Development Level

Tbio 16 | 10,625
Tchem 9 | 1,890
Tclin 1 | 602

IMPC Phenotype

preweaning lethality, complete... 2 | 633
abnormal lens morphology 1 | 73
decreased blood urea nitrogen ... 1 | 31
decreased body weight 1 | 174
decreased circulating choleste... 1 | 85
decreased circulating creatini... 1 | 31
decreased circulating fructosa... 1 | 31
decreased lean body mass 1 | 195
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular vol... 1 | 50
decreased startle reflex 1 | 48
embryonic lethality prior to t... 1 | 187

Disease

ovarian cancer 18 | 8,491
Cancer 15 | 2,346
osteosarcoma 14 | 7,933
glioblastoma 11 | 5,572
psoriasis 11 | 6,685
medulloblastoma, large-cell 9 | 6,234
lung cancer 8 | 4,473
atypical teratoid / rhabdoid tumor 7 | 4,369
dermatomyositis 6 | 966
juvenile dermatomyositis 6 | 1,189
tuberculosis 6 | 1,563
cystic fibrosis 5 | 1,670
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,289
malignant mesothelioma 5 | 3,163
pilocytic astrocytoma 5 | 3,086
ulcerative colitis 5 | 2,087
Breast cancer 4 | 3,098
Crohn's disease 4 | 304
astrocytoma 4 | 1,493
diabetes mellitus 4 | 1,663
ependymoma 4 | 2,514
interstitial cystitis 4 | 2,299
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,956
non-small cell lung cancer 4 | 2,798
oligodendroglioma 4 | 2,849
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,795
posterior fossa group A ependymoma 4 | 1,511
spina bifida 4 | 1,064
Amyotrophic Lateral Sclerosis 3 | 432
Bipolar Disorder 3 | 266
Dermatitis 3 | 141
Hypersensitivity reaction type II disease 3 | 235
Hypohidrotic ectodermal dysplasia 3 | 14
Juvenile rheumatoid arthritis 3 | 105
Multiple Sclerosis 3 | 498
Multiple myeloma 3 | 1,327
Rheumatoid Arthritis 3 | 1,170
Waldenstrons macroglobulinemia 3 | 764
acute myeloid leukemia 3 | 785
acute quadriplegic myopathy 3 | 1,157
adult high grade glioma 3 | 2,148
cutaneous lupus erythematosus 3 | 1,056
group 4 medulloblastoma 3 | 1,875
lung carcinoma 3 | 2,844
pediatric high grade glioma 3 | 2,712
primary pancreatic ductal adenocarcinoma 3 | 1,271
primitive neuroectodermal tumor 3 | 3,031
AMYOTROPHIC LATERAL SCLEROSIS 1 2 | 49
Alzheimer's disease 2 | 644
Amyloidosis 2 | 68
Anorexia 2 | 15
Arthritis 2 | 248
Atopic dermatitis 2 | 944
Bladder Neoplasm 2 | 109
Brain Ischemia 2 | 87
Cardiomegaly 2 | 66
Diabetes Mellitus, Experimental 2 | 106
Diabetes Mellitus, Non-Insulin-Dependent 2 | 161
Eosinophilia 2 | 65
Exanthem 2 | 39
Fatty Liver 2 | 48
Gout 2 | 93
HIV Infections 2 | 99
Heart failure 2 | 80
Hypersensitivity 2 | 63
IGA Glomerulonephritis 2 | 454
Inflammatory bowel disease 2 | 142
Kidney disease 2 | 397
Leishmaniasis 2 | 49
Leprosy 2 | 77
Leukemia 2 | 88
Listeriosis 2 | 17
Liver carcinoma 2 | 217
Liver disease 2 | 219
Lung Injury 2 | 20
Lung Neoplasms 2 | 171
Lung disease 2 | 136
Obesity 2 | 616
Pick disease 2 | 1,893
Pneumonia 2 | 133
Polycystic Ovary Syndrome 2 | 334
Primary immunodeficiency disease 2 | 52
Prostatic Neoplasms 2 | 471
Psoriatic arthritis 2 | 85
Schizophrenia 2 | 503
Stomach Neoplasms 2 | 282
active Crohn's disease 2 | 918
esophageal adenocarcinoma 2 | 737
group 3 medulloblastoma 2 | 2,254
hepatocellular carcinoma 2 | 550
lung adenocarcinoma 2 | 2,714
non primary Sjogren syndrome sicca 2 | 840
pancreatic cancer 2 | 2,300
pituitary cancer 2 | 1,972
primary Sjogren syndrome 2 | 788
sonic hedgehog group medulloblastoma 2 | 1,482
subependymal giant cell astrocytoma 2 | 2,287
systemic lupus erythematosus 2 | 172
tuberculosis and treatment for 6 months 2 | 686

Tissue

Blood and immune system 26 | 17,994
Cardiovascular System 26 | 17,957
Digestive Tract 26 | 18,472
Female tissues 26 | 18,646
Liver and Pancreas 26 | 18,135
Male tissues 26 | 17,968
Nervous System 26 | 18,560
Urinary Tract 26 | 18,443
Endocrine System 25 | 18,511
Respiratory system 25 | 17,483
Skin and soft tissues 24 | 18,114

Target Family

Non-IDG 12 | 11,969
Enzyme 8 | 4,146
Kinase 6 | 634

Reactome Pathway

TNFR1-induced NFkappaB signali... 26 | 26
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 TAB2 Tbio Enzyme -1.87718 69.0 145
Mitogen-activated protein kinase kinase kinase 7 MAP3K7 Tchem Kinase -1.41371 28.0 678
TNF receptor-associated factor 1 TRAF1 Tbio Non-IDG -2.11277 134.8 239
TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 TAB3 Tbio Enzyme -1.37963 22.0 191
Ubiquitin carboxyl-terminal hydrolase CYLD CYLD Tbio Enzyme -2.90259 806.3 176
Tumor necrosis factor receptor type 1-associated DEATH domain protein TRADD Tbio Non-IDG -2.02291 90.2 322
Ubiquitin carboxyl-terminal hydrolase 4 USP4 Tbio Enzyme -2.03223 105.6 253
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 TAB1 Tbio Kinase -1.90358 73.6 452
Ubiquitin carboxyl-terminal hydrolase 2 USP2 Tbio Enzyme -1.86985 74.1 252
Sharpin SHARPIN Tbio Non-IDG -1.26011 20.0 110