Development Level

Tbio 18 | 11,445
Tchem 11 | 1,598
Tclin 3 | 613
Tdark 1 | 6,588

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

abnormal heart morphology 2 | 162
enlarged heart 2 | 210
increased lean body mass 2 | 172
preweaning lethality, complete... 2 | 979
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal testis morphology 1 | 43
abnormal whole-body plethysmog... 1 | 4
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating amylase ... 1 | 28
decreased circulating calcium ... 1 | 36
decreased circulating serum al... 1 | 82
decreased circulating triglyce... 1 | 79
decreased lean body mass 1 | 135
decreased lymphocyte cell numb... 1 | 83
decreased neutrophil cell numb... 1 | 42
decreased red blood cell distr... 1 | 41
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
hyperactivity 1 | 148
hypoactivity 1 | 132
increased blood urea nitrogen ... 1 | 48
increased blood uric acid leve... 1 | 5
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased cellular hemoglobin ... 1 | 1
increased circulating alkaline... 1 | 122
increased circulating creatini... 1 | 38
increased circulating potassiu... 1 | 29
increased circulating sodium l... 1 | 71
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular vol... 1 | 92
increased mean platelet volume 1 | 45
increased monocyte cell number 1 | 63
macrophthalmia 1 | 2
male infertility 1 | 123
preweaning lethality, incomple... 1 | 499
prolonged PR interval 1 | 15
small testis 1 | 58
thrombocytopenia 1 | 56

Disease

Carcinoma 24 | 11,493
psoriasis 14 | 6,694
Night Blindness 13 | 101
osteosarcoma 13 | 7,950
Difficulties with night vision 12 | 87
Autosomal recessive predisposition 11 | 1,442
Intellectual disability 11 | 1,016
Photodysphoria 11 | 121
Photophobia 11 | 121
Retinitis Pigmentosa 11 | 226
Abnormality of retinal pigmentation 10 | 111
Electroretinogram abnormal 10 | 95
Retinal pigment epithelial abnormality 10 | 111
Blind Vision 9 | 111
Blindness, Legal 9 | 110
Cataract 9 | 297
Dull intelligence 9 | 645
Keratoconus 9 | 113
Lens Opacities 9 | 231
Low intelligence 9 | 645
Mental Retardation 9 | 645
Mental deficiency 9 | 645
Nystagmus 9 | 317
Poor school performance 9 | 645
Retinal Degeneration 9 | 106
Sensorineural Hearing Loss (disorder) 9 | 284
medulloblastoma, large-cell 9 | 6,241
ovarian cancer 9 | 8,520
Abnormality of the retinal vasculature 8 | 59
Anteverted nostril 8 | 191
Atypical scarring of skin 8 | 62
Broad flat nasal bridge 8 | 236
Conductive hearing loss 8 | 123
Cone dystrophy 8 | 71
Congenital anomaly of testis 8 | 52
Congenital hypoplasia of penis 8 | 176
Glaucoma 8 | 239
Hyperinsulinism 8 | 133
Hypogonadism 8 | 173
Nasal bridge wide 8 | 236
Night blindness, progressive 8 | 51
Obesity 8 | 678
Ophthalmoplegia 8 | 106
Optic Atrophy 8 | 242
ependymoma 8 | 4,679
glioblastoma 8 | 5,792
primitive neuroectodermal tumor 8 | 3,035
Fundus dystrophy 7 | 83
Reduced visual acuity 7 | 63
astrocytic glioma 7 | 2,597
atypical teratoid / rhabdoid tumor 7 | 5,112
group 4 medulloblastoma 7 | 1,855
Abnormality of macular pigmentation 6 | 16
Blindness 6 | 88
Congenital stationary night blindness 6 | 29
Hypoplasia of optic disc 6 | 12
Leber congenital amaurosis 6 | 69
Macular pigmentary changes 6 | 16
Night blindness, congenital stationary 6 | 16
Night blindness, congenital stationary, complete 6 | 10
Night blindness, stationary 6 | 10
Oguchi disease 6 | 10
Severe myopia 6 | 22
adult high grade glioma 6 | 3,801
group 3 medulloblastoma 6 | 4,104
lung cancer 6 | 4,740
oligodendroglioma 6 | 2,850
Low Vision 5 | 174
Visual Impairment 5 | 174
lung adenocarcinoma 5 | 2,716
subependymal giant cell astrocytoma 5 | 2,287
Bradyopsia 4 | 10
Breast cancer 4 | 3,578
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
lung carcinoma 4 | 2,843
non-small cell lung cancer 4 | 2,890
pituitary cancer 4 | 1,972
Astrocytoma, Pilocytic 3 | 3,081
Atrial Fibrillation 3 | 124
Cancer 3 | 2,499
Chronic heart failure 3 | 46
Decreased amplitudes on flash visual electroretinogram 3 | 13
Kidney cancer 3 | 2,613
Loss of peripheral vision 3 | 5
Multiple myeloma 3 | 1,332
Myocardial Perfusion Imaging Adjunct 3 | 25
Partial central choroid dystrophy 3 | 11
Platelet Aggregation Inhibition 3 | 22
Prevention of Cerebral Thrombosis 3 | 29
Rheumatoid arthritis 3 | 1,191
Tunnel visual field constriction 3 | 5
Uveitis 3 | 103
active Crohn's disease 3 | 922
cone-rod dystrophy 3 | 59
interstitial cystitis 3 | 2,312
malignant mesothelioma 3 | 3,232
non primary Sjogren syndrome sicca 3 | 891
invasive ductal carcinoma 2 | 2,951
ulcerative colitis 2 | 1,819

Tissue

Endocrine System 31 | 18,159
Digestive Tract 28 | 17,369
Skin and soft tissues 28 | 17,230
Nervous System 27 | 16,725
Blood and immune system 26 | 16,909
Urinary Tract 25 | 16,678
Female tissues 24 | 17,400
Male tissues 24 | 17,142
Cardiovascular System 23 | 15,192
Liver and Pancreas 22 | 16,750
Respiratory system 22 | 16,393

Target Family

Enzyme 14 | 4,145
Non-IDG 8 | 12,091
Kinase 7 | 634
Ion Channel 2 | 344
GPCR 1 | 408
Transporter 1 | 473

Reactome Pathway

The phototransduction cascade 33 | 33
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Retinal guanylyl cyclase 1 GUCY2D Tbio Kinase -2.20658 167.7 205
Guanylyl cyclase-activating protein 3 GUCA1C Tdark Enzyme 0.02 1.10 125
Rhodopsin kinase GRK7 Tchem Kinase -1.83396 45.0 180
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha PDE6A Tclin Enzyme -1.29228 20.3 111
Methionine aminopeptidase 1 METAP1 Tchem Enzyme -1.64901 44.4 149
Retinal guanylyl cyclase 2 GUCY2F Tbio Kinase -1.00236 7.60 84
Regulator of G-protein signaling 9-binding protein RGS9BP Tbio Non-IDG -1.27334 21.8 16
Guanylyl cyclase-activating protein 2 GUCA1B Tbio Enzyme -1.63232 42.4 122
Glycylpeptide N-tetradecanoyltransferase 2 NMT2 Tchem Enzyme -1.21261 12.8 255
G protein-coupled receptor kinase 4 GRK4 Tchem Kinase -1.71379 54.8 171