Development Level

Tbio 63 | 11,445
Tchem 6 | 1,598
Tdark 4 | 6,588

IMPC Phenotype

preweaning lethality, complete... 11 | 979
embryonic lethality prior to o... 6 | 239
embryonic lethality prior to t... 6 | 278
abnormal embryo size 2 | 220
abnormal heart morphology 2 | 162
abnormal retina morphology 2 | 71
enlarged heart 2 | 210
increased circulating potassiu... 2 | 29
abnormal epididymis morphology 1 | 42
abnormal pericardium morpholog... 1 | 26
abnormal skin morphology 1 | 50
decreased KLRG1+ CD4 alpha bet... 1 | 5
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating sodium l... 1 | 22
decreased lean body mass 1 | 135
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
enlarged epididymis 1 | 31
female infertility 1 | 60
hypoactivity 1 | 132
increased anti-nuclear antigen... 1 | 19
increased circulating HDL chol... 1 | 80
increased circulating free fat... 1 | 20
increased erythrocyte cell num... 1 | 39
increased heart rate 1 | 23
increased lean body mass 1 | 172
increased total body fat amoun... 1 | 134
male infertility 1 | 123
preweaning lethality, incomple... 1 | 499
short tibia 1 | 97
shortened RR interval 1 | 17

Disease

Carcinoma 42 | 11,493
ovarian cancer 38 | 8,520
osteosarcoma 28 | 7,950
lung cancer 22 | 4,740
psoriasis 17 | 6,694
Breast cancer 14 | 3,578
Multiple myeloma 14 | 1,332
Cockayne syndrome 13 | 60
Kidney cancer 12 | 2,613
medulloblastoma, large-cell 12 | 6,241
Photosensitive trichothiodystrophy 11 | 30
glioblastoma 11 | 5,792
malignant mesothelioma 10 | 3,232
Xeroderma pigmentosum group B 9 | 20
diabetes mellitus 9 | 1,728
ependymoma 9 | 4,679
group 3 medulloblastoma 9 | 4,104
Cancer 8 | 2,499
Intellectual disability 8 | 1,016
acute myeloid leukemia 8 | 783
atypical teratoid / rhabdoid tumor 8 | 5,112
primitive neuroectodermal tumor 8 | 3,035
acute quadriplegic myopathy 7 | 1,158
adult high grade glioma 7 | 3,801
group 4 medulloblastoma 7 | 1,855
oligodendroglioma 7 | 2,850
Autosomal recessive predisposition 6 | 1,442
Pick disease 6 | 1,894
Waldenstrons macroglobulinemia 6 | 765
astrocytic glioma 6 | 2,597
Dull intelligence 5 | 645
Epidermodysplasia verruciformis 5 | 21
Low intelligence 5 | 645
Mental Retardation 5 | 645
Mental deficiency 5 | 645
Poor school performance 5 | 645
Xeroderma pigmentosum 5 | 43
Xeroderma pigmentosum group D 5 | 33
astrocytoma 5 | 1,146
lung adenocarcinoma 5 | 2,716
Astrocytoma, Pilocytic 4 | 3,081
Cerebellar Ataxia 4 | 304
Cognitive delay 4 | 608
Global developmental delay 4 | 608
Hereditary spherocytosis type 5 4 | 12
Keratitis 4 | 62
Mental and motor retardation 4 | 608
Small head 4 | 374
Trichothiodystrophy Syndromes 4 | 6
breast carcinoma 4 | 1,638
dermatomyositis 4 | 966
hepatocellular carcinoma 4 | 547
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
pediatric high grade glioma 4 | 1,064
pituitary cancer 4 | 1,972
subependymal giant cell astrocytoma 4 | 2,287
Abnormally small eyeball 3 | 97
Asthma 3 | 385
Cataract 3 | 297
Chorea 3 | 29
Choreatic disease 3 | 52
Congenital deafness 3 | 185
Cryptorchidism 3 | 296
Deafness 3 | 198
Decreased size of eyeball 3 | 97
Dental abnormalities 3 | 60
Epilepsy 3 | 792
Failure to gain weight 3 | 365
Fetal Growth Retardation 3 | 189
Hearing Loss, Partial 3 | 185
Hemangioma 3 | 69
Hypoplastic mandible condyle 3 | 275
Impaired cognition 3 | 96
Infant, Small for Gestational Age 3 | 176
Intrauterine retardation 3 | 176
Lens Opacities 3 | 231
Mandibular hypoplasia 3 | 275
Melanoma 3 | 711
Mental impairment 3 | 95
Micrognathism 3 | 275
Microphthalmos 3 | 100
Muscle Spasticity 3 | 195
Optic Atrophy 3 | 242
Pediatric failure to thrive 3 | 365
Seizures 3 | 596
Short stature 3 | 531
Strabismus 3 | 270
Tooth Abnormalities 3 | 69
Trichothiodystrophy 1, photosensitive 3 | 4
Wolf-Hirschhorn syndrome 3 | 32
Xeroderma pigmentosum group G 3 | 16
hearing impairment 3 | 199
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
invasive ductal carcinoma 3 | 2,951
juvenile dermatomyositis 3 | 1,187
non-small cell lung cancer 3 | 2,890
pancreatic cancer 3 | 2,398
primary pancreatic ductal adenocarcinoma 3 | 1,109
Stomach Neoplasms 2 | 300
medulloblastoma 2 | 720

Tissue

Endocrine System 70 | 18,159
Blood and immune system 69 | 16,909
Digestive Tract 69 | 17,369
Female tissues 69 | 17,400
Liver and Pancreas 69 | 16,750
Nervous System 69 | 16,725
Respiratory system 69 | 16,393
Skin and soft tissues 69 | 17,230
Urinary Tract 69 | 16,678
Male tissues 68 | 17,142
Cardiovascular System 67 | 15,192

Target Family

Non-IDG 43 | 12,091
Enzyme 24 | 4,145
Kinase 3 | 634
Epigenetic 2 | 242
Transcription Factor 1 | 1,400

Reactome Pathway

Transcription of the HIV genom... 73 | 73
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

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