Development Level

Tbio 30 | 10,625
Tchem 12 | 1,890
Tclin 1 | 602

IMPC Phenotype

preweaning lethality, complete... 3 | 633
embryonic lethality prior to t... 2 | 187
abnormal embryo size 1 | 112
abnormal forebrain development 1 | 18
abnormal hindbrain development 1 | 24
abnormal lens morphology 1 | 73
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal vibrissa morphology 1 | 17
decreased blood urea nitrogen ... 1 | 31
decreased body weight 1 | 174
decreased bone mineral content 1 | 157
decreased circulating choleste... 1 | 85
decreased circulating creatini... 1 | 31
decreased circulating fructosa... 1 | 31
decreased lean body mass 1 | 195
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular vol... 1 | 50
decreased startle reflex 1 | 48
increased body weight 1 | 42
small superior vagus ganglion 1 | 20

Disease

ovarian cancer 30 | 8,491
osteosarcoma 22 | 7,933
glioblastoma 21 | 5,572
psoriasis 20 | 6,685
Cancer 19 | 2,346
lung cancer 13 | 4,473
atypical teratoid / rhabdoid tumor 12 | 4,369
medulloblastoma, large-cell 12 | 6,234
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,289
pilocytic astrocytoma 10 | 3,086
ependymoma 9 | 2,514
lung carcinoma 9 | 2,844
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,988
juvenile dermatomyositis 8 | 1,189
oligodendroglioma 8 | 2,849
ulcerative colitis 8 | 2,087
adult high grade glioma 7 | 2,148
dermatomyositis 7 | 966
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,956
malignant mesothelioma 7 | 3,163
pediatric high grade glioma 7 | 2,712
subependymal giant cell astrocytoma 7 | 2,287
tuberculosis 7 | 1,563
Breast cancer 6 | 3,098
astrocytic glioma 6 | 2,241
Alzheimer's disease 5 | 644
Crohn's disease 5 | 304
Multiple myeloma 5 | 1,327
Rheumatoid Arthritis 5 | 1,170
acute myeloid leukemia 5 | 785
acute quadriplegic myopathy 5 | 1,157
astrocytoma 5 | 1,493
cystic fibrosis 5 | 1,670
diabetes mellitus 5 | 1,663
group 3 medulloblastoma 5 | 2,254
interstitial cystitis 5 | 2,299
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,795
posterior fossa group A ependymoma 5 | 1,511
primitive neuroectodermal tumor 5 | 3,031
spina bifida 5 | 1,064
Amyotrophic Lateral Sclerosis 4 | 432
Juvenile rheumatoid arthritis 4 | 105
Multiple Sclerosis 4 | 498
Pick disease 4 | 1,893
atypical teratoid/rhabdoid tumor 4 | 1,095
cutaneous lupus erythematosus 4 | 1,056
hepatocellular carcinoma 4 | 550
non-small cell lung cancer 4 | 2,798
posterior fossa group B ependymoma 4 | 1,530
primary pancreatic ductal adenocarcinoma 4 | 1,271
sonic hedgehog group medulloblastoma 4 | 1,482
tuberculosis and treatment for 6 months 4 | 686
Atopic dermatitis 3 | 944
Bipolar Disorder 3 | 266
Carcinoma 3 | 2,147
Dermatitis 3 | 141
Diabetes Mellitus, Non-Insulin-Dependent 3 | 161
Hypersensitivity reaction type II disease 3 | 235
Hypohidrotic ectodermal dysplasia 3 | 14
Inflammatory bowel disease 3 | 142
Leukemia 3 | 88
Liver carcinoma 3 | 217
Lung Neoplasms 3 | 171
Stomach Neoplasms 3 | 282
Waldenstrons macroglobulinemia 3 | 764
colon cancer 3 | 1,475
group 4 medulloblastoma 3 | 1,875
pancreatic cancer 3 | 2,300
primary Sjogren syndrome 3 | 788
systemic lupus erythematosus 3 | 172
Allergic rhinitis 2 | 92
Arthritis 2 | 248
Bladder Neoplasm 2 | 109
Brain Ischemia 2 | 87
Colitis 2 | 46
Contact Dermatitis 2 | 80
Dermatitis, Allergic Contact 2 | 66
Eosinophilia 2 | 65
Hepatitis B 2 | 103
Hypersensitivity 2 | 63
IGA Glomerulonephritis 2 | 454
Keratitis 2 | 42
Kidney disease 2 | 397
Leishmaniasis 2 | 49
Listeriosis 2 | 17
Lung disease 2 | 136
Pneumonia 2 | 133
Polycystic Ovary Syndrome 2 | 334
Reperfusion Injury 2 | 84
Status Epilepticus 2 | 85
Toxic encephalopathy 2 | 131
Type 2 diabetes mellitus 2 | 192
Vascular disease 2 | 281
active Crohn's disease 2 | 918
esophageal adenocarcinoma 2 | 737
lung adenocarcinoma 2 | 2,714
medulloblastoma 2 | 1,524
non-small cell lung carcinoma 2 | 413
pituitary cancer 2 | 1,972
progressive supranuclear palsy 2 | 674

Tissue

Blood and immune system 43 | 17,994
Cardiovascular System 43 | 17,957
Digestive Tract 43 | 18,472
Female tissues 43 | 18,646
Liver and Pancreas 43 | 18,135
Male tissues 43 | 17,968
Nervous System 43 | 18,560
Urinary Tract 43 | 18,443
Endocrine System 42 | 18,511
Respiratory system 42 | 17,483
Skin and soft tissues 41 | 18,114

Target Family

Non-IDG 21 | 11,969
Enzyme 16 | 4,146
Kinase 6 | 634

Reactome Pathway

TNF signaling 43 | 43
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

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