Development Level

Tbio 29 | 11,445
Tdark 4 | 6,588
Tchem 1 | 1,598

IMPC Phenotype

embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
preweaning lethality, complete... 2 | 979
abnormal epididymis morphology 1 | 42
abnormal heart morphology 1 | 162
abnormal skin morphology 1 | 50
decreased circulating sodium l... 1 | 22
decreased vertical activity 1 | 208
enlarged epididymis 1 | 31
enlarged heart 1 | 210
increased circulating free fat... 1 | 20
increased heart rate 1 | 23
shortened RR interval 1 | 17

Disease

Carcinoma 17 | 11,493
ovarian cancer 17 | 8,520
Multiple myeloma 10 | 1,332
lung cancer 10 | 4,740
osteosarcoma 9 | 7,950
psoriasis 9 | 6,694
diabetes mellitus 8 | 1,728
Breast cancer 6 | 3,578
Kidney cancer 6 | 2,613
medulloblastoma, large-cell 6 | 6,241
atypical teratoid / rhabdoid tumor 5 | 5,112
glioblastoma 5 | 5,792
Cockayne syndrome 4 | 60
Hereditary spherocytosis type 5 4 | 12
astrocytoma 4 | 1,146
malignant mesothelioma 4 | 3,232
primitive neuroectodermal tumor 4 | 3,035
Cancer 3 | 2,499
Hemangioma 3 | 69
Wolf-Hirschhorn syndrome 3 | 32
acute myeloid leukemia 3 | 783
ependymoma 3 | 4,679
group 3 medulloblastoma 3 | 4,104
lung adenocarcinoma 3 | 2,716
pediatric high grade glioma 3 | 1,064
Autosomal recessive predisposition 2 | 1,442
Cerebellar Ataxia 2 | 304
Claw hand 2 | 26
Cognitive delay 2 | 608
Congenital clubfoot 2 | 109
Congenital myasthenic syndrome 5 2 | 11
Dull intelligence 2 | 645
Fetal Growth Retardation 2 | 189
Global developmental delay 2 | 608
Hypoplastic mandible condyle 2 | 275
Infant, Small for Gestational Age 2 | 176
Intellectual disability 2 | 1,016
Intrauterine retardation 2 | 176
Low intelligence 2 | 645
Mandibular hypoplasia 2 | 275
Mental Retardation 2 | 645
Mental and motor retardation 2 | 608
Mental deficiency 2 | 645
Micrognathism 2 | 275
Mixed connective tissue disease 2 | 16
Poor school performance 2 | 645
Tinea capitis 2 | 14
Waldenstrons macroglobulinemia 2 | 765
Xeroderma pigmentosum group B 2 | 20
acute quadriplegic myopathy 2 | 1,158
adult high grade glioma 2 | 3,801
astrocytic glioma 2 | 2,597
breast carcinoma 2 | 1,638
dermatomyositis 2 | 966
group 4 medulloblastoma 2 | 1,855
hepatocellular carcinoma 2 | 547
invasive ductal carcinoma 2 | 2,951
non primary Sjogren syndrome sicca 2 | 891
oligodendroglioma 2 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
subependymal giant cell astrocytoma 2 | 2,287
Abnormally-shaped vertebrae 1 | 31
Acquired immunodeficiency syndrome 1 | 197
Arachnodactyly 1 | 49
Atrial Septal Defects 1 | 85
Autosomal recessive limb-girdle muscular dystrophy type 2C 1 | 2
Carcinoma, Renal Cell 1 | 124
Cerebellar Dysmetria 1 | 56
Chikungunya 1 | 16
Congenital diaphragmatic hernia 1 | 67
Decreased motor NCV 1 | 22
Dental abnormalities 1 | 60
Endometriosis of ovary 1 | 5
Gaucher disease type 3 1 | 67
Heart valve disease 1 | 39
Hyperkyphosis 1 | 111
Hypodontia 1 | 81
Hypogonadism, Isolated Hypogonadotropic 1 | 71
Hypogonadotropic hypogonadism 1 | 89
Keratosis 1 | 37
Kyphoscoliosis deformity of spine 1 | 60
Kyphosis deformity of spine 1 | 114
La Crosse encephalitis 1 | 5
Low posterior hairline 1 | 52
Low serum estradiol levels 1 | 22
Macular degeneration 1 | 65
Meningioma 1 | 41
Mild Mental Retardation 1 | 70
Neuronal ceroid lipofuscinosis 2 1 | 17
Palmoplantar keratosis 1 | 74
Peripheral demyelination 1 | 16
Polydactyly preaxial type 1 1 | 9
Primary hypogonadism 1 | 37
Renal Cell Carcinoma 1 | 214
Skin Abnormalities 1 | 37
Specific language impairment 1 | 34
Staphyloenterotoxemia 1 | 18
Tooth Abnormalities 1 | 69
Tyrosinemia 1 | 10
sarcoidosis 1 | 370

Tissue

Blood and immune system 31 | 16,909
Digestive Tract 31 | 17,369
Endocrine System 31 | 18,159
Female tissues 31 | 17,400
Liver and Pancreas 31 | 16,750
Nervous System 31 | 16,725
Respiratory system 31 | 16,393
Skin and soft tissues 31 | 17,230
Urinary Tract 31 | 16,678
Cardiovascular System 30 | 15,192
Male tissues 30 | 17,142

Target Family

Enzyme 20 | 4,145
Non-IDG 12 | 12,091
Kinase 1 | 634
Transcription Factor 1 | 1,400

Reactome Pathway

Tat-mediated HIV elongation ar... 34 | 34
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Negative elongation factor B NELFB Tbio Non-IDG -1.16040 16.4 158
DNA-directed RNA polymerase II subunit RPB2 POLR2B Tbio Enzyme -2.49730 299.8 149
DNA-directed RNA polymerases I, II, and III subunit RPABC2 POLR2F Tbio Enzyme -1.13403 13.9 68
DNA-directed RNA polymerases I, II, and III subunit RPABC4 POLR2K Tbio Enzyme -0.90716 7.36 65
RNA polymerase II subunit A C-terminal domain phosphatase CTDP1 Tbio Enzyme -1.88697 80.7 113
FACT complex subunit SPT16 SUPT16H Tbio Enzyme -1.85453 70.7 324
DNA-directed RNA polymerases I, II, and III subunit RPABC3 POLR2H Tbio Enzyme -1.13403 13.5 180
DNA-directed RNA polymerases I, II, and III subunit RPABC5 POLR2L Tbio Enzyme -1.12793 13.8 66
Elongin-A3 ELOA3B Tdark Enzyme -0.30480 2.60 49
General transcription factor IIF subunit 2 GTF2F2 Tbio Non-IDG -1.55064 36.2 192