Development Level

Tbio 129 | 10,625
Tchem 45 | 1,890
Tdark 16 | 7,003
Tclin 7 | 602

Collection

Eligible Kinase Proteins 3 | 134

IMPC Term

preweaning lethality, complete... 7 | 633
abnormal bone mineralization 4 | 55
decreased body weight 4 | 174
decreased lean body mass 4 | 195
preweaning lethality, incomple... 4 | 260
decreased bone mineral density 3 | 126
increased mean corpuscular vol... 3 | 91
abnormal bone structure 2 | 131
abnormal retina morphology 2 | 100
abnormal retinal pigmentation 2 | 61
abnormal testis morphology 2 | 30
corneal opacity 2 | 25
decreased body length 2 | 108
decreased grip strength 2 | 123
decreased total body fat amoun... 2 | 186
enlarged heart 2 | 111
hydrops fetalis 2 | 22
increased bone mineral content 2 | 92
increased circulating alkaline... 2 | 119
increased lean body mass 2 | 107
increased or absent threshold ... 2 | 128
small testis 2 | 37
thrombocytosis 2 | 23
abnormal coping response 1 | 12
abnormal cornea morphology 1 | 24
abnormal eye morphology 1 | 38
abnormal eye size 1 | 11
abnormal eyelid morphology 1 | 6
abnormal forelimb morphology 1 | 2
abnormal glucose homeostasis 1 | 5
abnormal head morphology 1 | 10
abnormal heart morphology 1 | 51
abnormal iris morphology 1 | 12
abnormal kidney morphology 1 | 30
abnormal respiratory quotient 1 | 9
abnormal response to tactile s... 1 | 16
abnormal seminal vesicle morph... 1 | 47
abnormal skin morphology 1 | 23
abnormal startle reflex 1 | 14
abnormal vibrissa morphology 1 | 17
cataract 1 | 26
decreased CD4-positive, alpha ... 1 | 19
decreased T cell number 1 | 31
decreased bone mineral content 1 | 157
decreased caudal vertebrae num... 1 | 49
decreased circulating LDL chol... 1 | 37
decreased circulating choleste... 1 | 85
decreased circulating fructosa... 1 | 31
decreased circulating insulin ... 1 | 75
decreased circulating serum al... 1 | 79
decreased circulating total pr... 1 | 41
decreased circulating triglyce... 1 | 83
decreased hemoglobin content 1 | 53
decreased neutrophil cell numb... 1 | 37
decreased rib number 1 | 59
enlarged lymph nodes 1 | 27
female infertility 1 | 34
increased B cell number 1 | 23
increased bone mineral density 1 | 52
increased circulating LDL chol... 1 | 15
increased circulating choleste... 1 | 53
increased circulating magnesiu... 1 | 10
increased grip strength 1 | 83
increased heart weight 1 | 37
increased leukocyte cell numbe... 1 | 37
increased mean corpuscular hem... 1 | 25
increased neutrophil cell numb... 1 | 15
increased rib number 1 | 41
kinked tail 1 | 3
male infertility 1 | 62
microcephaly 1 | 3
microphthalmia 1 | 15
narrow eye opening 1 | 15
persistence of hyaloid vascula... 1 | 22
syndactyly 1 | 4
thrombocytopenia 1 | 46

Disease

ovarian cancer 120 | 8,484
psoriasis 93 | 6,685
osteosarcoma 83 | 7,933
lung cancer 70 | 4,466
Cancer 67 | 2,346
glioblastoma 67 | 5,572
medulloblastoma, large-cell 57 | 6,234
Breast cancer 55 | 3,094
atypical teratoid / rhabdoid tumor 51 | 4,369
Multiple myeloma 45 | 1,327
intraductal papillary-mucinous carcinoma (IPMC) 41 | 2,988
invasive ductal carcinoma 41 | 2,950
intraductal papillary-mucinous neoplasm (IPMN) 40 | 3,289
lung adenocarcinoma 38 | 2,713
malignant mesothelioma 37 | 3,162
primitive neuroectodermal tumor 36 | 3,031
non-small cell lung cancer 35 | 2,798
breast carcinoma 33 | 1,614
oligodendroglioma 33 | 2,849
pediatric high grade glioma 32 | 2,712
intraductal papillary-mucinous adenoma (IPMA) 30 | 2,956
lung carcinoma 30 | 2,844
pilocytic astrocytoma 29 | 3,086
ependymoma 28 | 2,514
group 4 medulloblastoma 28 | 1,875
subependymal giant cell astrocytoma 28 | 2,287
Carcinoma 27 | 2,147
astrocytic glioma 27 | 2,241
ductal carcinoma in situ 27 | 1,745
interstitial cystitis 26 | 2,299
pancreatic cancer 25 | 2,300
astrocytoma 23 | 1,493
pancreatic ductal adenocarcinoma liver metastasis 23 | 1,795
pituitary cancer 23 | 1,972
cystic fibrosis 21 | 1,665
group 3 medulloblastoma 21 | 2,254
Pick disease 20 | 1,893
Waldenstrons macroglobulinemia 20 | 765
diabetes mellitus 20 | 1,663
dermatomyositis 19 | 933
posterior fossa group A ependymoma 18 | 1,511
adrenocortical carcinoma 17 | 1,427
colon cancer 17 | 1,475
ulcerative colitis 17 | 2,087
Mammary Neoplasms 16 | 410
acute quadriplegic myopathy 16 | 1,157
adult high grade glioma 16 | 2,148
cutaneous lupus erythematosus 16 | 1,056
sonic hedgehog group medulloblastoma 16 | 1,482
HIV Infections 15 | 100
Osteoporosis 15 | 257
Colorectal Neoplasms 13 | 217
Intellectual disability 13 | 573
Rheumatoid Arthritis 13 | 1,160
juvenile dermatomyositis 13 | 1,189
posterior fossa group B ependymoma 13 | 1,530
esophageal adenocarcinoma 12 | 737
primary pancreatic ductal adenocarcinoma 12 | 1,271
Adenoma 11 | 165
medulloblastoma 11 | 1,524
non primary Sjogren syndrome sicca 11 | 840
Alzheimer's disease 10 | 644
Cleft palate 10 | 125
Obesity 10 | 616
acute myeloid leukemia 10 | 780
spina bifida 10 | 1,064
Parkinson's disease 9 | 364
Prostatic Neoplasms 9 | 471
nasopharyngeal carcinoma 9 | 1,056
non-small cell lung carcinoma 9 | 413
primary Sjogren syndrome 9 | 789
tuberculosis 9 | 1,557
tuberculosis and treatment for 6 months 9 | 686
Atopic dermatitis 8 | 944
Colonic Neoplasms 8 | 126
Lung Neoplasms 8 | 171
Schizophrenia 8 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 8 | 499
fibroadenoma 8 | 557
ovarian neoplasm 8 | 97
Duchenne muscular dystrophy 7 | 602
Squamous cell carcinoma of esophagus 7 | 82
aldosterone-producing adenoma 7 | 664
gastric carcinoma 7 | 832
Animal Mammary Neoplasms 6 | 136
Bipolar Disorder 6 | 266
Chronic Lymphocytic Leukemia 6 | 242
Craniofacial Abnormalities 6 | 147
Kidney cancer 6 | 118
Kidney disease 6 | 396
Malignant neoplasm of breast 6 | 63
Mammary Neoplasms, Experimental 6 | 150
Peripheral Neuropathy 6 | 303
Robinow syndrome 6 | 12
Squamous cell carcinoma 6 | 94
Stomach Neoplasms 6 | 282
atypical teratoid/rhabdoid tumor 6 | 1,095
inflammatory breast cancer 6 | 404
non-inflammatory breast cancer 6 | 208
progressive supranuclear palsy 6 | 674

Tissue

Female tissues 197 | 18,647
Male tissues 197 | 17,969
Digestive Tract 196 | 18,473
Endocrine System 196 | 18,512
Nervous System 196 | 18,561
Urinary Tract 196 | 18,444
Blood and immune system 195 | 17,995
Liver and Pancreas 194 | 18,136
Cardiovascular System 193 | 17,958
Respiratory system 193 | 17,484
Skin and soft tissues 188 | 18,115

Target Family

Non-IDG 91 | 11,971
Enzyme 62 | 4,146
Transcription Factor 15 | 1,400
Kinase 11 | 634
Epigenetic 9 | 242
GPCR 9 | 406

Reactome Pathway

TCF dependent signaling in res... 197 | 197
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Glycogen synthase kinase-3 beta GSK3B Tclin Kinase -2.94349 567.7 767
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.21113 124.2 150
26S proteasome non-ATPase regulatory subunit 8 PSMD8 Tbio Enzyme -1.35900 20.6 94
Ubiquitin-40S ribosomal protein S27a RPS27A Tbio Non-IDG 56.7 150
Low-density lipoprotein receptor-related protein 5 LRP5 Tbio Non-IDG -3.06756 1202.0 278
Casein kinase I isoform epsilon CSNK1E Tchem Kinase -1.76876 60.7 272
Histone H2B type 1-C/E/F/G/I HIST1H2BC Tbio Non-IDG -1.35785 22.1 103
E3 ubiquitin-protein ligase RBX1 RBX1 Tbio Enzyme -1.88715 67.2 211
Kelch-like protein 12 KLHL12 Tbio Non-IDG -0.95785 9.67 180
Proteasome activator complex subunit 3 PSME3 Tbio Non-IDG -1.80641 78.9 225