Development Level

Tbio 11 | 10,625
Tchem 4 | 1,890
Tclin 1 | 602

IMPC Term

decreased lean body mass 3 | 195
decreased bone mineral content 2 | 157
preweaning lethality, complete... 2 | 633
abnormal behavior 1 | 226
abnormal bone structure 1 | 131
abnormal craniofacial morpholo... 1 | 12
abnormal embryo size 1 | 112
abnormal forebrain morphology 1 | 4
abnormal neural tube closure 1 | 37
abnormal optic disc morphology 1 | 10
abnormal retina morphology 1 | 100
abnormal tail morphology 1 | 17
cyanosis 1 | 6
decreased effector memory CD8-... 1 | 24
decreased rib number 1 | 59
decreased spleen weight 1 | 13
decreased startle reflex 1 | 48
decreased total body fat amoun... 1 | 186
embryonic lethality prior to o... 1 | 148
embryonic lethality prior to t... 1 | 187
hemorrhage 1 | 12
hyperactivity 1 | 108
increased CD8-positive, naive ... 1 | 3
increased bone mineral content 1 | 92
increased circulating alanine ... 1 | 11
increased circulating alkaline... 1 | 119
increased circulating aspartat... 1 | 17
increased circulating iron lev... 1 | 25
increased lean body mass 1 | 107
increased total body fat amoun... 1 | 57
trunk curl 1 | 15

Disease

osteosarcoma 9 | 7,933
glioblastoma 8 | 5,572
ovarian cancer 8 | 8,484
pediatric high grade glioma 7 | 2,712
Cancer 6 | 2,346
lung cancer 6 | 4,466
malignant mesothelioma 6 | 3,162
astrocytoma 5 | 1,493
medulloblastoma, large-cell 5 | 6,234
non-small cell lung cancer 5 | 2,798
pancreatic cancer 5 | 2,300
pilocytic astrocytoma 5 | 3,086
Breast cancer 4 | 3,094
atypical teratoid / rhabdoid tumor 4 | 4,369
lung carcinoma 4 | 2,844
Aortic aneurysm 3 | 34
Carcinoma 3 | 2,147
Cleft palate 3 | 125
Kidney disease 3 | 396
Loeys-Dietz syndrome 3 | 23
Prostatic Neoplasms 3 | 471
acute myeloid leukemia 3 | 780
acute quadriplegic myopathy 3 | 1,157
astrocytic glioma 3 | 2,241
cystic fibrosis 3 | 1,665
ductal carcinoma in situ 3 | 1,745
invasive ductal carcinoma 3 | 2,950
posterior fossa group A ependymoma 3 | 1,511
primary pancreatic ductal adenocarcinoma 3 | 1,271
primitive neuroectodermal tumor 3 | 3,031
psoriasis 3 | 6,685
spina bifida 3 | 1,064
subependymal giant cell astrocytoma 3 | 2,287
tuberculosis 3 | 1,557
Adenoma 2 | 165
Alzheimer's disease 2 | 644
Aneurysm, Dissecting 2 | 5
Asthma 2 | 349
Atherosclerosis 2 | 275
Cerebrovascular disease 2 | 231
Colorectal Neoplasms 2 | 217
Connective tissue disease 2 | 59
Diabetic Nephropathy 2 | 37
Gaucher disease type 1 2 | 171
Heart disease 2 | 279
Hereditary hemorrhagic telangiectasia 2 | 14
Hypertension 2 | 287
IGA Glomerulonephritis 2 | 454
Liver Cirrhosis, Experimental 2 | 108
Lung Neoplasms 2 | 171
Lung disease 2 | 132
Marfan Syndrome 2 | 14
Migraine Disorders 2 | 26
Multiple myeloma 2 | 1,327
Myofibrillar myopathy 1 2 | 5
Myofibrillar myopathy 3 2 | 4
Neoplasm Invasiveness 2 | 127
Neoplasm Metastasis 2 | 138
Neurodegenerative disease 2 | 383
Obesity 2 | 616
Pick disease 2 | 1,893
Pick's disease 2 | 14
Proliferative vitreoretinopathy 2 | 17
Proteinuria 2 | 63
Pulmonary Fibrosis 2 | 66
Skin Neoplasms 2 | 49
Spontaneous abortion 2 | 108
Thoracic aortic aneurysm 2 | 12
Uremia 2 | 19
Ureteral disease 2 | 23
Waldenstrons macroglobulinemia 2 | 765
active ulcerative colitis 2 | 477
breast carcinoma 2 | 1,614
diabetes mellitus 2 | 1,663
group 3 medulloblastoma 2 | 2,254
interstitial cystitis 2 | 2,299
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,289
juvenile dermatomyositis 2 | 1,189
lung adenocarcinoma 2 | 2,713
medulloblastoma 2 | 1,524
mucosa-associated lymphoid tissue lymphoma 2 | 480
oligodendroglioma 2 | 2,849
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,795
pituitary cancer 2 | 1,972
posterior fossa group B ependymoma 2 | 1,530
progressive supranuclear palsy 2 | 674
ulcerative colitis 2 | 2,087
Carcinoma of breast 1 | 11
Chronic Obstructive Airway Disease 1 | 47
Human immunodeficiency virus infectious disease 1 | 92
Pancreatitis 1 | 97
Papilloma 1 | 27
Periodontal disease 1 | 37
Prevention of Cardiac Transplant Rejection 1 | 14
Prevention of Kidney Transplant Rejection 1 | 16
Prevention of Liver Transplant Rejection 1 | 14
Pulmonary emphysema 1 | 34
Sepsis 1 | 21

Tissue

Blood and immune system 16 | 17,995
Cardiovascular System 16 | 17,958
Digestive Tract 16 | 18,473
Endocrine System 16 | 18,512
Female tissues 16 | 18,647
Liver and Pancreas 16 | 18,136
Male tissues 16 | 17,969
Nervous System 16 | 18,561
Respiratory system 16 | 17,484
Skin and soft tissues 16 | 18,115
Urinary Tract 16 | 18,444

Target Family

Non-IDG 10 | 11,971
Enzyme 3 | 4,146
Kinase 3 | 634

Reactome Pathway

TGF-beta receptor signaling in... 16 | 16
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.21113 124.2 150
Ubiquitin-40S ribosomal protein S27a RPS27A Tbio Non-IDG 56.7 150
Peptidyl-prolyl cis-trans isomerase FKBP1A FKBP1A Tclin Enzyme -2.75744 370.6 255
Transforming protein RhoA RHOA Tbio Enzyme -3.48838 3096.5 467
Rho guanine nucleotide exchange factor 18 ARHGEF18 Tbio Non-IDG -0.76663 7.69 139
TGF-beta receptor type-2 TGFBR2 Tchem Kinase -2.72206 519.3 441
Polyubiquitin-C UBC Tbio Non-IDG -2.87012 56.7 130
Polyubiquitin-B UBB Tbio Non-IDG 92.3 370
E3 ubiquitin-protein ligase SMURF1 SMURF1 Tbio Enzyme -1.82429 75.1 274
Transforming growth factor beta-1 TGFB1 Tchem Non-IDG -4.32707 20956.6 961