Development Level

Tbio 88 | 10,625
Tclin 49 | 602
Tchem 17 | 1,890
Tdark 14 | 7,003

IMPC Term

preweaning lethality, complete... 20 | 633
embryonic lethality prior to o... 8 | 148
embryonic lethality prior to t... 5 | 187
abnormal embryo size 3 | 112
abnormal lens morphology 3 | 73
increased fasted circulating g... 3 | 68
pallor 3 | 13
prenatal lethality prior to he... 3 | 64
abnormal behavior 2 | 226
abnormal skin coloration 2 | 18
decreased body weight 2 | 174
decreased circulating HDL chol... 2 | 77
decreased lactate dehydrogenas... 2 | 14
decreased total body fat amoun... 2 | 186
decreased total retina thickne... 2 | 20
embryonic growth retardation 2 | 28
increased grip strength 2 | 83
increased lean body mass 2 | 107
abnormal QRS complex 1 | 25
abnormal coping response 1 | 12
abnormal embryo turning 1 | 15
abnormal foot plate morphology 1 | 2
abnormal heart morphology 1 | 51
abnormal hindbrain development 1 | 24
abnormal kidney morphology 1 | 30
abnormal limb bud morphology 1 | 15
abnormal liver size 1 | 4
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal placenta development 1 | 1
abnormal placenta morphology 1 | 4
abnormal placenta size 1 | 10
abnormal retina morphology 1 | 100
abnormal retinal blood vessel ... 1 | 18
abnormal retinal vasculature m... 1 | 15
abnormal skin appearance 1 | 8
abnormal tail movements 1 | 12
abnormal testis morphology 1 | 30
abnormal visceral yolk sac mor... 1 | 2
decreased IgM level 1 | 1
decreased blood urea nitrogen ... 1 | 31
decreased bone mineral content 1 | 157
decreased caudal vertebrae num... 1 | 49
decreased circulating alanine ... 1 | 53
decreased circulating alkaline... 1 | 41
decreased circulating chloride... 1 | 32
decreased circulating creatini... 1 | 31
decreased circulating sodium l... 1 | 18
decreased circulating triglyce... 1 | 83
decreased effector memory CD8-... 1 | 24
decreased erythrocyte cell num... 1 | 43
decreased follicular B cell nu... 1 | 4
decreased late germinal center... 1 | 2
decreased leukocyte cell numbe... 1 | 54
decreased mean platelet volume 1 | 12
decreased red blood cell distr... 1 | 11
decreased startle reflex 1 | 48
hyperactivity 1 | 108
hypoactivity 1 | 89
increased CD4-positive, CD25-p... 1 | 18
increased T cell number 1 | 15
increased alpha-beta T cell nu... 1 | 9
increased blood urea nitrogen ... 1 | 44
increased body weight 1 | 42
increased bone mineral content 1 | 92
increased circulating choleste... 1 | 53
increased circulating free fat... 1 | 17
increased circulating phosphat... 1 | 24
increased circulating potassiu... 1 | 31
increased circulating sodium l... 1 | 71
increased early germinal cente... 1 | 2
increased exploration in new e... 1 | 56
increased heart weight 1 | 37
increased mean corpuscular hem... 1 | 93
increased startle reflex 1 | 38
narrow eye opening 1 | 15
pale liver 1 | 5
prenatal lethality 1 | 16
preweaning lethality, incomple... 1 | 260
small testis 1 | 37

Disease

ovarian cancer 108 | 8,492
Multiple myeloma 66 | 1,328
osteosarcoma 65 | 7,933
Diabetes mellitus type 2 48 | 69
Leigh disease 48 | 81
Treatment Refractory Type 2 Diabetes Mellitus 48 | 53
medulloblastoma, large-cell 46 | 6,234
pancreatic ductal adenocarcinoma liver metastasis 46 | 1,795
lung cancer 45 | 4,473
psoriasis 44 | 6,685
glioblastoma 36 | 5,572
astrocytic glioma 34 | 2,241
Mitochondrial complex I deficiency 30 | 37
atypical teratoid / rhabdoid tumor 29 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 29 | 3,289
ependymoma 27 | 2,514
Mitochondrial Complex 1 Deficiency 26 | 28
Leigh syndrome 25 | 34
Pick disease 22 | 1,893
Waldenstrons macroglobulinemia 20 | 765
oligodendroglioma 20 | 2,849
NADH:Q(1) Oxidoreductase deficiency 19 | 20
medulloblastoma 19 | 1,524
ulcerative colitis 19 | 2,087
Breast cancer 18 | 3,099
invasive ductal carcinoma 18 | 2,950
astrocytoma 16 | 1,493
Lactic acidosis 15 | 43
malignant mesothelioma 15 | 3,163
non-small cell lung cancer 15 | 2,798
Cancer 14 | 2,346
Obesity 14 | 616
adult high grade glioma 14 | 2,148
diabetes mellitus 14 | 1,663
LEIGH SYNDROME DUE TO MITOCHONDRIAL COMPLEX I DEFICIENCY 13 | 14
lung adenocarcinoma 13 | 2,714
non primary Sjogren syndrome sicca 13 | 840
Mitochondrial myopathy 12 | 24
cytochrome-c oxidase deficiency disease 12 | 19
hereditary spastic paraplegia 12 | 313
Leber hereditary optic neuropathy 11 | 17
breast carcinoma 11 | 1,614
Cytochrome-c Oxidase Deficiency 10 | 15
colon cancer 10 | 1,475
ductal carcinoma in situ 10 | 1,745
pediatric high grade glioma 10 | 2,712
primitive neuroectodermal tumor 10 | 3,031
tuberculosis and treatment for 6 months 10 | 686
Leber's optic atrophy 9 | 10
Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke-Like Episodes 9 | 9
Optic Atrophy, Hereditary, Leber 9 | 14
acute myeloid leukemia 9 | 785
gastric carcinoma 9 | 832
group 4 medulloblastoma 9 | 1,875
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,988
pancreatic cancer 9 | 2,300
pituitary cancer 9 | 1,972
Alzheimer's disease 8 | 644
Cardiomyopathies 8 | 90
Degenerative polyarthritis 8 | 93
Down syndrome 8 | 548
Parkinson's disease 8 | 364
acute quadriplegic myopathy 8 | 1,157
dermatomyositis 8 | 967
group 3 medulloblastoma 8 | 2,254
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,956
lung carcinoma 8 | 2,844
pilocytic astrocytoma 8 | 3,086
subependymal giant cell astrocytoma 8 | 2,287
Disease Progression 7 | 125
Stomach Neoplasms 7 | 282
adrenocortical carcinoma 7 | 1,427
aldosterone-producing adenoma 7 | 664
juvenile dermatomyositis 7 | 1,189
3-methylglutaconic aciduria 6 | 29
MELAS syndrome 6 | 17
Neurodegenerative disease 6 | 383
Neuropathy 6 | 210
Pneumonia 6 | 133
pancreatic carcinoma 6 | 567
primary pancreatic ductal adenocarcinoma 6 | 1,271
tuberculosis 6 | 1,563
Cardiomyopathy 5 | 110
Duchenne muscular dystrophy 5 | 602
Dystonia 5 | 77
Mitochondrial complex IV deficiency 5 | 6
Mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes syndrome 5 | 5
Myocardial Ischemia 5 | 169
Neoplastic Syndromes, Hereditary 5 | 48
Polycystic Ovary Syndrome 5 | 335
Pyruvate decarboxylase deficiency 5 | 15
Retinitis pigmentosa 5 | 156
Rheumatoid Arthritis 5 | 1,171
cystic fibrosis 5 | 1,670
interstitial cystitis 5 | 2,299
Prostatic Neoplasms 4 | 471
Schizophrenia 4 | 503
cutaneous lupus erythematosus 4 | 1,056
posterior fossa group A ependymoma 4 | 1,511
sonic hedgehog group medulloblastoma 4 | 1,482

Tissue

Blood and immune system 168 | 17,995
Cardiovascular System 168 | 17,958
Digestive Tract 168 | 18,473
Endocrine System 168 | 18,512
Female tissues 168 | 18,647
Liver and Pancreas 168 | 18,136
Male tissues 168 | 17,969
Nervous System 168 | 18,561
Respiratory system 168 | 17,484
Skin and soft tissues 168 | 18,115
Urinary Tract 168 | 18,444

Target Family

Enzyme 125 | 4,146
Non-IDG 32 | 11,969
Transporter 5 | 473
Kinase 4 | 634
Nuclear Receptor 2 | 48

Reactome Pathway

The citric acid (TCA) cycle an... 168 | 168
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..