7 | 2,768
Arthralgia 6 | 85
Broad flat nasal bridge 6 | 232
Cognitive delay 6 | 596
Conjunctival telangiectasis 6 | 14
Deafness 6 | 193
Erythema 6 | 57
Global developmental delay 6 | 596
Keratitis 6 | 60
Low Vision 6 | 167
Mental and motor retardation 6 | 596
Nasal bridge wide 6 | 232
Pick disease 6 | 1,856
Poikiloderma 6 | 14
UV-sensitive syndrome 6 | 9
Visual Impairment 6 | 167
astrocytic glioma 6 | 2,530
astrocytoma 6 | 1,113
hearing impairment 6 | 194
nasopharyngeal carcinoma 6 | 1,024
pituitary cancer 6 | 1,915
Abnormally small eyeball 5 | 94
Cerebral atrophy 5 | 175
Decreased size of eyeball 5 | 94
Developmental regression 5 | 94
Impaired cognition 5 | 95
Loss of developmental milestones 5 | 94
Mental deterioration in childhood 5 | 94
Mental impairment 5 | 95
Neurodevelopmental regression 5 | 94
Psychomotor regression 5 | 94
Psychomotor regression beginning in infancy 5 | 94
Psychomotor regression in infants 5 | 94
Psychomotor regression, progressive 5 | 94
Rheumatoid arthritis 5 | 1,156
Thin skin 5 | 44
pancreatic cancer 5 | 2,322

Tissue

Blood and immune system 77 | 16,909
Cardiovascular System 77 | 15,192
Digestive Tract 77 | 17,369
Endocrine System 77 | 18,159
Female tissues 77 | 17,400
Liver and Pancreas 77 | 16,750
Male tissues 77 | 17,142
Nervous System 77 | 16,725
Respiratory system 77 | 16,393
Skin and soft tissues 77 | 17,230
Urinary Tract 77 | 16,678

Target Family

Non-IDG 44 | 12,091
Enzyme 32 | 4,145
Epigenetic 1 | 242
Kinase 1 | 634

Reactome Pathway

Transcription-Coupled Nucleoti... 78 | 78
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA damage-binding protein 1 DDB1 Tchem Non-IDG -2.34719 202.5 353
DNA-directed RNA polymerase II subunit RPB3 POLR2C Tbio Enzyme -1.40207 26.1 119
TFIIH basal transcription factor complex helicase XPD subunit ERCC2 Tbio Enzyme -2.58326 365.8 191
DNA polymerase kappa POLK Tbio Enzyme -2.42142 256.3 224
DNA excision repair protein ERCC-6 ERCC6 Tbio Non-IDG -2.31776 361.5 163
Zinc finger protein 830 ZNF830 Tdark Non-IDG -0.60070 4.56 91
COP9 signalosome complex subunit 7a COPS7A Tbio Non-IDG -1.50943 32.2 154
COP9 signalosome complex subunit 4 COPS4 Tbio Non-IDG -0.91181 7.39 88
DNA-directed RNA polymerase II subunit RPB2 POLR2B Tbio Enzyme -2.49730 299.8 149
DNA repair protein XRCC1 XRCC1 Tbio Non-IDG -2.99664 1034.1 418