Development Level

Tbio 7 | 11,651

IMPC Phenotype

cardiovascular system phenotyp... 1 | 36
decreased prepulse inhibition 1 | 82
decreased red blood cell distr... 1 | 41
increased aggression 1 | 4
increased circulating sodium l... 1 | 71
shortened RR interval 1 | 17

Disease

pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962
Carcinoma 5 | 11,493
Autosomal recessive predisposition 4 | 1,442
Melanoma 4 | 711
Meningitis 4 | 67
Skin cancer 4 | 469
lung adenocarcinoma 4 | 2,716
lung carcinoma 4 | 2,843
psoriasis 4 | 6,694
Immunologic Deficiency Syndromes 3 | 113
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
invasive ductal carcinoma 3 | 2,951
lung cancer 3 | 4,740
non-small cell lung cancer 3 | 2,890
ovarian cancer 3 | 8,520
pancreatic cancer 3 | 2,398
Arthritis, Juvenile 2 | 126
Atopic dermatitis 2 | 952
C8 deficiency 2 | 2
Complement deficiency 2 | 14
Complement deficiency disease 2 | 6
Increased susceptibility to Neisseria meningitidis infections 2 | 4
Juvenile arthritis 2 | 126
Kidney cancer 2 | 2,613
Liver Cirrhosis, Experimental 2 | 769
Lupus Erythematosus, Systemic 2 | 67
Neisseriaceae Infections 2 | 3
breast carcinoma 2 | 1,638
colon cancer 2 | 1,478
diabetes mellitus 2 | 1,728
ductal carcinoma in situ 2 | 1,745
group 3 medulloblastoma 2 | 4,104
malignant mesothelioma 2 | 3,232
pituitary cancer 2 | 1,972
primary Sjogren syndrome 2 | 735
AMYOTROPHIC LATERAL SCLEROSIS 1 1 | 49
Acute kidney injury 1 | 70
Adverse reaction to drug 1 | 61
Age related macular degeneration 1 | 72
Alzheimer Disease 1 | 83
Alzheimer's disease 1 | 658
Amyloidosis 1 | 67
Ascariasis 1 | 7
Atherosclerosis 1 | 291
Atrophic 1 | 10
Atrophy 1 | 10
Calcinosis 1 | 70
Cancer 1 | 2,499
Carcinoma, Hepatocellular 1 | 228
Chemical and Drug Induced Liver Injury 1 | 195
Cowpox 1 | 16
Degenerative polyarthritis 1 | 115
Dementia 1 | 175
Drug-Related Side Effects and Adverse Reactions 1 | 62
Erythema 1 | 58
Fuchs' endothelial dystrophy 1 | 24
Gaucher disease type 3 1 | 67
Heart Valve Diseases 1 | 25
Heart valve disease 1 | 39
Hypermobility syndrome 1 | 17
Intermittent claudication 1 | 20
Iris disease 1 | 10
Kidney Diseases 1 | 114
Kidney disease 1 | 430
Limb ischemia 1 | 15
Liver carcinoma 1 | 240
Macular degeneration 1 | 65
Mesothelioma, Malignant 1 | 105
Monkeypox 1 | 12
Neovascularization, Pathologic 1 | 6
Oophoritis 1 | 10
Opioid-Related Disorders 1 | 7
Osteoarthritis 1 | 184
Ovarian serous cystadenocarcinoma 1 | 5
Panic disorder 1 | 61
Parkinson's disease 1 | 392
Paroxysmal nocturnal hemoglobinuria 1 | 10
Pathologic Neovascularization 1 | 6
Salpingitis 1 | 6
Seizures 1 | 596
Ureteral obstruction 1 | 33
active ulcerative colitis 1 | 764
acute quadriplegic myopathy 1 | 1,158
adrenocortical adenoma 1 | 131
adrenocortical carcinoma 1 | 1,428
astrocytoma 1 | 1,146
autosomal dominant Emery-Dreifuss muscular dystrophy 1 | 510
chronic kidney disease 1 | 90
chronic rhinosinusitis 1 | 512
cystic fibrosis 1 | 1,696
dermatomyositis 1 | 966
hepatocellular carcinoma 1 | 547
limb girdle muscular dystrophy 2A 1 | 213
mucosa-associated lymphoid tissue lymphoma 1 | 484
nasopharyngeal carcinoma 1 | 1,058
pancreatic carcinoma 1 | 562
posterior fossa group B ependymoma 1 | 416
subependymal giant cell astrocytoma 1 | 2,287

Tissue

Liver and Pancreas 7 | 16,750
Urinary Tract 7 | 16,678
Endocrine System 6 | 18,159
Blood and immune system 5 | 16,909
Digestive Tract 5 | 17,369
Female tissues 5 | 17,400
Male tissues 5 | 17,142
Respiratory system 5 | 16,393
Skin and soft tissues 5 | 17,230
Cardiovascular System 4 | 15,192
Nervous System 4 | 16,725

Target Family

Non-IDG 7 | 12,091

Reactome Pathway

Terminal pathway of complement 7 | 7
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Complement component C9 C9 Tbio Non-IDG -1.88910 74.6 285
Complement component C6 C6 Tbio Non-IDG -1.55226 36.1 153
Clusterin CLU Tbio Non-IDG -3.28651 2016.4 826
Complement component C7 C7 Tbio Non-IDG -1.39617 24.3 164
Complement component C8 beta chain C8B Tbio Non-IDG -1.57123 37.0 104
Complement component C8 alpha chain C8A Tbio Non-IDG -1.72118 49.8 10
Complement component C8 gamma chain C8G Tbio Non-IDG -1.56799 34.0 40