Development Level

Tbio 88 | 10,625
Tclin 49 | 602
Tchem 17 | 1,890
Tdark 14 | 7,003

IMPC Term

preweaning lethality, complete... 20 | 633
embryonic lethality prior to o... 8 | 148
embryonic lethality prior to t... 5 | 187
abnormal embryo size 3 | 112
abnormal lens morphology 3 | 73
increased fasted circulating g... 3 | 68
pallor 3 | 13
prenatal lethality prior to he... 3 | 64
abnormal behavior 2 | 226
abnormal skin coloration 2 | 18
decreased body weight 2 | 174
decreased circulating HDL chol... 2 | 77
decreased lactate dehydrogenas... 2 | 14
decreased total body fat amoun... 2 | 186
decreased total retina thickne... 2 | 20
embryonic growth retardation 2 | 28
increased grip strength 2 | 83
increased lean body mass 2 | 107
abnormal QRS complex 1 | 25
abnormal coping response 1 | 12
abnormal embryo turning 1 | 15
abnormal foot plate morphology 1 | 2
abnormal heart morphology 1 | 51
abnormal hindbrain development 1 | 24
abnormal kidney morphology 1 | 30
abnormal limb bud morphology 1 | 15
abnormal liver size 1 | 4
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal placenta development 1 | 1
abnormal placenta morphology 1 | 4
abnormal placenta size 1 | 10
abnormal retina morphology 1 | 100
abnormal retinal blood vessel ... 1 | 18
abnormal retinal vasculature m... 1 | 15
abnormal skin appearance 1 | 8
abnormal tail movements 1 | 12
abnormal testis morphology 1 | 30
abnormal visceral yolk sac mor... 1 | 2
decreased IgM level 1 | 1
decreased blood urea nitrogen ... 1 | 31
decreased bone mineral content 1 | 157
decreased caudal vertebrae num... 1 | 49
decreased circulating alanine ... 1 | 53
decreased circulating alkaline... 1 | 41
decreased circulating chloride... 1 | 32
decreased circulating creatini... 1 | 31
decreased circulating sodium l... 1 | 18
decreased circulating triglyce... 1 | 83
decreased effector memory CD8-... 1 | 24
decreased erythrocyte cell num... 1 | 43
decreased follicular B cell nu... 1 | 4
decreased late germinal center... 1 | 2
decreased leukocyte cell numbe... 1 | 54
decreased mean platelet volume 1 | 12
decreased red blood cell distr... 1 | 11
decreased startle reflex 1 | 48
hyperactivity 1 | 108
hypoactivity 1 | 89
increased CD4-positive, CD25-p... 1 | 18
increased T cell number 1 | 15
increased alpha-beta T cell nu... 1 | 9
increased blood urea nitrogen ... 1 | 44
increased body weight 1 | 42
increased bone mineral content 1 | 92
increased circulating choleste... 1 | 53
increased circulating free fat... 1 | 17
increased circulating phosphat... 1 | 24
increased circulating potassiu... 1 | 31
increased circulating sodium l... 1 | 71
increased early germinal cente... 1 | 2
increased exploration in new e... 1 | 56
increased heart weight 1 | 37
increased mean corpuscular hem... 1 | 93
increased startle reflex 1 | 38
narrow eye opening 1 | 15
pale liver 1 | 5
prenatal lethality 1 | 16
preweaning lethality, incomple... 1 | 260
small testis 1 | 37

Disease

ovarian cancer 107 | 8,484
Multiple myeloma 66 | 1,327
osteosarcoma 65 | 7,933
Diabetes mellitus type 2 48 | 69
Leigh disease 48 | 81
Treatment Refractory Type 2 Diabetes Mellitus 48 | 53
medulloblastoma, large-cell 46 | 6,234
pancreatic ductal adenocarcinoma liver metastasis 46 | 1,795
lung cancer 45 | 4,466
psoriasis 44 | 6,685
glioblastoma 36 | 5,572
astrocytic glioma 34 | 2,241
MITOCHONDRIAL COMPLEX I DEFICIENCY 30 | 37
atypical teratoid / rhabdoid tumor 29 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 29 | 3,289
ependymoma 27 | 2,514
Pick disease 22 | 1,893
Waldenstrons macroglobulinemia 20 | 765
oligodendroglioma 20 | 2,849
NADH:Q(1) Oxidoreductase deficiency 19 | 20
medulloblastoma 19 | 1,524
ulcerative colitis 19 | 2,087
Breast cancer 18 | 3,094
invasive ductal carcinoma 18 | 2,950
astrocytoma 16 | 1,493
Lactic acidosis 15 | 42
malignant mesothelioma 15 | 3,162
non-small cell lung cancer 15 | 2,798
Cancer 14 | 2,346
Obesity 14 | 616
adult high grade glioma 14 | 2,148
diabetes mellitus 14 | 1,663
LEIGH SYNDROME DUE TO MITOCHONDRIAL COMPLEX I DEFICIENCY 13 | 14
lung adenocarcinoma 13 | 2,713
non primary Sjogren syndrome sicca 13 | 840
Mitochondrial myopathy 12 | 23
hereditary spastic paraplegia 12 | 313
Leber hereditary optic neuropathy 11 | 17
breast carcinoma 11 | 1,614
Cytochrome-c Oxidase Deficiency 10 | 15
colon cancer 10 | 1,475
cytochrome-c oxidase deficiency disease 10 | 14
ductal carcinoma in situ 10 | 1,745
pediatric high grade glioma 10 | 2,712
primitive neuroectodermal tumor 10 | 3,031
tuberculosis and treatment for 6 months 10 | 686
Optic Atrophy, Hereditary, Leber 9 | 14
acute myeloid leukemia 9 | 780
gastric carcinoma 9 | 832
group 4 medulloblastoma 9 | 1,875
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,988
pancreatic cancer 9 | 2,300
pituitary cancer 9 | 1,972
Alzheimer's disease 8 | 644
Cardiomyopathies 8 | 90
Degenerative polyarthritis 8 | 93
Down syndrome 8 | 548
Parkinson's disease 8 | 364
acute quadriplegic myopathy 8 | 1,157
dermatomyositis 8 | 933
group 3 medulloblastoma 8 | 2,254
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,956
lung carcinoma 8 | 2,844
pilocytic astrocytoma 8 | 3,086
subependymal giant cell astrocytoma 8 | 2,287
Disease Progression 7 | 125
Stomach Neoplasms 7 | 282
adrenocortical carcinoma 7 | 1,427
aldosterone-producing adenoma 7 | 664
juvenile dermatomyositis 7 | 1,189
3-methylglutaconic aciduria 6 | 29
MELAS syndrome 6 | 17
Neurodegenerative disease 6 | 383
Neuropathy 6 | 210
Pneumonia 6 | 133
pancreatic carcinoma 6 | 567
primary pancreatic ductal adenocarcinoma 6 | 1,271
tuberculosis 6 | 1,557
Cardiomyopathy 5 | 110
Duchenne muscular dystrophy 5 | 602
Dystonia 5 | 77
Myocardial Ischemia 5 | 169
Neoplastic Syndromes, Hereditary 5 | 48
Polycystic Ovary Syndrome 5 | 332
Pyruvate decarboxylase deficiency 5 | 15
Retinitis pigmentosa 5 | 153
Rheumatoid Arthritis 5 | 1,160
cystic fibrosis 5 | 1,665
interstitial cystitis 5 | 2,299
Atopic dermatitis 4 | 944
Endometriosis 4 | 535
IGA Glomerulonephritis 4 | 454
Malaria 4 | 140
Prostatic Neoplasms 4 | 471
Schizophrenia 4 | 501
active Crohn's disease 4 | 918
cutaneous lupus erythematosus 4 | 1,056
hepatocellular carcinoma 4 | 532
posterior fossa group A ependymoma 4 | 1,511
sonic hedgehog group medulloblastoma 4 | 1,482

Tissue

Blood and immune system 168 | 17,995
Cardiovascular System 168 | 17,958
Digestive Tract 168 | 18,473
Endocrine System 168 | 18,512
Female tissues 168 | 18,647
Liver and Pancreas 168 | 18,136
Male tissues 168 | 17,969
Nervous System 168 | 18,561
Respiratory system 168 | 17,484
Skin and soft tissues 168 | 18,115
Urinary Tract 168 | 18,444

Target Family

Enzyme 125 | 4,146
Non-IDG 32 | 11,971
Transporter 5 | 473
Kinase 4 | 634
Nuclear Receptor 2 | 48

Reactome Pathway

The citric acid (TCA) cycle an... 168 | 168
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
ATP synthase F(0) complex subunit C3, mitochondrial ATP5G3 Tdark Enzyme -1.10871 11.9 27
NADH-ubiquinone oxidoreductase chain 6 MT-ND6 Tclin Enzyme -2.74395 585.6 62
ATP synthase protein 8 MT-ATP8 Tbio Enzyme -2.30895 191.4 20
Malate dehydrogenase, mitochondrial MDH2 Tchem Enzyme -2.21960 180.2 229
Cytochrome c oxidase subunit 6A1, mitochondrial COX6A1 Tbio Enzyme -1.00384 11.8 165
Heat shock protein 75 kDa, mitochondrial TRAP1 Tchem Non-IDG -1.12188 14.9 328
Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B Tbio Enzyme -1.13428 13.6 146
Protein SCO2 homolog, mitochondrial SCO2 Tbio Non-IDG -2.16453 144.3 98
Cytochrome c oxidase subunit 7C, mitochondrial COX7C Tdark Enzyme -0.99133 9.67 34
Cytochrome b MT-CYB Tbio Non-IDG -3.74473 5676.0 122