Development Level

Tbio 91 | 11,651
Tchem 25 | 1,388
Tclin 11 | 612
Tdark 7 | 6,593

Collection

Kinase: IDG Consortium (Target... 2 | 125
RFA-RM-18-021 2 | 328

IMPC Phenotype

preweaning lethality, complete... 8 | 979
preweaning lethality, incomple... 3 | 499
abnormal bone structure 2 | 187
abnormal lens morphology 2 | 81
decreased circulating creatini... 2 | 39
decreased vertical activity 2 | 208
abnormal behavior 1 | 298
abnormal behavioral response t... 1 | 66
abnormal cornea morphology 1 | 31
abnormal eye morphology 1 | 68
abnormal heart morphology 1 | 162
abnormal kidney morphology 1 | 65
abnormal skin condition 1 | 6
abnormal skin morphology 1 | 50
abnormal testis morphology 1 | 43
anophthalmia 1 | 33
cataract 1 | 92
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased caudal vertebrae num... 1 | 53
decreased circulating amylase ... 1 | 28
decreased circulating choleste... 1 | 93
decreased circulating iron lev... 1 | 32
decreased circulating sodium l... 1 | 22
decreased circulating total pr... 1 | 49
decreased mean corpuscular hem... 1 | 31
decreased neutrophil cell numb... 1 | 42
decreased startle reflex 1 | 75
decreased thermal nociceptive ... 1 | 2
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
increased blood urea nitrogen ... 1 | 48
increased circulating alkaline... 1 | 122
increased circulating free fat... 1 | 20
increased circulating iron lev... 1 | 30
increased circulating triglyce... 1 | 42
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased thermal nociceptive ... 1 | 9
male infertility 1 | 123
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
small testis 1 | 58

Disease

ovarian cancer 73 | 8,520
Carcinoma 58 | 11,493
lung cancer 55 | 4,740
osteosarcoma 52 | 7,950
psoriasis 52 | 6,694
glioblastoma 45 | 5,792
Cancer 35 | 2,499
Rheumatoid arthritis 33 | 1,191
lung carcinoma 32 | 2,843
Multiple myeloma 31 | 1,332
medulloblastoma, large-cell 27 | 6,241
invasive ductal carcinoma 26 | 2,951
diabetes mellitus 25 | 1,728
ependymoma 24 | 4,679
adult high grade glioma 23 | 3,801
atypical teratoid / rhabdoid tumor 23 | 5,112
non-small cell lung cancer 22 | 2,890
interstitial cystitis 21 | 2,312
intraductal papillary-mucinous neoplasm (IPMN) 21 | 3,291
subependymal giant cell astrocytoma 21 | 2,287
cutaneous lupus erythematosus 20 | 1,057
intraductal papillary-mucinous carcinoma (IPMC) 20 | 2,989
sarcoidosis 20 | 370
Breast cancer 19 | 3,578
Waldenstrons macroglobulinemia 19 | 765
dermatomyositis 19 | 966
Narcolepsy 18 | 72
oligodendroglioma 18 | 2,850
malignant mesothelioma 17 | 3,232
primary Sjogren syndrome 17 | 735
Astrocytoma, Pilocytic 16 | 3,081
Autosomal recessive predisposition 16 | 1,442
astrocytoma 16 | 1,146
tuberculosis 16 | 2,010
Berylliosis 15 | 28
HIV Infections 15 | 102
Systemic lupus erythematosus 15 | 194
follicular lymphoma 15 | 20
juvenile dermatomyositis 15 | 1,187
Kidney cancer 14 | 2,613
Multiple Sclerosis, Susceptibility to 14 | 15
Narcolepsy-cataplexy 14 | 21
astrocytic glioma 14 | 2,597
breast carcinoma 14 | 1,638
group 3 medulloblastoma 14 | 4,104
pancreatic cancer 14 | 2,398
Diffuse cutaneous systemic sclerosis 13 | 17
Pick disease 13 | 1,894
Rheumatoid Arthritis, Systemic Juvenile 13 | 16
Sarcoidosis 1 13 | 14
intraductal papillary-mucinous adenoma (IPMA) 13 | 2,955
limited scleroderma 13 | 19
pancreatic ductal adenocarcinoma liver metastasis 13 | 1,962
Immunologic Deficiency Syndromes 12 | 113
ulcerative colitis 12 | 1,819
Hypersensitivity reaction type II disease 11 | 253
Multiple Sclerosis 11 | 540
group 4 medulloblastoma 11 | 1,855
Liver Cirrhosis, Experimental 10 | 769
Schizophrenia 10 | 1,160
active Crohn's disease 10 | 922
lung adenocarcinoma 10 | 2,716
primitive neuroectodermal tumor 10 | 3,035
Juvenile rheumatoid arthritis 9 | 111
Recurrent respiratory infections 9 | 141
cystic fibrosis 9 | 1,696
Arthritis, Rheumatoid 8 | 174
Autoimmune Diseases 8 | 67
Duchenne muscular dystrophy 8 | 601
Failure to gain weight 8 | 365
Pediatric failure to thrive 8 | 365
Proteinuria 8 | 144
Renal Cell Carcinoma 8 | 214
Type 1 diabetes mellitus 8 | 109
acute myeloid leukemia 8 | 783
non primary Sjogren syndrome sicca 8 | 891
primary pancreatic ductal adenocarcinoma 8 | 1,109
Arthritis 7 | 290
Asthma 7 | 385
Breast Neoplasms 7 | 445
Crohn's disease 7 | 321
Fatigue 7 | 182
Infantile onset 7 | 238
Mammary Neoplasms 7 | 425
Mantle cell lymphoma 7 | 23
Splenomegaly 7 | 190
ductal carcinoma in situ 7 | 1,745
Anemia 6 | 365
Diarrhea 6 | 253
Epilepsy 6 | 792
Fever 6 | 138
Frontal bossing 6 | 157
Hepatitis B 6 | 108
Seizures 6 | 596
Severe combined immunodeficiency 6 | 51
Weight decreased 6 | 103
active ulcerative colitis 6 | 764
acute quadriplegic myopathy 6 | 1,158
esophageal adenocarcinoma 6 | 737
pituitary cancer 6 | 1,972

Tissue

Blood and immune system 112 | 16,909
Endocrine System 112 | 18,159
Respiratory system 112 | 16,393
Digestive Tract 111 | 17,369
Female tissues 111 | 17,400
Liver and Pancreas 111 | 16,750
Male tissues 111 | 17,142
Skin and soft tissues 111 | 17,230
Urinary Tract 111 | 16,678
Cardiovascular System 109 | 15,192
Nervous System 108 | 16,725

Target Family

Non-IDG 66 | 12,091
Enzyme 49 | 4,145
Kinase 17 | 634
Transcription Factor 2 | 1,400

Reactome Pathway

TCR signaling 134 | 134
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Tyrosine-protein kinase ZAP-70 ZAP70 Tchem Kinase -2.91589 798.2 1515
T-cell surface glycoprotein CD3 zeta chain CD247 Tbio Non-IDG -2.61157 386.3 882
Serine/threonine-protein kinase PAK 1 PAK1 Tchem Kinase -2.29299 237.8 1060
NF-kappa-B essential modulator IKBKG Tbio Kinase -3.07452 1188.4 879
26S proteasome regulatory subunit 6A PSMC3 Tbio Enzyme -1.29086 19.3 302
F-box/WD repeat-containing protein 11 FBXW11 Tbio Non-IDG -0.75887 5.88 183
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 PAG1 Tbio Non-IDG -1.69647 50.1 216
Cytoplasmic protein NCK1 NCK1 Tbio Non-IDG -2.25032 186.5 398
TNF receptor-associated factor 6 TRAF6 Tbio Non-IDG -2.74221 511.1 403
S-phase kinase-associated protein 1 SKP1 Tbio Enzyme -2.57150 310.1 381