Development Level

Tbio 3 | 11,445
Tchem 3 | 1,598

Disease

Carcinoma 6 | 11,493
Cancer 5 | 2,499
glioblastoma 5 | 5,792
osteosarcoma 5 | 7,950
Acquired scoliosis 4 | 281
Aortic Valve Insufficiency 4 | 40
Astrocytoma, Pilocytic 4 | 3,081
Coronary artery disease 4 | 268
Curvature of spine 4 | 282
Hypertensive disease 4 | 292
Kidney cancer 4 | 2,613
Loeys-Dietz syndrome 4 | 23
Pulmonary Fibrosis 4 | 106
Ureteral obstruction 4 | 33
malignant mesothelioma 4 | 3,232
ovarian cancer 4 | 8,520
Abnormality of the iris 3 | 14
Acquired flat foot 3 | 72
Aneurysm, Dissecting 3 | 8
Aortic aneurysm 3 | 38
Aortic aneurysm, familial thoracic 3 3 | 13
Arachnodactyly 3 | 49
Arterial tortuosity 3 | 5
Ascending aortic dissection 3 | 13
Breast cancer 3 | 3,578
Byzanthine arch palate 3 | 194
Cardiomegaly 3 | 116
Chest Pain 3 | 38
Cleft Palate 3 | 271
Craniofacial Abnormalities 3 | 151
Cutis marmorata 3 | 32
Cystic medial necrosis of aorta 3 | 13
Descending aortic dissection 3 | 13
Dissection of aorta 3 | 9
Dyspnea on exertion 3 | 24
Dyspnea, Paroxysmal 3 | 13
Familial thoracic aortic aneurysm and aortic dissection 3 | 13
Flatfoot 3 | 73
Impaired left ventricular function 3 | 16
Increase in blood pressure 3 | 119
Kidney disease 3 | 430
Left-Sided Heart Failure 3 | 16
Linear atrophy 3 | 15
Liver Cirrhosis 3 | 181
Liver Cirrhosis, Experimental 3 | 769
Liver disease 3 | 237
Loeys-Dietz Aortic Aneurysm Syndrome 3 | 13
Orbital separation excessive 3 | 244
Peyronie's disease 3 | 9
Pneumonia 3 | 174
Systemic scleroderma 3 | 60
Thoracic aortic aneurysm 3 | 15
Ventricular Remodeling 3 | 5
Waldenstrons macroglobulinemia 3 | 765
adult high grade glioma 3 | 3,801
atypical teratoid / rhabdoid tumor 3 | 5,112
dermatomyositis 3 | 966
diabetes mellitus 3 | 1,728
ependymoma 3 | 4,679
group 3 medulloblastoma 3 | 4,104
pancreatic cancer 3 | 2,398
primitive neuroectodermal tumor 3 | 3,035
Abortion, Spontaneous 2 | 109
Atypical scarring of skin 2 | 62
Blue sclera 2 | 32
Cleft palate with cleft lip 2 | 23
Colorectal Neoplasms 2 | 243
Congenital Camptodactyly 2 | 40
Craniosynostosis 2 | 74
Dental caries 2 | 164
Depressive disorder 2 | 409
Diabetic Nephropathies 2 | 37
Exophthalmos 2 | 112
Flexion contracture of proximal interphalangeal joint 2 | 75
Gaucher disease type 1 2 | 180
Heart disease 2 | 306
Hernia, Inguinal 2 | 89
Hypertension 2 | 396
Hypotrophic malar bone 2 | 129
Inflammatory bowel disease 2 | 151
Lung Neoplasms 2 | 232
Malabsorption 2 | 82
Malar flattening 2 | 129
Neoplasm Metastasis 2 | 168
Osteoarthritis 2 | 184
Prominent eyes 2 | 96
Prominent globes 2 | 96
Protruding eyes 2 | 96
Skull malformation 2 | 38
Spontaneous abortion 2 | 113
Squamous cell carcinoma 2 | 129
Tall stature 2 | 34
Vascular disease 2 | 319
active ulcerative colitis 2 | 764
acute quadriplegic myopathy 2 | 1,158
cystic fibrosis 2 | 1,696
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
juvenile dermatomyositis 2 | 1,187
lung adenocarcinoma 2 | 2,716
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962

Tissue

Blood and immune system 6 | 16,909
Cardiovascular System 6 | 15,192
Digestive Tract 6 | 17,369
Endocrine System 6 | 18,159
Female tissues 6 | 17,400
Liver and Pancreas 6 | 16,750
Male tissues 6 | 17,142
Nervous System 6 | 16,725
Respiratory system 6 | 16,393
Skin and soft tissues 6 | 17,230
Urinary Tract 6 | 16,678

Target Family

Kinase 2 | 634
Non-IDG 2 | 12,091
Transcription Factor 2 | 1,400

Reactome Pathway

TGFBR1 KD Mutants in Cancer 6 | 6
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
TGF-beta receptor type-2 TGFBR2 Tchem Kinase -2.84120 665.1 548
Mothers against decapentaplegic homolog 3 SMAD3 Tbio Transcription Factor -3.19667 1403.6 1526
Zinc finger FYVE domain-containing protein 9 ZFYVE9 Tbio Non-IDG -2.17333 130.4 54
Transforming growth factor beta-1 TGFB1 Tchem Non-IDG -3.84680 5672.0 1222
TGF-beta receptor type-1 TGFBR1 Tchem Kinase -2.94747 847.9 413
Mothers against decapentaplegic homolog 2 SMAD2 Tbio Transcription Factor -3.26675 1515.7 1396