Development Level

Tbio 39 | 11,651
Tdark 4 | 6,593
Tchem 3 | 1,388

IMPC Phenotype

preweaning lethality, complete... 5 | 979
embryonic lethality prior to o... 3 | 239
embryonic lethality prior to t... 3 | 278
abnormal epididymis morphology 1 | 42
abnormal heart morphology 1 | 162
abnormal retina morphology 1 | 71
abnormal skin morphology 1 | 50
decreased KLRG1+ CD4 alpha bet... 1 | 5
decreased circulating sodium l... 1 | 22
decreased vertical activity 1 | 208
enlarged epididymis 1 | 31
enlarged heart 1 | 210
increased anti-nuclear antigen... 1 | 19
increased circulating free fat... 1 | 20
increased circulating potassiu... 1 | 29
increased heart rate 1 | 23
shortened RR interval 1 | 17

Disease

Carcinoma 23 | 11,493
ovarian cancer 23 | 8,520
lung cancer 14 | 4,740
osteosarcoma 13 | 7,950
Cockayne syndrome 12 | 60
psoriasis 11 | 6,694
Multiple myeloma 10 | 1,332
Photosensitive trichothiodystrophy 9 | 30
Breast cancer 8 | 3,578
diabetes mellitus 8 | 1,728
Kidney cancer 7 | 2,613
Xeroderma pigmentosum group B 7 | 20
glioblastoma 7 | 5,792
medulloblastoma, large-cell 7 | 6,241
atypical teratoid / rhabdoid tumor 6 | 5,112
Cancer 5 | 2,499
Xeroderma pigmentosum 5 | 43
acute myeloid leukemia 5 | 783
acute quadriplegic myopathy 5 | 1,158
astrocytoma 5 | 1,146
ependymoma 5 | 4,679
malignant mesothelioma 5 | 3,232
Autosomal recessive predisposition 4 | 1,442
Cerebellar Ataxia 4 | 304
Dull intelligence 4 | 645
Hereditary spherocytosis type 5 4 | 12
Intellectual disability 4 | 1,016
Low intelligence 4 | 645
Mental Retardation 4 | 645
Mental deficiency 4 | 645
Poor school performance 4 | 645
Xeroderma pigmentosum group D 4 | 33
breast carcinoma 4 | 1,638
group 3 medulloblastoma 4 | 4,104
lung adenocarcinoma 4 | 2,716
pediatric high grade glioma 4 | 1,064
primitive neuroectodermal tumor 4 | 3,035
Abnormally small eyeball 3 | 97
Cataract 3 | 297
Cognitive delay 3 | 608
Congenital deafness 3 | 185
Cryptorchidism 3 | 296
Deafness 3 | 198
Decreased size of eyeball 3 | 97
Dental abnormalities 3 | 60
Failure to gain weight 3 | 365
Fetal Growth Retardation 3 | 189
Global developmental delay 3 | 608
Hearing Loss, Partial 3 | 185
Hemangioma 3 | 69
Hypoplastic mandible condyle 3 | 275
Impaired cognition 3 | 96
Infant, Small for Gestational Age 3 | 176
Intrauterine retardation 3 | 176
Keratitis 3 | 62
Lens Opacities 3 | 231
Mandibular hypoplasia 3 | 275
Mental and motor retardation 3 | 608
Mental impairment 3 | 95
Micrognathism 3 | 275
Microphthalmos 3 | 100
Optic Atrophy 3 | 242
Pediatric failure to thrive 3 | 365
Pick disease 3 | 1,894
Short stature 3 | 531
Small head 3 | 374
Strabismus 3 | 270
Tooth Abnormalities 3 | 69
Trichothiodystrophy 1, photosensitive 3 | 4
Trichothiodystrophy Syndromes 3 | 6
Waldenstrons macroglobulinemia 3 | 765
Wolf-Hirschhorn syndrome 3 | 32
Xeroderma pigmentosum group G 3 | 16
adult high grade glioma 3 | 3,801
hearing impairment 3 | 199
hepatocellular carcinoma 3 | 547
non-small cell lung cancer 3 | 2,890
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
Broad flat nasal bridge 2 | 236
Cerebral atrophy 2 | 178
Congenital anomaly of face 2 | 56
Congenital clubfoot 2 | 109
Developmental regression 2 | 95
Electroencephalogram abnormal 2 | 101
Epilepsy 2 | 792
Loss of developmental milestones 2 | 95
Melanoma 2 | 711
Mental deterioration in childhood 2 | 95
Muscle Spasticity 2 | 195
Nasal bridge wide 2 | 236
Neurodevelopmental regression 2 | 95
Psychomotor regression 2 | 95
Psychomotor regression beginning in infancy 2 | 95
Psychomotor regression in infants 2 | 95
Psychomotor regression, progressive 2 | 95
Seizures 2 | 596
aldosterone-producing adenoma 2 | 665
pancreatic carcinoma 2 | 562
pituitary cancer 2 | 1,972
tuberculosis and treatment for 3 months 2 | 179

Tissue

Blood and immune system 43 | 16,909
Digestive Tract 43 | 17,369
Endocrine System 43 | 18,159
Female tissues 43 | 17,400
Liver and Pancreas 43 | 16,750
Nervous System 43 | 16,725
Respiratory system 43 | 16,393
Skin and soft tissues 43 | 17,230
Urinary Tract 43 | 16,678
Cardiovascular System 42 | 15,192
Male tissues 42 | 17,142

Target Family

Enzyme 23 | 4,145
Non-IDG 20 | 12,091
Kinase 2 | 634
Transcription Factor 1 | 1,400

Reactome Pathway

Tat-mediated elongation of the... 46 | 46
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
General transcription factor IIH subunit 1 GTF2H1 Tbio Non-IDG -1.65323 46.0 231
Nuclear cap-binding protein subunit 2 NCBP2 Tbio Non-IDG -1.45099 24.2 110
DNA-directed RNA polymerase II subunit RPB11-a POLR2J Tbio Enzyme -1.43224 29.3 213
Nuclear cap-binding protein subunit 1 NCBP1 Tbio Non-IDG -2.34134 207.7 172
DNA-directed RNA polymerase II subunit RPB7 POLR2G Tbio Enzyme -1.77350 60.4 174
General transcription factor IIH subunit 3 GTF2H3 Tbio Non-IDG -0.87291 7.21 78
Transcription elongation factor SPT4 SUPT4H1 Tbio Non-IDG -1.65513 43.4 92
Tyrosine aminotransferase TAT Tbio Enzyme -3.06741 1138.7 162
DNA-directed RNA polymerase II subunit RPB2 POLR2B Tbio Enzyme -2.49730 299.8 149
Negative elongation factor B NELFB Tbio Non-IDG -1.16040 16.4 158