Development Level

Tbio 75 | 10,625
Tchem 44 | 1,890
Tclin 10 | 602
Tdark 5 | 7,003

Collection

Eligible Kinase Proteins 2 | 134

IMPC Term

preweaning lethality, complete... 4 | 633
decreased lean body mass 3 | 195
abnormal bone structure 2 | 131
decreased bone mineral content 2 | 157
decreased circulating creatini... 2 | 31
increased fasted circulating g... 2 | 68
abnormal cornea morphology 1 | 24
abnormal lens morphology 1 | 73
abnormal skin condition 1 | 6
abnormal testis morphology 1 | 30
decreased body length 1 | 108
decreased body weight 1 | 174
decreased circulating amylase ... 1 | 24
decreased circulating iron lev... 1 | 25
decreased circulating sodium l... 1 | 18
decreased grip strength 1 | 123
decreased lumbar vertebrae num... 1 | 62
decreased mean corpuscular hem... 1 | 19
decreased startle reflex 1 | 48
decreased thermal nociceptive ... 1 | 4
embryonic lethality prior to t... 1 | 187
increased blood urea nitrogen ... 1 | 44
increased circulating alkaline... 1 | 119
increased circulating free fat... 1 | 17
increased circulating iron lev... 1 | 25
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 37
increased mean corpuscular hem... 1 | 93
increased mean corpuscular vol... 1 | 91
increased respiratory quotient 1 | 12
increased thermal nociceptive ... 1 | 9
male infertility 1 | 62
polydactyly 1 | 22
preweaning lethality, incomple... 1 | 260
small testis 1 | 37

Disease

ovarian cancer 73 | 8,484
lung cancer 55 | 4,466
osteosarcoma 53 | 7,933
psoriasis 51 | 6,685
glioblastoma 43 | 5,572
lung carcinoma 33 | 2,844
Cancer 32 | 2,346
Multiple myeloma 31 | 1,327
medulloblastoma, large-cell 28 | 6,234
invasive ductal carcinoma 27 | 2,950
diabetes mellitus 26 | 1,663
dermatomyositis 23 | 933
Rheumatoid Arthritis 22 | 1,160
atypical teratoid / rhabdoid tumor 22 | 4,369
interstitial cystitis 22 | 2,299
intraductal papillary-mucinous neoplasm (IPMN) 22 | 3,289
cutaneous lupus erythematosus 21 | 1,056
intraductal papillary-mucinous carcinoma (IPMC) 21 | 2,988
non-small cell lung cancer 21 | 2,798
subependymal giant cell astrocytoma 21 | 2,287
primary Sjogren syndrome 20 | 789
Breast cancer 19 | 3,094
Waldenstrons macroglobulinemia 19 | 765
oligodendroglioma 19 | 2,849
malignant mesothelioma 17 | 3,162
pilocytic astrocytoma 17 | 3,086
astrocytoma 16 | 1,493
ependymoma 16 | 2,514
ulcerative colitis 16 | 2,087
HIV Infections 15 | 100
astrocytic glioma 15 | 2,241
juvenile dermatomyositis 15 | 1,189
pancreatic cancer 15 | 2,300
pediatric high grade glioma 15 | 2,712
tuberculosis 15 | 1,557
Carcinoma 14 | 2,147
IGA Glomerulonephritis 13 | 454
Pick disease 13 | 1,893
adult high grade glioma 13 | 2,148
breast carcinoma 13 | 1,614
intraductal papillary-mucinous adenoma (IPMA) 13 | 2,956
primary pancreatic ductal adenocarcinoma 12 | 1,271
medulloblastoma 11 | 1,524
sarcoidosis 11 | 358
Hypersensitivity reaction type II disease 10 | 235
Multiple Sclerosis 10 | 498
active Crohn's disease 10 | 918
lung adenocarcinoma 10 | 2,713
pancreatic ductal adenocarcinoma liver metastasis 10 | 1,795
posterior fossa group A ependymoma 10 | 1,511
primitive neuroectodermal tumor 10 | 3,031
acute myeloid leukemia 9 | 780
cystic fibrosis 9 | 1,665
Asthma 8 | 349
Duchenne muscular dystrophy 8 | 602
Narcolepsy 8 | 58
Renal Cell Carcinoma 8 | 199
Type 1 diabetes mellitus 8 | 101
group 3 medulloblastoma 8 | 2,254
group 4 medulloblastoma 8 | 1,875
Juvenile rheumatoid arthritis 7 | 104
Mantle cell lymphoma 7 | 18
ductal carcinoma in situ 7 | 1,745
Diabetes Mellitus, Insulin-Dependent 6 | 76
Mammary Neoplasms 6 | 410
Severe Combined Immunodeficiency 6 | 46
Systemic scleroderma 6 | 66
acute quadriplegic myopathy 6 | 1,157
colon cancer 6 | 1,475
esophageal adenocarcinoma 6 | 737
non primary Sjogren syndrome sicca 6 | 840
pituitary cancer 6 | 1,972
Addison's disease 5 | 29
Celiac disease 5 | 112
Diffuse large B-cell lymphoma 5 | 41
Graves' disease 5 | 25
Hypersensitivity 5 | 63
Lupus Erythematosus, Systemic 5 | 73
Lymphoma 5 | 56
Parkinson's disease 5 | 364
Proteinuria 5 | 63
Schizophrenia 5 | 501
head and neck cancer and chronic obstructive pulmonary disease 5 | 237
pancreatic carcinoma 5 | 567
Arthritis 4 | 248
Atopic dermatitis 4 | 944
Autoimmune thyroiditis 4 | 24
Chronic Lymphocytic Leukemia 4 | 242
Crohn's disease 4 | 304
Hepatitis B, Chronic 4 | 15
Leprosy 4 | 77
Liver disease 4 | 219
Sezary Syndrome 4 | 26
Vasculitis 4 | 64
active ulcerative colitis 4 | 477
adrenocortical carcinoma 4 | 1,427
hepatocellular carcinoma 4 | 532
limb girdle muscular dystrophy 2I 4 | 56
mucosa-associated lymphoid tissue lymphoma 4 | 480
tuberculosis and treatment for 6 months 4 | 686

Tissue

Blood and immune system 119 | 17,995
Digestive Tract 119 | 18,473
Endocrine System 119 | 18,512
Female tissues 119 | 18,647
Liver and Pancreas 119 | 18,136
Male tissues 119 | 17,969
Nervous System 119 | 18,561
Urinary Tract 119 | 18,444
Respiratory system 118 | 17,484
Cardiovascular System 117 | 17,958
Skin and soft tissues 112 | 18,115

Target Family

Non-IDG 66 | 11,971
Enzyme 49 | 4,146
Kinase 17 | 634
Transcription Factor 2 | 1,400

Reactome Pathway

TCR signaling 134 | 134
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

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