Development Level

Tbio 41 | 11,445
Tchem 3 | 1,598
Tclin 3 | 613

IMPC Phenotype

hydrometra 2 | 53
increased leukocyte cell numbe... 2 | 47
preweaning lethality, complete... 2 | 979
small superior vagus ganglion 2 | 74
abnormal cecum morphology 1 | 7
abnormal embryo size 1 | 220
abnormal heart morphology 1 | 162
abnormal heart shape 1 | 5
abnormal seminal vesicle morph... 1 | 114
abnormal skin morphology 1 | 50
absent pinna reflex 1 | 23
decreased T cell number 1 | 15
decreased fasted circulating g... 1 | 65
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged cecum 1 | 5
enlarged heart 1 | 210
enlarged seminal vesicle 1 | 10
increased CD4-positive, alpha ... 1 | 4
increased circulating free fat... 1 | 20
increased grip strength 1 | 41
increased mean corpuscular hem... 1 | 96
preweaning lethality, incomple... 1 | 499
prolonged PR interval 1 | 15

Disease

Carcinoma 41 | 11,493
diabetes mellitus 29 | 1,728
Cancer 27 | 2,499
tuberculosis 25 | 2,010
Acquired immunodeficiency syndrome 24 | 197
Hypersensitivity reaction type II disease 24 | 253
Kidney disease 24 | 430
Anemia 22 | 365
Ankylosing spondylitis 22 | 140
Arthritis 22 | 290
Hemochromatosis 22 | 54
Juvenile rheumatoid arthritis 22 | 111
Liver disease 22 | 237
Primary immunodeficiency disease 22 | 54
Uveitis 22 | 103
Behcet's disease 21 | 89
Birdshot chorioretinopathy 21 | 23
Hepatitis B 21 | 108
Herpes zoster 21 | 68
Leprosy 21 | 73
Multiple Sclerosis 21 | 540
Skin disease 21 | 66
ovarian cancer 19 | 8,520
osteosarcoma 14 | 7,950
psoriasis 13 | 6,694
glioblastoma 12 | 5,792
interstitial cystitis 11 | 2,312
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,291
lung cancer 9 | 4,740
ulcerative colitis 9 | 1,819
atypical teratoid / rhabdoid tumor 8 | 5,112
lung carcinoma 8 | 2,843
medulloblastoma, large-cell 8 | 6,241
subependymal giant cell astrocytoma 8 | 2,287
Astrocytoma, Pilocytic 7 | 3,081
adult high grade glioma 7 | 3,801
cutaneous lupus erythematosus 7 | 1,057
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,955
invasive ductal carcinoma 7 | 2,951
Kidney cancer 6 | 2,613
Rheumatoid arthritis 6 | 1,191
ependymoma 6 | 4,679
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989
non-small cell lung cancer 6 | 2,890
Autosomal recessive predisposition 5 | 1,442
Multiple myeloma 5 | 1,332
breast carcinoma 5 | 1,638
primary Sjogren syndrome 5 | 735
Breast cancer 4 | 3,578
Cataract 8 multiple types 4 | 33
Immunologic Deficiency Syndromes 4 | 113
Pick disease 4 | 1,894
Schizophrenia 4 | 1,160
group 4 medulloblastoma 4 | 1,855
juvenile dermatomyositis 4 | 1,187
lung adenocarcinoma 4 | 2,716
malignant mesothelioma 4 | 3,232
oligodendroglioma 4 | 2,850
pancreatic cancer 4 | 2,398
sarcoidosis 4 | 370
spina bifida 4 | 1,074
Autoimmune Diseases 3 | 67
Blastic phase chronic myeloid leukemia 3 | 58
Chronic Myelocytic Leukemia Accelerated Phase 3 | 59
Cognitive delay 3 | 608
Global developmental delay 3 | 608
Intellectual disability 3 | 1,016
Liver Cirrhosis, Experimental 3 | 769
Lung disease 3 | 142
Lymphoma, T-Cell, Peripheral 3 | 9
Mental and motor retardation 3 | 608
Pain agnosia 3 | 104
Peripheral T-cell lymphoma 3 | 25
Waldenstrons macroglobulinemia 3 | 765
astrocytic glioma 3 | 2,597
astrocytoma 3 | 1,146
ductal carcinoma in situ 3 | 1,745
group 3 medulloblastoma 3 | 4,104
head and neck cancer and chronic obstructive pulmonary disease 3 | 239
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
pediatric high grade glioma 3 | 1,064
primitive neuroectodermal tumor 3 | 3,035
Alzheimer's disease 2 | 658
Atopic dermatitis 2 | 952
Cholestasis 2 | 155
Diarrhea 2 | 253
Down syndrome 2 | 499
Hepatomegaly 2 | 285
Hypertension 2 | 396
Macrotia 2 | 87
Melanoma 2 | 711
Proteinuria 2 | 144
Skin cancer 2 | 469
acute quadriplegic myopathy 2 | 1,158
adrenocortical carcinoma 2 | 1,428
colon cancer 2 | 1,478
cystic fibrosis 2 | 1,696
esophageal adenocarcinoma 2 | 737
medulloblastoma 2 | 720
progressive supranuclear palsy 2 | 676

Tissue

Blood and immune system 27 | 16,909
Cardiovascular System 27 | 15,192
Digestive Tract 27 | 17,369
Endocrine System 27 | 18,159
Female tissues 27 | 17,400
Liver and Pancreas 27 | 16,750
Male tissues 27 | 17,142
Nervous System 27 | 16,725
Respiratory system 27 | 16,393
Skin and soft tissues 27 | 17,230
Urinary Tract 27 | 16,678

Target Family

Non-IDG 40 | 12,091
Kinase 4 | 634
Enzyme 3 | 4,145

Reactome Pathway

The role of Nef in HIV-1 repli... 47 | 47
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

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