Development Level

Tbio 5 | 10,625
Tclin 2 | 602
Tdark 1 | 7,003

IMPC Term

increased circulating sodium l... 1 | 71
preweaning lethality, complete... 1 | 633

Disease

medulloblastoma, large-cell 6 | 6,234
non-small cell lung cancer 6 | 2,798
malignant mesothelioma 5 | 3,162
glioblastoma 4 | 5,572
group 3 medulloblastoma 4 | 2,254
osteosarcoma 4 | 7,933
pediatric high grade glioma 4 | 2,712
primitive neuroectodermal tumor 4 | 3,031
psoriasis 4 | 6,685
atypical teratoid / rhabdoid tumor 3 | 4,369
lung cancer 3 | 4,466
ovarian cancer 3 | 8,484
Acute lymphoid leukemia 2 | 25
Acute myeloid leukemia, disease 2 | 16
Acute promyelocytic leukemia, FAB M3 2 | 10
Adenocarcinoma of pancreas 2 | 12
Lymphomatous meningitis 2 | 3
Malignant tumor of ovary 2 | 25
Meningeal Leukemia 2 | 7
Metastatic Breast Carcinoma 2 | 21
Waldenstrons macroglobulinemia 2 | 765
adrenocortical carcinoma 2 | 1,427
colon cancer 2 | 1,475
posterior fossa group A ependymoma 2 | 1,511
sonic hedgehog group medulloblastoma 2 | 1,482
tuberculosis 2 | 1,557
Adenoma 1 | 165
Age related macular degeneration 1 | 84
Breast cancer 1 | 3,094
COLORECTAL CANCER, SUSCEPTIBILITY TO, 12 1 | 1
Cancer 1 | 2,346
Carcinoma 1 | 2,147
Chronic lymphoid leukemia, disease 1 | 10
Colorectal Neoplasms 1 | 217
FACIAL DYSMORPHISM, IMMUNODEFICIENCY, LIVEDO, AND SHORT STATURE 1 | 1
Familial adenomatous polyposis 1 | 31
Gaucher disease type 1 1 | 171
IGA Glomerulonephritis 1 | 454
Lynch syndrome 1 | 33
Menopause present (finding) 1 | 20
Multiple myeloma 1 | 1,327
Ovarian serous carcinoma 1 | 7
Seckel syndrome 1 | 34
Syphilis 1 | 18
Thoracic outlet syndrome 1 | 8
acute myeloid leukemia 1 | 780
astrocytic glioma 1 | 2,241
diabetes mellitus 1 | 1,663
ductal carcinoma in situ 1 | 1,745
group 4 medulloblastoma 1 | 1,875
intraductal papillary-mucinous carcinoma (IPMC) 1 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 1 | 3,289
invasive ductal carcinoma 1 | 2,950
lung adenocarcinoma 1 | 2,713
lung carcinoma 1 | 2,844
non primary Sjogren syndrome sicca 1 | 840
oligodendroglioma 1 | 2,849
pilocytic astrocytoma 1 | 3,086
primary Sjogren syndrome 1 | 789

Tissue

Blood and immune system 8 | 17,995
Cardiovascular System 8 | 17,958
Digestive Tract 8 | 18,473
Endocrine System 8 | 18,512
Female tissues 8 | 18,647
Liver and Pancreas 8 | 18,136
Male tissues 8 | 17,969
Nervous System 8 | 18,561
Respiratory system 8 | 17,484
Skin and soft tissues 8 | 18,115
Urinary Tract 8 | 18,444

Target Family

Enzyme 8 | 4,146

Reactome Pathway

Telomere C-strand synthesis in... 8 | 8
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA primase large subunit PRIM2 Tbio Enzyme 0.00000 76
DNA primase small subunit PRIM1 Tbio Enzyme -0.88906 8.05 121
DNA polymerase alpha subunit B POLA2 Tbio Enzyme -0.38860 3.09 163
DNA polymerase epsilon subunit 2 POLE2 Tbio Enzyme -1.20476 16.8 88
DNA polymerase alpha catalytic subunit POLA1 Tclin Enzyme -2.37398 244.4 128
DNA polymerase epsilon catalytic subunit A POLE Tclin Enzyme -2.10763 141.2 65
DNA polymerase epsilon subunit 4 POLE4 Tdark Enzyme -0.37180 2.18 29
DNA polymerase epsilon subunit 3 POLE3 Tbio Enzyme -0.73813 5.86 173