Development Level

Tbio 44 | 11,445
Tchem 37 | 1,598
Tclin 2 | 613
Tdark 1 | 6,588

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, incomple... 5 | 499
preweaning lethality, complete... 4 | 979
abnormal bone structure 3 | 187
decreased circulating sodium l... 3 | 22
decreased mean corpuscular vol... 3 | 79
decreased circulating bilirubi... 2 | 19
decreased circulating creatini... 2 | 39
decreased mean corpuscular hem... 2 | 50
decreased mean corpuscular hem... 2 | 31
decreased vertical activity 2 | 208
increased circulating free fat... 2 | 20
male infertility 2 | 123
abnormal clavicle morphology 1 | 6
abnormal coat appearance 1 | 31
abnormal coat-hair pigmentatio... 1 | 64
abnormal cornea morphology 1 | 31
abnormal epididymis morphology 1 | 42
abnormal heart shape 1 | 5
abnormal humerus morphology 1 | 11
abnormal joint morphology 1 | 23
abnormal lens morphology 1 | 81
abnormal optic disc morphology 1 | 10
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal skin condition 1 | 6
abnormal spleen morphology 1 | 55
abnormal startle reflex 1 | 15
decreased circulating HDL chol... 1 | 68
decreased circulating amylase ... 1 | 28
decreased circulating choleste... 1 | 93
decreased circulating fructosa... 1 | 30
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased circulating potassiu... 1 | 20
decreased circulating triglyce... 1 | 79
decreased fasted circulating g... 1 | 65
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased neutrophil cell numb... 1 | 42
decreased thermal nociceptive ... 1 | 2
embryonic lethality prior to t... 1 | 278
enlarged epididymis 1 | 31
enlarged heart 1 | 210
enlarged spleen 1 | 41
female infertility 1 | 60
increased blood urea nitrogen ... 1 | 48
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased circulating glucose ... 1 | 24
increased circulating iron lev... 1 | 30
increased circulating magnesiu... 1 | 10
increased circulating sodium l... 1 | 71
increased erythrocyte cell num... 1 | 39
increased hematocrit 1 | 46
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased thermal nociceptive ... 1 | 9
premature death 1 | 5

Disease

Carcinoma 57 | 11,493
glioblastoma 52 | 5,792
ovarian cancer 49 | 8,520
osteosarcoma 44 | 7,950
Cancer 43 | 2,499
atypical teratoid / rhabdoid tumor 39 | 5,112
medulloblastoma, large-cell 39 | 6,241
psoriasis 38 | 6,694
lung cancer 32 | 4,740
adult high grade glioma 26 | 3,801
ependymoma 26 | 4,679
subependymal giant cell astrocytoma 23 | 2,287
Breast cancer 20 | 3,578
primitive neuroectodermal tumor 20 | 3,035
group 3 medulloblastoma 19 | 4,104
malignant mesothelioma 19 | 3,232
Astrocytoma, Pilocytic 18 | 3,081
astrocytic glioma 16 | 2,597
group 4 medulloblastoma 16 | 1,855
lung carcinoma 16 | 2,843
Rheumatoid arthritis 15 | 1,191
oligodendroglioma 15 | 2,850
tuberculosis 15 | 2,010
Kidney cancer 13 | 2,613
Schizophrenia 13 | 1,160
astrocytoma 13 | 1,146
pituitary cancer 13 | 1,972
ulcerative colitis 13 | 1,819
Arthritis 12 | 290
Multiple myeloma 12 | 1,332
Pick disease 12 | 1,894
Vascular disease 12 | 319
acute myeloid leukemia 12 | 783
diabetes mellitus 12 | 1,728
pancreatic cancer 12 | 2,398
Epilepsy 11 | 792
Intellectual disability 11 | 1,016
colon cancer 11 | 1,478
dermatomyositis 11 | 966
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,291
Alzheimer's disease 10 | 658
Brain Ischemia 10 | 110
Cholestasis, Extrahepatic 10 | 25
Parkinson's disease 10 | 392
Waldenstrons macroglobulinemia 10 | 765
cystic fibrosis 10 | 1,696
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,989
invasive ductal carcinoma 10 | 2,951
Asthma 9 | 385
Dull intelligence 9 | 645
Low intelligence 9 | 645
Lung Neoplasms 9 | 232
Mental Retardation 9 | 645
Mental deficiency 9 | 645
Poor school performance 9 | 645
Seizures 9 | 596
juvenile dermatomyositis 9 | 1,187
non-small cell lung cancer 9 | 2,890
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,962
primary pancreatic ductal adenocarcinoma 9 | 1,109
Depressive disorder 8 | 409
Disease Models, Animal 8 | 155
Mental Depression 8 | 333
Toxic encephalopathy 8 | 141
breast carcinoma 8 | 1,638
lung adenocarcinoma 8 | 2,716
pediatric high grade glioma 8 | 1,064
Hyperalgesia 7 | 83
Inflammatory bowel disease 7 | 151
Osteoporosis 7 | 363
acute quadriplegic myopathy 7 | 1,158
esophageal adenocarcinoma 7 | 737
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,955
medulloblastoma 7 | 720
Autosomal recessive predisposition 6 | 1,442
Bipolar Disorder 6 | 666
Brain disease 6 | 96
Breast Neoplasms 6 | 445
Cell Transformation, Neoplastic 6 | 97
Immunologic Deficiency Syndromes 6 | 113
Kidney disease 6 | 430
Liver Cirrhosis, Experimental 6 | 769
Lung disease 6 | 142
Mammary Neoplasms 6 | 425
Myocardial Ischemia 6 | 169
Obesity 6 | 678
Orbital separation excessive 6 | 244
Reperfusion Injury 6 | 86
active ulcerative colitis 6 | 764
gastric cancer 6 | 459
interstitial cystitis 6 | 2,312
posterior fossa group A ependymoma 6 | 468
Atopic dermatitis 5 | 952
Cognitive delay 5 | 608
Crohn's disease 5 | 321
Global developmental delay 5 | 608
Heart disease 5 | 306
Hypertension 5 | 396
Mental and motor retardation 5 | 608
adrenocortical carcinoma 5 | 1,428

Tissue

Blood and immune system 84 | 16,909
Cardiovascular System 84 | 15,192
Digestive Tract 84 | 17,369
Endocrine System 84 | 18,159
Female tissues 84 | 17,400
Liver and Pancreas 84 | 16,750
Male tissues 84 | 17,142
Nervous System 84 | 16,725
Respiratory system 84 | 16,393
Skin and soft tissues 84 | 17,230
Urinary Tract 84 | 16,678

Target Family

Kinase 31 | 634
Non-IDG 23 | 12,091
Enzyme 18 | 4,145
Transcription Factor 12 | 1,400

Reactome Pathway

Toll Like Receptor 5 (TLR5) Ca... 84 | 84
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform PPP2R5D Tbio Enzyme -0.70843 3.59 261
Ubiquitin-conjugating enzyme E2 variant 1 UBE2V1 Tbio Non-IDG -1.33153 18.0 188
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Nucleotide-binding oligomerization domain-containing protein 2 NOD2 Tclin Non-IDG -3.13621 1445.5 370
Ribosomal protein S6 kinase alpha-3 RPS6KA3 Tchem Kinase -2.50143 325.4 425
Polyubiquitin-B UBB Tbio Non-IDG -1.98860 97.4 427
Polyubiquitin-C UBC Tbio Non-IDG -2.90157 61.9 143
NF-kappa-B inhibitor-interacting Ras-like protein 1 NKIRAS1 Tbio Enzyme -0.82896 5.23 242
ATP-dependent RNA helicase A DHX9 Tbio Enzyme -2.85807 734.3 204
Serum amyloid A-1 protein SAA1 Tbio Non-IDG -3.09466 1265.8 371