Development Level

Tbio 80 | 11,651
Tclin 9 | 612
Tchem 8 | 1,388
Tdark 3 | 6,593

Collection

Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 6 | 979
decreased vertical activity 3 | 208
increased lymphocyte cell numb... 3 | 32
abnormal bone structure 2 | 187
abnormal seminal vesicle morph... 2 | 114
cardiovascular system phenotyp... 2 | 36
decreased lean body mass 2 | 135
enlarged heart 2 | 210
increased leukocyte cell numbe... 2 | 47
preweaning lethality, incomple... 2 | 499
abnormal behavioral response t... 1 | 66
abnormal heart morphology 1 | 162
abnormal kidney morphology 1 | 65
decreased T cell number 1 | 15
decreased caudal vertebrae num... 1 | 53
decreased circulating choleste... 1 | 93
decreased circulating creatini... 1 | 39
decreased circulating total pr... 1 | 49
decreased heart rate 1 | 18
decreased monocyte cell number 1 | 8
embryonic lethality prior to o... 1 | 239
enlarged seminal vesicle 1 | 10
female infertility 1 | 60
increased basophil cell number 1 | 7
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating alkaline... 1 | 122
increased eosinophil cell numb... 1 | 11
increased large unstained cell... 1 | 5
increased mean corpuscular vol... 1 | 92
increased neutrophil cell numb... 1 | 46
increased startle reflex 1 | 112
prolonged QT interval 1 | 38
prolonged RR interval 1 | 8
prolonged ST segment 1 | 36

Disease

ovarian cancer 52 | 8,520
Carcinoma 42 | 11,493
psoriasis 42 | 6,694
lung cancer 40 | 4,740
osteosarcoma 40 | 7,950
Cancer 39 | 2,499
Multiple myeloma 32 | 1,332
glioblastoma 26 | 5,792
tuberculosis 25 | 2,010
malignant mesothelioma 20 | 3,232
interstitial cystitis 19 | 2,312
medulloblastoma, large-cell 18 | 6,241
HIV Infections 16 | 102
Rheumatoid arthritis 16 | 1,191
dermatomyositis 14 | 966
ulcerative colitis 14 | 1,819
pancreatic ductal adenocarcinoma liver metastasis 13 | 1,962
subependymal giant cell astrocytoma 13 | 2,287
adult high grade glioma 12 | 3,801
diabetes mellitus 12 | 1,728
invasive ductal carcinoma 12 | 2,951
lung carcinoma 12 | 2,843
non-small cell lung cancer 12 | 2,890
primary Sjogren syndrome 12 | 735
Breast cancer 11 | 3,578
Waldenstrons macroglobulinemia 11 | 765
atypical teratoid / rhabdoid tumor 11 | 5,112
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,291
pancreatic cancer 11 | 2,398
Astrocytoma, Pilocytic 10 | 3,081
Autosomal recessive predisposition 10 | 1,442
Hypersensitivity reaction type II disease 10 | 253
Multiple Sclerosis 10 | 540
Splenomegaly 10 | 190
cutaneous lupus erythematosus 10 | 1,057
ependymoma 10 | 4,679
Kidney disease 9 | 430
astrocytoma 9 | 1,146
Anemia 8 | 365
Crohn's disease 8 | 321
Liver Cirrhosis, Experimental 8 | 769
Lymphadenopathy 8 | 62
Osteoporosis 8 | 363
Pneumonia 8 | 174
active Crohn's disease 8 | 922
cystic fibrosis 8 | 1,696
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,989
lung adenocarcinoma 8 | 2,716
oligodendroglioma 8 | 2,850
Asthma 7 | 385
Common variable immunodeficiency 7 | 101
Immunologic Deficiency Syndromes 7 | 113
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,955
periodontitis 7 | 293
Ankylosing spondylitis 6 | 140
Brain Injuries 6 | 65
Diarrhea 6 | 253
Hepatomegaly 6 | 285
Influenza 6 | 142
Mantle cell lymphoma 6 | 23
Pick disease 6 | 1,894
Schizophrenia 6 | 1,160
group 4 medulloblastoma 6 | 1,855
non primary Sjogren syndrome sicca 6 | 891
pituitary cancer 6 | 1,972
sarcoidosis 6 | 370
Alzheimer's disease 5 | 658
Arthritis, Rheumatoid 5 | 174
Atherosclerosis 5 | 291
Bronchiectasis 5 | 64
Coronary artery disease 5 | 268
Dermatitis 5 | 157
Fever 5 | 138
Hypohidrotic ectodermal dysplasia 5 | 15
Inflammatory bowel disease 5 | 151
Leprosy 5 | 73
Lupus erythematosus 5 | 57
Myocardial Infarction 5 | 151
active ulcerative colitis 5 | 764
astrocytic glioma 5 | 2,597
colon cancer 5 | 1,478
gastric carcinoma 5 | 807
group 3 medulloblastoma 5 | 4,104
hepatocellular carcinoma 5 | 547
juvenile dermatomyositis 5 | 1,187
Allergic hypersensitivity disease 4 | 126
Arthritis 4 | 290
Atopic dermatitis 4 | 952
Cerebrovascular disease 4 | 238
Diabetes Mellitus, Non-Insulin-Dependent 4 | 145
Diabetes Mellitus, Type 2 4 | 142
Leishmaniasis 4 | 47
Neuropathy 4 | 261
Vascular disease 4 | 319
Vasculitis 4 | 80
acute myeloid leukemia 4 | 783
esophageal adenocarcinoma 4 | 737
nasopharyngeal carcinoma 4 | 1,058
primary pancreatic ductal adenocarcinoma 4 | 1,109
sonic hedgehog group medulloblastoma 4 | 467

Tissue

Blood and immune system 98 | 16,909
Digestive Tract 98 | 17,369
Endocrine System 98 | 18,159
Respiratory system 98 | 16,393
Urinary Tract 98 | 16,678
Female tissues 97 | 17,400
Male tissues 97 | 17,142
Liver and Pancreas 96 | 16,750
Skin and soft tissues 96 | 17,230
Nervous System 94 | 16,725
Cardiovascular System 89 | 15,192

Target Family

Non-IDG 56 | 12,091
Enzyme 40 | 4,145
Kinase 2 | 634
Transcription Factor 2 | 1,400

Reactome Pathway

TNFR2 non-canonical NF-kB path... 100 | 100
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Tumor necrosis factor receptor superfamily member 4 TNFRSF4 Tbio Non-IDG -2.60147 430.2 524
Tumor necrosis factor receptor superfamily member 18 TNFRSF18 Tbio Non-IDG -2.34111 233.7 604
26S proteasome regulatory subunit 6A PSMC3 Tbio Enzyme -1.29086 19.3 302
F-box/WD repeat-containing protein 11 FBXW11 Tbio Non-IDG -0.75887 5.88 183
Tumor necrosis factor receptor superfamily member EDAR EDAR Tbio Non-IDG -2.21203 161.3 194
Tumor necrosis factor ligand superfamily member 18 TNFSF18 Tbio Non-IDG -1.75189 62.8 371
S-phase kinase-associated protein 1 SKP1 Tbio Enzyme -2.57150 310.1 381
Nuclear factor NF-kappa-B p100 subunit NFKB2 Tchem Transcription Factor -2.29577 191.3 637
26S proteasome non-ATPase regulatory subunit 13 PSMD13 Tbio Enzyme -1.09295 11.9 110
26S proteasome non-ATPase regulatory subunit 3 PSMD3 Tbio Enzyme -1.22269 15.9 168