Development Level

Tbio 79 | 11,445
Tchem 9 | 1,598
Tclin 9 | 613
Tdark 3 | 6,588

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 6 | 979
decreased vertical activity 3 | 208
increased lymphocyte cell numb... 3 | 32
abnormal bone structure 2 | 187
abnormal seminal vesicle morph... 2 | 114
cardiovascular system phenotyp... 2 | 36
decreased lean body mass 2 | 135
enlarged heart 2 | 210
increased leukocyte cell numbe... 2 | 47
preweaning lethality, incomple... 2 | 499
abnormal behavioral response t... 1 | 66
abnormal heart morphology 1 | 162
abnormal kidney morphology 1 | 65
decreased T cell number 1 | 15
decreased caudal vertebrae num... 1 | 53
decreased circulating choleste... 1 | 93
decreased circulating creatini... 1 | 39
decreased circulating total pr... 1 | 49
decreased heart rate 1 | 18
decreased monocyte cell number 1 | 8
embryonic lethality prior to o... 1 | 239
enlarged seminal vesicle 1 | 10
female infertility 1 | 60
increased basophil cell number 1 | 7
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating alkaline... 1 | 122
increased eosinophil cell numb... 1 | 11
increased large unstained cell... 1 | 5
increased mean corpuscular vol... 1 | 92
increased neutrophil cell numb... 1 | 46
increased startle reflex 1 | 112
prolonged QT interval 1 | 38
prolonged RR interval 1 | 8
prolonged ST segment 1 | 36

Disease

ovarian cancer 52 | 8,520
Carcinoma 42 | 11,493
psoriasis 42 | 6,694
lung cancer 40 | 4,740
osteosarcoma 40 | 7,950
Cancer 39 | 2,499
Multiple myeloma 32 | 1,332
glioblastoma 26 | 5,792
tuberculosis 25 | 2,010
malignant mesothelioma 20 | 3,232
interstitial cystitis 19 | 2,312
medulloblastoma, large-cell 18 | 6,241
HIV Infections 16 | 102
Rheumatoid arthritis 16 | 1,191
dermatomyositis 14 | 966
ulcerative colitis 14 | 1,819
pancreatic ductal adenocarcinoma liver metastasis 13 | 1,962
subependymal giant cell astrocytoma 13 | 2,287
adult high grade glioma 12 | 3,801
diabetes mellitus 12 | 1,728
invasive ductal carcinoma 12 | 2,951
lung carcinoma 12 | 2,843
non-small cell lung cancer 12 | 2,890
primary Sjogren syndrome 12 | 735
Breast cancer 11 | 3,578
Waldenstrons macroglobulinemia 11 | 765
atypical teratoid / rhabdoid tumor 11 | 5,112
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,291
pancreatic cancer 11 | 2,398
Astrocytoma, Pilocytic 10 | 3,081
Autosomal recessive predisposition 10 | 1,442
Hypersensitivity reaction type II disease 10 | 253
Multiple Sclerosis 10 | 540
Splenomegaly 10 | 190
cutaneous lupus erythematosus 10 | 1,057
ependymoma 10 | 4,679
Kidney disease 9 | 430
astrocytoma 9 | 1,146
Anemia 8 | 365
Crohn's disease 8 | 321
Liver Cirrhosis, Experimental 8 | 769
Lymphadenopathy 8 | 62
Osteoporosis 8 | 363
Pneumonia 8 | 174
active Crohn's disease 8 | 922
cystic fibrosis 8 | 1,696
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,989
lung adenocarcinoma 8 | 2,716
oligodendroglioma 8 | 2,850
Asthma 7 | 385
Common variable immunodeficiency 7 | 101
Immunologic Deficiency Syndromes 7 | 113
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,955
periodontitis 7 | 293
Ankylosing spondylitis 6 | 140
Brain Injuries 6 | 65
Diarrhea 6 | 253
Hepatomegaly 6 | 285
Influenza 6 | 142
Mantle cell lymphoma 6 | 23
Pick disease 6 | 1,894
Schizophrenia 6 | 1,160
group 4 medulloblastoma 6 | 1,855
non primary Sjogren syndrome sicca 6 | 891
pituitary cancer 6 | 1,972
sarcoidosis 6 | 370
Alzheimer's disease 5 | 658
Arthritis, Rheumatoid 5 | 174
Atherosclerosis 5 | 291
Bronchiectasis 5 | 64
Coronary artery disease 5 | 268
Dermatitis 5 | 157
Fever 5 | 138
Hypohidrotic ectodermal dysplasia 5 | 15
Inflammatory bowel disease 5 | 151
Leprosy 5 | 73
Lupus erythematosus 5 | 57
Myocardial Infarction 5 | 151
active ulcerative colitis 5 | 764
astrocytic glioma 5 | 2,597
colon cancer 5 | 1,478
gastric carcinoma 5 | 807
group 3 medulloblastoma 5 | 4,104
hepatocellular carcinoma 5 | 547
juvenile dermatomyositis 5 | 1,187
Allergic hypersensitivity disease 4 | 126
Arthritis 4 | 290
Atopic dermatitis 4 | 952
Cerebrovascular disease 4 | 238
Diabetes Mellitus, Non-Insulin-Dependent 4 | 145
Diabetes Mellitus, Type 2 4 | 142
Leishmaniasis 4 | 47
Neuropathy 4 | 261
Vascular disease 4 | 319
Vasculitis 4 | 80
acute myeloid leukemia 4 | 783
esophageal adenocarcinoma 4 | 737
nasopharyngeal carcinoma 4 | 1,058
primary pancreatic ductal adenocarcinoma 4 | 1,109
sonic hedgehog group medulloblastoma 4 | 467

Tissue

Blood and immune system 98 | 16,909
Digestive Tract 98 | 17,369
Endocrine System 98 | 18,159
Respiratory system 98 | 16,393
Urinary Tract 98 | 16,678
Female tissues 97 | 17,400
Male tissues 97 | 17,142
Liver and Pancreas 96 | 16,750
Skin and soft tissues 96 | 17,230
Nervous System 94 | 16,725
Cardiovascular System 89 | 15,192

Target Family

Non-IDG 56 | 12,091
Enzyme 40 | 4,145
Kinase 2 | 634
Transcription Factor 2 | 1,400

Reactome Pathway

TNFR2 non-canonical NF-kB path... 100 | 100
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Tumor necrosis factor receptor superfamily member 11A TNFRSF11A Tbio Non-IDG -3.26478 1689.0 464
Tumor necrosis factor receptor superfamily member 13C TNFRSF13C Tbio Non-IDG -2.48953 288.2 437
Proteasome activator complex subunit 2 PSME2 Tbio Non-IDG -1.47440 29.1 305
Proteasome subunit beta type-10 PSMB10 Tchem Enzyme -1.88722 74.3 178
Ectodysplasin-A receptor-associated adapter protein EDARADD Tbio Non-IDG -1.44120 23.1 27
Tumor necrosis factor ligand superfamily member 9 TNFSF9 Tbio Non-IDG -2.23604 185.9 371
Tumor necrosis factor receptor superfamily member 25 TNFRSF25 Tbio Non-IDG -3.25237 1888.2 535
Polyubiquitin-B UBB Tbio Non-IDG -1.98860 97.4 427
Polyubiquitin-C UBC Tbio Non-IDG -2.90157 61.9 143
Tumor necrosis factor ligand superfamily member 12 TNFSF12 Tbio Non-IDG -2.49751 362.7 413