Development Level

Tbio 36 | 10,625
Tchem 3 | 1,890
Tdark 1 | 7,003

IMPC Phenotype

preweaning lethality, complete... 3 | 633
embryonic lethality prior to o... 2 | 148
embryonic lethality prior to t... 2 | 187
abnormal epididymis morphology 1 | 31
abnormal heart morphology 1 | 51
abnormal retina morphology 1 | 100
abnormal skin morphology 1 | 23
decreased body length 1 | 108
decreased circulating sodium l... 1 | 18
enlarged epididymis 1 | 27
enlarged heart 1 | 111
increased circulating free fat... 1 | 17
increased circulating potassiu... 1 | 31
increased or absent threshold ... 1 | 128

Disease

ovarian cancer 21 | 8,491
lung cancer 14 | 4,473
osteosarcoma 13 | 7,933
Cockayne syndrome 10 | 54
psoriasis 9 | 6,685
Multiple myeloma 8 | 1,327
Photosensitive trichothiodystrophy 8 | 24
diabetes mellitus 7 | 1,663
Cancer 6 | 2,346
Xeroderma pigmentosum 6 | 41
glioblastoma 6 | 5,572
medulloblastoma, large-cell 6 | 6,234
Breast cancer 5 | 3,098
acute quadriplegic myopathy 5 | 1,157
malignant mesothelioma 5 | 3,163
pediatric high grade glioma 5 | 2,712
Peripheral Neuropathy 4 | 303
Pick disease 4 | 1,893
Wolf-Hirschhorn syndrome 4 | 32
acute myeloid leukemia 4 | 785
astrocytoma 4 | 1,493
atypical teratoid / rhabdoid tumor 4 | 4,369
breast carcinoma 4 | 1,614
ependymoma 4 | 2,514
lung adenocarcinoma 4 | 2,714
primitive neuroectodermal tumor 4 | 3,031
Carcinoma 3 | 2,147
Trichothiodystrophy 1, photosensitive 3 | 4
Trichothiodystrophy Syndromes 3 | 5
group 3 medulloblastoma 3 | 2,254
hepatocellular carcinoma 3 | 550
medulloblastoma 3 | 1,524
non-small cell lung cancer 3 | 2,798
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,795
Acquired immunodeficiency syndrome 2 | 164
Baller-Gerold syndrome 2 | 14
Cataract 2 | 104
Mixed connective tissue disease 2 | 16
Rothmund-Thomson syndrome 2 | 22
Waldenstrons macroglobulinemia 2 | 764
Xeroderma pigmentosum-Cockayne syndrome complex 2 | 4
aldosterone-producing adenoma 2 | 664
astrocytic glioma 2 | 2,241
atypical teratoid/rhabdoid tumor 2 | 1,095
inflammatory breast cancer 2 | 404
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,988
non primary Sjogren syndrome sicca 2 | 840
oligodendroglioma 2 | 2,849
pancreatic cancer 2 | 2,300
pancreatic carcinoma 2 | 567
pilocytic astrocytoma 2 | 3,086
pituitary cancer 2 | 1,972
subependymal giant cell astrocytoma 2 | 2,287
tuberculosis 2 | 1,563
Age related macular degeneration 1 | 84
Animal Mammary Neoplasms 1 | 135
Arsenic Poisoning 1 | 59
Asthenopia 1 | 11
Barrett's esophagus 1 | 185
Bladder Neoplasm 1 | 109
Chikungunya 1 | 12
Ciliary Dyskinesia, Primary, 1 1 | 27
Colorectal Neoplasms 1 | 217
Dermatologic disorders 1 | 65
Eumycotic mycetoma 1 | 3
Ewing sarcoma 1 | 27
Fusariosis 1 | 6
Gaucher disease type 3 1 | 76
Hypogonadism 1 | 70
Keratitis 1 | 42
Keratosis 1 | 34
La Crosse encephalitis 1 | 6
Macular degeneration 1 | 44
Malignant neoplasm of breast 1 | 63
Malignant neoplasm of lung 1 | 16
Mammary Neoplasms, Experimental 1 | 149
Megaloblastic anemia 1 | 18
Mental depression 1 | 58
Microcephaly 1 | 149
Muscular atrophy 1 | 67
Myoglobinuria 1 | 11
Neuropathy 1 | 210
Orchitis 1 | 16
Palmoplantar keratosis 1 | 36
Progressive multifocal leukoencephalopathy 1 | 24
Rift Valley fever 1 | 13
Skin Neoplasms 1 | 49
Skin benign neoplasm 1 | 5
Specific language impairment 1 | 31
Squamous cell carcinoma 1 | 96
Staphyloenterotoxemia 1 | 20
Stomach Neoplasms 1 | 282
Subcutaneous mycosis 1 | 1
Sunburn 1 | 3
Tinea pedis 1 | 30
Tyrosinemia 1 | 12
Vaccinia 1 | 37
Werner syndrome 1 | 29
sarcoidosis 1 | 368
tuberculosis and treatment for 3 months 1 | 327

Tissue

Blood and immune system 40 | 17,994
Cardiovascular System 40 | 17,957
Digestive Tract 40 | 18,472
Endocrine System 40 | 18,511
Female tissues 40 | 18,646
Liver and Pancreas 40 | 18,135
Male tissues 40 | 17,968
Nervous System 40 | 18,560
Respiratory system 40 | 17,483
Skin and soft tissues 40 | 18,114
Urinary Tract 40 | 18,443

Target Family

Enzyme 19 | 4,146
Non-IDG 18 | 11,969
Kinase 2 | 634
Transcription Factor 1 | 1,400

Reactome Pathway

Tat-mediated elongation of the... 40 | 40
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA-directed RNA polymerase II subunit RPB2 POLR2B Tbio Enzyme -2.47495 286.5 135
Nuclear cap-binding protein subunit 1 NCBP1 Tbio Non-IDG -2.31776 194.4 161
DNA-directed RNA polymerases I, II, and III subunit RPABC3 POLR2H Tbio Enzyme -1.14104 13.5 159
DNA-directed RNA polymerase II subunit RPB11-a POLR2J Tbio Enzyme -1.42612 28.8 182
General transcription factor IIH subunit 3 GTF2H3 Tbio Non-IDG -0.87291 6.02 65
General transcription factor IIH subunit 2 GTF2H2 Tbio Non-IDG -1.31733 6.84 120
DNA-directed RNA polymerases I, II, and III subunit RPABC4 POLR2K Tbio Enzyme -0.89072 7.36 47
General transcription factor IIH subunit 1 GTF2H1 Tbio Non-IDG -1.64263 41.9 218
Negative elongation factor E NELFE Tbio Non-IDG -1.43797 27.6 85
FACT complex subunit SSRP1 SSRP1 Tbio Transcription Factor -1.70343 51.1 240