Development Level

Tbio 82 | 11,445
Tclin 50 | 613
Tchem 15 | 1,598
Tdark 11 | 6,588

IMPC Phenotype

preweaning lethality, complete... 28 | 979
embryonic lethality prior to o... 7 | 239
cataract 5 | 92
abnormal embryo size 4 | 220
embryonic lethality prior to t... 4 | 278
pallor 4 | 34
abnormal lens morphology 3 | 81
decreased total body fat amoun... 3 | 207
increased lean body mass 3 | 172
prenatal lethality prior to he... 3 | 87
abnormal behavior 2 | 298
abnormal placenta size 2 | 20
abnormal skin coloration 2 | 25
decreased circulating creatini... 2 | 39
decreased erythrocyte cell num... 2 | 62
decreased lactate dehydrogenas... 2 | 16
embryonic growth retardation 2 | 106
increased circulating phosphat... 2 | 26
abnormal allantois morphology 1 | 8
abnormal chorioallantoic fusio... 1 | 8
abnormal digit morphology 1 | 10
abnormal embryo development 1 | 7
abnormal embryo turning 1 | 31
abnormal embryonic autopod pla... 1 | 2
abnormal heart morphology 1 | 162
abnormal hindbrain development 1 | 16
abnormal kidney morphology 1 | 65
abnormal limb bud morphology 1 | 17
abnormal liver size 1 | 5
abnormal lung morphology 1 | 26
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal neural tube morpholog... 1 | 12
abnormal placenta development 1 | 1
abnormal placenta morphology 1 | 5
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal stomach morphology 1 | 10
abnormal tail movements 1 | 12
abnormal testis morphology 1 | 43
abnormal visceral yolk sac mor... 1 | 6
abnormal vitelline vasculature... 1 | 6
absent pinna reflex 1 | 23
decreased IgM level 1 | 1
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased circulating HDL chol... 1 | 68
decreased circulating alanine ... 1 | 47
decreased circulating alkaline... 1 | 46
decreased circulating chloride... 1 | 30
decreased circulating choleste... 1 | 93
decreased circulating phosphat... 1 | 27
decreased circulating triglyce... 1 | 79
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular vol... 1 | 79
decreased total retina thickne... 1 | 17
decreased vertical activity 1 | 208
hemorrhage 1 | 23
hyperactivity 1 | 148
hypoactivity 1 | 132
increased body weight 1 | 25
increased bone mineral content 1 | 108
increased circulating alkaline... 1 | 122
increased circulating amylase ... 1 | 25
increased circulating calcium ... 1 | 34
increased circulating choleste... 1 | 66
increased circulating glucose ... 1 | 24
increased circulating sodium l... 1 | 71
increased eosinophil cell numb... 1 | 11
increased fasted circulating g... 1 | 76
increased grip strength 1 | 41
increased heart weight 1 | 62
increased mean corpuscular hem... 1 | 96
increased monocyte cell number 1 | 63
increased startle reflex 1 | 112
long tibia 1 | 25
narrow eye opening 1 | 12
pale liver 1 | 6
pale yolk sac 1 | 25
persistence of hyaloid vascula... 1 | 33
prenatal lethality 1 | 28
small superior vagus ganglion 1 | 74
small testis 1 | 58
thrombocytopenia 1 | 56

Disease

ovarian cancer 100 | 8,520
Carcinoma 64 | 11,493
osteosarcoma 64 | 7,950
Multiple myeloma 57 | 1,332
Leigh disease 50 | 100
Autosomal recessive predisposition 48 | 1,442
Diabetes mellitus type 2 48 | 69
Treatment Refractory Type 2 Diabetes Mellitus 48 | 53
medulloblastoma, large-cell 47 | 6,241
Cerebellar Ataxia 46 | 304
pancreatic ductal adenocarcinoma liver metastasis 46 | 1,962
Acidosis, Lactic 43 | 97
psoriasis 43 | 6,694
Cognitive delay 42 | 608
Global developmental delay 42 | 608
Lactic acidemia 42 | 95
Mental and motor retardation 42 | 608
lung cancer 41 | 4,740
glioblastoma 40 | 5,792
Muscle hypotonia 39 | 571
Mitochondrial complex I deficiency 37 | 46
Epilepsy 36 | 792
atypical teratoid / rhabdoid tumor 35 | 5,112
astrocytic glioma 34 | 2,597
Blepharoptosis 33 | 231
Seizures 33 | 596
ependymoma 32 | 4,679
Sensorineural Hearing Loss (disorder) 31 | 284
Failure to gain weight 29 | 365
Pediatric failure to thrive 29 | 365
Increased serum lactate 28 | 60
intraductal papillary-mucinous neoplasm (IPMN) 27 | 3,291
Mitochondrial Complex 1 Deficiency 26 | 28
Nystagmus 26 | 317
CSF lactate increased 25 | 33
Muscle Weakness 25 | 170
Optic Atrophy 25 | 242
Hypoglycemia 24 | 152
Dystonia 23 | 164
NADH:Q(1) Oxidoreductase deficiency 23 | 24
Strabismus 23 | 270
adult high grade glioma 23 | 3,801
Developmental regression 22 | 95
Dystonic disease 22 | 106
Highly variable clinical phenotype 22 | 150
Highly variable phenotype and severity 22 | 150
Highly variable phenotype, even within families 22 | 150
Hyperreflexia 22 | 209
Loss of developmental milestones 22 | 95
Mental deterioration in childhood 22 | 95
Neurodevelopmental regression 22 | 95
Phenotypic variability 22 | 150
Pick disease 22 | 1,894
Psychomotor regression 22 | 95
Psychomotor regression beginning in infancy 22 | 95
Psychomotor regression in infants 22 | 95
Psychomotor regression, progressive 22 | 95
Leigh syndrome 21 | 28
Muscle Spasticity 21 | 195
Respiratory Failure 21 | 104
Breast cancer 20 | 3,578
Hypertrophic Cardiomyopathy 20 | 117
Intellectual disability 20 | 1,016
Abnormal mitochondria in muscle tissue 19 | 20
Dull intelligence 19 | 645
Impaired exercise tolerance 19 | 42
Low intelligence 19 | 645
Mental Retardation 19 | 645
Mental deficiency 19 | 645
Ophthalmoplegia 19 | 106
Poor school performance 19 | 645
diabetes mellitus 19 | 1,728
invasive ductal carcinoma 19 | 2,951
oligodendroglioma 19 | 2,850
group 3 medulloblastoma 18 | 4,104
Lactic acidosis 17 | 51
Neurogenic Muscular Atrophy 17 | 139
Neurogenic muscle atrophy, especially in the lower limbs 17 | 139
Skeletal muscle atrophy 17 | 139
Vomiting 17 | 116
muscle degeneration 17 | 139
Decreased tendon reflex 16 | 122
Infantile onset 16 | 238
Lethargy 16 | 77
Obesity 16 | 678
Retinitis Pigmentosa 16 | 226
Waldenstrons macroglobulinemia 16 | 765
X-linked dominant 16 | 57
non-small cell lung cancer 16 | 2,890
Babinski Reflex 15 | 100
Blind Vision 15 | 111
Blindness, Legal 15 | 110
Cancer 15 | 2,499
Feeding difficulties in infancy 15 | 175
Schizophrenia 15 | 1,160
malignant mesothelioma 15 | 3,232
Atrophy of cerebellum 14 | 103
Cerebellar degeneration 14 | 103
breast carcinoma 14 | 1,638
ulcerative colitis 14 | 1,819

Tissue

Endocrine System 158 | 18,159
Digestive Tract 157 | 17,369
Female tissues 157 | 17,400
Liver and Pancreas 157 | 16,750
Blood and immune system 156 | 16,909
Skin and soft tissues 156 | 17,230
Urinary Tract 156 | 16,678
Cardiovascular System 155 | 15,192
Male tissues 155 | 17,142
Nervous System 155 | 16,725
Respiratory system 155 | 16,393

Target Family

Enzyme 112 | 4,145
Non-IDG 35 | 12,091
Transporter 5 | 473
Kinase 4 | 634
Nuclear Receptor 2 | 48

Reactome Pathway

The citric acid (TCA) cycle an... 158 | 158
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..