Development Level

Tbio 15 | 11,651
Tchem 4 | 1,388
Tclin 3 | 612
Tdark 1 | 6,593

IMPC Phenotype

preweaning lethality, complete... 6 | 979
embryonic lethality prior to o... 5 | 239
embryonic lethality prior to t... 2 | 278
increased mean corpuscular vol... 2 | 92
abnormal embryo size 1 | 220
abnormal embryo turning 1 | 31
abnormal pharyngeal arch morph... 1 | 8
decreased circulating glucose ... 1 | 126
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased mean corpuscular hem... 1 | 31
embryonic growth retardation 1 | 106
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased heart weight 1 | 62
increased mean corpuscular hem... 1 | 96
prenatal lethality prior to he... 1 | 87

Disease

group 3 medulloblastoma 16 | 4,104
malignant mesothelioma 15 | 3,232
non-small cell lung cancer 13 | 2,890
ovarian cancer 13 | 8,520
medulloblastoma, large-cell 12 | 6,241
lung cancer 10 | 4,740
osteosarcoma 10 | 7,950
primitive neuroectodermal tumor 10 | 3,035
psoriasis 10 | 6,694
Carcinoma 9 | 11,493
atypical teratoid / rhabdoid tumor 8 | 5,112
glioblastoma 8 | 5,792
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,291
Waldenstrons macroglobulinemia 6 | 765
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989
Breast cancer 5 | 3,578
adrenocortical carcinoma 5 | 1,428
adult high grade glioma 5 | 3,801
nasopharyngeal carcinoma 5 | 1,058
Cancer 4 | 2,499
Colorectal Neoplasms 4 | 243
Kidney cancer 4 | 2,613
Xeroderma pigmentosum 4 | 43
colon cancer 4 | 1,478
diabetes mellitus 4 | 1,728
ductal carcinoma in situ 4 | 1,745
ependymoma 4 | 4,679
lung adenocarcinoma 4 | 2,716
oligodendroglioma 4 | 2,850
Acute lymphoid leukemia 3 | 25
Acute myeloid leukemia, disease 3 | 30
Acute promyelocytic leukemia, FAB M3 3 | 11
Adenocarcinoma of pancreas 3 | 14
Lymphomatous meningitis 3 | 3
Malignant tumor of ovary 3 | 25
Meningeal Leukemia 3 | 7
Metastatic Breast Carcinoma 3 | 21
Short stature 3 | 531
invasive ductal carcinoma 3 | 2,951
pediatric high grade glioma 3 | 1,064
Ataxia telangiectasia 2 | 34
Autosomal recessive predisposition 2 | 1,442
Bloom syndrome 2 | 29
Broad forehead 2 | 59
Chronic Lymphocytic Leukemia 2 | 262
Cockayne syndrome 2 | 60
Cognitive delay 2 | 608
Colonic Neoplasms 2 | 142
Cryptorchidism 2 | 296
Deafness 2 | 198
Dull intelligence 2 | 645
Endometriosis 2 | 540
Failure to thrive in infancy 2 | 32
Familial adenomatous polyposis 2 | 32
Global developmental delay 2 | 608
Hernia, Inguinal 2 | 89
Hyperkyphosis 2 | 111
Hypoplastic mandible condyle 2 | 275
Intellectual disability 2 | 1,016
Kyphosis deformity of spine 2 | 114
Low Vision 2 | 174
Low intelligence 2 | 645
Lynch syndrome 2 | 35
Mandibular hypoplasia 2 | 275
Mental Retardation 2 | 645
Mental and motor retardation 2 | 608
Mental deficiency 2 | 645
Micrognathism 2 | 275
Muscle Spasticity 2 | 195
Poor school performance 2 | 645
Seckel syndrome 2 | 34
Sensorineural Hearing Loss (disorder) 2 | 284
Visual Impairment 2 | 174
acute myeloid leukemia 2 | 783
astrocytic glioma 2 | 2,597
astrocytoma 2 | 1,146
dermatomyositis 2 | 966
non primary Sjogren syndrome sicca 2 | 891
pituitary cancer 2 | 1,972
primary Sjogren syndrome 2 | 735
tuberculosis 2 | 2,010
Acquired flat foot 1 | 72
Cellulitis of periorbital region 1 | 13
Cerebellar Dysmetria 1 | 56
Cerebral Ischemia 1 | 37
Elfin facies 1 | 10
Hyperacusis 1 | 11
Hypoplastic toenails 1 | 22
Microdontia (disorder) 1 | 59
Mitral Valve Prolapse Syndrome 1 | 39
Narrow face 1 | 54
Obsessive compulsive behavior 1 | 25
Open Bite 1 | 21
Pelvic kidney 1 | 10
Periorbital edema 1 | 13
Periorbital swelling 1 | 13
Peripheral pulmonary artery stenosis 1 | 14
Phonophobia 1 | 11
Sleeplessness 1 | 16
Williams Syndrome 1 | 10

Tissue

Blood and immune system 23 | 16,909
Cardiovascular System 23 | 15,192
Digestive Tract 23 | 17,369
Endocrine System 23 | 18,159
Female tissues 23 | 17,400
Liver and Pancreas 23 | 16,750
Male tissues 23 | 17,142
Nervous System 23 | 16,725
Respiratory system 23 | 16,393
Skin and soft tissues 23 | 17,230
Urinary Tract 23 | 16,678

Target Family

Enzyme 14 | 4,145
Non-IDG 9 | 12,091

Reactome Pathway

Telomere C-strand (Lagging Str... 23 | 23
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA polymerase delta catalytic subunit POLD1 Tclin Enzyme -2.06760 110.4 225
Flap endonuclease 1 FEN1 Tchem Enzyme -2.79171 617.0 406
DNA polymerase delta subunit 2 POLD2 Tbio Enzyme -0.95222 8.52 115
Replication protein A 70 kDa DNA-binding subunit RPA1 Tchem Non-IDG -2.48277 297.9 350
Replication factor C subunit 4 RFC4 Tbio Non-IDG -1.17661 13.7 195
Replication factor C subunit 5 RFC5 Tbio Non-IDG -1.06074 11.3 79
Proliferating cell nuclear antigen PCNA Tchem Non-IDG -1.13711 11.3 1721
Replication protein A 32 kDa subunit RPA2 Tbio Non-IDG -1.79461 61.4 510
DNA polymerase epsilon catalytic subunit A POLE Tclin Enzyme -2.22644 169.3 112
DNA primase small subunit PRIM1 Tbio Enzyme -0.87865 7.80 138