Development Level

Tbio 22 | 11,445
Tclin 3 | 613
Tchem 2 | 1,598

IMPC Phenotype

abnormal seminal vesicle morph... 2 | 114
enlarged heart 2 | 210
increased leukocyte cell numbe... 2 | 47
increased lymphocyte cell numb... 2 | 32
preweaning lethality, incomple... 2 | 499
abnormal bone structure 1 | 187
abnormal heart morphology 1 | 162
cardiovascular system phenotyp... 1 | 36
decreased T cell number 1 | 15
decreased circulating creatini... 1 | 39
decreased heart rate 1 | 18
decreased lean body mass 1 | 135
decreased vertical activity 1 | 208
enlarged seminal vesicle 1 | 10
female infertility 1 | 60
increased basophil cell number 1 | 7
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating alkaline... 1 | 122
increased eosinophil cell numb... 1 | 11
increased large unstained cell... 1 | 5
increased neutrophil cell numb... 1 | 46
increased startle reflex 1 | 112
prolonged RR interval 1 | 8

Disease

Cancer 15 | 2,499
Carcinoma 12 | 11,493
lung cancer 11 | 4,740
interstitial cystitis 10 | 2,312
osteosarcoma 10 | 7,950
tuberculosis 10 | 2,010
Rheumatoid arthritis 9 | 1,191
psoriasis 9 | 6,694
ovarian cancer 8 | 8,520
ulcerative colitis 8 | 1,819
Hypersensitivity reaction type II disease 7 | 253
malignant mesothelioma 7 | 3,232
medulloblastoma, large-cell 7 | 6,241
Kidney disease 6 | 430
invasive ductal carcinoma 6 | 2,951
lung carcinoma 6 | 2,843
Astrocytoma, Pilocytic 5 | 3,081
Autosomal recessive predisposition 5 | 1,442
Crohn's disease 5 | 321
Multiple Sclerosis 5 | 540
Splenomegaly 5 | 190
pancreatic cancer 5 | 2,398
Hypohidrotic ectodermal dysplasia 4 | 15
Lymphadenopathy 4 | 62
Schizophrenia 4 | 1,160
adult high grade glioma 4 | 3,801
cutaneous lupus erythematosus 4 | 1,057
cystic fibrosis 4 | 1,696
diabetes mellitus 4 | 1,728
glioblastoma 4 | 5,792
group 4 medulloblastoma 4 | 1,855
non-small cell lung cancer 4 | 2,890
pituitary cancer 4 | 1,972
primary Sjogren syndrome 4 | 735
subependymal giant cell astrocytoma 4 | 2,287
Anodontia 3 | 12
Arthritis 3 | 290
Arthritis, Rheumatoid 3 | 174
Asthma 3 | 385
Autoimmune Diseases 3 | 67
Brain Injuries 3 | 65
Christ-Siemens-Touraine syndrome 3 | 3
Common variable immunodeficiency 3 | 101
Dry skin 3 | 75
Hepatomegaly 3 | 285
Hypodontia 3 | 81
Hypohidrosis 3 | 34
Immunologic Deficiency Syndromes 3 | 113
Leprosy 3 | 73
Lupus erythematosus 3 | 57
Pneumonia 3 | 174
Tooth agenesis 3 | 44
Xerosis 3 | 75
active Crohn's disease 3 | 922
colon cancer 3 | 1,478
ependymoma 3 | 4,679
gastric carcinoma 3 | 807
hepatocellular carcinoma 3 | 547
inflammatory breast cancer 3 | 286
lung adenocarcinoma 3 | 2,716
nasopharyngeal carcinoma 3 | 1,058
pancreatic carcinoma 3 | 562
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
periodontitis 3 | 293
sarcoidosis 3 | 370
Alopecia 2 | 115
Ankylosing spondylitis 2 | 140
Autosomal dominant hypohidrotic ectodermal dysplasia syndrome (disorder) 2 | 3
Big calvaria 2 | 147
Clouston syndrome 2 | 9
Congenital deafness 2 | 185
Deafness 2 | 198
Ectodermal Dysplasia 3, Anhidrotic 2 | 2
Ectodermal Dysplasia, Hypohidrotic, Autosomal Recessive 2 | 3
Fever 2 | 138
Frequent fractures 2 | 53
Fuhrmann syndrome 2 | 7
Hearing Loss, Partial 2 | 185
Hyperparathyroidism 2 | 48
Hypersensitivity 2 | 63
Hypotrichosis 2 | 47
Increased fracture rate 2 | 53
Increased head circumference 2 | 147
Increased size of cranium 2 | 147
Increased size of skull 2 | 147
Inflammation 2 | 120
Influenza 2 | 142
Late tooth eruption 2 | 61
Liver disease 2 | 237
Lymphoma 2 | 81
Myocardial Infarction 2 | 151
Narcolepsy 2 | 72
Osteonecrosis 2 | 27
Osteopetrosis 2 | 43
Osteoporosis 2 | 363
Precocious exfoliation of primary tooth 2 | 11
Pruritus 2 | 58
Systemic lupus erythematosus 2 | 194
Varying degree of multiple fractures 2 | 53
hearing impairment 2 | 199

Tissue

Blood and immune system 27 | 16,909
Digestive Tract 27 | 17,369
Respiratory system 27 | 16,393
Urinary Tract 27 | 16,678
Endocrine System 26 | 18,159
Female tissues 26 | 17,400
Liver and Pancreas 26 | 16,750
Male tissues 26 | 17,142
Skin and soft tissues 26 | 17,230
Nervous System 25 | 16,725
Cardiovascular System 21 | 15,192

Target Family

Non-IDG 27 | 12,091

Reactome Pathway

TNFs bind their physiological ... 27 | 27
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

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