Development Level

Tbio 6 | 11,445
Tchem 5 | 1,598

IMPC Phenotype

cataract 1 | 92
decreased bone mineral content 1 | 151
decreased circulating glycerol... 1 | 16
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
hypoactivity 1 | 132
increased circulating calcium ... 1 | 34
increased hemoglobin content 1 | 45
increased total body fat amoun... 1 | 134
preweaning lethality, complete... 1 | 979
thrombocytopenia 1 | 56

Disease

ovarian cancer 8 | 8,520
Carcinoma 7 | 11,493
invasive ductal carcinoma 7 | 2,951
lung cancer 7 | 4,740
Cancer 6 | 2,499
non-small cell lung cancer 6 | 2,890
osteosarcoma 6 | 7,950
psoriasis 6 | 6,694
Arthritis 5 | 290
Breast cancer 5 | 3,578
Familial cold autoinflammatory syndrome 5 | 10
diabetes mellitus 5 | 1,728
malignant mesothelioma 5 | 3,232
pancreatic cancer 5 | 2,398
Muckle-Wells syndrome 4 | 12
adult high grade glioma 4 | 3,801
cutaneous lupus erythematosus 4 | 1,057
glioblastoma 4 | 5,792
lung carcinoma 4 | 2,843
medulloblastoma, large-cell 4 | 6,241
tuberculosis 4 | 2,010
Astrocytoma, Pilocytic 3 | 3,081
Inflammatory bowel disease 3 | 151
Kidney disease 3 | 430
Liver Cirrhosis, Experimental 3 | 769
Multiple Sclerosis 3 | 540
Multiple myeloma 3 | 1,332
Neurodegenerative disease 3 | 414
Peritonitis 3 | 43
Vascular disease 3 | 319
cystic fibrosis 3 | 1,696
gastric cancer 3 | 459
group 3 medulloblastoma 3 | 4,104
interstitial cystitis 3 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
lung adenocarcinoma 3 | 2,716
oligodendroglioma 3 | 2,850
pancreatic carcinoma 3 | 562
subependymal giant cell astrocytoma 3 | 2,287
ulcerative colitis 3 | 1,819
Acne 2 | 52
Albuminuria 2 | 21
Amyloidosis 2 | 67
Amyotrophic lateral sclerosis 2 | 451
Aphthous stomatitis 2 | 16
Arthralgia 2 | 90
Behcet's syndrome 2 | 50
Bipolar Disorder 2 | 666
Blau syndrome 2 | 9
CINCA Syndrome 2 | 2
Chronic Lymphocytic Leukemia 2 | 262
Dermatitis 2 | 157
Epilepsy 2 | 792
Exanthem 2 | 37
Familial Mediterranean fever 2 | 13
Fatigue 2 | 182
Fever 2 | 138
Hyperhomocysteinemia 2 | 37
Hypersensitivity reaction type II disease 2 | 253
Hyperuricemia 2 | 49
Inflammation 2 | 120
Kidney Diseases 2 | 114
Lymphadenitis 2 | 15
Meningitis 2 | 67
Mesothelioma, Malignant 2 | 105
Mevalonic aciduria 2 | 16
Obesity 2 | 678
Pharyngitis 2 | 17
Pick disease 2 | 1,894
Pyoderma gangrenosum 2 | 9
Rheumatoid arthritis 2 | 1,191
Urticaria 2 | 67
Waldenstrons macroglobulinemia 2 | 765
active Crohn's disease 2 | 922
acute quadriplegic myopathy 2 | 1,158
atypical teratoid / rhabdoid tumor 2 | 5,112
colon cancer 2 | 1,478
ductal carcinoma in situ 2 | 1,745
ependymoma 2 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
juvenile dermatomyositis 2 | 1,187
nephrosclerosis 2 | 333
Calcinosis 1 | 70
Confusion 1 | 21
Conjunctivitis 1 | 53
Cowpox 1 | 16
Diabetic Nephropathy 1 | 34
Diffuse large B-cell lymphoma 1 | 39
Drug allergy 1 | 36
Human immunodeficiency virus infectious disease 1 | 138
Hyperglycemia 1 | 137
Leukokeratosis 1 | 19
Leukoplakia, Oral 1 | 20
Nephrotic Syndrome 1 | 78
Papilledema 1 | 11
Pericarditis 1 | 13
Pimples 1 | 10
Pulmonary Fibrosis 1 | 106
Tularemia 1 | 23
pustule 1 | 10

Tissue

Blood and immune system 11 | 16,909
Cardiovascular System 11 | 15,192
Digestive Tract 11 | 17,369
Endocrine System 11 | 18,159
Female tissues 11 | 17,400
Liver and Pancreas 11 | 16,750
Male tissues 11 | 17,142
Nervous System 11 | 16,725
Respiratory system 11 | 16,393
Skin and soft tissues 11 | 17,230
Urinary Tract 11 | 16,678

Target Family

Non-IDG 7 | 12,091
Enzyme 2 | 4,145
Ion Channel 2 | 344

Reactome Pathway

The NLRP3 inflammasome 11 | 11
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Pannexin-1 PANX1 Tbio Ion Channel -2.59888 418.5 154
NACHT, LRR and PYD domains-containing protein 3 NLRP3 Tchem Non-IDG -3.29685 1936.6 519
Protein SGT1 homolog SUGT1 Tbio Non-IDG -0.79781 9.93 183
Pyrin MEFV Tbio Non-IDG -3.02735 980.3 176
Proline-serine-threonine phosphatase-interacting protein 1 PSTPIP1 Tbio Enzyme -1.89883 82.3 119
P2X purinoceptor 7 P2RX7 Tchem Ion Channel -2.96940 962.2 272
Apoptosis-associated speck-like protein containing a CARD PYCARD Tbio Non-IDG -1.86744 55.9 477
Thioredoxin-interacting protein TXNIP Tbio Non-IDG -2.47583 365.2 216
Heat shock protein HSP 90-beta HSP90AB1 Tchem Non-IDG -2.04844 173.5 988
Thioredoxin TXN Tchem Non-IDG -3.19880 1494.7 530