Development Level

Tchem 18 | 1,598
Tbio 3 | 11,445
Tclin 3 | 613

IMPC Phenotype

limb grasping 2 | 41
abnormal forelimb morphology 1 | 2
abnormal gait 1 | 69
abnormal locomotor activation 1 | 16
abnormal response to new envir... 1 | 10
corneal vascularization 1 | 6
decreased body weight 1 | 161
decreased circulating amylase ... 1 | 28
decreased circulating glycerol... 1 | 16
decreased circulating triglyce... 1 | 79
decreased prepulse inhibition 1 | 82
hyperactivity 1 | 148
increased lean body mass 1 | 172
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
mammalian phenotype 1 | 17
preweaning lethality, complete... 1 | 979
preweaning lethality, incomple... 1 | 499
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36

Disease

Carcinoma 23 | 11,493
Kidney cancer 14 | 2,613
osteosarcoma 8 | 7,950
psoriasis 8 | 6,694
medulloblastoma, large-cell 7 | 6,241
ovarian cancer 7 | 8,520
Dentin sensitivity 6 | 14
Hypertension 6 | 396
atypical teratoid / rhabdoid tumor 6 | 5,112
glioblastoma 6 | 5,792
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
lung cancer 6 | 4,740
Melanoma 5 | 711
adult high grade glioma 5 | 3,801
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
Cancer 4 | 2,499
Neuropathy 4 | 261
cutaneous lupus erythematosus 4 | 1,057
cystic fibrosis 4 | 1,696
lung adenocarcinoma 4 | 2,716
malignant mesothelioma 4 | 3,232
Asthma 3 | 385
Bipolar Disorder 3 | 666
Breast cancer 3 | 3,578
Hyperalgesia 3 | 83
Migraine 3 | 83
Neurodegenerative disease 3 | 414
Pain 3 | 103
Pain agnosia 3 | 104
Pick disease 3 | 1,894
adrenocortical carcinoma 3 | 1,428
colon cancer 3 | 1,478
diabetes mellitus 3 | 1,728
ependymoma 3 | 4,679
group 3 medulloblastoma 3 | 4,104
interstitial cystitis 3 | 2,312
invasive ductal carcinoma 3 | 2,951
lung carcinoma 3 | 2,843
non-small cell lung cancer 3 | 2,890
ulcerative colitis 3 | 1,819
Allergic hypersensitivity disease 2 | 126
Arthritic Pain 2 | 5
Astrocytoma, Pilocytic 2 | 3,081
Atopic dermatitis 2 | 952
Backache 2 | 8
Cough 2 | 23
Endometrial cancer 2 | 311
Endometriosis 2 | 540
Gangliosidosis 2 | 20
Hypertensive disease 2 | 292
Hypervitaminosis D 2 | 8
Inflammation 2 | 120
Irritable bowel syndrome 2 | 60
Kidney disease 2 | 430
Liver cancer 2 | 604
Pain disorder 2 | 15
Rickets 2 | 49
Skin cancer 2 | 469
Sneezing 2 | 12
Sprains and Strains 2 | 6
Vascular disease 2 | 319
active Crohn's disease 2 | 922
group 4 medulloblastoma 2 | 1,855
head and neck cancer 2 | 271
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
pancreatic cancer 2 | 2,398
pituitary cancer 2 | 1,972
posterior fossa group B ependymoma 2 | 416
primitive neuroectodermal tumor 2 | 3,035
progressive supranuclear palsy 2 | 676
sonic hedgehog group medulloblastoma 2 | 467
subependymal giant cell astrocytoma 2 | 2,287
tuberculosis 2 | 2,010
Autosomal dominant nonsyndromic deafness 25 1 | 6
Autosomal recessive Robinow syndrome 1 | 27
Beriberi 1 | 12
Bone disease 1 | 10
Bradycardia 1 | 36
Chronic Kidney Diseases 1 | 13
Chronic Obstructive Airway Disease 1 | 37
Common Migraine 1 | 7
Cri-Du-Chat syndrome 1 | 16
Cystitis 1 | 15
Disturbance in mood 1 | 3
Epilepsy, Temporal Lobe 1 | 23
Esophagitis 1 | 35
Fascioliasis 1 | 17
Gait, Unsteady 1 | 29
Hypertrophy 1 | 17
Hypoparathyroidism 1 | 41
Intestinal perforation 1 | 7
Migraine without Aura 1 | 11
Neoplasms 1 | 63
Primary hypomagnesemia 1 | 7
Progressive renal failure 1 | 13
Pulmonary Disease, Chronic Obstructive 1 | 31
Reduced visual acuity 1 | 63
SPINOCEREBELLAR ATAXIA 41 1 | 1
Sialolithiasis 1 | 2
Spinocerebellar ataxia type 14 1 | 1

Tissue

Endocrine System 23 | 18,159
Urinary Tract 23 | 16,678
Digestive Tract 22 | 17,369
Liver and Pancreas 22 | 16,750
Male tissues 21 | 17,142
Skin and soft tissues 21 | 17,230
Blood and immune system 20 | 16,909
Nervous System 20 | 16,725
Female tissues 19 | 17,400
Respiratory system 19 | 16,393
Cardiovascular System 16 | 15,192

Target Family

Ion Channel 22 | 344
Kinase 1 | 634
Non-IDG 1 | 12,091

Reactome Pathway

TRP channels 24 | 24
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

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