Development Level

Tbio 151 | 11,651
Tchem 26 | 1,388
Tdark 15 | 6,593
Tclin 7 | 612

Collection

Kinase: IDG Consortium (Target... 3 | 125

IMPC Phenotype

preweaning lethality, complete... 16 | 979
decreased vertical activity 6 | 208
increased mean corpuscular vol... 5 | 92
preweaning lethality, incomple... 5 | 499
decreased body weight 4 | 161
embryonic lethality prior to o... 4 | 239
enlarged heart 4 | 210
increased startle reflex 4 | 112
abnormal bone mineralization 3 | 38
abnormal bone structure 3 | 187
abnormal embryo size 3 | 220
abnormal eye morphology 3 | 68
abnormal heart morphology 3 | 162
abnormal kidney morphology 3 | 65
decreased circulating choleste... 3 | 93
decreased circulating total pr... 3 | 49
decreased lymphocyte cell numb... 3 | 83
embryonic lethality prior to t... 3 | 278
increased lean body mass 3 | 172
thrombocytosis 3 | 27
abnormal behavior 2 | 298
abnormal iris morphology 2 | 13
abnormal locomotor behavior 2 | 24
abnormal retina morphology 2 | 71
abnormal seminal vesicle morph... 2 | 114
abnormal testis morphology 2 | 43
cataract 2 | 92
corneal opacity 2 | 32
decreased caudal vertebrae num... 2 | 53
decreased circulating serum al... 2 | 82
decreased total body fat amoun... 2 | 207
decreased total retina thickne... 2 | 17
edema 2 | 59
hydrometra 2 | 53
increased bone mineral density 2 | 72
increased circulating choleste... 2 | 66
increased neutrophil cell numb... 2 | 46
increased total body fat amoun... 2 | 134
mammalian phenotype 2 | 17
microphthalmia 2 | 26
short tibia 2 | 97
small superior vagus ganglion 2 | 74
small testis 2 | 58
abnormal behavioral response t... 1 | 66
abnormal body wall morphology 1 | 9
abnormal cornea morphology 1 | 31
abnormal craniofacial morpholo... 1 | 33
abnormal eye anterior chamber ... 1 | 9
abnormal eyelid morphology 1 | 7
abnormal facial morphology 1 | 17
abnormal forelimb morphology 1 | 2
abnormal head morphology 1 | 10
abnormal head shape 1 | 10
abnormal head size 1 | 6
abnormal hindbrain morphology 1 | 10
abnormal lens morphology 1 | 81
abnormal neural tube closure 1 | 46
abnormal pericardium morpholog... 1 | 26
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal startle reflex 1 | 15
abnormal tail movements 1 | 12
abnormal vibrissa morphology 1 | 25
abnormal vitreous body morphol... 1 | 10
anophthalmia 1 | 33
cardiovascular system phenotyp... 1 | 36
decreased CD4-positive, alpha ... 1 | 7
decreased IgG1 level 1 | 8
decreased T cell number 1 | 15
decreased body length 1 | 101
decreased circulating insulin ... 1 | 76
decreased circulating triglyce... 1 | 79
decreased grip strength 1 | 116
decreased heart left ventricle... 1 | 28
decreased heart weight 1 | 27
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 31
decreased mean platelet volume 1 | 25
decreased neutrophil cell numb... 1 | 42
enlarged lymph nodes 1 | 37
female infertility 1 | 60
hypoactivity 1 | 132
impaired pupillary reflex 1 | 26
increased B cell number 1 | 9
increased T cell number 1 | 6
increased bone mineral content 1 | 108
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating glucose ... 1 | 24
increased circulating magnesiu... 1 | 10
increased heart weight 1 | 62
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased monocyte cell number 1 | 63
narrow eye opening 1 | 12
persistence of hyaloid vascula... 1 | 33
syndactyly 1 | 23

Disease

Carcinoma 124 | 11,493
ovarian cancer 120 | 8,520
psoriasis 94 | 6,694
osteosarcoma 83 | 7,950
lung cancer 76 | 4,740
Cancer 71 | 2,499
glioblastoma 69 | 5,792
Breast cancer 65 | 3,578
medulloblastoma, large-cell 57 | 6,241
atypical teratoid / rhabdoid tumor 56 | 5,112
ependymoma 48 | 4,679
Multiple myeloma 45 | 1,332
group 3 medulloblastoma 42 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 41 | 2,989
invasive ductal carcinoma 41 | 2,951
intraductal papillary-mucinous neoplasm (IPMN) 40 | 3,291
malignant mesothelioma 40 | 3,232
lung adenocarcinoma 38 | 2,716
non-small cell lung cancer 38 | 2,890
primitive neuroectodermal tumor 36 | 3,035
adult high grade glioma 35 | 3,801
breast carcinoma 34 | 1,638
astrocytic glioma 33 | 2,597
oligodendroglioma 33 | 2,850
pancreatic cancer 31 | 2,398
intraductal papillary-mucinous adenoma (IPMA) 30 | 2,955
lung carcinoma 30 | 2,843
Astrocytoma, Pilocytic 29 | 3,081
subependymal giant cell astrocytoma 29 | 2,287
Kidney cancer 27 | 2,613
ductal carcinoma in situ 27 | 1,745
interstitial cystitis 27 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 26 | 1,962
pituitary cancer 23 | 1,972
cystic fibrosis 21 | 1,696
Osteoporosis 20 | 363
Pick disease 20 | 1,894
Waldenstrons macroglobulinemia 20 | 765
group 4 medulloblastoma 20 | 1,855
Intellectual disability 19 | 1,016
dermatomyositis 19 | 966
diabetes mellitus 19 | 1,728
Schizophrenia 18 | 1,160
astrocytoma 18 | 1,146
colon cancer 18 | 1,478
adrenocortical carcinoma 17 | 1,428
Breast Neoplasms 16 | 445
acute quadriplegic myopathy 16 | 1,158
cutaneous lupus erythematosus 16 | 1,057
ulcerative colitis 16 | 1,819
Bipolar Disorder 15 | 666
Cleft Palate 15 | 271
HIV Infections 15 | 102
Mammary Neoplasms 15 | 425
Short stature 15 | 531
tuberculosis 15 | 2,010
pediatric high grade glioma 14 | 1,064
Cognitive delay 13 | 608
Colorectal Neoplasms 13 | 243
Cryptorchidism 13 | 296
Epilepsy 13 | 792
Global developmental delay 13 | 608
Mental and motor retardation 13 | 608
Rheumatoid arthritis 13 | 1,191
Seizures 13 | 596
juvenile dermatomyositis 13 | 1,187
Dull intelligence 12 | 645
Low intelligence 12 | 645
Mental Retardation 12 | 645
Mental deficiency 12 | 645
Poor school performance 12 | 645
esophageal adenocarcinoma 12 | 737
Lymphoid leukemia 11 | 160
Obesity 11 | 678
acute myeloid leukemia 11 | 783
medulloblastoma 11 | 720
non primary Sjogren syndrome sicca 11 | 891
Adenoma 10 | 167
Autosomal recessive predisposition 10 | 1,442
Carcinoma, Squamous Cell 10 | 110
Hypoplastic mandible condyle 10 | 275
Liver Cirrhosis, Experimental 10 | 769
Liver cancer 10 | 604
Mandibular hypoplasia 10 | 275
Micrognathism 10 | 275
Muscle hypotonia 10 | 571
Polycystic ovary syndrome 10 | 360
Small head 10 | 374
Stomach Neoplasms 10 | 300
Strabismus 10 | 270
spina bifida 10 | 1,074
Broad flat nasal bridge 9 | 236
Congenital hypoplasia of penis 9 | 176
Immune system cancer 9 | 140
Nasal bridge wide 9 | 236
Orbital separation excessive 9 | 244
Prostatic Neoplasms 9 | 495
nasopharyngeal carcinoma 9 | 1,058
primary Sjogren syndrome 9 | 735
primary pancreatic ductal adenocarcinoma 9 | 1,109

Tissue

Endocrine System 196 | 18,159
Digestive Tract 193 | 17,369
Female tissues 193 | 17,400
Nervous System 192 | 16,725
Blood and immune system 191 | 16,909
Male tissues 190 | 17,142
Skin and soft tissues 190 | 17,230
Urinary Tract 188 | 16,678
Respiratory system 187 | 16,393
Liver and Pancreas 186 | 16,750
Cardiovascular System 181 | 15,192

Target Family

Non-IDG 93 | 12,091
Enzyme 62 | 4,145
Transcription Factor 16 | 1,400
Kinase 10 | 634
Epigenetic 9 | 242
GPCR 9 | 408

Reactome Pathway

TCF dependent signaling in res... 199 | 199
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform PPP2R1B Tbio Enzyme -1.20793 16.9 203
Runt-related transcription factor 3 RUNX3 Tbio Transcription Factor -2.71721 536.2 438
Wnt inhibitory factor 1 WIF1 Tbio Non-IDG -2.11284 143.2 350
26S proteasome regulatory subunit 6A PSMC3 Tbio Enzyme -1.29086 19.3 302
RNA polymerase-associated protein LEO1 LEO1 Tbio Enzyme -2.07251 114.4 293
Pygopus homolog 2 PYGO2 Tbio Epigenetic -1.26911 24.4 92
Chromodomain-helicase-DNA-binding protein 8 CHD8 Tbio Epigenetic -1.64766 47.4 81
Pygopus homolog 1 PYGO1 Tdark Epigenetic -0.48368 2.66 135
B-cell CLL/lymphoma 9-like protein BCL9L Tbio Non-IDG -1.02513 10.8 100
Protein chibby homolog 1 CBY1 Tbio Non-IDG -2.29880 197.7 79