Development Level

Tbio 16 | 10,625
Tchem 9 | 1,890
Tclin 1 | 602

IMPC Term

preweaning lethality, complete... 2 | 633
abnormal lens morphology 1 | 73
decreased blood urea nitrogen ... 1 | 31
decreased body weight 1 | 174
decreased circulating choleste... 1 | 85
decreased circulating creatini... 1 | 31
decreased circulating fructosa... 1 | 31
decreased lean body mass 1 | 195
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular vol... 1 | 50
decreased startle reflex 1 | 48
embryonic lethality prior to t... 1 | 187

Disease

ovarian cancer 18 | 8,484
Cancer 15 | 2,346
osteosarcoma 14 | 7,933
glioblastoma 11 | 5,572
psoriasis 11 | 6,685
medulloblastoma, large-cell 9 | 6,234
lung cancer 8 | 4,466
atypical teratoid / rhabdoid tumor 7 | 4,369
dermatomyositis 6 | 933
juvenile dermatomyositis 6 | 1,189
tuberculosis 6 | 1,557
cystic fibrosis 5 | 1,665
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,289
malignant mesothelioma 5 | 3,162
pilocytic astrocytoma 5 | 3,086
ulcerative colitis 5 | 2,087
Breast cancer 4 | 3,094
Crohn's disease 4 | 304
astrocytoma 4 | 1,493
diabetes mellitus 4 | 1,663
ependymoma 4 | 2,514
interstitial cystitis 4 | 2,299
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,956
non-small cell lung cancer 4 | 2,798
oligodendroglioma 4 | 2,849
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,795
posterior fossa group A ependymoma 4 | 1,511
spina bifida 4 | 1,064
Amyotrophic Lateral Sclerosis 3 | 431
Bipolar Disorder 3 | 266
Dermatitis 3 | 107
Hypersensitivity reaction type II disease 3 | 235
Hypohidrotic ectodermal dysplasia 3 | 13
Juvenile rheumatoid arthritis 3 | 104
Multiple Sclerosis 3 | 498
Multiple myeloma 3 | 1,327
Rheumatoid Arthritis 3 | 1,160
Waldenstrons macroglobulinemia 3 | 765
acute myeloid leukemia 3 | 780
acute quadriplegic myopathy 3 | 1,157
adult high grade glioma 3 | 2,148
cutaneous lupus erythematosus 3 | 1,056
group 4 medulloblastoma 3 | 1,875
lung carcinoma 3 | 2,844
pediatric high grade glioma 3 | 2,712
primary pancreatic ductal adenocarcinoma 3 | 1,271
primitive neuroectodermal tumor 3 | 3,031
AMYOTROPHIC LATERAL SCLEROSIS 1 2 | 49
Alzheimer's disease 2 | 644
Amyloidosis 2 | 68
Anorexia 2 | 15
Arthritis 2 | 248
Atopic dermatitis 2 | 944
Bladder Neoplasm 2 | 109
Brain Ischemia 2 | 87
Cardiomegaly 2 | 66
Diabetes Mellitus, Experimental 2 | 106
Diabetes Mellitus, Non-Insulin-Dependent 2 | 157
Eosinophilia 2 | 65
Exanthem 2 | 39
Fatty Liver 2 | 48
Gout 2 | 93
HIV Infections 2 | 100
Heart failure 2 | 80
Hypersensitivity 2 | 63
IGA Glomerulonephritis 2 | 454
Inflammatory bowel disease 2 | 142
Kidney disease 2 | 396
Leishmaniasis 2 | 49
Leprosy 2 | 77
Leukemia 2 | 88
Listeriosis 2 | 17
Liver carcinoma 2 | 217
Liver disease 2 | 219
Lung Injury 2 | 20
Lung Neoplasms 2 | 171
Lung disease 2 | 132
Obesity 2 | 616
Pick disease 2 | 1,893
Pneumonia 2 | 133
Polycystic Ovary Syndrome 2 | 332
Primary immunodeficiency disease 2 | 52
Prostatic Neoplasms 2 | 471
Psoriatic arthritis 2 | 83
Schizophrenia 2 | 501
Stomach Neoplasms 2 | 282
active Crohn's disease 2 | 918
esophageal adenocarcinoma 2 | 737
group 3 medulloblastoma 2 | 2,254
hepatocellular carcinoma 2 | 532
lung adenocarcinoma 2 | 2,713
non primary Sjogren syndrome sicca 2 | 840
pancreatic cancer 2 | 2,300
pituitary cancer 2 | 1,972
primary Sjogren syndrome 2 | 789
sonic hedgehog group medulloblastoma 2 | 1,482
subependymal giant cell astrocytoma 2 | 2,287
systemic lupus erythematosus 2 | 156
tuberculosis and treatment for 6 months 2 | 686

Tissue

Blood and immune system 26 | 17,995
Cardiovascular System 26 | 17,958
Digestive Tract 26 | 18,473
Female tissues 26 | 18,647
Liver and Pancreas 26 | 18,136
Male tissues 26 | 17,969
Nervous System 26 | 18,561
Urinary Tract 26 | 18,444
Endocrine System 25 | 18,512
Respiratory system 25 | 17,484
Skin and soft tissues 24 | 18,115

Target Family

Non-IDG 12 | 11,971
Enzyme 8 | 4,146
Kinase 6 | 634

Reactome Pathway

TNFR1-induced NFkappaB signali... 26 | 26
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
TNF receptor-associated factor 2 TRAF2 Tbio Non-IDG -1.85843 68.9 516
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 TAB2 Tbio Enzyme -1.83055 69.0 145
Sharpin SHARPIN Tbio Non-IDG -1.20569 20.0 110
NF-kappa-B essential modulator IKBKG Tchem Kinase -3.03588 1121.7 849
Inhibitor of nuclear factor kappa-B kinase subunit alpha CHUK Tchem Kinase -2.35199 201.1 1028
E3 ubiquitin-protein ligase XIAP XIAP Tchem Enzyme -3.08341 1302.7 462
RanBP-type and C3HC4-type zinc finger-containing protein 1 RBCK1 Tbio Non-IDG -1.54422 36.9 193
Receptor of activated protein C kinase 1 RACK1 Tbio Non-IDG -2.55353 408.6 282
Ubiquitin carboxyl-terminal hydrolase 21 USP21 Tbio Enzyme -1.62273 43.6 243
Receptor-interacting serine/threonine-protein kinase 1 RIPK1 Tchem Kinase -2.18735 169.4 285