Development Level

Tbio 13 | 11,445
Tclin 2 | 613
Tdark 2 | 6,588
Tchem 1 | 1,598

IMPC Phenotype

preweaning lethality, incomple... 2 | 499
abnormal lens morphology 1 | 81
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased hemoglobin content 1 | 45
preweaning lethality, complete... 1 | 979

Disease

ovarian cancer 14 | 8,520
Carcinoma 12 | 11,493
Cancer 10 | 2,499
atypical teratoid / rhabdoid tumor 10 | 5,112
group 3 medulloblastoma 10 | 4,104
medulloblastoma, large-cell 10 | 6,241
osteosarcoma 10 | 7,950
glioblastoma 9 | 5,792
lung cancer 8 | 4,740
psoriasis 8 | 6,694
Breast cancer 7 | 3,578
primitive neuroectodermal tumor 7 | 3,035
Astrocytoma, Pilocytic 5 | 3,081
ependymoma 5 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
invasive ductal carcinoma 5 | 2,951
malignant mesothelioma 5 | 3,232
Endometriosis 4 | 540
Retinoblastoma 4 | 19
adrenocortical carcinoma 4 | 1,428
adult high grade glioma 4 | 3,801
astrocytoma 4 | 1,146
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
lung adenocarcinoma 4 | 2,716
nasopharyngeal carcinoma 4 | 1,058
non-small cell lung cancer 4 | 2,890
oligodendroglioma 4 | 2,850
ulcerative colitis 4 | 1,819
Atopic dermatitis 3 | 952
Kidney cancer 3 | 2,613
Multiple myeloma 3 | 1,332
Waldenstrons macroglobulinemia 3 | 765
acute quadriplegic myopathy 3 | 1,158
dermatomyositis 3 | 966
ductal carcinoma in situ 3 | 1,745
pancreatic cancer 3 | 2,398
primary Sjogren syndrome 3 | 735
subependymal giant cell astrocytoma 3 | 2,287
Adenocarcinoma 2 | 122
Adenocarcinoma of lung 2 | 142
Autosomal recessive predisposition 2 | 1,442
Breast Neoplasms 2 | 445
Carcinoma, Hepatocellular 2 | 228
Carcinoma, Squamous Cell 2 | 110
Chronic Lymphocytic Leukemia 2 | 262
Cognitive delay 2 | 608
Colonic Neoplasms 2 | 142
Disease Models, Animal 2 | 155
Disease Progression 2 | 136
Global developmental delay 2 | 608
Liver Cirrhosis, Experimental 2 | 769
Liver carcinoma 2 | 240
Lung Neoplasms 2 | 232
Mammary Neoplasms 2 | 425
Mental and motor retardation 2 | 608
Neuroblastoma 2 | 80
Ovarian Neoplasms 2 | 102
Pick disease 2 | 1,894
Pleural empyema 2 | 12
Polycystic ovary syndrome 2 | 360
Prostatic Neoplasms 2 | 495
Squamous cell carcinoma 2 | 129
active Crohn's disease 2 | 922
astrocytic glioma 2 | 2,597
breast carcinoma 2 | 1,638
chronic rhinosinusitis 2 | 512
colon cancer 2 | 1,478
cystic fibrosis and chronic rhinosinusitis 2 | 214
esophageal adenocarcinoma 2 | 737
group 4 medulloblastoma 2 | 1,855
juvenile dermatomyositis 2 | 1,187
lung carcinoma 2 | 2,843
ovarian neoplasm 2 | 99
pediatric high grade glioma 2 | 1,064
tuberculosis 2 | 2,010
Acquired immunodeficiency syndrome 1 | 197
Acute myeloid leukemia, disease 1 | 30
Burkitt Lymphoma 1 | 20
Carcinoma of breast 1 | 11
Carcinoma, Non-Small-Cell Lung 1 | 107
Common variable immunodeficiency 1 | 101
Deglutition Disorders 1 | 132
Dental fluorosis 1 | 20
Familial adenomatous polyposis 1 | 32
Fatty Liver 1 | 70
Glioma 1 | 74
Hodgkin's disease 1 | 18
Hyperuricemia 1 | 49
Kaposi's sarcoma 1 | 22
Leukemia, Myelocytic, Acute 1 | 120
Leukemia, Myeloid, Acute 1 | 105
Malignant tumor of ovary 1 | 25
Metastatic Prostate Carcinoma 1 | 18
Myelodysplastic Syndromes 1 | 26
Nephroblastoma 1 | 51
Neuronal ceroid lipofuscinosis 1 | 28
Patellar aplasia 1 | 8
Salivary Gland Neoplasms 1 | 46
Wilms Tumor 1 | 28

Tissue

Blood and immune system 18 | 16,909
Cardiovascular System 18 | 15,192
Digestive Tract 18 | 17,369
Endocrine System 18 | 18,159
Female tissues 18 | 17,400
Liver and Pancreas 18 | 16,750
Male tissues 18 | 17,142
Nervous System 18 | 16,725
Respiratory system 18 | 16,393
Skin and soft tissues 18 | 17,230
Urinary Tract 18 | 16,678

Target Family

Non-IDG 9 | 12,091
Transcription Factor 7 | 1,400
Enzyme 1 | 4,145
Epigenetic 1 | 242

Reactome Pathway

Transcription of E2F targets u... 18 | 18
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA topoisomerase 2-alpha TOP2A Tclin Enzyme -2.88264 723.0 847
Protein lin-52 homolog LIN52 Tbio Non-IDG -0.97901 7.87 61
Protein lin-54 homolog LIN54 Tdark Non-IDG -1.29119 19.5 45
Myc proto-oncogene protein MYC Tbio Transcription Factor -4.11278 12358.0 2705
Cell division control protein 6 homolog CDC6 Tbio Non-IDG -2.51683 336.8 574
Histone deacetylase 1 HDAC1 Tclin Epigenetic -3.03775 954.3 1201
Protein max MAX Tbio Transcription Factor -2.14268 110.6 398
Retinoblastoma-like protein 1 RBL1 Tbio Non-IDG -2.62435 385.9 321
Histone-binding protein RBBP4 RBBP4 Tbio Non-IDG -1.71209 53.9 310
Protein lin-9 homolog LIN9 Tbio Non-IDG -1.92491 83.2 101