Development Level

Tbio 77 | 10,625
Tchem 66 | 1,890
Tclin 6 | 602
Tdark 1 | 7,003

Collection

Kinase: IDG Consortium (Targets) 1 | 125

IMPC Phenotype

preweaning lethality, complete... 6 | 633
abnormal retinal pigmentation 4 | 61
decreased bone mineral content 4 | 157
decreased body weight 3 | 174
decreased circulating sodium l... 3 | 18
decreased grip strength 3 | 123
decreased lean body mass 3 | 195
embryonic lethality prior to t... 3 | 187
preweaning lethality, incomple... 3 | 260
short tibia 3 | 82
abnormal bone structure 2 | 131
abnormal retina morphology 2 | 100
abnormal seminal vesicle morph... 2 | 47
decreased body length 2 | 108
decreased circulating bilirubi... 2 | 14
decreased circulating creatini... 2 | 31
decreased circulating triglyce... 2 | 83
decreased mean corpuscular vol... 2 | 50
decreased total body fat amoun... 2 | 186
enlarged heart 2 | 111
increased bone mineral content 2 | 92
increased bone mineral density 2 | 52
increased erythrocyte cell num... 2 | 26
increased or absent threshold ... 2 | 128
male infertility 2 | 62
small superior vagus ganglion 2 | 20
abnormal bone mineralization 1 | 55
abnormal coat-hair pigmentatio... 1 | 54
abnormal coping response 1 | 12
abnormal cornea morphology 1 | 24
abnormal embryo size 1 | 112
abnormal forebrain development 1 | 18
abnormal hindbrain development 1 | 24
abnormal humerus morphology 1 | 11
abnormal joint morphology 1 | 14
abnormal lens morphology 1 | 73
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal optic disc morphology 1 | 10
abnormal skin condition 1 | 6
abnormal spleen morphology 1 | 36
abnormal startle reflex 1 | 14
absent vibrissae 1 | 14
decreased B cell number 1 | 30
decreased KLRG1+ CD8 alpha bet... 1 | 8
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 49
decreased circulating alkaline... 1 | 41
decreased circulating amylase ... 1 | 24
decreased circulating aspartat... 1 | 27
decreased circulating choleste... 1 | 85
decreased circulating free fat... 1 | 39
decreased circulating fructosa... 1 | 31
decreased circulating glucose ... 1 | 121
decreased circulating insulin ... 1 | 75
decreased circulating iron lev... 1 | 25
decreased circulating potassiu... 1 | 17
decreased circulating serum al... 1 | 79
decreased fasted circulating g... 1 | 49
decreased heart weight 1 | 44
decreased lumbar vertebrae num... 1 | 62
decreased mature B cell number 1 | 25
decreased mean corpuscular hem... 1 | 19
decreased neutrophil cell numb... 1 | 37
decreased prepulse inhibition 1 | 52
decreased rib number 1 | 59
decreased startle reflex 1 | 48
decreased thermal nociceptive ... 1 | 4
decreased thoracic vertebrae n... 1 | 7
dilated heart left ventricle 1 | 10
enlarged spleen 1 | 26
female infertility 1 | 34
hypoactivity 1 | 89
improved glucose tolerance 1 | 56
increased CD4-positive, alpha ... 1 | 15
increased IgG1 level 1 | 1
increased NK cell number 1 | 19
increased T cell number 1 | 15
increased blood urea nitrogen ... 1 | 44
increased body weight 1 | 42
increased circulating alkaline... 1 | 119
increased circulating choleste... 1 | 53
increased circulating free fat... 1 | 17
increased circulating glucose ... 1 | 16
increased circulating iron lev... 1 | 25
increased circulating magnesiu... 1 | 10
increased circulating sodium l... 1 | 71
increased fasted circulating g... 1 | 68
increased hematocrit 1 | 36
increased leukocyte cell numbe... 1 | 37
increased mean corpuscular vol... 1 | 91
increased neutrophil cell numb... 1 | 15
increased sacral vertebrae num... 1 | 62
increased thermal nociceptive ... 1 | 9
polydactyly 1 | 22
premature death 1 | 5

Disease

ovarian cancer 92 | 8,491
glioblastoma 86 | 5,572
osteosarcoma 86 | 7,933
Cancer 74 | 2,346
psoriasis 70 | 6,685
medulloblastoma, large-cell 68 | 6,234
lung cancer 60 | 4,473
atypical teratoid / rhabdoid tumor 49 | 4,369
lung carcinoma 44 | 2,844
malignant mesothelioma 40 | 3,163
subependymal giant cell astrocytoma 38 | 2,287
pilocytic astrocytoma 37 | 3,086
pediatric high grade glioma 36 | 2,712
tuberculosis 36 | 1,563
ulcerative colitis 34 | 2,087
Breast cancer 30 | 3,098
ependymoma 30 | 2,514
intraductal papillary-mucinous neoplasm (IPMN) 28 | 3,289
Rheumatoid Arthritis 27 | 1,170
cutaneous lupus erythematosus 26 | 1,056
invasive ductal carcinoma 26 | 2,950
diabetes mellitus 25 | 1,663
juvenile dermatomyositis 25 | 1,189
non-small cell lung cancer 25 | 2,798
adult high grade glioma 23 | 2,148
lung adenocarcinoma 23 | 2,714
pancreatic cancer 23 | 2,300
pituitary cancer 23 | 1,972
Carcinoma 22 | 2,147
astrocytic glioma 22 | 2,241
dermatomyositis 22 | 966
group 4 medulloblastoma 22 | 1,875
interstitial cystitis 22 | 2,299
primitive neuroectodermal tumor 22 | 3,031
astrocytoma 21 | 1,493
cystic fibrosis 21 | 1,670
intraductal papillary-mucinous adenoma (IPMA) 21 | 2,956
oligodendroglioma 21 | 2,849
Arthritis 20 | 248
pancreatic ductal adenocarcinoma liver metastasis 20 | 1,795
Vascular disease 19 | 281
acute quadriplegic myopathy 19 | 1,157
intraductal papillary-mucinous carcinoma (IPMC) 19 | 2,988
medulloblastoma 19 | 1,524
Multiple myeloma 17 | 1,327
Pick disease 17 | 1,893
breast carcinoma 17 | 1,614
colon cancer 16 | 1,475
IGA Glomerulonephritis 15 | 454
primary Sjogren syndrome 15 | 788
Alzheimer's disease 14 | 644
Asthma 14 | 349
active Crohn's disease 14 | 918
esophageal adenocarcinoma 14 | 737
posterior fossa group A ependymoma 14 | 1,511
Obesity 13 | 616
Reperfusion Injury 13 | 84
acute myeloid leukemia 13 | 785
group 3 medulloblastoma 13 | 2,254
Atopic dermatitis 12 | 944
Multiple Sclerosis 12 | 498
gastric carcinoma 12 | 832
primary pancreatic ductal adenocarcinoma 12 | 1,271
Atherosclerosis 11 | 275
Duchenne muscular dystrophy 11 | 602
Influenza 11 | 142
Lung Neoplasms 11 | 171
Osteoporosis 11 | 259
Waldenstrons macroglobulinemia 11 | 764
adrenocortical carcinoma 11 | 1,427
hepatocellular carcinoma 11 | 550
mucosa-associated lymphoid tissue lymphoma 11 | 480
posterior fossa group B ependymoma 11 | 1,530
sonic hedgehog group medulloblastoma 11 | 1,482
Kidney disease 10 | 397
Lung disease 10 | 136
Parkinson's disease 10 | 364
Pneumonia 10 | 133
Toxic encephalopathy 10 | 131
atypical teratoid/rhabdoid tumor 10 | 1,095
ductal carcinoma in situ 10 | 1,745
gastric cancer 10 | 436
pancreatic carcinoma 10 | 567
Brain Ischemia 9 | 87
Heart disease 9 | 279
Inflammatory bowel disease 9 | 142
Liver disease 9 | 219
Prostatic Neoplasms 9 | 471
Stomach Neoplasms 9 | 282
aldosterone-producing adenoma 9 | 664
chronic lymphosyte leukemia 9 | 232
inflammatory breast cancer 9 | 404
tuberculosis and treatment for 6 months 9 | 686
Mammary Neoplasms 8 | 410
Neoplasm Invasiveness 8 | 127
periodontitis 8 | 269
Down syndrome 7 | 548
Intellectual disability 7 | 573
Myocardial Ischemia 7 | 169
progressive supranuclear palsy 7 | 674

Tissue

Blood and immune system 150 | 17,994
Digestive Tract 150 | 18,472
Female tissues 150 | 18,646
Liver and Pancreas 150 | 18,135
Nervous System 150 | 18,560
Urinary Tract 150 | 18,443
Cardiovascular System 149 | 17,957
Endocrine System 149 | 18,511
Male tissues 149 | 17,968
Respiratory system 148 | 17,483
Skin and soft tissues 147 | 18,114

Target Family

Non-IDG 70 | 11,969
Kinase 39 | 634
Enzyme 27 | 4,146
Transcription Factor 14 | 1,400

Reactome Pathway

Toll-Like Receptors Cascades 150 | 150
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Receptor-interacting serine/threonine-protein kinase 3 RIPK3 Tchem Kinase -2.11581 129.5 456
Dynamin-3 DNM3 Tbio Non-IDG -1.39919 21.9 126
Lymphocyte antigen 96 LY96 Tbio Non-IDG -2.73333 490.7 314
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 PLCG2 Tchem Enzyme -2.39396 233.2 634
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.12726 13094.7 961
Mitogen-activated protein kinase 10 MAPK10 Tchem Kinase -2.27384 181.6 339
Toll-like receptor 10 TLR10 Tbio Non-IDG -1.75724 56.1 295
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 TAB2 Tbio Enzyme -1.87718 69.0 145
Toll-like receptor 7 TLR7 Tclin Non-IDG -2.97887 974.2 670
S-phase kinase-associated protein 1 SKP1 Tbio Enzyme -2.54884 305.8 337