Development Level

Tbio 40 | 10,625
Tdark 13 | 7,003
Tchem 6 | 1,890
Tclin 3 | 602

IMPC Phenotype

preweaning lethality, complete... 7 | 633
embryonic lethality prior to o... 3 | 148
prenatal lethality prior to he... 2 | 64
abnormal embryo size 1 | 112
abnormal embryo turning 1 | 15
abnormal pharyngeal arch morph... 1 | 2
abnormal rib morphology 1 | 28
decreased KLRG1+ CD4 alpha bet... 1 | 2
decreased body weight 1 | 174
embryonic growth retardation 1 | 28
embryonic lethality prior to t... 1 | 187
increased circulating HDL chol... 1 | 63
increased circulating sodium l... 1 | 71
increased granulocyte number 1 | 8
increased heart weight 1 | 37
increased mean corpuscular hem... 1 | 93
increased mean corpuscular vol... 1 | 91
increased mean platelet volume 1 | 19
polydactyly 1 | 22

Disease

ovarian cancer 32 | 8,491
lung cancer 26 | 4,473
psoriasis 25 | 6,685
malignant mesothelioma 22 | 3,163
Breast cancer 20 | 3,098
non-small cell lung cancer 20 | 2,798
group 3 medulloblastoma 19 | 2,254
medulloblastoma, large-cell 17 | 6,234
osteosarcoma 16 | 7,933
lung adenocarcinoma 14 | 2,714
glioblastoma 13 | 5,572
invasive ductal carcinoma 13 | 2,950
ductal carcinoma in situ 12 | 1,745
intraductal papillary-mucinous neoplasm (IPMN) 12 | 3,289
primitive neuroectodermal tumor 12 | 3,031
colon cancer 11 | 1,475
Cancer 10 | 2,346
atypical teratoid / rhabdoid tumor 10 | 4,369
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,988
Multiple myeloma 9 | 1,327
Waldenstrons macroglobulinemia 9 | 764
breast carcinoma 9 | 1,614
nasopharyngeal carcinoma 8 | 1,056
Dyskeratosis congenita 7 | 24
adrenocortical carcinoma 7 | 1,427
non-small cell lung carcinoma 7 | 413
pediatric high grade glioma 7 | 2,712
cystic fibrosis 6 | 1,670
dermatomyositis 5 | 966
diabetes mellitus 5 | 1,663
oligodendroglioma 5 | 2,849
pancreatic cancer 5 | 2,300
pituitary cancer 5 | 1,972
sonic hedgehog group medulloblastoma 5 | 1,482
subependymal giant cell astrocytoma 5 | 2,287
Carcinoma 4 | 2,147
Colorectal Neoplasms 4 | 217
Endometriosis 4 | 535
HOYERAAL-HREIDARSSON SYNDROME 4 | 7
Mammary Neoplasms 4 | 410
Seckel syndrome 4 | 35
atypical teratoid/rhabdoid tumor 4 | 1,095
chronic lymphocytic leukemia 4 | 244
cutaneous lupus erythematosus 4 | 1,056
ependymoma 4 | 2,514
group 4 medulloblastoma 4 | 1,875
lung carcinoma 4 | 2,844
non primary Sjogren syndrome sicca 4 | 840
posterior fossa group A ependymoma 4 | 1,511
Acute lymphoid leukemia 3 | 25
Acute myeloid leukemia, disease 3 | 16
Acute promyelocytic leukemia, FAB M3 3 | 10
Adenocarcinoma of pancreas 3 | 12
Anemia 3 | 252
Ataxia telangiectasia 3 | 32
Cleft palate 3 | 125
Connective tissue disease 3 | 59
IGA Glomerulonephritis 3 | 454
Leishmaniasis 3 | 49
Lupus erythematosus 3 | 80
Lymphomatous meningitis 3 | 3
Malignant tumor of ovary 3 | 25
Meningeal Leukemia 3 | 7
Metastatic Breast Carcinoma 3 | 21
Werner syndrome 3 | 29
Xeroderma pigmentosum 3 | 41
acute myeloid leukemia 3 | 785
astrocytoma 3 | 1,493
familial melanoma 3 | 10
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,956
posterior fossa group B ependymoma 3 | 1,530
ulcerative colitis 3 | 2,087
Adenocarcinoma 2 | 115
Adenoma 2 | 165
Bipolar Disorder 2 | 266
Bladder Neoplasm 2 | 109
Cockayne syndrome 2 | 54
Colonic Neoplasms 2 | 126
Crohn's disease 2 | 304
Fanconi's anemia 2 | 50
Intellectual disability 2 | 573
Lung Neoplasms 2 | 171
Lynch syndrome 2 | 35
Melanoma 2 | 261
Nijmegen breakage syndrome 2 | 23
Pick disease 2 | 1,893
Testicular cancer 2 | 24
Vaccinia 2 | 37
adult high grade glioma 2 | 2,148
astrocytic glioma 2 | 2,241
gastric cancer 2 | 436
gastric carcinoma 2 | 832
pancreatic carcinoma 2 | 567
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,795
pilocytic astrocytoma 2 | 3,086
primary Sjogren syndrome 2 | 788
primary pancreatic ductal adenocarcinoma 2 | 1,271
spina bifida 2 | 1,064
tuberculosis 2 | 1,563
tuberculosis and treatment for 6 months 2 | 686

Tissue

Female tissues 62 | 18,646
Male tissues 62 | 17,968
Blood and immune system 61 | 17,994
Cardiovascular System 61 | 17,957
Digestive Tract 61 | 18,472
Endocrine System 61 | 18,511
Nervous System 61 | 18,560
Urinary Tract 61 | 18,443
Liver and Pancreas 60 | 18,135
Respiratory system 60 | 17,483
Skin and soft tissues 54 | 18,114

Target Family

Non-IDG 43 | 11,969
Enzyme 17 | 4,146
Transcription Factor 2 | 1,400

Reactome Pathway

Telomere Maintenance 62 | 62
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone H2A type 1-J HIST1H2AJ Tdark Non-IDG -0.13212 1.19 10
Histone H2B type 1-M HIST1H2BM Tdark Non-IDG 0.16 0.33 20
Histone H2B type 1-L HIST1H2BL Tdark Non-IDG 0.35 0.40 42
Histone H2B type 1-N HIST1H2BN Tdark Non-IDG -1.51554 30.2 48
Histone H2A type 1-B/E HIST1H2AB Tbio Non-IDG -1.26707 18.9 109
Flap endonuclease 1 FEN1 Tchem Enzyme -2.77484 533.8 332
Telomeric repeat-binding factor 2-interacting protein 1 TERF2IP Tchem Non-IDG -0.74218 5.60 257
DNA polymerase epsilon subunit 3 POLE3 Tbio Enzyme -0.73319 5.86 173
Telomeric repeat-binding factor 1 TERF1 Tbio Transcription Factor -2.59468 394.2 416
DNA polymerase epsilon subunit 4 POLE4 Tdark Enzyme -0.36530 2.18 29