Development Level

Tbio 25 | 10,625
Tdark 3 | 7,003
Tchem 2 | 1,890

IMPC Term

decreased lean body mass 2 | 195
decreased total body fat amoun... 2 | 186
preweaning lethality, complete... 2 | 633
abnormal bone structure 1 | 131
abnormal optic disc morphology 1 | 10
abnormal retina morphology 1 | 100
abnormal sleep behavior 1 | 63
decreased bone mineral content 1 | 157
decreased circulating free fat... 1 | 39
decreased circulating insulin ... 1 | 75
decreased circulating triglyce... 1 | 83
decreased effector memory CD8-... 1 | 24
decreased spleen weight 1 | 13
embryonic lethality prior to o... 1 | 148
embryonic lethality prior to t... 1 | 187
increased CD8-positive, naive ... 1 | 3
increased bone mineral content 1 | 92
increased lean body mass 1 | 107
increased total body fat amoun... 1 | 57
shortened PQ interval 1 | 6
shortened PR interval 1 | 5
shortened RR interval 1 | 19

Disease

ovarian cancer 15 | 8,484
psoriasis 14 | 6,685
interstitial cystitis 11 | 2,299
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,988
osteosarcoma 11 | 7,933
atypical teratoid / rhabdoid tumor 10 | 4,369
pancreatic cancer 10 | 2,300
non-small cell lung cancer 9 | 2,798
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,956
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,289
lung adenocarcinoma 8 | 2,713
medulloblastoma, large-cell 8 | 6,234
Cancer 7 | 2,346
active Crohn's disease 7 | 918
Breast cancer 6 | 3,094
ductal carcinoma in situ 6 | 1,745
glioblastoma 6 | 5,572
invasive ductal carcinoma 6 | 2,950
lung cancer 6 | 4,466
breast carcinoma 5 | 1,614
cystic fibrosis 5 | 1,665
subependymal giant cell astrocytoma 5 | 2,287
Down syndrome 4 | 548
Prostatic Neoplasms 4 | 471
lung carcinoma 4 | 2,844
malignant mesothelioma 4 | 3,162
medulloblastoma 4 | 1,524
nasopharyngeal carcinoma 4 | 1,056
pediatric high grade glioma 4 | 2,712
pituitary cancer 4 | 1,972
primary pancreatic ductal adenocarcinoma 4 | 1,271
primitive neuroectodermal tumor 4 | 3,031
spina bifida 4 | 1,064
ulcerative colitis 4 | 2,087
Atopic dermatitis 3 | 944
Carcinoma 3 | 2,147
Inflammatory bowel disease 3 | 142
Muscle Weakness 3 | 92
Nephrocalcinosis 3 | 18
active ulcerative colitis 3 | 477
astrocytoma 3 | 1,493
ependymoma 3 | 2,514
gastric carcinoma 3 | 832
interstitial lung disease 3 | 291
pilocytic astrocytoma 3 | 3,086
Barrett's esophagus 2 | 183
Leber congenital amaurosis 2 | 72
Mammary Neoplasms 2 | 410
Multiple Sclerosis 2 | 498
Myopia 2 | 99
Nephrolithiasis 2 | 30
Obesity 2 | 616
Oxyphilic adenoma 2 | 21
Pellagra 2 | 25
Renal oncocytoma 2 | 22
Retinitis pigmentosa 2 | 153
adult high grade glioma 2 | 2,148
atypical teratoid/rhabdoid tumor 2 | 1,095
colon cancer 2 | 1,475
cutaneous lupus erythematosus 2 | 1,056
esophageal adenocarcinoma 2 | 737
non primary Sjogren syndrome sicca 2 | 840
oligodendroglioma 2 | 2,849
periodontitis 2 | 269
posterior fossa group B ependymoma 2 | 1,530
sonic hedgehog group medulloblastoma 2 | 1,482
tuberculosis and treatment for 3 months 2 | 327
Barth syndrome 1 | 23
Bipolar Disorder 1 | 266
Brain Ischemia 1 | 87
Cellulitis 1 | 13
Cerebrovascular disease 1 | 231
Contact Dermatitis 1 | 80
Deafness 1 | 18
Endometriosis 1 | 535
Heart conduction disease 1 | 65
Kabuki syndrome 1 | 27
Lymphedema 1 | 26
Male infertility 1 | 170
Mental depression 1 | 58
Nonsyndromic deafness 1 | 121
Parkinson's disease 1 | 364
Polycystic Ovary Syndrome 1 | 332
Primary hyperoxaluria 1 | 15
Prostate cancer 1 | 172
Pseudohypoaldosteronism 1 | 22
Rickets 1 | 42
Sensorineural hearing loss 1 | 107
Stomach Neoplasms 1 | 282
Substance-Related Disorders 1 | 114
adrenocortical carcinoma 1 | 1,427
fibroadenoma 1 | 557
head and neck cancer and chronic obstructive pulmonary disease 1 | 237
inflammatory breast cancer 1 | 404
limb girdle muscular dystrophy 2B 1 | 74
non-inflammatory breast cancer 1 | 208
sarcoidosis 1 | 358
severe Alzheimer's disease 1 | 49
tuberculosis 1 | 1,557
urothelial carcinoma 1 | 318

Tissue

Digestive Tract 29 | 18,473
Endocrine System 29 | 18,512
Female tissues 29 | 18,647
Nervous System 29 | 18,561
Skin and soft tissues 29 | 18,115
Urinary Tract 29 | 18,444
Blood and immune system 28 | 17,995
Cardiovascular System 28 | 17,958
Liver and Pancreas 28 | 18,136
Male tissues 28 | 17,969
Respiratory system 28 | 17,484

Target Family

Non-IDG 29 | 11,971
Kinase 1 | 634

Reactome Pathway

Tight junction interactions 30 | 30
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
InaD-like protein PATJ Tbio Non-IDG -1.88739 77.1 91
Claudin-3 CLDN3 Tbio Non-IDG -2.30333 205.5 260
Protein crumbs homolog 3 CRB3 Tbio Non-IDG -1.16045 14.3 66
Claudin-16 CLDN16 Tbio Non-IDG -1.95188 99.5 103
Protein kinase C iota type PRKCI Tchem Kinase -1.72458 51.8 122
Claudin-1 CLDN1 Tbio Non-IDG -1.97380 111.2 472
Partitioning defective 6 homolog beta PARD6B Tbio Non-IDG -0.78485 5.86 101
Partitioning defective 6 homolog gamma PARD6G Tbio Non-IDG -0.39051 2.62 59
Junctional adhesion molecule A F11R Tbio Non-IDG -2.50100 351.0 319
Claudin-23 CLDN23 Tbio Non-IDG -0.55888 2.83 79