Development Level

Tbio 5 | 11,651
Tclin 1 | 612
Tdark 1 | 6,593

IMPC Phenotype

decreased erythrocyte cell num... 1 | 62
decreased mean corpuscular hem... 1 | 31
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
increased mean corpuscular vol... 1 | 92
preweaning lethality, complete... 1 | 979

Disease

group 3 medulloblastoma 5 | 4,104
medulloblastoma, large-cell 5 | 6,241
non-small cell lung cancer 5 | 2,890
malignant mesothelioma 4 | 3,232
osteosarcoma 4 | 7,950
psoriasis 4 | 6,694
glioblastoma 3 | 5,792
lung cancer 3 | 4,740
ovarian cancer 3 | 8,520
primitive neuroectodermal tumor 3 | 3,035
Waldenstrons macroglobulinemia 2 | 765
adrenocortical carcinoma 2 | 1,428
adult high grade glioma 2 | 3,801
atypical teratoid / rhabdoid tumor 2 | 5,112
Acute lymphoid leukemia 1 | 25
Acute myeloid leukemia, disease 1 | 30
Acute promyelocytic leukemia, FAB M3 1 | 11
Adenocarcinoma of pancreas 1 | 14
Astrocytoma, Pilocytic 1 | 3,081
Autosomal recessive predisposition 1 | 1,442
Breast cancer 1 | 3,578
Broad forehead 1 | 59
COLORECTAL CANCER, SUSCEPTIBILITY TO, 12 1 | 1
Cancer 1 | 2,499
Carcinoma 1 | 11,493
Colorectal Neoplasms 1 | 243
Congenital anomaly of face 1 | 56
Distortion of face 1 | 46
Dysmorphic facies 1 | 46
Endometrial cancer 1 | 311
FACIAL DYSMORPHISM, IMMUNODEFICIENCY, LIVEDO, AND SHORT STATURE 1 | 1
Familial adenomatous polyposis 1 | 32
Funny looking face 1 | 46
Gaucher disease type 1 1 | 180
Hypotrophic malar bone 1 | 129
Immunologic Deficiency Syndromes 1 | 113
Kidney cancer 1 | 2,613
Lymphomatous meningitis 1 | 3
Lynch syndrome 1 | 35
Malar flattening 1 | 129
Malignant tumor of ovary 1 | 25
Meningeal Leukemia 1 | 7
Metastatic Breast Carcinoma 1 | 21
Multiple myeloma 1 | 1,332
Ovarian serous carcinoma 1 | 5
Prenatal onset 1 | 139
Recurrent respiratory infections 1 | 141
Relative macrocephaly 1 | 12
Seckel syndrome 1 | 34
Short stature 1 | 531
Telangiectasia on the cheeks 1 | 1
acute myeloid leukemia 1 | 783
astrocytic glioma 1 | 2,597
colon cancer 1 | 1,478
diabetes mellitus 1 | 1,728
ductal carcinoma in situ 1 | 1,745
ependymoma 1 | 4,679
facial deformity 1 | 46
group 4 medulloblastoma 1 | 1,855
intraductal papillary-mucinous carcinoma (IPMC) 1 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 1 | 3,291
invasive ductal carcinoma 1 | 2,951
lung adenocarcinoma 1 | 2,716
lung carcinoma 1 | 2,843
non primary Sjogren syndrome sicca 1 | 891
oligodendroglioma 1 | 2,850
pediatric high grade glioma 1 | 1,064
posterior fossa group A ependymoma 1 | 468
primary Sjogren syndrome 1 | 735
tuberculosis 1 | 2,010

Tissue

Blood and immune system 7 | 16,909
Cardiovascular System 7 | 15,192
Digestive Tract 7 | 17,369
Endocrine System 7 | 18,159
Female tissues 7 | 17,400
Liver and Pancreas 7 | 16,750
Male tissues 7 | 17,142
Nervous System 7 | 16,725
Respiratory system 7 | 16,393
Skin and soft tissues 7 | 17,230
Urinary Tract 7 | 16,678

Target Family

Enzyme 7 | 4,145

Reactome Pathway

Telomere C-strand synthesis in... 7 | 7
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA polymerase epsilon catalytic subunit A POLE Tclin Enzyme -2.22644 169.3 112
DNA primase small subunit PRIM1 Tbio Enzyme -0.87865 7.80 138
DNA polymerase epsilon subunit 2 POLE2 Tbio Enzyme -1.21461 16.8 91
DNA polymerase alpha subunit B POLA2 Tbio Enzyme -0.54940 3.76 182
DNA primase large subunit PRIM2 Tbio Enzyme 0.00000 89
DNA polymerase epsilon subunit 4 POLE4 Tdark Enzyme -0.42363 2.18 40
DNA polymerase epsilon subunit 3 POLE3 Tbio Enzyme -0.78662 5.86 154