Development Level

Tbio 25 | 10,625
Tdark 3 | 7,003
Tchem 2 | 1,890

IMPC Phenotype

decreased lean body mass 2 | 195
decreased total body fat amoun... 2 | 186
preweaning lethality, complete... 2 | 633
abnormal bone structure 1 | 131
abnormal optic disc morphology 1 | 10
abnormal retina morphology 1 | 100
abnormal sleep behavior 1 | 63
decreased bone mineral content 1 | 157
decreased circulating free fat... 1 | 39
decreased circulating insulin ... 1 | 75
decreased circulating triglyce... 1 | 83
decreased effector memory CD8-... 1 | 24
decreased spleen weight 1 | 13
embryonic lethality prior to o... 1 | 148
embryonic lethality prior to t... 1 | 187
increased CD8-positive, naive ... 1 | 3
increased bone mineral content 1 | 92
increased lean body mass 1 | 107
increased total body fat amoun... 1 | 57
shortened PQ interval 1 | 6
shortened PR interval 1 | 5
shortened RR interval 1 | 19

Disease

ovarian cancer 15 | 8,491
psoriasis 14 | 6,685
interstitial cystitis 11 | 2,299
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,988
osteosarcoma 11 | 7,933
atypical teratoid / rhabdoid tumor 10 | 4,369
pancreatic cancer 10 | 2,300
non-small cell lung cancer 9 | 2,798
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,956
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,289
lung adenocarcinoma 8 | 2,714
medulloblastoma, large-cell 8 | 6,234
Cancer 7 | 2,346
active Crohn's disease 7 | 918
Breast cancer 6 | 3,098
ductal carcinoma in situ 6 | 1,745
glioblastoma 6 | 5,572
invasive ductal carcinoma 6 | 2,950
lung cancer 6 | 4,473
breast carcinoma 5 | 1,614
cystic fibrosis 5 | 1,670
subependymal giant cell astrocytoma 5 | 2,287
Down syndrome 4 | 548
Prostatic Neoplasms 4 | 471
lung carcinoma 4 | 2,844
malignant mesothelioma 4 | 3,163
medulloblastoma 4 | 1,524
nasopharyngeal carcinoma 4 | 1,056
pediatric high grade glioma 4 | 2,712
pituitary cancer 4 | 1,972
primary pancreatic ductal adenocarcinoma 4 | 1,271
primitive neuroectodermal tumor 4 | 3,031
spina bifida 4 | 1,064
ulcerative colitis 4 | 2,087
Atopic dermatitis 3 | 944
Carcinoma 3 | 2,147
Inflammatory bowel disease 3 | 142
Muscle Weakness 3 | 92
Nephrocalcinosis 3 | 18
active ulcerative colitis 3 | 477
astrocytoma 3 | 1,493
ependymoma 3 | 2,514
gastric carcinoma 3 | 832
interstitial lung disease 3 | 292
pilocytic astrocytoma 3 | 3,086
Barrett's esophagus 2 | 185
Leber congenital amaurosis 2 | 72
Mammary Neoplasms 2 | 410
Multiple Sclerosis 2 | 498
Myopia 2 | 99
Nephrolithiasis 2 | 31
Obesity 2 | 616
Oxyphilic adenoma 2 | 21
Pellagra 2 | 25
Renal oncocytoma 2 | 22
Retinitis pigmentosa 2 | 156
adult high grade glioma 2 | 2,148
atypical teratoid/rhabdoid tumor 2 | 1,095
colon cancer 2 | 1,475
cutaneous lupus erythematosus 2 | 1,056
esophageal adenocarcinoma 2 | 737
non primary Sjogren syndrome sicca 2 | 840
oligodendroglioma 2 | 2,849
periodontitis 2 | 269
posterior fossa group B ependymoma 2 | 1,530
sonic hedgehog group medulloblastoma 2 | 1,482
tuberculosis and treatment for 3 months 2 | 327
Barth syndrome 1 | 23
Bipolar Disorder 1 | 266
Brain Ischemia 1 | 87
Cellulitis 1 | 13
Cerebrovascular disease 1 | 231
Deafness 1 | 18
Epithelial ovarian cancer 1 | 19
Heart conduction disease 1 | 65
Kabuki syndrome 1 | 29
Lymphedema 1 | 26
MEDNIK syndrome 1 | 8
Male infertility 1 | 170
Mental depression 1 | 58
Neoplasm Recurrence, Local 1 | 23
Nonsyndromic deafness 1 | 121
Parkinson's disease 1 | 364
Polycystic Ovary Syndrome 1 | 334
Primary hyperoxaluria 1 | 16
Prostate cancer 1 | 172
Pseudohypoaldosteronism 1 | 22
Renal Cell Carcinoma 1 | 199
Rickets 1 | 42
Sensorineural hearing loss 1 | 107
Stomach Neoplasms 1 | 282
Substance-Related Disorders 1 | 114
fibroadenoma 1 | 557
head and neck cancer and chronic obstructive pulmonary disease 1 | 237
inflammatory breast cancer 1 | 404
limb girdle muscular dystrophy 2B 1 | 74
non-inflammatory breast cancer 1 | 208
sarcoidosis 1 | 368
severe Alzheimer's disease 1 | 49
tuberculosis 1 | 1,563

Tissue

Digestive Tract 29 | 18,472
Endocrine System 29 | 18,511
Female tissues 29 | 18,646
Nervous System 29 | 18,560
Skin and soft tissues 29 | 18,114
Urinary Tract 29 | 18,443
Blood and immune system 28 | 17,994
Cardiovascular System 28 | 17,957
Liver and Pancreas 28 | 18,135
Male tissues 28 | 17,968
Respiratory system 28 | 17,483

Target Family

Non-IDG 29 | 11,969
Kinase 1 | 634

Reactome Pathway

Tight junction interactions 30 | 30
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Protein kinase C iota type PRKCI Tchem Kinase -1.69816 51.8 122
Claudin-18 CLDN18 Tchem Non-IDG -1.57275 38.7 120
Claudin-9 CLDN9 Tbio Non-IDG -0.87632 6.84 58
Claudin-7 CLDN7 Tbio Non-IDG -1.98351 102.3 325
Claudin-17 CLDN17 Tdark Non-IDG -0.40666 3.21 35
Claudin-20 CLDN20 Tdark Non-IDG -0.17609 1.50 23
Claudin-12 CLDN12 Tbio Non-IDG -1.00039 8.02 93
Claudin-8 CLDN8 Tbio Non-IDG -1.44362 24.6 135
Claudin-6 CLDN6 Tbio Non-IDG -1.74560 60.1 255
Claudin-15 CLDN15 Tbio Non-IDG -1.24445 14.8 104