Development Level

Tbio 7 | 10,625
Tclin 1 | 602

IMPC Term

abnormal locomotor activation 1 | 26
cardiovascular system phenotyp... 1 | 35
decreased heart rate variabili... 1 | 11
decreased prepulse inhibition 1 | 52
increased aggression 1 | 2
increased circulating sodium l... 1 | 71
shortened RR interval 1 | 19

Disease

pancreatic ductal adenocarcinoma liver metastasis 8 | 1,795
psoriasis 5 | 6,685
Immunologic Deficiency Syndromes 4 | 16
Meningitis 4 | 46
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,289
lung adenocarcinoma 4 | 2,713
lung cancer 4 | 4,466
lung carcinoma 4 | 2,844
non-small cell lung cancer 4 | 2,798
ovarian cancer 4 | 8,484
pancreatic cancer 4 | 2,300
Complement deficiency 3 | 15
invasive ductal carcinoma 3 | 2,950
Atopic dermatitis 2 | 944
Juvenile arthritis 2 | 124
Neisseriaceae Infections 2 | 3
Paroxysmal nocturnal hemoglobinuria 2 | 11
atypical teratoid / rhabdoid tumor 2 | 4,369
breast carcinoma 2 | 1,614
colon cancer 2 | 1,475
ductal carcinoma in situ 2 | 1,745
glioblastoma 2 | 5,572
hepatocellular carcinoma 2 | 532
malignant mesothelioma 2 | 3,162
osteosarcoma 2 | 7,933
pituitary cancer 2 | 1,972
posterior fossa group B ependymoma 2 | 1,530
primary Sjogren syndrome 2 | 789
AMYOTROPHIC LATERAL SCLEROSIS 1 1 | 49
Acute kidney injury 1 | 65
Adverse reaction to drug 1 | 54
Age related macular degeneration 1 | 84
Alzheimer's disease 1 | 644
Amyloidosis 1 | 68
Anemia 1 | 252
Ascariasis 1 | 7
Atherosclerosis 1 | 275
Atrophic 1 | 10
Breast cancer 1 | 3,094
Calcinosis 1 | 62
Cancer 1 | 2,346
Carcinoma 1 | 2,147
Complement component 5 deficiency 1 | 1
Congenital hemolytic uremic syndrome 1 | 1
Cowpox 1 | 15
Degenerative polyarthritis 1 | 93
Dementia 1 | 129
Drug-Induced Liver Injury 1 | 118
Duchenne muscular dystrophy 1 | 602
ECULIZUMAB, POOR RESPONSE TO 1 | 1
Erythema 1 | 4
Facial Dermatoses 1 | 1
Gaucher disease type 3 1 | 76
Heart valve disease 1 | 24
Hypermobility syndrome 1 | 17
Intermittent claudication 1 | 16
Iris disease 1 | 9
Kidney Diseases 1 | 86
Kidney disease 1 | 396
Limb ischemia 1 | 12
Liver carcinoma 1 | 217
Lupus Erythematosus, Systemic 1 | 73
Melanoma 1 | 261
Meningococcal meningitis 1 | 3
Monkeypox 1 | 10
Oophoritis 1 | 9
Opioid-Related Disorders 1 | 7
Ovarian serous cystadenocarcinoma 1 | 4
Panic disorder 1 | 55
Parkinson's disease 1 | 364
Pathologic Neovascularization 1 | 6
Peritonitis 1 | 37
Prostatic Neoplasms 1 | 471
Salpingitis 1 | 6
Seizures 1 | 95
Ureteral disease 1 | 23
active ulcerative colitis 1 | 477
acute quadriplegic myopathy 1 | 1,157
adrenocortical adenoma 1 | 134
adrenocortical carcinoma 1 | 1,427
astrocytoma 1 | 1,493
autosomal dominant Emery-Dreifuss muscular dystrophy 1 | 499
chronic kidney disease 1 | 90
chronic rhinosinusitis 1 | 512
cystic fibrosis 1 | 1,665
dermatomyositis 1 | 933
diabetes mellitus 1 | 1,663
juvenile dermatomyositis 1 | 1,189
limb girdle muscular dystrophy 2A 1 | 156
medulloblastoma 1 | 1,524
mucosa-associated lymphoid tissue lymphoma 1 | 480
nasopharyngeal carcinoma 1 | 1,056
pancreatic carcinoma 1 | 567
pilocytic astrocytoma 1 | 3,086
sonic hedgehog group medulloblastoma 1 | 1,482
subependymal giant cell astrocytoma 1 | 2,287
tuberculosis 1 | 1,557
ulcerative colitis 1 | 2,087

Tissue

Blood and immune system 8 | 17,995
Cardiovascular System 8 | 17,958
Digestive Tract 8 | 18,473
Endocrine System 8 | 18,512
Female tissues 8 | 18,647
Liver and Pancreas 8 | 18,136
Male tissues 8 | 17,969
Nervous System 8 | 18,561
Respiratory system 8 | 17,484
Skin and soft tissues 8 | 18,115
Urinary Tract 8 | 18,444

Target Family

Non-IDG 8 | 11,971

Reactome Pathway

Terminal pathway of complement 8 | 8
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Complement component C9 C9 Tbio Non-IDG -1.85517 71.0 229
Complement component C6 C6 Tbio Non-IDG -1.53803 35.0 124
Complement C5 C5 Tclin Non-IDG -2.19589 154.9 317
Clusterin CLU Tbio Non-IDG -3.24940 1930.4 726
Complement component C7 C7 Tbio Non-IDG -1.37566 24.2 122
Complement component C8 alpha chain C8A Tbio Non-IDG -1.66101 47.5 19
Complement component C8 beta chain C8B Tbio Non-IDG -1.54853 35.4 86
Complement component C8 gamma chain C8G Tbio Non-IDG -1.54943 33.4 22