Development Level

Tbio 62 | 10,625
Tchem 27 | 1,890
Tclin 9 | 602
Tdark 1 | 7,003

Collection

Eligible Kinase Proteins 1 | 134

IMPC Term

preweaning lethality, complete... 4 | 633
decreased lean body mass 3 | 195
abnormal bone structure 2 | 131
decreased monocyte cell number 2 | 28
enlarged heart 2 | 111
preweaning lethality, incomple... 2 | 260
abnormal QRS complex 1 | 25
abnormal heart morphology 1 | 51
abnormal seminal vesicle morph... 1 | 47
cardiovascular system phenotyp... 1 | 35
decreased T cell number 1 | 31
decreased body length 1 | 108
decreased bone mineral content 1 | 157
decreased circulating creatini... 1 | 31
decreased grip strength 1 | 123
decreased heart rate 1 | 10
embryonic lethality prior to o... 1 | 148
female infertility 1 | 34
hypoactivity 1 | 89
increased bone mineral content 1 | 92
increased bone mineral density 1 | 52
increased circulating alkaline... 1 | 119
increased circulating calcium ... 1 | 32
increased circulating serum al... 1 | 25
increased circulating total pr... 1 | 20
increased eosinophil cell numb... 1 | 9
increased grip strength 1 | 83
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 37
increased lymphocyte cell numb... 1 | 9
increased mean corpuscular vol... 1 | 91
increased neutrophil cell numb... 1 | 15
prolonged RR interval 1 | 2

Disease

ovarian cancer 53 | 8,484
psoriasis 43 | 6,685
osteosarcoma 40 | 7,933
lung cancer 39 | 4,466
Cancer 37 | 2,346
Multiple myeloma 33 | 1,327
glioblastoma 26 | 5,572
tuberculosis 22 | 1,557
interstitial cystitis 19 | 2,299
malignant mesothelioma 18 | 3,162
medulloblastoma, large-cell 18 | 6,234
HIV Infections 17 | 100
Rheumatoid Arthritis 16 | 1,160
ulcerative colitis 16 | 2,087
dermatomyositis 15 | 933
diabetes mellitus 12 | 1,663
invasive ductal carcinoma 12 | 2,950
lung carcinoma 12 | 2,844
primary Sjogren syndrome 12 | 789
subependymal giant cell astrocytoma 12 | 2,287
Breast cancer 11 | 3,094
Waldenstrons macroglobulinemia 11 | 765
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,289
non-small cell lung cancer 11 | 2,798
pancreatic cancer 11 | 2,300
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,795
Hypersensitivity reaction type II disease 10 | 235
Kidney disease 10 | 396
atypical teratoid / rhabdoid tumor 10 | 4,369
cutaneous lupus erythematosus 10 | 1,056
pilocytic astrocytoma 10 | 3,086
Multiple Sclerosis 9 | 498
astrocytoma 9 | 1,493
Crohn's disease 8 | 304
active Crohn's disease 8 | 918
cystic fibrosis 8 | 1,665
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,988
lung adenocarcinoma 8 | 2,713
oligodendroglioma 8 | 2,849
pediatric high grade glioma 8 | 2,712
posterior fossa group A ependymoma 8 | 1,511
Lupus erythematosus 7 | 80
Peripheral Neuropathy 7 | 303
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,956
periodontitis 7 | 269
Ankylosing spondylitis 6 | 138
Asthma 6 | 349
Common variable immunodeficiency 6 | 72
Influenza 6 | 142
Mantle cell lymphoma 6 | 18
Osteoporosis 6 | 257
Pick disease 6 | 1,893
adult high grade glioma 6 | 2,148
group 4 medulloblastoma 6 | 1,875
juvenile dermatomyositis 6 | 1,189
non primary Sjogren syndrome sicca 6 | 840
pituitary cancer 6 | 1,972
primary pancreatic ductal adenocarcinoma 6 | 1,271
sarcoidosis 6 | 358
Alzheimer's disease 5 | 644
Atherosclerosis 5 | 275
Coronary artery disease 5 | 240
Dermatitis 5 | 107
Hypohidrotic ectodermal dysplasia 5 | 13
IGA Glomerulonephritis 5 | 454
Inflammatory bowel disease 5 | 142
Leprosy 5 | 77
Myocardial Infarction 5 | 126
astrocytic glioma 5 | 2,241
colon cancer 5 | 1,475
ependymoma 5 | 2,514
gastric carcinoma 5 | 832
hepatocellular carcinoma 5 | 532
tuberculosis and treatment for 6 months 5 | 686
Acquired immunodeficiency syndrome 4 | 164
Allergic hypersensitivity disease 4 | 123
Amyloidosis 4 | 68
Arthritis 4 | 248
Atopic dermatitis 4 | 944
Cerebrovascular disease 4 | 231
Crohn Disease 4 | 97
Diabetes Mellitus, Non-Insulin-Dependent 4 | 157
Diarrhea 4 | 155
Exanthem 4 | 39
Hypercalcemia 4 | 37
Hypersensitivity 4 | 63
Leishmaniasis 4 | 49
Narcolepsy 4 | 58
Pneumonia 4 | 133
Psoriatic arthritis 4 | 83
Stomach Neoplasms 4 | 282
Tetanus 4 | 66
Uveitis 4 | 103
Vascular disease 4 | 281
Vasculitis 4 | 64
acute myeloid leukemia 4 | 780
esophageal adenocarcinoma 4 | 737
inflammatory breast cancer 4 | 404
nasopharyngeal carcinoma 4 | 1,056
sonic hedgehog group medulloblastoma 4 | 1,482

Tissue

Blood and immune system 99 | 17,995
Digestive Tract 99 | 18,473
Endocrine System 98 | 18,512
Female tissues 98 | 18,647
Liver and Pancreas 98 | 18,136
Male tissues 98 | 17,969
Nervous System 98 | 18,561
Urinary Tract 98 | 18,444
Cardiovascular System 97 | 17,958
Respiratory system 97 | 17,484
Skin and soft tissues 97 | 18,115

Target Family

Non-IDG 55 | 11,971
Enzyme 40 | 4,146
Kinase 2 | 634
Transcription Factor 2 | 1,400

Reactome Pathway

TNFR2 non-canonical NF-kB path... 99 | 99
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Lymphotoxin-alpha LTA Tbio Non-IDG -2.84770 612.8 461
TNF receptor-associated factor 2 TRAF2 Tbio Non-IDG -1.85843 68.9 516
Tumor necrosis factor receptor superfamily member 9 TNFRSF9 Tbio Non-IDG -2.71753 714.2 490
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.21113 124.2 150
26S proteasome non-ATPase regulatory subunit 8 PSMD8 Tbio Enzyme -1.35900 20.6 94
Ubiquitin-40S ribosomal protein S27a RPS27A Tbio Non-IDG 56.7 150
Tumor necrosis factor receptor superfamily member 5 CD40 Tchem Non-IDG -3.44068 3018.0 1385
Tumor necrosis factor receptor superfamily member 25 TNFRSF25 Tbio Non-IDG -3.25501 1848.4 483
NEDD8-conjugating enzyme Ubc12 UBE2M Tbio Non-IDG -1.23759 14.6 104
Proteasome activator complex subunit 3 PSME3 Tbio Non-IDG -1.80641 78.9 225