Development Level

Tbio 14 | 10,625
Tchem 3 | 1,890

IMPC Term

preweaning lethality, complete... 2 | 633
abnormal lens morphology 1 | 73
embryonic lethality prior to t... 1 | 187
polydactyly 1 | 22

Disease

medulloblastoma, large-cell 10 | 6,234
ovarian cancer 9 | 8,492
glioblastoma 8 | 5,572
osteosarcoma 8 | 7,933
lung cancer 7 | 4,473
psoriasis 7 | 6,685
group 4 medulloblastoma 6 | 1,875
lung carcinoma 6 | 2,844
juvenile dermatomyositis 5 | 1,189
malignant mesothelioma 5 | 3,163
Cancer 4 | 2,346
acute myeloid leukemia 4 | 785
dermatomyositis 4 | 967
tuberculosis 4 | 1,563
Arthritis 3 | 248
Asthma 3 | 349
IGA Glomerulonephritis 3 | 454
Rheumatoid Arthritis 3 | 1,171
astrocytic glioma 3 | 2,241
atypical teratoid / rhabdoid tumor 3 | 4,369
cutaneous lupus erythematosus 3 | 1,056
cystic fibrosis 3 | 1,670
diabetes mellitus 3 | 1,663
ependymoma 3 | 2,514
interstitial cystitis 3 | 2,299
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,289
lung adenocarcinoma 3 | 2,714
non-small cell lung cancer 3 | 2,798
pancreatic cancer 3 | 2,300
pediatric high grade glioma 3 | 2,712
pilocytic astrocytoma 3 | 3,086
subependymal giant cell astrocytoma 3 | 2,287
ulcerative colitis 3 | 2,087
Age related macular degeneration 2 | 84
Breast cancer 2 | 3,099
Carcinoma 2 | 2,147
Colorectal Neoplasms 2 | 217
Coronary artery disease 2 | 240
Duchenne muscular dystrophy 2 | 602
Gaucher disease type 3 2 | 76
Herpes Simplex Encephalitis, Susceptibility To, 1 2 | 5
Hypersensitivity reaction type II disease 2 | 235
Hypohidrotic ectodermal dysplasia 2 | 14
Influenza 2 | 142
Liver disease 2 | 219
Lung disease 2 | 136
Myofibrillar myopathy 1 2 | 6
Myofibrillar myopathy 3 2 | 5
Neoplasm Metastasis 2 | 138
Osteoporosis 2 | 259
Perinatal necrotizing enterocolitis 2 | 18
Pick's disease 2 | 14
Prostatic Neoplasms 2 | 471
Reperfusion Injury 2 | 84
Respiratory Syncytial Virus Infections 2 | 5
active Crohn's disease 2 | 918
active ulcerative colitis 2 | 477
adrenocortical carcinoma 2 | 1,427
aldosterone-producing adenoma 2 | 664
astrocytoma 2 | 1,493
gastric carcinoma 2 | 832
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,988
invasive ductal carcinoma 2 | 2,950
oligodendroglioma 2 | 2,849
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,795
periodontitis 2 | 269
pituitary cancer 2 | 1,972
primary pancreatic ductal adenocarcinoma 2 | 1,271
progressive supranuclear palsy 2 | 674
Autosomal dominant hypohidrotic ectodermal dysplasia syndrome (disorder) 1 | 3
Brain disease 1 | 84
Encephalitis 1 | 54
Fatty Liver 1 | 48
Fatty liver disease 1 | 86
Gout 1 | 93
Hepatitis B 1 | 103
Hepatitis C 1 | 90
Hypogonadism 1 | 70
Inflammation 1 | 109
Keratitis 1 | 42
Leishmaniasis 1 | 49
Leptospirosis 1 | 17
Liver Cirrhosis 1 | 101
Lung Neoplasms 1 | 171
Mastitis 1 | 48
Melanoma 1 | 261
Meningitis 1 | 46
Muscular atrophy 1 | 67
Neonatal abstinence syndrome 1 | 9
Neoplasm Invasiveness 1 | 127
Neurogenic bowel 1 | 6
Non-alcoholic Fatty Liver Disease 1 | 40
Osteopetrosis 1 | 40
Pneumonia 1 | 133
Stevens-Johnson syndrome 1 | 91
Vitiligo 1 | 71
atypical teratoid/rhabdoid tumor 1 | 1,095
head and neck cancer and chronic obstructive pulmonary disease 1 | 237
ovarian neoplasm 1 | 97

Tissue

Blood and immune system 17 | 17,995
Cardiovascular System 17 | 17,958
Digestive Tract 17 | 18,473
Endocrine System 17 | 18,512
Female tissues 17 | 18,647
Liver and Pancreas 17 | 18,136
Male tissues 17 | 17,969
Nervous System 17 | 18,561
Respiratory system 17 | 17,484
Skin and soft tissues 17 | 18,115
Urinary Tract 17 | 18,444

Target Family

Non-IDG 12 | 11,969
Kinase 3 | 634
Enzyme 2 | 4,146

Reactome Pathway

TRAF6 mediated induction of TA... 17 | 17
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
TNF receptor-associated factor 6 TRAF6 Tbio Non-IDG -2.67984 438.1 349
Polyubiquitin-C UBC Tbio Non-IDG -2.87696 56.7 130
Polyubiquitin-B UBB Tbio Non-IDG -1.96206 92.3 370
Interleukin-1 receptor-associated kinase-like 2 IRAK2 Tbio Kinase -1.50491 31.1 496
TIR domain-containing adapter molecule 2 TICAM2 Tbio Non-IDG -1.09259 11.6 230
TIR domain-containing adapter molecule 1 TICAM1 Tbio Non-IDG -1.46541 31.8 191
Toll-like receptor 3 TLR3 Tchem Non-IDG -3.04822 1147.2 751
Mitogen-activated protein kinase kinase kinase 7 MAP3K7 Tchem Kinase -1.41371 28.0 678
Lymphocyte antigen 96 LY96 Tbio Non-IDG -2.73333 490.7 314
Sterile alpha and TIR motif-containing protein 1 SARM1 Tbio Non-IDG -2.18272 143.9 141