Development Level

Tbio 60 | 11,445
Tchem 17 | 1,598
Tdark 5 | 6,588
Tclin 4 | 613

IMPC Phenotype

preweaning lethality, complete... 9 | 979
embryonic lethality prior to o... 6 | 239
embryonic lethality prior to t... 4 | 278
preweaning lethality, incomple... 4 | 499
abnormal embryo size 3 | 220
abnormal skin coloration 3 | 25
decreased circulating LDL chol... 3 | 38
pallor 3 | 34
abnormal heart morphology 2 | 162
abnormal placenta size 2 | 20
decreased circulating choleste... 2 | 93
decreased mean platelet volume 2 | 25
edema 2 | 59
enlarged spleen 2 | 41
increased circulating LDL chol... 2 | 13
increased circulating alkaline... 2 | 122
increased mean corpuscular hem... 2 | 96
increased mean platelet volume 2 | 45
prenatal lethality prior to he... 2 | 87
abnormal bone mineralization 1 | 38
abnormal embryonic autopod pla... 1 | 2
abnormal glucose homeostasis 1 | 4
abnormal hindbrain development 1 | 16
abnormal lens morphology 1 | 81
abnormal limb bud morphology 1 | 17
abnormal liver size 1 | 5
abnormal lung morphology 1 | 26
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal pericardium morpholog... 1 | 26
abnormal placenta development 1 | 1
abnormal placenta morphology 1 | 5
abnormal response to new envir... 1 | 10
abnormal retina morphology 1 | 71
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal skin morphology 1 | 50
abnormal spleen morphology 1 | 55
abnormal stomach morphology 1 | 10
abnormal thymus morphology 1 | 7
anophthalmia 1 | 33
cataract 1 | 92
decreased blood urea nitrogen ... 1 | 51
decreased body weight 1 | 161
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating amylase ... 1 | 28
decreased circulating creatini... 1 | 39
decreased circulating iron lev... 1 | 32
decreased circulating magnesiu... 1 | 13
decreased circulating phosphat... 1 | 27
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
embryonic growth retardation 1 | 106
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
enlarged thymus 1 | 5
hyperactivity 1 | 148
impaired glucose tolerance 1 | 75
increased aggression 1 | 4
increased circulating bilirubi... 1 | 16
increased circulating chloride... 1 | 41
increased circulating choleste... 1 | 66
increased circulating glucose ... 1 | 24
increased circulating phosphat... 1 | 26
increased circulating sodium l... 1 | 71
increased fasted circulating g... 1 | 76
increased glycosylated hemoglo... 1 | 1
increased grip strength 1 | 41
increased lean body mass 1 | 172
increased monocyte cell number 1 | 63
increased red blood cell distr... 1 | 34
increased spleen weight 1 | 10
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
pale liver 1 | 6
prenatal lethality 1 | 28
short tibia 1 | 97
thrombocytopenia 1 | 56
thrombocytosis 1 | 27

Disease

ovarian cancer 53 | 8,520
Carcinoma 45 | 11,493
osteosarcoma 41 | 7,950
medulloblastoma, large-cell 38 | 6,241
glioblastoma 32 | 5,792
lung cancer 31 | 4,740
psoriasis 30 | 6,694
Cancer 29 | 2,499
astrocytic glioma 27 | 2,597
atypical teratoid / rhabdoid tumor 27 | 5,112
ependymoma 25 | 4,679
oligodendroglioma 24 | 2,850
Breast cancer 23 | 3,578
pancreatic ductal adenocarcinoma liver metastasis 23 | 1,962
Multiple myeloma 21 | 1,332
adult high grade glioma 19 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 19 | 3,291
Pick disease 17 | 1,894
Epilepsy 16 | 792
intraductal papillary-mucinous carcinoma (IPMC) 16 | 2,989
diabetes mellitus 15 | 1,728
Autosomal recessive predisposition 14 | 1,442
intraductal papillary-mucinous adenoma (IPMA) 14 | 2,955
subependymal giant cell astrocytoma 14 | 2,287
Seizures 13 | 596
group 3 medulloblastoma 13 | 4,104
group 4 medulloblastoma 13 | 1,855
non-small cell lung cancer 13 | 2,890
tuberculosis 13 | 2,010
Cerebellar Ataxia 12 | 304
Cognitive delay 12 | 608
Global developmental delay 12 | 608
Intellectual disability 12 | 1,016
Mental and motor retardation 12 | 608
acute quadriplegic myopathy 12 | 1,158
cytochrome-c oxidase deficiency disease 12 | 19
juvenile dermatomyositis 12 | 1,187
lung adenocarcinoma 12 | 2,716
Dull intelligence 11 | 645
Low intelligence 11 | 645
Mental Retardation 11 | 645
Mental deficiency 11 | 645
Poor school performance 11 | 645
malignant mesothelioma 11 | 3,232
pancreatic cancer 11 | 2,398
Acidosis, Lactic 10 | 97
Cytochrome-c Oxidase Deficiency 10 | 17
Kidney cancer 10 | 2,613
Lactic acidemia 10 | 95
Leigh disease 10 | 100
Waldenstrons macroglobulinemia 10 | 765
interstitial cystitis 10 | 2,312
invasive ductal carcinoma 10 | 2,951
primitive neuroectodermal tumor 10 | 3,035
Blepharoptosis 9 | 231
Increased serum lactate 9 | 60
Muscle hypotonia 9 | 571
Astrocytoma, Pilocytic 8 | 3,081
Obesity 8 | 678
Optic Atrophy 8 | 242
Schizophrenia 8 | 1,160
Vascular disease 8 | 319
breast carcinoma 8 | 1,638
Alzheimer's disease 7 | 658
Anemia 7 | 365
Bipolar Disorder 7 | 666
Breast Neoplasms 7 | 445
Carcinoma, Hepatocellular 7 | 228
Mammary Neoplasms 7 | 425
Parkinson's disease 7 | 392
Renal Cell Carcinoma 7 | 214
Rheumatoid arthritis 7 | 1,191
Sensorineural Hearing Loss (disorder) 7 | 284
Short stature 7 | 531
Squamous cell carcinoma 7 | 129
Wolff-Parkinson-White syndrome 7 | 19
nasopharyngeal carcinoma 7 | 1,058
Amyotrophic lateral sclerosis 6 | 451
CSF lactate increased 6 | 33
Cachexia 6 | 50
Carcinoma, Squamous Cell 6 | 110
Cardiomyopathies 6 | 110
Failure to gain weight 6 | 365
Heart disease 6 | 306
Hypertensive disease 6 | 292
Hypertrophic Cardiomyopathy 6 | 117
Kidney disease 6 | 430
Liver carcinoma 6 | 240
Orbital separation excessive 6 | 244
Pediatric failure to thrive 6 | 365
colon cancer 6 | 1,478
cutaneous lupus erythematosus 6 | 1,057
cystic fibrosis 6 | 1,696
non primary Sjogren syndrome sicca 6 | 891
primary pancreatic ductal adenocarcinoma 6 | 1,109
Attention deficit hyperactivity disorder 5 | 278
Prostatic Neoplasms 5 | 495
dermatomyositis 5 | 966
lung carcinoma 5 | 2,843
ulcerative colitis 5 | 1,819

Tissue

Digestive Tract 86 | 17,369
Endocrine System 86 | 18,159
Female tissues 86 | 17,400
Male tissues 86 | 17,142
Skin and soft tissues 86 | 17,230
Blood and immune system 85 | 16,909
Cardiovascular System 85 | 15,192
Liver and Pancreas 85 | 16,750
Nervous System 85 | 16,725
Respiratory system 85 | 16,393
Urinary Tract 85 | 16,678

Target Family

Non-IDG 40 | 12,091
Enzyme 35 | 4,145
Kinase 8 | 634
Transcription Factor 2 | 1,400
Transporter 1 | 473

Reactome Pathway

TP53 Regulates Metabolic Genes 86 | 86
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cytochrome c oxidase assembly protein COX11, mitochondrial COX11 Tbio Enzyme -1.42359 24.4 86
14-3-3 protein theta YWHAQ Tchem Non-IDG -2.43493 235.4 358
DNA damage-inducible transcript 4 protein DDIT4 Tbio Non-IDG -2.11497 150.3 231
Sestrin-1 SESN1 Tbio Non-IDG -1.95681 82.0 172
Putative helicase MOV-10 MOV10 Tbio Enzyme -1.55297 38.5 121
Protein argonaute-4 AGO4 Tbio Non-IDG -1.42077 23.0 121
Translational activator of cytochrome c oxidase 1 TACO1 Tdark Enzyme -0.64509 4.57 123
Leucine-rich PPR motif-containing protein, mitochondrial LRPPRC Tbio Non-IDG -1.67434 54.1 80
Glutaminase liver isoform, mitochondrial GLS2 Tbio Enzyme -3.14287 1343.1 167
Glutaminase kidney isoform, mitochondrial GLS Tchem Enzyme -2.92171 795.3 268