Development Level

Tbio 49 | 11,445
Tchem 11 | 1,598
Tdark 4 | 6,588

Collection

Kinase: IDG Consortium (Comple... 2 | 37

IMPC Phenotype

preweaning lethality, complete... 6 | 979
embryonic lethality prior to o... 4 | 239
embryonic lethality prior to t... 4 | 278
male infertility 2 | 123
preweaning lethality, incomple... 2 | 499
abnormal embryo size 1 | 220
abnormal epididymis morphology 1 | 42
abnormal heart morphology 1 | 162
abnormal retina morphology 1 | 71
abnormal skin morphology 1 | 50
abnormal spinal cord morpholog... 1 | 9
decreased KLRG1+ CD4 alpha bet... 1 | 5
decreased circulating glucose ... 1 | 126
decreased circulating sodium l... 1 | 22
decreased vertical activity 1 | 208
enlarged epididymis 1 | 31
enlarged heart 1 | 210
female infertility 1 | 60
increased anti-nuclear antigen... 1 | 19
increased circulating free fat... 1 | 20
increased circulating potassiu... 1 | 29
increased heart rate 1 | 23
increased startle reflex 1 | 112
shortened RR interval 1 | 17
small testis 1 | 58

Disease

ovarian cancer 42 | 8,520
Carcinoma 40 | 11,493
osteosarcoma 25 | 7,950
lung cancer 23 | 4,740
Cancer 21 | 2,499
psoriasis 21 | 6,694
glioblastoma 17 | 5,792
malignant mesothelioma 17 | 3,232
Breast cancer 16 | 3,578
medulloblastoma, large-cell 16 | 6,241
Cockayne syndrome 15 | 60
Kidney cancer 15 | 2,613
group 3 medulloblastoma 15 | 4,104
atypical teratoid / rhabdoid tumor 14 | 5,112
diabetes mellitus 14 | 1,728
Autosomal recessive predisposition 13 | 1,442
ependymoma 12 | 4,679
primitive neuroectodermal tumor 11 | 3,035
Multiple myeloma 10 | 1,332
Photosensitive trichothiodystrophy 10 | 30
Xeroderma pigmentosum 10 | 43
Epilepsy 9 | 792
Intellectual disability 9 | 1,016
Pick disease 9 | 1,894
Seizures 9 | 596
acute myeloid leukemia 9 | 783
breast carcinoma 9 | 1,638
non-small cell lung cancer 9 | 2,890
Dull intelligence 8 | 645
Low intelligence 8 | 645
Mental Retardation 8 | 645
Mental deficiency 8 | 645
Poor school performance 8 | 645
Short stature 8 | 531
Strabismus 8 | 270
Xeroderma pigmentosum group B 8 | 20
lung adenocarcinoma 8 | 2,716
pancreatic cancer 8 | 2,398
Basal cell carcinoma 7 | 54
Cryptorchidism 7 | 296
Fatigue 7 | 182
Leukemia 7 | 104
Small head 7 | 374
adult high grade glioma 7 | 3,801
astrocytoma 7 | 1,146
colon cancer 7 | 1,478
Basal cell nevi 6 | 23
Birthmark 6 | 35
Breast Neoplasms 6 | 445
Cafe-au-Lait Spots 6 | 37
Cognitive delay 6 | 608
Global developmental delay 6 | 608
Hematologic Neoplasms 6 | 22
Hyperpigmented macules 6 | 42
Mammary Neoplasms 6 | 425
Mental and motor retardation 6 | 608
Nijmegen breakage syndrome 6 | 24
Prostatic Neoplasms 6 | 495
Rheumatoid arthritis 6 | 1,191
Schizophrenia 6 | 1,160
Stomach Neoplasms 6 | 300
Waldenstrons macroglobulinemia 6 | 765
acute quadriplegic myopathy 6 | 1,158
ductal carcinoma in situ 6 | 1,745
hepatocellular carcinoma 6 | 547
hypopigmented skin patch 6 | 59
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989
nasopharyngeal carcinoma 6 | 1,058
pituitary cancer 6 | 1,972
Abnormally small eyeball 5 | 97
Acquired scoliosis 5 | 281
Anemia 5 | 365
Cataract 5 | 297
Cerebellar Ataxia 5 | 304
Congenital deafness 5 | 185
Curvature of spine 5 | 282
Deafness 5 | 198
Decreased size of eyeball 5 | 97
Depressive disorder 5 | 409
Endometriosis 5 | 540
Fanconi anemia 5 | 56
Hearing Loss, Partial 5 | 185
Impaired cognition 5 | 96
Lynch syndrome 5 | 35
Melanoma 5 | 711
Mental impairment 5 | 95
Microphthalmos 5 | 100
Muscle hypotonia 5 | 571
Xeroderma pigmentosum group D 5 | 33
adrenocortical carcinoma 5 | 1,428
astrocytic glioma 5 | 2,597
dermatomyositis 5 | 966
group 4 medulloblastoma 5 | 1,855
hearing impairment 5 | 199
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
invasive ductal carcinoma 5 | 2,951
non primary Sjogren syndrome sicca 5 | 891
oligodendroglioma 5 | 2,850
ovarian neoplasm 5 | 99
ulcerative colitis 5 | 1,819

Tissue

Blood and immune system 61 | 16,909
Cardiovascular System 61 | 15,192
Digestive Tract 61 | 17,369
Endocrine System 61 | 18,159
Female tissues 61 | 17,400
Liver and Pancreas 61 | 16,750
Male tissues 61 | 17,142
Nervous System 61 | 16,725
Respiratory system 61 | 16,393
Skin and soft tissues 61 | 17,230
Urinary Tract 61 | 16,678

Target Family

Non-IDG 30 | 12,091
Enzyme 23 | 4,145
Kinase 7 | 634
Transcription Factor 4 | 1,400

Reactome Pathway

TP53 Regulates Transcription o... 64 | 64
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Negative elongation factor B NELFB Tbio Non-IDG -1.16040 16.4 158
DNA-directed RNA polymerase II subunit RPB2 POLR2B Tbio Enzyme -2.49730 299.8 149
Serine/threonine-protein kinase ATR ATR Tchem Kinase -2.80362 549.6 376
DNA-directed RNA polymerases I, II, and III subunit RPABC2 POLR2F Tbio Enzyme -1.13403 13.9 68
Cyclin-dependent kinase 12 CDK12 Tchem Kinase -1.38476 29.4 157
Fanconi anemia group C protein FANCC Tbio Non-IDG -2.85516 703.4 348
General transcription factor IIH subunit 2 GTF2H2 Tbio Non-IDG -1.32757 20.2 148
DNA-directed RNA polymerases I, II, and III subunit RPABC4 POLR2K Tbio Enzyme -0.90716 7.36 65
RNA polymerase II subunit A C-terminal domain phosphatase CTDP1 Tbio Enzyme -1.88697 80.7 113
FACT complex subunit SPT16 SUPT16H Tbio Enzyme -1.85453 70.7 324