Development Level

Tchem 9 | 1,598
Tbio 8 | 11,445

IMPC Phenotype

preweaning lethality, complete... 3 | 979
preweaning lethality, incomple... 2 | 499
decreased neutrophil cell numb... 1 | 42
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
increased circulating creatini... 1 | 38
increased startle reflex 1 | 112
urinary bladder obstruction 1 | 4

Disease

ovarian cancer 13 | 8,520
psoriasis 13 | 6,694
Cancer 12 | 2,499
group 3 medulloblastoma 12 | 4,104
lung cancer 12 | 4,740
medulloblastoma, large-cell 11 | 6,241
atypical teratoid / rhabdoid tumor 10 | 5,112
osteosarcoma 10 | 7,950
Carcinoma 9 | 11,493
glioblastoma 9 | 5,792
adult high grade glioma 8 | 3,801
Breast cancer 7 | 3,578
adrenocortical carcinoma 7 | 1,428
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,291
malignant mesothelioma 7 | 3,232
non-small cell lung cancer 7 | 2,890
primitive neuroectodermal tumor 7 | 3,035
lung adenocarcinoma 6 | 2,716
pancreatic cancer 6 | 2,398
Endometriosis 5 | 540
ductal carcinoma in situ 5 | 1,745
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
Astrocytoma, Pilocytic 4 | 3,081
Kidney cancer 4 | 2,613
Rheumatoid arthritis 4 | 1,191
Waldenstrons macroglobulinemia 4 | 765
breast carcinoma 4 | 1,638
colon cancer 4 | 1,478
dermatomyositis 4 | 966
ependymoma 4 | 4,679
invasive ductal carcinoma 4 | 2,951
nasopharyngeal carcinoma 4 | 1,058
oligodendroglioma 4 | 2,850
tuberculosis 4 | 2,010
Adenocarcinoma of lung (disorder) 3 | 60
Atopic dermatitis 3 | 952
Breast Neoplasms 3 | 445
Carcinoma, Squamous Cell 3 | 110
Colonic Neoplasms 3 | 142
Esophageal Neoplasms 3 | 69
Esophageal Squamous Cell Carcinoma 3 | 77
Ischemia 3 | 28
Mammary Neoplasms 3 | 425
Neurodegenerative disease 3 | 414
Polycystic ovary syndrome 3 | 360
Prostatic Neoplasms 3 | 495
Schizophrenia 3 | 1,160
Squamous cell carcinoma 3 | 129
Squamous cell carcinoma of esophagus 3 | 77
Stomach Neoplasms 3 | 300
astrocytic glioma 3 | 2,597
diabetes mellitus 3 | 1,728
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
primary Sjogren syndrome 3 | 735
ulcerative colitis 3 | 1,819
Acute kidney injury 2 | 70
Adenocarcinoma of lung 2 | 142
Adenoid Cystic Carcinoma 2 | 99
Alcoholic Intoxication, Chronic 2 | 289
Amyotrophic lateral sclerosis 2 | 451
Arthritis, Juvenile 2 | 126
Bladder Neoplasm 2 | 112
Carcinoma of colon 2 | 32
Carcinoma, Adenoid Cystic 2 | 99
Carcinoma, Hepatocellular 2 | 228
Carcinoma, Transitional Cell 2 | 32
Chemical and Drug Induced Liver Injury 2 | 195
Colorectal Neoplasms 2 | 243
Endometrial cancer 2 | 311
Epilepsy 2 | 792
HIV Infections 2 | 102
Infertility, Male 2 | 46
Juvenile arthritis 2 | 126
Kidney disease 2 | 430
Large intestine cancer 2 | 126
Leukemia, Lymphocytic, Chronic, B-Cell 2 | 34
Liver Cirrhosis, Experimental 2 | 769
Liver cancer 2 | 604
Liver carcinoma 2 | 240
Lung Neoplasms 2 | 232
Lymphoid leukemia 2 | 160
Lymphoma 2 | 81
Male infertility 2 | 206
Melanoma 2 | 711
Mesothelioma, Malignant 2 | 105
Mouth Neoplasms 2 | 55
Myocardial Infarction 2 | 151
Nerve Degeneration 2 | 121
Ovarian Neoplasms 2 | 102
Pancreatic Neoplasm 2 | 85
Pancreatic Neoplasms 2 | 85
Seizures 2 | 596
Urinary Bladder Neoplasms 2 | 114
Vascular disease 2 | 319
acute quadriplegic myopathy 2 | 1,158
astrocytoma 2 | 1,146
juvenile dermatomyositis 2 | 1,187
ovarian neoplasm 2 | 99
pituitary cancer 2 | 1,972
spina bifida 2 | 1,074

Tissue

Blood and immune system 17 | 16,909
Cardiovascular System 17 | 15,192
Digestive Tract 17 | 17,369
Endocrine System 17 | 18,159
Female tissues 17 | 17,400
Liver and Pancreas 17 | 16,750
Male tissues 17 | 17,142
Nervous System 17 | 16,725
Respiratory system 17 | 16,393
Skin and soft tissues 17 | 17,230
Urinary Tract 17 | 16,678

Target Family

Non-IDG 8 | 12,091
Transcription Factor 4 | 1,400
Epigenetic 3 | 242
Enzyme 1 | 4,145
Kinase 1 | 634

Reactome Pathway

TP53 Regulates Transcription o... 17 | 17
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone-arginine methyltransferase CARM1 CARM1 Tchem Epigenetic -2.04034 130.8 476
Zinc finger protein 385A ZNF385A Tbio Non-IDG -0.03141 1.24 99
Protein arginine N-methyltransferase 1 PRMT1 Tchem Epigenetic -2.35804 229.5 394
Cellular tumor antigen p53 TP53 Tchem Transcription Factor -4.74112 54026.3 6298
Retinoblastoma-like protein 1 RBL1 Tbio Non-IDG -2.62435 385.9 321
Histone acetyltransferase p300 EP300 Tchem Epigenetic -3.79743 6016.7 775
G2/mitotic-specific cyclin-B1 CCNB1 Tchem Non-IDG -3.14393 1189.3 1251
Proliferating cell nuclear antigen PCNA Tchem Non-IDG -1.13711 11.3 1721
Growth arrest and DNA damage-inducible protein GADD45 alpha GADD45A Tbio Non-IDG -2.61061 373.3 249
14-3-3 protein sigma SFN Tbio Non-IDG -2.56638 391.2 550