Development Level

Tbio 83 | 11,445
Tchem 61 | 1,598
Tclin 6 | 613
Tdark 1 | 6,588

Collection

Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 9 | 979
preweaning lethality, incomple... 5 | 499
abnormal bone structure 4 | 187
decreased mean corpuscular vol... 4 | 79
embryonic lethality prior to t... 4 | 278
decreased body weight 3 | 161
decreased bone mineral density 3 | 126
decreased circulating sodium l... 3 | 22
increased neutrophil cell numb... 3 | 46
small superior vagus ganglion 3 | 74
abnormal seminal vesicle morph... 2 | 114
decreased bone mineral content 2 | 151
decreased circulating bilirubi... 2 | 19
decreased circulating choleste... 2 | 93
decreased circulating creatini... 2 | 39
decreased circulating triglyce... 2 | 79
decreased hematocrit 2 | 46
decreased hemoglobin content 2 | 68
decreased lymphocyte cell numb... 2 | 83
decreased mean corpuscular hem... 2 | 50
decreased mean corpuscular hem... 2 | 31
decreased neutrophil cell numb... 2 | 42
decreased vertical activity 2 | 208
enlarged heart 2 | 210
increased bone mineral content 2 | 108
increased bone mineral density 2 | 72
increased circulating free fat... 2 | 20
increased erythrocyte cell num... 2 | 39
increased lean body mass 2 | 172
increased mean corpuscular vol... 2 | 92
increased monocyte cell number 2 | 63
male infertility 2 | 123
short tibia 2 | 97
abnormal bone mineralization 1 | 38
abnormal cecum morphology 1 | 7
abnormal clavicle morphology 1 | 6
abnormal coat appearance 1 | 31
abnormal coat-hair pigmentatio... 1 | 64
abnormal cornea morphology 1 | 31
abnormal digit morphology 1 | 10
abnormal embryo size 1 | 220
abnormal epididymis morphology 1 | 42
abnormal humerus morphology 1 | 11
abnormal joint morphology 1 | 23
abnormal lens morphology 1 | 81
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal optic disc morphology 1 | 10
abnormal retina morphology 1 | 71
abnormal skin condition 1 | 6
abnormal spleen morphology 1 | 55
abnormal startle reflex 1 | 15
abnormal vibrissa morphology 1 | 25
absent vibrissae 1 | 12
decreased circulating HDL chol... 1 | 68
decreased circulating alkaline... 1 | 46
decreased circulating amylase ... 1 | 28
decreased circulating aspartat... 1 | 34
decreased circulating free fat... 1 | 31
decreased circulating fructosa... 1 | 30
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased circulating phosphat... 1 | 27
decreased circulating potassiu... 1 | 20
decreased eosinophil cell numb... 1 | 24
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased heart weight 1 | 27
decreased lean body mass 1 | 135
decreased mature B cell number 1 | 7
decreased prepulse inhibition 1 | 82
decreased total body fat amoun... 1 | 207
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
enlarged cecum 1 | 5
enlarged epididymis 1 | 31
enlarged spleen 1 | 41
enlarged uterus 1 | 11
female infertility 1 | 60
hypoactivity 1 | 132
increased T cell number 1 | 6
increased blood urea nitrogen ... 1 | 48
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased circulating glucose ... 1 | 24
increased circulating iron lev... 1 | 30
increased circulating magnesiu... 1 | 10
increased circulating sodium l... 1 | 71
increased eosinophil cell numb... 1 | 11
increased fasted circulating g... 1 | 76
increased hematocrit 1 | 46
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased thermal nociceptive ... 1 | 9
increased total body fat amoun... 1 | 134
premature death 1 | 5
prenatal lethality prior to he... 1 | 87

Disease

Carcinoma 106 | 11,493
ovarian cancer 94 | 8,520
glioblastoma 89 | 5,792
osteosarcoma 85 | 7,950
Cancer 76 | 2,499
medulloblastoma, large-cell 70 | 6,241
psoriasis 68 | 6,694
lung cancer 61 | 4,740
atypical teratoid / rhabdoid tumor 58 | 5,112
adult high grade glioma 47 | 3,801
ependymoma 45 | 4,679
lung carcinoma 44 | 2,843
Breast cancer 41 | 3,578
tuberculosis 41 | 2,010
malignant mesothelioma 39 | 3,232
subependymal giant cell astrocytoma 39 | 2,287
Astrocytoma, Pilocytic 37 | 3,081
group 3 medulloblastoma 31 | 4,104
Kidney cancer 30 | 2,613
intraductal papillary-mucinous neoplasm (IPMN) 28 | 3,291
ulcerative colitis 28 | 1,819
Rheumatoid arthritis 27 | 1,191
cutaneous lupus erythematosus 26 | 1,057
invasive ductal carcinoma 26 | 2,951
Schizophrenia 25 | 1,160
astrocytic glioma 25 | 2,597
diabetes mellitus 25 | 1,728
group 4 medulloblastoma 25 | 1,855
juvenile dermatomyositis 25 | 1,187
non-small cell lung cancer 25 | 2,890
pancreatic cancer 25 | 2,398
primitive neuroectodermal tumor 24 | 3,035
pituitary cancer 23 | 1,972
cystic fibrosis 22 | 1,696
dermatomyositis 22 | 966
interstitial cystitis 22 | 2,312
lung adenocarcinoma 22 | 2,716
oligodendroglioma 22 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 22 | 1,962
Arthritis 21 | 290
intraductal papillary-mucinous adenoma (IPMA) 21 | 2,955
Vascular disease 19 | 319
acute quadriplegic myopathy 19 | 1,158
astrocytoma 19 | 1,146
intraductal papillary-mucinous carcinoma (IPMC) 19 | 2,989
Asthma 18 | 385
Liver Cirrhosis, Experimental 18 | 769
Autosomal recessive predisposition 17 | 1,442
Multiple myeloma 17 | 1,332
Pick disease 17 | 1,894
breast carcinoma 17 | 1,638
colon cancer 16 | 1,478
Alzheimer's disease 15 | 658
primary Sjogren syndrome 15 | 735
Obesity 14 | 678
Pneumonia 14 | 174
active Crohn's disease 14 | 922
acute myeloid leukemia 14 | 783
esophageal adenocarcinoma 14 | 737
Bipolar Disorder 13 | 666
Epilepsy 13 | 792
Osteoporosis 13 | 363
Reperfusion Injury 13 | 86
Atopic dermatitis 12 | 952
Intellectual disability 12 | 1,016
Multiple Sclerosis 12 | 540
Parkinson's disease 12 | 392
mucosa-associated lymphoid tissue lymphoma 12 | 484
pediatric high grade glioma 12 | 1,064
Atherosclerosis 11 | 291
Cholestasis, Extrahepatic 11 | 25
Duchenne muscular dystrophy 11 | 601
Inflammatory bowel disease 11 | 151
Influenza 11 | 142
Kidney disease 11 | 430
Liver disease 11 | 237
Lung Neoplasms 11 | 232
Seizures 11 | 596
Waldenstrons macroglobulinemia 11 | 765
active ulcerative colitis 11 | 764
adrenocortical carcinoma 11 | 1,428
gastric cancer 11 | 459
gastric carcinoma 11 | 807
hepatocellular carcinoma 11 | 547
primary pancreatic ductal adenocarcinoma 11 | 1,109
Brain Injuries 10 | 65
Brain Ischemia 10 | 110
Dull intelligence 10 | 645
Low intelligence 10 | 645
Lung disease 10 | 142
Mental Retardation 10 | 645
Mental deficiency 10 | 645
Poor school performance 10 | 645
ductal carcinoma in situ 10 | 1,745
pancreatic carcinoma 10 | 562
Mental Depression 9 | 333
Prostatic Neoplasms 9 | 495
Short stature 9 | 531
aldosterone-producing adenoma 9 | 665
periodontitis 9 | 293

Tissue

Blood and immune system 151 | 16,909
Digestive Tract 151 | 17,369
Endocrine System 151 | 18,159
Female tissues 151 | 17,400
Liver and Pancreas 151 | 16,750
Male tissues 151 | 17,142
Skin and soft tissues 151 | 17,230
Urinary Tract 151 | 16,678
Respiratory system 149 | 16,393
Cardiovascular System 148 | 15,192
Nervous System 148 | 16,725

Target Family

Non-IDG 69 | 12,091
Kinase 39 | 634
Enzyme 29 | 4,145
Transcription Factor 14 | 1,400

Reactome Pathway

Toll-Like Receptors Cascades 151 | 151
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
TIR domain-containing adapter molecule 2 TICAM2 Tbio Non-IDG -1.18212 14.6 258
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Ubiquitin-conjugating enzyme E2 variant 1 UBE2V1 Tbio Non-IDG -1.33153 18.0 188
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform PPP2R5D Tbio Enzyme -0.70843 3.59 261
Nucleotide-binding oligomerization domain-containing protein 2 NOD2 Tclin Non-IDG -3.13621 1445.5 370
Polyubiquitin-B UBB Tbio Non-IDG -1.98860 97.4 427
Polyubiquitin-C UBC Tbio Non-IDG -2.90157 61.9 143
Sterile alpha and TIR motif-containing protein 1 SARM1 Tbio Non-IDG -2.22753 163.9 159
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 PLCG2 Tchem Enzyme -2.41628 245.1 733
NF-kappa-B inhibitor-interacting Ras-like protein 1 NKIRAS1 Tbio Enzyme -0.82896 5.23 242