Development Level

Tbio 10 | 11,178
Tchem 4 | 1,885
Tclin 1 | 612

IMPC Phenotype

preweaning lethality, complete... 2 | 979
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal craniofacial morpholo... 1 | 33
abnormal embryo size 1 | 220
abnormal forebrain morphology 1 | 10
abnormal neural tube closure 1 | 46
abnormal optic disc morphology 1 | 10
abnormal retina morphology 1 | 71
abnormal tail morphology 1 | 25
cyanosis 1 | 7
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased lean body mass 1 | 135
decreased red blood cell distr... 1 | 41
decreased startle reflex 1 | 75
decreased total body fat amoun... 1 | 207
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
hemorrhage 1 | 23
increased body length 1 | 32
increased bone mineral content 1 | 108
increased circulating alanine ... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating aspartat... 1 | 15
increased circulating iron lev... 1 | 30
increased lean body mass 1 | 172
increased total body fat amoun... 1 | 134
trunk curl 1 | 16

Disease

Carcinoma 9 | 11,192
osteosarcoma 9 | 7,766
glioblastoma 8 | 5,635
ovarian cancer 8 | 8,297
Cancer 7 | 2,388
ependymoma 6 | 4,559
lung cancer 6 | 4,607
malignant mesothelioma 6 | 3,135
pancreatic cancer 6 | 2,322
Astrocytoma, Pilocytic 5 | 3,006
medulloblastoma, large-cell 5 | 6,086
non-small cell lung cancer 5 | 2,799
Breast cancer 4 | 3,469
Cleft Palate 4 | 265
Prostatic Neoplasms 4 | 472
adult high grade glioma 4 | 3,701
astrocytic glioma 4 | 2,530
astrocytoma 4 | 1,113
atypical teratoid / rhabdoid tumor 4 | 4,971
group 3 medulloblastoma 4 | 4,002
lung carcinoma 4 | 2,755
Acquired scoliosis 3 | 274
Aortic Valve Insufficiency 3 | 39
Bipolar Disorder 3 | 646
Cardiomegaly 3 | 114
Cleft uvula 3 | 27
Coronary artery disease 3 | 253
Curvature of spine 3 | 275
Hypertensive disease 3 | 278
Hypoplastic mandible condyle 3 | 273
Kidney cancer 3 | 2,548
Liver Cirrhosis, Experimental 3 | 733
Mandibular hypoplasia 3 | 273
Micrognathism 3 | 273
Schizophrenia 3 | 1,136
acute myeloid leukemia 3 | 760
acute quadriplegic myopathy 3 | 1,133
cystic fibrosis 3 | 1,629
ductal carcinoma in situ 3 | 1,686
invasive ductal carcinoma 3 | 2,867
pediatric high grade glioma 3 | 1,035
primary pancreatic ductal adenocarcinoma 3 | 1,071
primitive neuroectodermal tumor 3 | 2,957
psoriasis 3 | 6,514
spina bifida 3 | 1,053
subependymal giant cell astrocytoma 3 | 2,230
Abortion, Spontaneous 2 | 93
Anemia 2 | 353
Aortic aneurysm 2 | 33
Arachnodactyly 2 | 49
Arterial tortuosity 2 | 5
Atherosclerosis 2 | 276
Atypical scarring of skin 2 | 61
Blue sclera 2 | 32
Byzanthine arch palate 2 | 194
Cerebrovascular disease 2 | 223
Chest Pain 2 | 38
Cleft palate with cleft lip 2 | 23
Colorectal Neoplasms 2 | 235
Craniosynostosis 2 | 73
Dental caries 2 | 157
Depressive disorder 2 | 401
Diabetic Nephropathies 2 | 34
Epilepsy 2 | 775
Exophthalmos 2 | 110
Flexion contracture of proximal interphalangeal joint 2 | 74
Gaucher disease type 1 2 | 177
Heart disease 2 | 288
Hypertension 2 | 372
Hypotrophic malar bone 2 | 129
Impotence 2 | 44
Kidney disease 2 | 411
Liver Cirrhosis 2 | 173
Lung Neoplasms 2 | 217
Lung disease 2 | 135
Malabsorption 2 | 81
Malar flattening 2 | 129
Neoplasm Invasiveness 2 | 151
Neoplasm Metastasis 2 | 160
Neurodegenerative disease 2 | 402
Oral cleft 2 | 18
Pick disease 2 | 1,856
Prominent eyes 2 | 95
Prominent globes 2 | 95
Proteinuria 2 | 143
Protruding eyes 2 | 95
Seizures 2 | 584
Skull malformation 2 | 37
Spontaneous abortion 2 | 97
Squamous cell carcinoma 2 | 125
Tall stature 2 | 33
Waldenstrons macroglobulinemia 2 | 742
active ulcerative colitis 2 | 736
breast carcinoma 2 | 1,589
lung adenocarcinoma 2 | 2,627
mucosa-associated lymphoid tissue lymphoma 2 | 473
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,911
pituitary cancer 2 | 1,915
progressive supranuclear palsy 2 | 656
tuberculosis 2 | 1,963

Tissue

Blood and immune system 15 | 16,909
Cardiovascular System 15 | 15,192
Digestive Tract 15 | 17,369
Endocrine System 15 | 18,159
Female tissues 15 | 17,400
Liver and Pancreas 15 | 16,750
Male tissues 15 | 17,142
Nervous System 15 | 16,725
Respiratory system 15 | 16,393
Skin and soft tissues 15 | 17,230
Urinary Tract 15 | 16,678

Target Family

Non-IDG 9 | 12,091
Enzyme 3 | 4,145
Kinase 3 | 634

Reactome Pathway

TGF-beta receptor signaling in... 15 | 15
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Junctional adhesion molecule A F11R Tbio Non-IDG -2.56739 380.0 394
Polyubiquitin-C UBC Tbio Non-IDG -2.90157 61.9 143
Polyubiquitin-B UBB Tbio Non-IDG -1.98860 97.4 427
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.12534 131.4 181
Ubiquitin-40S ribosomal protein S27a RPS27A Tbio Non-IDG -1.66231 61.9 139
E3 ubiquitin-protein ligase SMURF1 SMURF1 Tbio Enzyme -1.95365 89.3 331
Transforming growth factor beta-1 TGFB1 Tchem Non-IDG -3.84680 5672.0 1222
TGF-beta receptor type-2 TGFBR2 Tchem Kinase -2.84120 665.1 548
Peptidyl-prolyl cis-trans isomerase FKBP1A FKBP1A Tclin Enzyme -2.77923 382.8 271
Transforming protein RhoA RHOA Tbio Enzyme -3.54095 3332.7 501