Development Level

Tbio 77 | 10,625
Tchem 66 | 1,890
Tclin 6 | 602
Tdark 1 | 7,003

IMPC Term

preweaning lethality, complete... 6 | 633
abnormal retinal pigmentation 4 | 61
decreased bone mineral content 4 | 157
decreased body weight 3 | 174
decreased circulating sodium l... 3 | 18
decreased grip strength 3 | 123
decreased lean body mass 3 | 195
embryonic lethality prior to t... 3 | 187
preweaning lethality, incomple... 3 | 260
short tibia 3 | 82
abnormal bone structure 2 | 131
abnormal retina morphology 2 | 100
abnormal seminal vesicle morph... 2 | 47
decreased body length 2 | 108
decreased circulating bilirubi... 2 | 14
decreased circulating creatini... 2 | 31
decreased circulating triglyce... 2 | 83
decreased mean corpuscular vol... 2 | 50
decreased total body fat amoun... 2 | 186
enlarged heart 2 | 111
increased bone mineral content 2 | 92
increased bone mineral density 2 | 52
increased erythrocyte cell num... 2 | 26
increased or absent threshold ... 2 | 128
male infertility 2 | 62
small superior vagus ganglion 2 | 20
abnormal bone mineralization 1 | 55
abnormal coat/hair pigmentatio... 1 | 54
abnormal coping response 1 | 12
abnormal cornea morphology 1 | 24
abnormal embryo size 1 | 112
abnormal forebrain development 1 | 18
abnormal hindbrain development 1 | 24
abnormal humerus morphology 1 | 11
abnormal joint morphology 1 | 14
abnormal lens morphology 1 | 73
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal optic disc morphology 1 | 10
abnormal skin condition 1 | 6
abnormal spleen morphology 1 | 36
abnormal startle reflex 1 | 14
absent vibrissae 1 | 14
decreased B cell number 1 | 30
decreased KLRG1+ CD8 alpha bet... 1 | 8
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 49
decreased circulating alkaline... 1 | 41
decreased circulating amylase ... 1 | 24
decreased circulating aspartat... 1 | 27
decreased circulating choleste... 1 | 85
decreased circulating free fat... 1 | 39
decreased circulating fructosa... 1 | 31
decreased circulating glucose ... 1 | 121
decreased circulating insulin ... 1 | 75
decreased circulating iron lev... 1 | 25
decreased circulating potassiu... 1 | 17
decreased circulating serum al... 1 | 79
decreased fasted circulating g... 1 | 49
decreased heart weight 1 | 44
decreased lumbar vertebrae num... 1 | 62
decreased mature B cell number 1 | 25
decreased mean corpuscular hem... 1 | 19
decreased neutrophil cell numb... 1 | 37
decreased prepulse inhibition 1 | 52
decreased rib number 1 | 59
decreased startle reflex 1 | 48
decreased thermal nociceptive ... 1 | 4
decreased thoracic vertebrae n... 1 | 7
dilated heart left ventricle 1 | 10
enlarged spleen 1 | 26
female infertility 1 | 34
hypoactivity 1 | 89
improved glucose tolerance 1 | 56
increased CD4-positive, alpha ... 1 | 15
increased IgG1 level 1 | 1
increased NK cell number 1 | 19
increased T cell number 1 | 15
increased blood urea nitrogen ... 1 | 44
increased body weight 1 | 42
increased circulating alkaline... 1 | 119
increased circulating choleste... 1 | 53
increased circulating free fat... 1 | 17
increased circulating glucose ... 1 | 16
increased circulating iron lev... 1 | 25
increased circulating magnesiu... 1 | 10
increased circulating sodium l... 1 | 71
increased fasted circulating g... 1 | 68
increased hematocrit 1 | 36
increased leukocyte cell numbe... 1 | 37
increased mean corpuscular vol... 1 | 91
increased neutrophil cell numb... 1 | 15
increased sacral vertebrae num... 1 | 62
increased thermal nociceptive ... 1 | 9
polydactyly 1 | 22
premature death 1 | 5

Disease

ovarian cancer 92 | 8,484
glioblastoma 86 | 5,572
osteosarcoma 86 | 7,933
Cancer 74 | 2,346
psoriasis 70 | 6,685
medulloblastoma, large-cell 68 | 6,234
lung cancer 60 | 4,466
atypical teratoid / rhabdoid tumor 49 | 4,369
lung carcinoma 44 | 2,844
malignant mesothelioma 40 | 3,162
subependymal giant cell astrocytoma 38 | 2,287
pilocytic astrocytoma 37 | 3,086
pediatric high grade glioma 36 | 2,712
tuberculosis 36 | 1,557
ulcerative colitis 34 | 2,087
Breast cancer 30 | 3,094
ependymoma 30 | 2,514
intraductal papillary-mucinous neoplasm (IPMN) 28 | 3,289
Rheumatoid Arthritis 27 | 1,160
cutaneous lupus erythematosus 26 | 1,056
invasive ductal carcinoma 26 | 2,950
diabetes mellitus 25 | 1,663
juvenile dermatomyositis 25 | 1,189
non-small cell lung cancer 25 | 2,798
adult high grade glioma 23 | 2,148
lung adenocarcinoma 23 | 2,713
pancreatic cancer 23 | 2,300
pituitary cancer 23 | 1,972
Carcinoma 22 | 2,147
astrocytic glioma 22 | 2,241
dermatomyositis 22 | 933
group 4 medulloblastoma 22 | 1,875
interstitial cystitis 22 | 2,299
primitive neuroectodermal tumor 22 | 3,031
astrocytoma 21 | 1,493
cystic fibrosis 21 | 1,665
intraductal papillary-mucinous adenoma (IPMA) 21 | 2,956
oligodendroglioma 21 | 2,849
Arthritis 20 | 248
pancreatic ductal adenocarcinoma liver metastasis 20 | 1,795
Vascular disease 19 | 281
acute quadriplegic myopathy 19 | 1,157
intraductal papillary-mucinous carcinoma (IPMC) 19 | 2,988
medulloblastoma 19 | 1,524
Multiple myeloma 17 | 1,327
Pick disease 17 | 1,893
breast carcinoma 17 | 1,614
colon cancer 16 | 1,475
IGA Glomerulonephritis 15 | 454
primary Sjogren syndrome 15 | 789
Alzheimer's disease 14 | 644
Asthma 14 | 349
active Crohn's disease 14 | 918
esophageal adenocarcinoma 14 | 737
posterior fossa group A ependymoma 14 | 1,511
Obesity 13 | 616
Reperfusion Injury 13 | 84
acute myeloid leukemia 13 | 780
group 3 medulloblastoma 13 | 2,254
Atopic dermatitis 12 | 944
Multiple Sclerosis 12 | 498
gastric carcinoma 12 | 832
primary pancreatic ductal adenocarcinoma 12 | 1,271
Atherosclerosis 11 | 275
Duchenne muscular dystrophy 11 | 602
Influenza 11 | 142
Lung Neoplasms 11 | 171
Osteoporosis 11 | 257
Waldenstrons macroglobulinemia 11 | 765
adrenocortical carcinoma 11 | 1,427
mucosa-associated lymphoid tissue lymphoma 11 | 480
posterior fossa group B ependymoma 11 | 1,530
sonic hedgehog group medulloblastoma 11 | 1,482
Kidney disease 10 | 396
Lung disease 10 | 132
Parkinson's disease 10 | 364
Pneumonia 10 | 133
Toxic encephalopathy 10 | 131
atypical teratoid/rhabdoid tumor 10 | 1,095
ductal carcinoma in situ 10 | 1,745
gastric cancer 10 | 430
hepatocellular carcinoma 10 | 532
pancreatic carcinoma 10 | 567
Brain Ischemia 9 | 87
Heart disease 9 | 279
Inflammatory bowel disease 9 | 142
Liver disease 9 | 219
Prostatic Neoplasms 9 | 471
Stomach Neoplasms 9 | 282
aldosterone-producing adenoma 9 | 664
chronic lymphosyte leukemia 9 | 232
inflammatory breast cancer 9 | 404
tuberculosis and treatment for 6 months 9 | 686
Mammary Neoplasms 8 | 410
Neoplasm Invasiveness 8 | 127
periodontitis 8 | 269
Down syndrome 7 | 548
Intellectual disability 7 | 573
Myocardial Ischemia 7 | 169
progressive supranuclear palsy 7 | 674

Tissue

Blood and immune system 150 | 17,995
Digestive Tract 150 | 18,473
Female tissues 150 | 18,647
Liver and Pancreas 150 | 18,136
Nervous System 150 | 18,561
Urinary Tract 150 | 18,444
Cardiovascular System 149 | 17,958
Endocrine System 149 | 18,512
Male tissues 149 | 17,969
Respiratory system 148 | 17,484
Skin and soft tissues 147 | 18,115

Target Family

Non-IDG 70 | 11,971
Kinase 39 | 634
Enzyme 27 | 4,146
Transcription Factor 14 | 1,400

Reactome Pathway

Toll-Like Receptors Cascades 150 | 150
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Endoplasmin HSP90B1 Tchem Non-IDG -2.72785 604.5 748
Interleukin-1 receptor-associated kinase 1 IRAK1 Tchem Kinase -2.51851 320.4 729
Fibrinogen alpha chain FGA Tbio Non-IDG -2.84597 716.2 457
Toll-like receptor 7 TLR7 Tclin Non-IDG -2.92878 974.2 670
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 TAB2 Tbio Enzyme -1.83055 69.0 145
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.21113 124.2 150
Suppressor of cytokine signaling 1 SOCS1 Tbio Non-IDG -3.00271 1072.1 392
NF-kappa-B inhibitor alpha NFKBIA Tchem Non-IDG -3.34160 1960.9 1181
Ubiquitin-40S ribosomal protein S27a RPS27A Tbio Non-IDG 56.7 150