Development Level

Tbio 7 | 10,625
Tchem 6 | 1,890

IMPC Phenotype

abnormal bone structure 1 | 131
abnormal embryo size 1 | 112
abnormal epididymis morphology 1 | 31
abnormal heart morphology 1 | 51
abnormal limb bud morphology 1 | 15
abnormal placenta morphology 1 | 4
abnormal spleen morphology 1 | 36
abnormal testis morphology 1 | 30
decreased anxiety-related resp... 1 | 12
decreased body length 1 | 108
decreased circulating insulin ... 1 | 75
embryonic lethality prior to t... 1 | 187
enlarged epididymis 1 | 27
enlarged heart 1 | 111
enlarged spleen 1 | 26
hemorrhage 1 | 12
increased mean corpuscular hem... 1 | 93
prenatal lethality prior to he... 1 | 64
preweaning lethality, complete... 1 | 633
small testis 1 | 37

Disease

Cancer 9 | 2,346
medulloblastoma, large-cell 9 | 6,234
ovarian cancer 9 | 8,491
psoriasis 9 | 6,685
glioblastoma 7 | 5,572
malignant mesothelioma 7 | 3,163
osteosarcoma 7 | 7,933
lung cancer 6 | 4,473
Breast cancer 5 | 3,098
Liver carcinoma 5 | 217
adrenocortical carcinoma 5 | 1,427
ductal carcinoma in situ 5 | 1,745
non-small cell lung cancer 5 | 2,798
pediatric high grade glioma 5 | 2,712
primitive neuroectodermal tumor 5 | 3,031
Endometriosis 4 | 535
Mammary Neoplasms 4 | 410
atypical teratoid / rhabdoid tumor 4 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,289
subependymal giant cell astrocytoma 4 | 2,287
Adenoma 3 | 165
Atopic dermatitis 3 | 944
Bladder Neoplasm 3 | 109
Lung Neoplasms 3 | 171
Melanoma 3 | 261
Prostatic Neoplasms 3 | 471
Stomach Neoplasms 3 | 282
group 3 medulloblastoma 3 | 2,254
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,988
invasive ductal carcinoma 3 | 2,950
lung adenocarcinoma 3 | 2,714
medulloblastoma 3 | 1,524
nasopharyngeal carcinoma 3 | 1,056
oligodendroglioma 3 | 2,849
pancreatic cancer 3 | 2,300
pilocytic astrocytoma 3 | 3,086
posterior fossa group A ependymoma 3 | 1,511
posterior fossa group B ependymoma 3 | 1,530
sonic hedgehog group medulloblastoma 3 | 1,482
Carcinoma, Transitional Cell 2 | 31
Colonic Neoplasms 2 | 126
Intestinal Neoplasms 2 | 11
Liver neoplasms 2 | 108
Multiple Endocrine Neoplasia Type 1 2 | 30
Papilloma 2 | 27
Polycystic Ovary Syndrome 2 | 334
Rheumatoid Arthritis 2 | 1,170
Sezary Syndrome 2 | 26
Squamous cell carcinoma of esophagus 2 | 82
Squamous cell carcinoma of the head and neck 2 | 24
Urinary bladder cancer 2 | 34
active Crohn's disease 2 | 918
astrocytoma 2 | 1,493
breast carcinoma 2 | 1,614
colon cancer 2 | 1,475
ovarian neoplasm 2 | 97
pancreatic carcinoma 2 | 567
tuberculosis 2 | 1,563
ulcerative colitis 2 | 2,087
Acute Megakaryocytic Leukemias 1 | 4
Adrenal Gland Neoplasms 1 | 11
Balkan Nephropathy 1 | 6
Basal cell carcinoma 7 1 | 1
Carotid Artery Diseases 1 | 11
Central Nervous System Neoplasms 1 | 1
Cervix uteri carcinoma in situ 1 | 14
Chloracne 1 | 32
Choroid Plexus Papilloma 1 | 10
Chronic Obstructive Airway Disease 1 | 47
Demyelinating Diseases 1 | 7
Esophageal cancer 1 | 30
Gastritis 1 | 44
Genitourinary Neoplasms 1 | 3
Hemangioma 1 | 35
Hemangiosarcoma 1 | 18
Hepatoblastoma 1 | 17
Hypertrophic Cardiomyopathy 1 | 56
Ischemia 1 | 27
Keratosis 1 | 34
Large intestine cancer 1 | 12
Li-Fraumeni syndrome 1 | 13
Liver Diseases, Parasitic 1 | 9
Liver Neoplasms, Experimental 1 | 48
Lymphoid leukemia 1 | 69
Mouth Neoplasms 1 | 44
Neoplastic Cell Transformation 1 | 81
Neurofibromatosis 1 | 37
Papilloma of choroid plexus 1 | 1
Pathological accumulation of air in tissues 1 | 11
Penile Neoplasms 1 | 4
Primary hyperparathyroidism 1 | 4
Prostatic Intraepithelial Neoplasias 1 | 11
Skin Neoplasms 1 | 49
Small cell carcinoma of lung 1 | 45
T-Cell Lymphoma 1 | 11
Thymoma 1 | 16
Urologic Neoplasms 1 | 7
Vulvar Lichen Sclerosus 1 | 2
Xeroderma pigmentosum 1 | 41
gallbladder neoplasm 1 | 9

Tissue

Blood and immune system 13 | 17,994
Cardiovascular System 13 | 17,957
Digestive Tract 13 | 18,472
Endocrine System 13 | 18,511
Female tissues 13 | 18,646
Liver and Pancreas 13 | 18,135
Male tissues 13 | 17,968
Nervous System 13 | 18,560
Respiratory system 13 | 17,483
Skin and soft tissues 13 | 18,114
Urinary Tract 13 | 18,443

Target Family

Non-IDG 6 | 11,969
Transcription Factor 4 | 1,400
Enzyme 2 | 4,146
Kinase 1 | 634

Reactome Pathway

TP53 Regulates Transcription o... 13 | 13
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
AT-rich interactive domain-containing protein 3A ARID3A Tbio Transcription Factor -2.07434 111.0 153
Transcription factor E2F1 E2F1 Tchem Transcription Factor -2.27364 187.2 928
G1/S-specific cyclin-E1 CCNE1 Tchem Non-IDG -2.43326 239.2 741
Cyclin-dependent kinase 2 CDK2 Tchem Kinase -3.41871 2399.0 886
Cyclin-dependent kinase inhibitor 1B CDKN1B Tbio Enzyme -3.10737 1211.3 1609
Cyclin-A2 CCNA2 Tchem Non-IDG -2.28335 164.5 356
G1/S-specific cyclin-E2 CCNE2 Tbio Non-IDG -1.80819 50.3 194
Transcription factor E2F7 E2F7 Tbio Transcription Factor -1.43083 27.3 115
Zinc finger protein 385A ZNF385A Tbio Non-IDG 0.20 0.99 87
Poly(rC)-binding protein 4 PCBP4 Tbio Non-IDG -1.31930 22.9 119